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Items: 1 to 50 of 65

1.

Targeting EGFR and uPAR on human rhabdomyosarcoma, osteosarcoma, and ovarian adenocarcinoma with a bispecific ligand-directed toxin.

Oh F, Todhunter D, Taras E, Vallera DA, Borgatti A.

Clin Pharmacol. 2018 Sep 26;10:113-121. doi: 10.2147/CPAA.S160262. eCollection 2018.

2.

Development of a Deimmunized Bispecific Immunotoxin dDT2219 against B-Cell Malignancies.

Schmohl JU, Todhunter D, Taras E, Bachanova V, Vallera DA.

Toxins (Basel). 2018 Jan 6;10(1). pii: E32. doi: 10.3390/toxins10010032.

3.

Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR.

Borgatti A, Koopmeiners JS, Sarver AL, Winter AL, Stuebner K, Todhunter D, Rizzardi AE, Henriksen JC, Schmechel S, Forster CL, Kim JH, Froelich J, Walz J, Henson MS, Breen M, Lindblad-Toh K, Oh F, Pilbeam K, Modiano JF, Vallera DA.

Mol Cancer Ther. 2017 May;16(5):956-965. doi: 10.1158/1535-7163.MCT-16-0637. Epub 2017 Feb 13.

4.

Tetraspecific scFv construct provides NK cell mediated ADCC and self-sustaining stimuli via insertion of IL-15 as a cross-linker.

Schmohl JU, Felices M, Todhunter D, Taras E, Miller JS, Vallera DA.

Oncotarget. 2016 Nov 8;7(45):73830-73844. doi: 10.18632/oncotarget.12073.

5.

Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development.

Schmohl JU, Todhunter D, Oh S, Vallera DA.

Toxins (Basel). 2015 Oct 10;7(10):4067-82. doi: 10.3390/toxins7104067.

6.

Bispecific and trispecific killer cell engagers directly activate human NK cells through CD16 signaling and induce cytotoxicity and cytokine production.

Gleason MK, Verneris MR, Todhunter DA, Zhang B, McCullar V, Zhou SX, Panoskaltsis-Mortari A, Weiner LM, Vallera DA, Miller JS.

Mol Cancer Ther. 2012 Dec;11(12):2674-84. doi: 10.1158/1535-7163.MCT-12-0692. Epub 2012 Oct 17.

7.

A deimmunized bispecific ligand-directed toxin that shows an impressive anti-pancreatic cancer effect in a systemic nude mouse orthotopic model.

Oh S, Todhunter DA, Panoskaltsis-Mortari A, Buchsbaum DJ, Toma S, Vallera DA.

Pancreas. 2012 Jul;41(5):789-96. doi: 10.1097/MPA.0b013e31823b5f2e.

8.

Intracranial elimination of human glioblastoma brain tumors in nude rats using the bispecific ligand-directed toxin, DTEGF13 and convection enhanced delivery.

Oh S, Ohlfest JR, Todhunter DA, Vallera VD, Hall WA, Chen H, Vallera DA.

J Neurooncol. 2009 Dec;95(3):331-342. doi: 10.1007/s11060-009-9932-2. Epub 2009 Jun 11.

PMID:
19517064
9.

Intracranial therapy of glioblastoma with the fusion protein DTAT in immunodeficient mice.

Rustamzadeh E, Hall WA, Todhunter DA, Vallera VD, Low WC, Liu H, Panoskaltsis-Mortari A, Vallera DA.

Int J Cancer. 2007 Jan 15;120(2):411-9.

10.

Intracranial therapy of glioblastoma with the fusion protein DTIL13 in immunodeficient mice.

Rustamzadeh E, Hall WA, Todhunter DA, Low WC, Liu H, Panoskaltsis-Mortari A, Vallera DA.

Int J Cancer. 2006 May 15;118(10):2594-601.

11.

Immunotoxin pharmacokinetics: a comparison of the anti-glioblastoma bi-specific fusion protein (DTAT13) to DTAT and DTIL13.

Rustamzadeh E, Vallera DA, Todhunter DA, Low WC, Panoskaltsis-Mortari A, Hall WA.

J Neurooncol. 2006 May;77(3):257-66.

PMID:
16314943
12.

A bispecific recombinant immunotoxin, DT2219, targeting human CD19 and CD22 receptors in a mouse xenograft model of B-cell leukemia/lymphoma.

Vallera DA, Todhunter DA, Kuroki DW, Shu Y, Sicheneder A, Chen H.

Clin Cancer Res. 2005 May 15;11(10):3879-88.

13.

Molecular modification of a recombinant, bivalent anti-human CD3 immunotoxin (Bic3) results in reduced in vivo toxicity in mice.

Vallera DA, Todhunter D, Kuroki DW, Shu Y, Sicheneder A, Panoskaltsis-Mortari A, Vallera VD, Chen H.

Leuk Res. 2005 Mar;29(3):331-41.

PMID:
15661270
14.

A bispecific immunotoxin (DTAT13) targeting human IL-13 receptor (IL-13R) and urokinase-type plasminogen activator receptor (uPAR) in a mouse xenograft model.

Todhunter DA, Hall WA, Rustamzadeh E, Shu Y, Doumbia SO, Vallera DA.

Protein Eng Des Sel. 2004 Feb;17(2):157-64. Epub 2004 Feb 13.

PMID:
15047912
15.

Targeting glioblastoma multiforme with an IL-13/diphtheria toxin fusion protein in vitro and in vivo in nude mice.

Li C, Hall WA, Jin N, Todhunter DA, Panoskaltsis-Mortari A, Vallera DA.

Protein Eng. 2002 May;15(5):419-27.

PMID:
12034862
16.
17.
18.

Antigenic crossreactivity and lipopolysaccharide neutralization properties of bovine immunoglobulin G.

Tomita GM, Todhunter DA, Hogan JS, Smith KL.

J Dairy Sci. 1995 Dec;78(12):2745-52.

19.

Efficacy of a barrier teat dip containing .55% chlorhexidine for prevention of bovine mastitis.

Hogan JS, Smith KL, Todhunter DA, Schoenberger PS.

J Dairy Sci. 1995 Nov;78(11):2502-6.

20.

Environmental streptococcal intramammary infections of the bovine mammary gland.

Todhunter DA, Smith KL, Hogan JS.

J Dairy Sci. 1995 Nov;78(11):2366-74.

21.

Immunization of dairy cows with an Escherichia coli J5 lipopolysaccharide vaccine.

Tomita GM, Todhunter DA, Hogan JS, Smith KL.

J Dairy Sci. 1995 Oct;78(10):2178-85.

22.

Efficacy of recombinant bovine interleukin-2 as an adjunct to dry cow therapy.

Hogan JS, Smith KL, Todhunter DA, Schoenberger PS, Shuster D.

J Dairy Sci. 1995 May;78(5):1062-7.

23.

Effects of an Escherichia coli J5 vaccine on mild clinical coliform mastitis.

Hogan JS, Weiss WP, Smith KL, Todhunter DA, Schoenberger PS, Sordillo LM.

J Dairy Sci. 1995 Feb;78(2):285-90.

24.

Efficacy of dry cow therapy and a Propionibacterium acnes product in herds with low somatic cell count.

Hogan JS, Smith KL, Todhunter DA, Schoenberger PS, Dinsmore RP, Canttell MB, Gabel CS.

J Dairy Sci. 1994 Nov;77(11):3331-7.

25.

Therapy of experimentally induced coliform mastitis with a Propionibacterium acnes product.

Hogan JS, Smith KL, Todhunter DA, Schoenberger PS.

J Dairy Sci. 1994 Feb;77(2):462-7.

26.

Association of abnormal uterine discharge with new intramammary infection in the early postpartum period in multiparous dairy cows.

Epperson WB, Hoblet KH, Smith KL, Hogan JS, Todhunter DA.

J Am Vet Med Assoc. 1993 May 1;202(9):1461-4.

PMID:
8496101
27.

Characteristics of coagulase-negative Staphylococci isolated from bovine intramammary infections.

Todhunter DA, Cantwell LL, Smith KL, Hoblet KH, Hogan JS.

Vet Microbiol. 1993 Apr;34(4):373-80.

PMID:
8506610
28.

Growth responses of coliform bacteria to recombinant bovine cytokines.

Hogan JS, Todhunter DA, Smith KL, Schoenberger PS, Sordillo LM.

J Dairy Sci. 1993 Apr;76(4):978-82.

29.

Vitamin E as an adjuvant in an Escherichia coli J5 vaccine.

Hogan JS, Weiss WP, Smith KL, Todhunter DA, Schoenberger PS, Williams SN.

J Dairy Sci. 1993 Feb;76(2):401-7.

30.

Effect of supplementing periparturient cows with vitamin E on distribution of alpha-tocopherol in blood.

Weiss WP, Hogan JS, Smith KL, Todhunter DA, Williams SN.

J Dairy Sci. 1992 Dec;75(12):3479-85.

31.

Susceptibility of Escherichia coli isolated from intramammary infections to phagocytosis by bovine neutrophils.

Hogan JS, Todhunter DA, Smith KL, Schoenberger PS, Wilson RA.

J Dairy Sci. 1992 Dec;75(12):3324-9.

32.

Efficacy of an Escherichia coli J5 mastitis vaccine in an experimental challenge trial.

Hogan JS, Weiss WP, Todhunter DA, Smith KL, Schoenberger PS.

J Dairy Sci. 1992 Feb;75(2):415-22.

33.

Bovine neutrophil responses to parenteral vitamin E.

Hogan JS, Weiss WP, Todhunter DA, Smith KL, Schoenberger PS.

J Dairy Sci. 1992 Feb;75(2):399-405.

34.

Field trial to determine efficacy of an Escherichia coli J5 mastitis vaccine.

Hogan JS, Smith KL, Todhunter DA, Schoenberger PS.

J Dairy Sci. 1992 Jan;75(1):78-84.

35.

Opsonic activity of bovine serum and mammary secretion after Escherichia coli J5 vaccination.

Hogan JS, Todhunter DA, Tomita GM, Smith KL, Schoenberger PS.

J Dairy Sci. 1992 Jan;75(1):72-7.

36.

Comparison of probiotic and antibiotic intramammary therapy of cattle with elevated somatic cell counts.

Greene WA, Gano AM, Smith KL, Hogan JS, Todhunter DA.

J Dairy Sci. 1991 Sep;74(9):2976-81.

37.

Costs associated with selected preventive practices and with episodes of clinical mastitis in nine herds with low somatic cell counts.

Hoblet KH, Schnitkey GD, Arbaugh D, Hogan JS, Smith KL, Schoenberger PS, Todhunter DA, Hueston WD, Pritchard DE, Bowman GL, et al.

J Am Vet Med Assoc. 1991 Jul 15;199(2):190-6.

PMID:
1890027
38.

Serratia species isolated from bovine intramammary infections.

Todhunter DA, Smith KL, Hogan JS.

J Dairy Sci. 1991 Jun;74(6):1860-5.

39.

Antibodies to iron-regulated outer membrane proteins of coliform bacteria isolated from bovine intramammary infections.

Todhunter DA, Smith KL, Hogan JS.

Vet Immunol Immunopathol. 1991 Apr;28(2):107-15.

PMID:
1866891
40.

Intramammary challenge with Escherichia coli following immunization with a curli-producing Escherichia coli.

Todhunter DA, Smith KL, Hogan JS, Nelson L.

J Dairy Sci. 1991 Mar;74(3):819-25.

41.

Gram-negative bacterial infections of the mammary gland in cows.

Todhunter DA, Smith KL, Hogan JS, Schoenberger PS.

Am J Vet Res. 1991 Feb;52(2):184-8.

PMID:
2012328
42.

Effect of duration of supplementation of selenium and vitamin E on periparturient dairy cows.

Weiss WP, Todhunter DA, Hogan JS, Smith KL.

J Dairy Sci. 1990 Nov;73(11):3187-94.

43.

Hemagglutination and hemolysis by Escherichia coli isolated from bovine intramammary infections.

Hogan JS, Todhunter DA, Smith KL, Schoenberger PS.

J Dairy Sci. 1990 Nov;73(11):3126-31.

44.

Relationships among vitamin E, selenium, and bovine blood neutrophils.

Hogan JS, Smith KL, Weiss WP, Todhunter DA, Schockey WL.

J Dairy Sci. 1990 Sep;73(9):2372-8.

45.

Bacterial counts associated with recycled newspaper bedding.

Hogan JS, Smith KL, Todhunter DA, Schoenberger PS.

J Dairy Sci. 1990 Jul;73(7):1756-61.

46.
47.

Growth of gram-negative bacteria in dry cow secretion.

Todhunter D, Smith KL, Hogan JS.

J Dairy Sci. 1990 Feb;73(2):363-72.

48.

Collaborative Study to Determine Effects of Milk Composition on Somatic Cell Counts.

Hogan JS, Smith KL, Todhunter DA, Schoenberger PS.

J Food Prot. 1990 Jan;53(1):67-71. doi: 10.4315/0362-028X-53.1.67.

PMID:
31003315
49.

Serum susceptibility of coliforms isolated from bovine intramammary infections.

Hogan JS, Todhunter DA, Smith KL, Schoenberger PS.

J Dairy Sci. 1989 Jul;72(7):1893-9.

50.

Field survey of clinical mastitis in low somatic cell count herds.

Hogan JS, Smith KL, Hoblet KH, Schoenberger PS, Todhunter DA, Hueston WD, Pritchard DE, Bowman GL, Heider LE, Brockett BL, et al.

J Dairy Sci. 1989 Jun;72(6):1547-56.

PMID:
2760314

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