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Items: 1 to 50 of 194

1.

Endogenous production of n-3 long-chain polyunsaturated fatty acids from first feeding and the influence of dietary linoleic acid and the α-linolenic:linoleic ratio in Atlantic salmon (Salmo salar).

Sprague M, Xu G, Betancor MB, Olsen RE, Torrissen O, Glencross BD, Tocher DR.

Br J Nutr. 2019 Aug 14:1-32. doi: 10.1017/S0007114519001946. [Epub ahead of print]

PMID:
31409428
2.

Functional diversification of teleost Fads2 fatty acyl desaturases occurs independently of the trophic level.

Garrido D, Kabeya N, Betancor MB, Pérez JA, Acosta NG, Tocher DR, Rodríguez C, Monroig Ó.

Sci Rep. 2019 Aug 1;9(1):11199. doi: 10.1038/s41598-019-47709-0.

3.

MicroRNAs Involved in the Regulation of LC-PUFA Biosynthesis in Teleosts: miR-33 Enhances LC-PUFA Biosynthesis in Siganus canaliculatus by Targeting insig1 which in Turn Upregulates srebp1.

Sun JJ, Zheng LG, Chen CY, Zhang JY, You CH, Zhang QH, Ma HY, Monroig Ó, Tocher DR, Wang SQ, Li YY.

Mar Biotechnol (NY). 2019 Aug;21(4):475-487. doi: 10.1007/s10126-019-09895-w. Epub 2019 Apr 24.

PMID:
31020472
4.

Biosynthesis of long-chain polyunsaturated fatty acids in the razor clam Sinonovacula constricta: Characterization of four fatty acyl elongases and a novel desaturase capacity.

Ran Z, Xu J, Liao K, Monroig Ó, Navarro JC, Oboh A, Jin M, Zhou Q, Zhou C, Tocher DR, Yan X.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1083-1090. doi: 10.1016/j.bbalip.2019.04.004. Epub 2019 Apr 16.

PMID:
31002943
5.

miR-24 is involved in vertebrate LC-PUFA biosynthesis as demonstrated in marine teleost Siganus canaliculatus.

Chen C, Wang S, Zhang M, Chen B, You C, Xie D, Liu Y, Monroig Ó, Tocher DR, Waiho K, Li Y.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):619-628. doi: 10.1016/j.bbalip.2019.01.010. Epub 2019 Jan 23.

PMID:
30684680
6.

Omega-3 Long-Chain Polyunsaturated Fatty Acids, EPA and DHA: Bridging the Gap between Supply and Demand.

Tocher DR, Betancor MB, Sprague M, Olsen RE, Napier JA.

Nutrients. 2019 Jan 4;11(1). pii: E89. doi: 10.3390/nu11010089. Review.

7.

Impact of Dietary Carbohydrate/Protein Ratio on Hepatic Metabolism in Land-Locked Atlantic Salmon (Salmo salar L.).

Betancor MB, Olsen RE, Marandel L, Skulstad OF, Madaro A, Tocher DR, Panserat S.

Front Physiol. 2018 Dec 6;9:1751. doi: 10.3389/fphys.2018.01751. eCollection 2018.

8.

Update on GM canola crops as novel sources of omega-3 fish oils.

Napier JA, Olsen RE, Tocher DR.

Plant Biotechnol J. 2019 Apr;17(4):703-705. doi: 10.1111/pbi.13045. Epub 2018 Dec 13. No abstract available.

9.

Performance, feed utilization, and hepatic metabolic response of weaned juvenile Atlantic bluefin tuna (Thunnus thynnus L.): effects of dietary lipid level and source.

Betancor MB, Ortega A, de la Gándara F, Tocher DR, Mourente G.

Fish Physiol Biochem. 2019 Apr;45(2):697-718. doi: 10.1007/s10695-018-0587-9. Epub 2018 Nov 23.

10.

Mass Production of Lemna minor and Its Amino Acid and Fatty Acid Profiles.

Chakrabarti R, Clark WD, Sharma JG, Goswami RK, Shrivastav AK, Tocher DR.

Front Chem. 2018 Oct 15;6:479. doi: 10.3389/fchem.2018.00479. eCollection 2018.

11.

The effect of micronutrient supplementation on growth and hepatic metabolism in diploid and triploid Atlantic salmon (Salmo salar) parr fed a low marine ingredient diet.

Taylor JF, Vera LM, De Santis C, Lock EJ, Espe M, Skjærven KH, Leeming D, Del Pozo J, Mota-Velasco J, Migaud H, Hamre K, Tocher DR.

Comp Biochem Physiol B Biochem Mol Biol. 2019 Jan;227:106-121. doi: 10.1016/j.cbpb.2018.10.004. Epub 2018 Oct 24.

PMID:
30367964
12.

Retention of fatty acyl desaturase 1 (fads1) in Elopomorpha and Cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates.

Lopes-Marques M, Kabeya N, Qian Y, Ruivo R, Santos MM, Venkatesh B, Tocher DR, Castro LFC, Monroig Ó.

BMC Evol Biol. 2018 Oct 19;18(1):157. doi: 10.1186/s12862-018-1271-5.

13.

Pparγ Is Involved in the Transcriptional Regulation of Liver LC-PUFA Biosynthesis by Targeting the Δ6Δ5 Fatty Acyl Desaturase Gene in the Marine Teleost Siganus canaliculatus.

Li Y, Yin Z, Dong Y, Wang S, Monroig Ó, Tocher DR, You C.

Mar Biotechnol (NY). 2019 Feb;21(1):19-29. doi: 10.1007/s10126-018-9854-0. Epub 2018 Sep 11.

PMID:
30206714
14.

Oil from transgenic Camelina sativa containing over 25 % n-3 long-chain PUFA as the major lipid source in feed for Atlantic salmon (Salmo salar).

Betancor MB, Li K, Bucerzan VS, Sprague M, Sayanova O, Usher S, Han L, Norambuena F, Torrissen O, Napier JA, Tocher DR, Olsen RE.

Br J Nutr. 2018 Jun;119(12):1378-1392. doi: 10.1017/S0007114518001125.

PMID:
29845899
15.

Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals.

Kabeya N, Fonseca MM, Ferrier DEK, Navarro JC, Bay LK, Francis DS, Tocher DR, Castro LFC, Monroig Ó.

Sci Adv. 2018 May 2;4(5):eaar6849. doi: 10.1126/sciadv.aar6849. eCollection 2018 May.

16.

Characteristics of the fads2 gene promoter in marine teleost Epinephelus coioides and role of Sp1-binding site in determining promoter activity.

Xie D, Fu Z, Wang S, You C, Monroig Ó, Tocher DR, Li Y.

Sci Rep. 2018 Mar 28;8(1):5305. doi: 10.1038/s41598-018-23668-w.

17.

Hnf4α is involved in the regulation of vertebrate LC-PUFA biosynthesis: insights into the regulatory role of Hnf4α on expression of liver fatty acyl desaturases in the marine teleost Siganus canaliculatus.

Wang S, Chen J, Jiang D, Zhang Q, You C, Tocher DR, Monroig Ó, Dong Y, Li Y.

Fish Physiol Biochem. 2018 Jun;44(3):805-815. doi: 10.1007/s10695-018-0470-8. Epub 2018 Jan 19.

PMID:
29352428
18.

Cloning and characterization of ∆6/∆5 fatty acyl desaturase (Fad) gene promoter in the marine teleost Siganus canaliculatus.

Dong Y, Zhao J, Chen J, Wang S, Liu Y, Zhang Q, You C, Monroig Ó, Tocher DR, Li Y.

Gene. 2018 Mar 20;647:174-180. doi: 10.1016/j.gene.2018.01.031. Epub 2018 Jan 9.

PMID:
29329928
19.

The compositional and metabolic responses of gilthead seabream (Sparus aurata) to a gradient of dietary fish oil and associated n-3 long-chain PUFA content.

Houston SJS, Karalazos V, Tinsley J, Betancor MB, Martin SAM, Tocher DR, Monroig O.

Br J Nutr. 2017 Dec;118(12):1010-1022. doi: 10.1017/S0007114517002975. Epub 2017 Nov 20.

PMID:
29151385
20.

Early nutritional programming affects liver transcriptome in diploid and triploid Atlantic salmon, Salmo salar.

Vera LM, Metochis C, Taylor JF, Clarkson M, Skjærven KH, Migaud H, Tocher DR.

BMC Genomics. 2017 Nov 17;18(1):886. doi: 10.1186/s12864-017-4264-7.

21.

Elongation of very Long-Chain (>C24) Fatty Acids in Clarias gariepinus: Cloning, Functional Characterization and Tissue Expression of elovl4 Elongases.

Oboh A, Navarro JC, Tocher DR, Monroig O.

Lipids. 2017 Oct;52(10):837-848. doi: 10.1007/s11745-017-4289-3. Epub 2017 Aug 30.

22.

Early nutritional intervention can improve utilisation of vegetable-based diets in diploid and triploid Atlantic salmon (Salmo salar L.).

Clarkson M, Migaud H, Metochis C, Vera LM, Leeming D, Tocher DR, Taylor JF.

Br J Nutr. 2017 Jul;118(1):17-29. doi: 10.1017/S0007114517001842. Epub 2017 Jul 24.

23.

Microbial and genetically engineered oils as replacements for fish oil in aquaculture feeds.

Sprague M, Betancor MB, Tocher DR.

Biotechnol Lett. 2017 Nov;39(11):1599-1609. doi: 10.1007/s10529-017-2402-6. Epub 2017 Jul 18. Review.

24.

Molecular and functional characterisation of two elovl4 elongases involved in the biosynthesis of very long-chain (>C24) polyunsaturated fatty acids in black seabream Acanthopagrus schlegelii.

Jin M, Monroig Ó, Navarro JC, Tocher DR, Zhou QC.

Comp Biochem Physiol B Biochem Mol Biol. 2017 Oct;212:41-50. doi: 10.1016/j.cbpb.2017.06.008. Epub 2017 Jun 29.

PMID:
28668330
25.

Two alternative pathways for docosahexaenoic acid (DHA, 22:6n-3) biosynthesis are widespread among teleost fish.

Oboh A, Kabeya N, Carmona-Antoñanzas G, Castro LFC, Dick JR, Tocher DR, Monroig O.

Sci Rep. 2017 Jun 20;7(1):3889. doi: 10.1038/s41598-017-04288-2.

26.

Functional characterization and differential nutritional regulation of putative Elovl5 and Elovl4 elongases in large yellow croaker (Larimichthys crocea).

Li S, Monroig Ó, Wang T, Yuan Y, Carlos Navarro J, Hontoria F, Liao K, Tocher DR, Mai K, Xu W, Ai Q.

Sci Rep. 2017 May 23;7(1):2303. doi: 10.1038/s41598-017-02646-8.

27.

Dietary DHA/EPA ratio affected tissue fatty acid profiles, antioxidant capacity, hematological characteristics and expression of lipid-related genes but not growth in juvenile black seabream (Acanthopagrus schlegelii).

Jin M, Monroig Ó, Lu Y, Yuan Y, Li Y, Ding L, Tocher DR, Zhou Q.

PLoS One. 2017 Apr 21;12(4):e0176216. doi: 10.1371/journal.pone.0176216. eCollection 2017.

28.

Erratum to: Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.).

Betancor MB, Sprague M, Montero D, Usher S, Sayanova O, Campbell PJ, Napier JA, Caballero MJ, Izquierdo M, Tocher DR.

Lipids. 2017 May;52(5):463. doi: 10.1007/s11745-017-4248-z. No abstract available.

PMID:
28421424
29.

An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry.

Betancor MB, Li K, Sprague M, Bardal T, Sayanova O, Usher S, Han L, Måsøval K, Torrissen O, Napier JA, Tocher DR, Olsen RE.

PLoS One. 2017 Apr 12;12(4):e0175415. doi: 10.1371/journal.pone.0175415. eCollection 2017.

30.

Biosynthesis of Polyunsaturated Fatty Acids in Octopus vulgaris: Molecular Cloning and Functional Characterisation of a Stearoyl-CoA Desaturase and an Elongation of Very Long-Chain Fatty Acid 4 Protein.

Monroig Ó, de Llanos R, Varó I, Hontoria F, Tocher DR, Puig S, Navarro JC.

Mar Drugs. 2017 Mar 21;15(3). pii: E82. doi: 10.3390/md15030082.

31.

Comparative study on fatty acid metabolism of early stages of two crustacean species: Artemia sp. metanauplii and Grapsus adscensionis zoeae, as live prey for marine animals.

Reis DB, Acosta NG, Almansa E, Navarro JC, Tocher DR, Andrade JP, Sykes AV, Rodríguez C.

Comp Biochem Physiol B Biochem Mol Biol. 2017 Feb;204:53-60. doi: 10.1016/j.cbpb.2016.11.002. Epub 2016 Nov 11.

PMID:
27840242
32.

Lipid metabolism-related gene expression pattern of Atlantic bluefin tuna (Thunnus thynnus L.) larvae fed on live prey.

Betancor MB, Ortega A, de la Gándara F, Tocher DR, Mourente G.

Fish Physiol Biochem. 2017 Apr;43(2):493-516. doi: 10.1007/s10695-016-0305-4. Epub 2016 Nov 4.

33.

Molecular and functional characterization of a fads2 orthologue in the Amazonian teleost, Arapaima gigas.

Lopes-Marques M, Ozório R, Amaral R, Tocher DR, Monroig Ó, Castro LF.

Comp Biochem Physiol B Biochem Mol Biol. 2017 Jan;203:84-91. doi: 10.1016/j.cbpb.2016.09.007. Epub 2016 Sep 29.

34.

Temperature Increase Negatively Affects the Fatty Acid Bioconversion Capacity of Rainbow Trout (Oncorhynchus mykiss) Fed a Linseed Oil-Based Diet.

Mellery J, Geay F, Tocher DR, Kestemont P, Debier C, Rollin X, Larondelle Y.

PLoS One. 2016 Oct 13;11(10):e0164478. doi: 10.1371/journal.pone.0164478. eCollection 2016.

35.

The miR-33 gene is identified in a marine teleost: a potential role in regulation of LC-PUFA biosynthesis in Siganus canaliculatus.

Zhang Q, You C, Wang S, Dong Y, Monroig Ó, Tocher DR, Li Y.

Sci Rep. 2016 Sep 19;6:32909. doi: 10.1038/srep32909.

36.

Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.).

Betancor MB, Sprague M, Montero D, Usher S, Sayanova O, Campbell PJ, Napier JA, Caballero MJ, Izquierdo M, Tocher DR.

Lipids. 2016 Oct;51(10):1171-1191. doi: 10.1007/s11745-016-4191-4. Epub 2016 Sep 2. Erratum in: Lipids. 2017 May;52(5):463.

37.

Hepatocyte Nuclear Factor 4α (HNF4α) Is a Transcription Factor of Vertebrate Fatty Acyl Desaturase Gene as Identified in Marine Teleost Siganus canaliculatus.

Dong Y, Wang S, Chen J, Zhang Q, Liu Y, You C, Monroig Ó, Tocher DR, Li Y.

PLoS One. 2016 Jul 29;11(7):e0160361. doi: 10.1371/journal.pone.0160361. eCollection 2016.

38.

Cloning and Characterization of Lxr and Srebp1, and Their Potential Roles in Regulation of LC-PUFA Biosynthesis in Rabbitfish Siganus canaliculatus.

Zhang Q, You C, Liu F, Zhu W, Wang S, Xie D, Monroig Ó, Tocher DR, Li Y.

Lipids. 2016 Sep;51(9):1051-63. doi: 10.1007/s11745-016-4176-3. Epub 2016 Jul 27.

PMID:
27464514
39.

Nutritional Evaluation of an EPA-DHA Oil from Transgenic Camelina sativa in Feeds for Post-Smolt Atlantic Salmon (Salmo salar L.).

Betancor MB, Sprague M, Sayanova O, Usher S, Metochis C, Campbell PJ, Napier JA, Tocher DR.

PLoS One. 2016 Jul 25;11(7):e0159934. doi: 10.1371/journal.pone.0159934. eCollection 2016.

40.

Regulatory divergence of homeologous Atlantic salmon elovl5 genes following the salmonid-specific whole-genome duplication.

Carmona-Antoñanzas G, Zheng X, Tocher DR, Leaver MJ.

Gene. 2016 Oct 10;591(1):34-42. doi: 10.1016/j.gene.2016.06.056. Epub 2016 Jun 30.

PMID:
27374149
41.

Composition and metabolism of phospholipids in Octopus vulgaris and Sepia officinalis hatchlings.

Reis DB, Acosta NG, Almansa E, Tocher DR, Andrade JP, Sykes AV, Rodríguez C.

Comp Biochem Physiol B Biochem Mol Biol. 2016 Oct;200:62-8. doi: 10.1016/j.cbpb.2016.06.001. Epub 2016 Jun 4.

PMID:
27267253
42.

Long-chain polyunsaturated fatty acid biosynthesis in the euryhaline herbivorous teleost Scatophagus argus: Functional characterization, tissue expression and nutritional regulation of two fatty acyl elongases.

Xie D, Chen F, Lin S, You C, Wang S, Zhang Q, Monroig Ó, Tocher DR, Li Y.

Comp Biochem Physiol B Biochem Mol Biol. 2016 Aug;198:37-45. doi: 10.1016/j.cbpb.2016.03.009. Epub 2016 Apr 3.

PMID:
27050407
43.

Nutritional regulation of long-chain PUFA biosynthetic genes in rainbow trout (Oncorhynchus mykiss).

Gregory MK, Collins RO, Tocher DR, James MJ, Turchini GM.

Br J Nutr. 2016 May 28;115(10):1721-9. doi: 10.1017/S0007114516000830. Epub 2016 Mar 18.

PMID:
26987422
44.

Isolation and Functional Characterisation of a fads2 in Rainbow Trout (Oncorhynchus mykiss) with Δ5 Desaturase Activity.

Abdul Hamid NK, Carmona-Antoñanzas G, Monroig Ó, Tocher DR, Turchini GM, Donald JA.

PLoS One. 2016 Mar 4;11(3):e0150770. doi: 10.1371/journal.pone.0150770. eCollection 2016.

45.

Differential responses of the gut transcriptome to plant protein diets in farmed Atlantic salmon.

Król E, Douglas A, Tocher DR, Crampton VO, Speakman JR, Secombes CJ, Martin SA.

BMC Genomics. 2016 Feb 29;17:156. doi: 10.1186/s12864-016-2473-0.

46.

Modulation of selenium tissue distribution and selenoprotein expression in Atlantic salmon (Salmo salar L.) fed diets with graded levels of plant ingredients.

Betancor MB, Dam TM, Walton J, Morken T, Campbell PJ, Tocher DR.

Br J Nutr. 2016 Apr;115(8):1325-38. doi: 10.1017/S0007114516000416. Epub 2016 Feb 24.

PMID:
26907361
47.

Impact of sustainable feeds on omega-3 long-chain fatty acid levels in farmed Atlantic salmon, 2006-2015.

Sprague M, Dick JR, Tocher DR.

Sci Rep. 2016 Feb 22;6:21892. doi: 10.1038/srep21892.

48.

Evolutionary functional elaboration of the Elovl2/5 gene family in chordates.

Monroig Ó, Lopes-Marques M, Navarro JC, Hontoria F, Ruivo R, Santos MM, Venkatesh B, Tocher DR, Castro LF.

Sci Rep. 2016 Feb 9;6:20510. doi: 10.1038/srep20510.

49.

A Transgenic Camelina sativa Seed Oil Effectively Replaces Fish Oil as a Dietary Source of Eicosapentaenoic Acid in Mice.

Tejera N, Vauzour D, Betancor MB, Sayanova O, Usher S, Cochard M, Rigby N, Ruiz-Lopez N, Menoyo D, Tocher DR, Napier JA, Minihane AM.

J Nutr. 2016 Feb;146(2):227-35. doi: 10.3945/jn.115.223941. Epub 2016 Jan 20.

50.

Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire.

Castro LF, Tocher DR, Monroig O.

Prog Lipid Res. 2016 Apr;62:25-40. doi: 10.1016/j.plipres.2016.01.001. Epub 2016 Jan 6. Review.

PMID:
26769304

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