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Items: 1 to 50 of 88

1.

Pharmacological Antagonism of T-Type Calcium Channels Constrains Rebound Burst Firing in Two Distinct Subpopulations of GABA Neurons in the Rat Ventral Tegmental Area: Implications for α-Lipoic Acid.

Woodward TJ, Tesic V, Stamenic TT, Jevtovic-Todorovic V, Todorovic SM.

Front Pharmacol. 2019 Nov 26;10:1402. doi: 10.3389/fphar.2019.01402. eCollection 2019.

2.

Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain.

Joksimovic SL, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM.

Br J Pharmacol. 2019 Nov 15. doi: 10.1111/bph.14930. [Epub ahead of print]

PMID:
31732978
3.

A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca2+ channels.

Chemin J, Stamenic TT, Cazade M, Llinares J, Blesneac I, Todorovic SM, Lory P.

Sci Rep. 2019 Oct 30;9(1):15642. doi: 10.1038/s41598-019-52194-6.

4.

The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development.

Joksimovic SM, DiGruccio MR, Boscolo A, Jevtovic-Todorovic V, Todorovic SM.

Mol Neurobiol. 2020 Jan;57(1):208-216. doi: 10.1007/s12035-019-01770-y. Epub 2019 Sep 6.

PMID:
31493241
5.

Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum.

Joksimovic SM, Izumi Y, Joksimovic SL, Tesic V, Krishnan K, Asnake B, Jevtovic-Todorovic V, Covey DF, Zorumski CF, Todorovic SM.

Br J Anaesth. 2019 May;122(5):643-651. doi: 10.1016/j.bja.2019.01.029. Epub 2019 Feb 28.

PMID:
30916017
6.

Neonatal general anesthesia causes lasting alterations in excitatory and inhibitory synaptic transmission in the ventrobasal thalamus of adolescent female rats.

Woodward TJ, Timic Stamenic T, Todorovic SM.

Neurobiol Dis. 2019 Jul;127:472-481. doi: 10.1016/j.nbd.2019.01.016. Epub 2019 Feb 28.

PMID:
30825640
7.

Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia.

Timic Stamenic T, Feseha S, Valdez R, Zhao W, Klawitter J, Todorovic SM.

Cereb Cortex. 2019 Dec 17;29(11):4679-4696. doi: 10.1093/cercor/bhz002.

PMID:
30715245
8.

Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision.

Joksimovic SL, Donald RR, Park JY, Todorovic SM.

Channels (Austin). 2019 Dec;13(1):48-61. doi: 10.1080/19336950.2018.1564420.

9.

Neurosteroids in Pain Management: A New Perspective on an Old Player.

Joksimovic SL, Covey DF, Jevtovic-Todorovic V, Todorovic SM.

Front Pharmacol. 2018 Oct 2;9:1127. doi: 10.3389/fphar.2018.01127. eCollection 2018. Review.

10.

Selective inhibition of CaV3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain.

Joksimovic SL, Joksimovic SM, Tesic V, García-Caballero A, Feseha S, Zamponi GW, Jevtovic-Todorovic V, Todorovic SM.

Sci Signal. 2018 Aug 28;11(545). pii: eaao4425. doi: 10.1126/scisignal.aao4425.

11.

CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons.

Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM.

Neuropharmacology. 2018 Jun;135:343-354. doi: 10.1016/j.neuropharm.2018.03.028. Epub 2018 Mar 23.

12.

A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain.

Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V.

Br J Anaesth. 2018 Apr;120(4):768-778. doi: 10.1016/j.bja.2017.12.039. Epub 2018 Feb 9.

13.

Cytosolic ATP Relieves Voltage-Dependent Inactivation of T-Type Calcium Channels and Facilitates Excitability of Neurons in the Rat Central Medial Thalamus.

Stamenic TT, Todorovic SM.

eNeuro. 2018 Feb 15;5(1). pii: ENEURO.0016-18.2018. doi: 10.1523/ENEURO.0016-18.2018. eCollection 2018 Jan-Feb.

14.

Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus.

Joksimovic SM, Osuru HP, Oklopcic A, Beenhakker MP, Jevtovic-Todorovic V, Todorovic SM.

Mol Neurobiol. 2018 Jan;55(1):222-228. doi: 10.1007/s12035-017-0735-8.

15.

The role of T-type calcium channels in the subiculum: to burst or not to burst?

Joksimovic SM, Eggan P, Izumi Y, Joksimovic SL, Tesic V, Dietz RM, Orfila JE, DiGruccio MR, Herson PS, Jevtovic-Todorovic V, Zorumski CF, Todorovic SM.

J Physiol. 2017 Oct 1;595(19):6327-6348. doi: 10.1113/JP274565. Epub 2017 Aug 18.

16.

Painful Diabetic Neuropathy: Prevention or Suppression?

Todorovic SM.

Int Rev Neurobiol. 2016;127:211-25. doi: 10.1016/bs.irn.2016.03.005. Epub 2016 Apr 2. Review.

17.

General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus.

Dalla Massara L, Osuru HP, Oklopcic A, Milanovic D, Joksimovic SM, Caputo V, DiGruccio MR, Ori C, Wang G, Todorovic SM, Jevtovic-Todorovic V.

Anesthesiology. 2016 Jun;124(6):1311-1327. doi: 10.1097/ALN.0000000000001111.

18.

Is Diabetic Nerve Pain Caused by Dysregulated Ion Channels in Sensory Neurons?

Todorovic SM.

Diabetes. 2015 Dec;64(12):3987-9. doi: 10.2337/dbi15-0006. No abstract available.

19.

Redox and trace metal regulation of ion channels in the pain pathway.

Evans JG, Todorovic SM.

Biochem J. 2015 Sep 15;470(3):275-80. doi: 10.1042/BJ20150522. Review.

20.

CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy.

Wang G, Bochorishvili G, Chen Y, Salvati KA, Zhang P, Dubel SJ, Perez-Reyes E, Snutch TP, Stornetta RL, Deisseroth K, Erisir A, Todorovic SM, Luo JH, Kapur J, Beenhakker MP, Zhu JJ.

Genes Dev. 2015 Jul 15;29(14):1535-51. doi: 10.1101/gad.260869.115.

21.

Silencing the α2 subunit of γ-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injury.

Obradovic AL, Scarpa J, Osuru HP, Weaver JL, Park JY, Pathirathna S, Peterkin A, Lim Y, Jagodic MM, Todorovic SM, Jevtovic-Todorovic V.

Anesthesiology. 2015 Sep;123(3):654-67. doi: 10.1097/ALN.0000000000000767.

22.

Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus.

Joksovic PM, Lunardi N, Jevtovic-Todorovic V, Todorovic SM.

Mol Neurobiol. 2015 Oct;52(2):952-8. doi: 10.1007/s12035-015-9247-6. Epub 2015 Jun 6.

23.

Hyperexcitability of rat thalamocortical networks after exposure to general anesthesia during brain development.

DiGruccio MR, Joksimovic S, Joksovic PM, Lunardi N, Salajegheh R, Jevtovic-Todorovic V, Beenhakker MP, Goodkin HP, Todorovic SM.

J Neurosci. 2015 Jan 28;35(4):1481-92. doi: 10.1523/JNEUROSCI.4883-13.2015.

24.

Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone.

Ayoola C, Hwang SM, Hong SJ, Rose KE, Boyd C, Bozic N, Park JY, Osuru HP, DiGruccio MR, Covey DF, Jevtovic-Todorovic V, Todorovic SM.

Psychopharmacology (Berl). 2014 Sep;231(17):3503-3515. doi: 10.1007/s00213-014-3588-0. Epub 2014 May 7.

25.

CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy.

Obradovic ALj, Hwang SM, Scarpa J, Hong SJ, Todorovic SM, Jevtovic-Todorovic V.

PLoS One. 2014 Apr 4;9(4):e91467. doi: 10.1371/journal.pone.0091467. eCollection 2014.

26.

Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy.

Todorovic SM, Jevtovic-Todorovic V.

Pflugers Arch. 2014 Apr;466(4):701-6. doi: 10.1007/s00424-014-1452-z. Epub 2014 Jan 31. Review.

PMID:
24482063
27.

Redox regulation of neuronal voltage-gated calcium channels.

Todorovic SM, Jevtovic-Todorovic V.

Antioxid Redox Signal. 2014 Aug 20;21(6):880-91. doi: 10.1089/ars.2013.5610. Epub 2013 Oct 25. Review.

28.

Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse.

Rose KE, Lunardi N, Boscolo A, Dong X, Erisir A, Jevtovic-Todorovic V, Todorovic SM.

Neuroscience. 2013 Oct 10;250:263-74. doi: 10.1016/j.neuroscience.2013.07.005. Epub 2013 Jul 15.

29.

Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels.

Orestes P, Osuru HP, McIntire WE, Jacus MO, Salajegheh R, Jagodic MM, Choe W, Lee J, Lee SS, Rose KE, Poiro N, Digruccio MR, Krishnan K, Covey DF, Lee JH, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM.

Diabetes. 2013 Nov;62(11):3828-38. doi: 10.2337/db13-0813. Epub 2013 Jul 8.

30.

Redox mechanism of S-nitrosothiol modulation of neuronal CaV3.2 T-type calcium channels.

Lee J, Nelson MT, Rose KE, Todorovic SM.

Mol Neurobiol. 2013 Oct;48(2):274-80. doi: 10.1007/s12035-013-8493-8. Epub 2013 Jun 28.

31.

Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling.

Todorovic SM, Jevtovic-Todorovic V.

Pflugers Arch. 2013 Jul;465(7):921-7. doi: 10.1007/s00424-012-1211-y. Epub 2013 Jan 16. Review.

PMID:
23322114
32.

Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons.

Jacus MO, Uebele VN, Renger JJ, Todorovic SM.

J Neurosci. 2012 Jul 4;32(27):9374-82. doi: 10.1523/JNEUROSCI.0068-12.2012.

33.

Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane.

Eckle VS, Digruccio MR, Uebele VN, Renger JJ, Todorovic SM.

Neuropharmacology. 2012 Aug;63(2):266-73. doi: 10.1016/j.neuropharm.2012.03.018. Epub 2012 Apr 2.

34.

Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels.

Shcheglovitov A, Vitko I, Lazarenko RM, Orestes P, Todorovic SM, Perez-Reyes E.

J Gen Physiol. 2012 Mar;139(3):219-34. doi: 10.1085/jgp.201110699. Erratum in: J Gen Physiol. 2012 May;139(5):389.

35.

General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain.

Sanchez V, Feinstein SD, Lunardi N, Joksovic PM, Boscolo A, Todorovic SM, Jevtovic-Todorovic V.

Anesthesiology. 2011 Nov;115(5):992-1002. doi: 10.1097/ALN.0b013e3182303a63.

36.

TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent.

Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM.

Mol Pharmacol. 2011 Nov;80(5):900-10. doi: 10.1124/mol.111.073205. Epub 2011 Aug 5.

37.

T-type voltage-gated calcium channels as targets for the development of novel pain therapies.

Todorovic SM, Jevtovic-Todorovic V.

Br J Pharmacol. 2011 Jun;163(3):484-95. doi: 10.1111/j.1476-5381.2011.01256.x. Review.

38.

Are neuronal voltage-gated calcium channels valid cellular targets for general anesthetics?

Orestes P, Todorovic SM.

Channels (Austin). 2010 Nov-Dec;4(6):518-22. Epub 2010 Nov 1. Review.

39.

Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway.

Orestes P, Bojadzic D, Lee J, Leach E, Salajegheh R, Digruccio MR, Nelson MT, Todorovic SM.

J Physiol. 2011 Jan 1;589(Pt 1):135-48. doi: 10.1113/jphysiol.2010.196220. Epub 2010 Nov 8.

40.

Isoflurane modulates neuronal excitability of the nucleus reticularis thalami in vitro.

Joksovic PM, Todorovic SM.

Ann N Y Acad Sci. 2010 Jun;1199:36-42. doi: 10.1111/j.1749-6632.2009.05172.x.

41.

Mechanisms of inhibition of CaV3.1 T-type calcium current by aliphatic alcohols.

Eckle VS, Todorovic SM.

Neuropharmacology. 2010 Jul-Aug;59(1-2):58-69. doi: 10.1016/j.neuropharm.2010.03.016. Epub 2010 Apr 2.

42.

A modeling study of T-type Ca2+ channel gating and modulation by L-cysteine in rat nociceptors.

Nelson MT, Milescu LS, Todorovic SM, Scroggs RS.

Biophys J. 2010 Jan 20;98(2):197-206. doi: 10.1016/j.bpj.2009.10.007.

43.

Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway.

Joksovic PM, Choe WJ, Nelson MT, Orestes P, Brimelow BC, Todorovic SM.

Mol Pharmacol. 2010 Jan;77(1):87-94. doi: 10.1124/mol.109.059931. Epub 2009 Oct 21.

44.

[What do we know about anesthetic mechanisms?: hypnosis, unresponsiveness to surgical incision and amnesia].

Eckle VS, Hucklenbruch C, Todorovic SM.

Anaesthesist. 2009 Nov;58(11):1144-9. doi: 10.1007/s00101-009-1618-9. Review. German.

45.

Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice.

Latham JR, Pathirathna S, Jagodic MM, Choe WJ, Levin ME, Nelson MT, Lee WY, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V.

Diabetes. 2009 Nov;58(11):2656-65. doi: 10.2337/db08-1763. Epub 2009 Aug 3.

46.

Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway.

Lee WY, Orestes P, Latham J, Naik AK, Nelson MT, Vitko I, Perez-Reyes E, Jevtovic-Todorovic V, Todorovic SM.

J Neurosci. 2009 Jul 29;29(30):9500-9. doi: 10.1523/JNEUROSCI.5803-08.2009.

47.

Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?

Jevtovic-Todorovic V, Covey DF, Todorovic SM.

Psychoneuroendocrinology. 2009 Dec;34 Suppl 1:S178-85. doi: 10.1016/j.psyneuen.2009.06.001.

48.

In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy.

Messinger RB, Naik AK, Jagodic MM, Nelson MT, Lee WY, Choe WJ, Orestes P, Latham JR, Todorovic SM, Jevtovic-Todorovic V.

Pain. 2009 Sep;145(1-2):184-95. doi: 10.1016/j.pain.2009.06.012. Epub 2009 Jul 3.

49.

Isoflurane-sensitive presynaptic R-type calcium channels contribute to inhibitory synaptic transmission in the rat thalamus.

Joksovic PM, Weiergräber M, Lee W, Struck H, Schneider T, Todorovic SM.

J Neurosci. 2009 Feb 4;29(5):1434-45. doi: 10.1523/JNEUROSCI.5574-08.2009.

50.

Role of voltage-gated calcium channels in ascending pain pathways.

Zamponi GW, Lewis RJ, Todorovic SM, Arneric SP, Snutch TP.

Brain Res Rev. 2009 Apr;60(1):84-9. doi: 10.1016/j.brainresrev.2008.12.021. Epub 2008 Dec 31. Review.

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