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Items: 1 to 50 of 68

1.

Generation of in situ sequencing based OncoMaps to spatially resolve gene expression profiles of diagnostic and prognostic markers in breast cancer.

Svedlund J, Strell C, Qian X, Zilkens KJC, Tobin NP, Bergh J, Sieuwerts AM, Nilsson M.

EBioMedicine. 2019 Sep 13. pii: S2352-3964(19)30607-3. doi: 10.1016/j.ebiom.2019.09.009. [Epub ahead of print]

2.

Astrocytes enhance glioblastoma growth.

Mega A, Hartmark Nilsen M, Leiss LW, Tobin NP, Miletic H, Sleire L, Strell C, Nelander S, Krona C, Hägerstrand D, Enger PØ, Nistér M, Östman A.

Glia. 2019 Sep 11. doi: 10.1002/glia.23718. [Epub ahead of print]

PMID:
31509308
3.

Assessment of Long-term Distant Recurrence-Free Survival Associated With Tamoxifen Therapy in Postmenopausal Patients With Luminal A or Luminal B Breast Cancer.

Yu NY, Iftimi A, Yau C, Tobin NP, van 't Veer L, Hoadley KA, Benz CC, Nordenskjöld B, Fornander T, Stål O, Czene K, Esserman LJ, Lindström LS.

JAMA Oncol. 2019 Aug 8. doi: 10.1001/jamaoncol.2019.1856. [Epub ahead of print]

PMID:
31393518
4.

An immunosuppressive macrophage profile attenuates the prognostic impact of CD20-positive B cells in human soft tissue sarcoma.

Tsagozis P, Augsten M, Zhang Y, Li T, Hesla A, Bergh J, Haglund F, Tobin NP, Ehnman M.

Cancer Immunol Immunother. 2019 Jun;68(6):927-936. doi: 10.1007/s00262-019-02322-y. Epub 2019 Mar 16.

5.

Separation of breast cancer and organ microenvironment transcriptomes in metastases.

Alzubi MA, Turner TH, Olex AL, Sohal SS, Tobin NP, Recio SG, Bergh J, Hatschek T, Parker JS, Sartorius CA, Perou CM, Dozmorov MG, Harrell JC.

Breast Cancer Res. 2019 Mar 6;21(1):36. doi: 10.1186/s13058-019-1123-2.

6.

The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours.

Lundberg A, Lindström LS, Li J, Harrell JC, Darai-Ramqvist E, Sifakis EG, Foukakis T, Perou CM, Czene K, Bergh J, Tobin NP.

Breast Cancer Res. 2019 Feb 28;21(1):34. doi: 10.1186/s13058-019-1121-4.

7.

Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ.

Strell C, Paulsson J, Jin SB, Tobin NP, Mezheyeuski A, Roswall P, Mutgan C, Mitsios N, Johansson H, Wickberg SM, Svedlund J, Nilsson M, Hall P, Mulder J, Radisky DC, Pietras K, Bergh J, Lendahl U, Wärnberg F, Östman A.

J Natl Cancer Inst. 2019 Sep 1;111(9):983-995. doi: 10.1093/jnci/djy234.

PMID:
30816935
8.

Effects of HIV viremia on the gastrointestinal microbiome of young MSM.

Cook RR, Fulcher JA, Tobin NH, Li F, Lee D, Javanbakht M, Brookmeyer R, Shoptaw S, Bolan R, Aldrovandi GM, Gorbach PM.

AIDS. 2019 Apr 1;33(5):793-804. doi: 10.1097/QAD.0000000000002132.

PMID:
30649052
9.

Quantification of variation and the impact of biomass in targeted 16S rRNA gene sequencing studies.

Bender JM, Li F, Adisetiyo H, Lee D, Zabih S, Hung L, Wilkinson TA, Pannaraj PS, She RC, Bard JD, Tobin NH, Aldrovandi GM.

Microbiome. 2018 Sep 10;6(1):155. doi: 10.1186/s40168-018-0543-z.

10.

Effects of Substance Use and Sex Practices on the Intestinal Microbiome During HIV-1 Infection.

Fulcher JA, Hussain SK, Cook R, Li F, Tobin NH, Ragsdale A, Shoptaw S, Gorbach PM, Aldrovandi GM.

J Infect Dis. 2018 Oct 5;218(10):1560-1570. doi: 10.1093/infdis/jiy349.

PMID:
29982500
11.

Combination Antibiotics Improves Disease Activity and Alters Microbial Communities in Children With Ulcerative Colitis.

Kordy K, Romeo AC, Lee DJ, Li F, Zabih S, Saavedra M, Cunningham NJ, Tobin N, Aldrovandi GM.

J Pediatr Gastroenterol Nutr. 2018 Sep;67(3):e60-e63. doi: 10.1097/MPG.0000000000002034. No abstract available.

12.

A Method for Targeted 16S Sequencing of Human Milk Samples.

Tobin NH, Woodward C, Zabih S, Lee DJ, Li F, Aldrovandi GM.

J Vis Exp. 2018 Mar 23;(133). doi: 10.3791/56974.

13.

Prognostic value of Ki67 analysed by cytology or histology in primary breast cancer.

Robertson S, Stålhammar G, Darai-Ramqvist E, Rantalainen M, Tobin NP, Bergh J, Hartman J.

J Clin Pathol. 2018 Sep;71(9):787-794. doi: 10.1136/jclinpath-2017-204976. Epub 2018 Mar 27.

PMID:
29588372
14.

Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs).

Kjällquist U, Erlandsson R, Tobin NP, Alkodsi A, Ullah I, Stålhammar G, Karlsson E, Hatschek T, Hartman J, Linnarsson S, Bergh J.

BMC Cancer. 2018 Feb 12;18(1):174. doi: 10.1186/s12885-018-4021-6.

15.

Immune gene expression and response to chemotherapy in advanced breast cancer.

Foukakis T, Lövrot J, Matikas A, Zerdes I, Lorent J, Tobin N, Suzuki C, Brage SE, Carlsson L, Einbeigi Z, Linderholm B, Loman N, Malmberg M, Fernö M, Skoog L, Bergh J, Hatschek T.

Br J Cancer. 2018 Feb 20;118(4):480-488. doi: 10.1038/bjc.2017.446. Epub 2018 Jan 25.

16.

Towards uncovering the structure of power fluctuations of wind farms.

Liu H, Jin Y, Tobin N, Chamorro LP.

Phys Rev E. 2017 Dec;96(6-1):063117. doi: 10.1103/PhysRevE.96.063117. Epub 2017 Dec 26.

PMID:
29347277
17.

The importance of the microbiome in pediatrics and pediatric infectious diseases.

Gaufin T, Tobin NH, Aldrovandi GM.

Curr Opin Pediatr. 2018 Feb;30(1):117-124. doi: 10.1097/MOP.0000000000000576. Review.

18.

Gene Expression Signatures and Immunohistochemical Subtypes Add Prognostic Value to Each Other in Breast Cancer Cohorts.

Lundberg A, Lindström LS, Harrell JC, Falato C, Carlson JW, Wright PK, Foukakis T, Perou CM, Czene K, Bergh J, Tobin NP.

Clin Cancer Res. 2017 Dec 15;23(24):7512-7520. doi: 10.1158/1078-0432.CCR-17-1535. Epub 2017 Sep 29.

19.

PAM50 Provides Prognostic Information When Applied to the Lymph Node Metastases of Advanced Breast Cancer Patients.

Tobin NP, Lundberg A, Lindström LS, Harrell JC, Foukakis T, Carlsson L, Einbeigi Z, Linderholm BK, Loman N, Malmberg M, Fernö M, Czene K, Perou CM, Bergh J, Hatschek T; TEX Trialists Group.

Clin Cancer Res. 2017 Dec 1;23(23):7225-7231. doi: 10.1158/1078-0432.CCR-17-2301. Epub 2017 Sep 29.

20.

Breast cancer in young women and prognosis: How important are proliferation markers?

Fredholm H, Magnusson K, Lindström LS, Tobin NP, Lindman H, Bergh J, Holmberg L, Pontén F, Frisell J, Fredriksson I.

Eur J Cancer. 2017 Oct;84:278-289. doi: 10.1016/j.ejca.2017.07.044. Epub 2017 Aug 29.

PMID:
28844016
21.

Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades.

Esserman LJ, Yau C, Thompson CK, van 't Veer LJ, Borowsky AD, Hoadley KA, Tobin NP, Nordenskjöld B, Fornander T, Stål O, Benz CC, Lindström LS.

JAMA Oncol. 2017 Nov 1;3(11):1503-1510. doi: 10.1001/jamaoncol.2017.1261. Erratum in: JAMA Oncol. 2017 Nov 1;3(11):1589.

22.

Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer.

Krüger K, Wik E, Knutsvik G, Nalwoga H, Klingen TA, Arnes JB, Chen Y, Mannelqvist M, Dimitrakopoulou K, Stefansson IM, Birkeland E, Aas T, Tobin NP, Jonassen I, Bergh J, Foulkes WD, Akslen LA.

Sci Rep. 2017 Apr 24;7(1):1089. doi: 10.1038/s41598-017-00862-w.

23.

Improving outcomes in veterans with oropharyngeal squamous cell carcinoma through implementation of a multidisciplinary clinic.

Light T, Rassi EE, Maggiore RJ, Holland J, Reed J, Suriano K, Stooksbury M, Tobin N, Gross N, Clayburgh D.

Head Neck. 2017 Jun;39(6):1106-1112. doi: 10.1002/hed.24721. Epub 2017 Mar 29.

PMID:
28370667
24.

High expression of stromal PDGFRβ is associated with reduced benefit of tamoxifen in breast cancer.

Paulsson J, Rydén L, Strell C, Frings O, Tobin NP, Fornander T, Bergh J, Landberg G, Stål O, Östman A.

J Pathol Clin Res. 2016 Sep 14;3(1):38-43. doi: 10.1002/cjp2.56. eCollection 2017 Jan.

25.

Breast milk and in utero transmission of HIV-1 select for envelope variants with unique molecular signatures.

Nakamura KJ, Heath L, Sobrera ER, Wilkinson TA, Semrau K, Kankasa C, Tobin NH, Webb NE, Lee B, Thea DM, Kuhn L, Mullins JI, Aldrovandi GM.

Retrovirology. 2017 Jan 26;14(1):6. doi: 10.1186/s12977-017-0331-z.

26.

Molecular Differences between Screen-Detected and Interval Breast Cancers Are Largely Explained by PAM50 Subtypes.

Li J, Ivansson E, Klevebring D, Tobin NP, Lindström LS, Holm J, Prochazka G, Cristando C, Palmgren J, Törnberg S, Humphreys K, Hartman J, Frisell J, Rantalainen M, Lindberg J, Hall P, Bergh J, Grönberg H, Czene K.

Clin Cancer Res. 2017 May 15;23(10):2584-2592. doi: 10.1158/1078-0432.CCR-16-0967. Epub 2016 Sep 1.

27.

Maternal HIV infection influences the microbiome of HIV-uninfected infants.

Bender JM, Li F, Martelly S, Byrt E, Rouzier V, Leo M, Tobin N, Pannaraj PS, Adisetiyo H, Rollie A, Santiskulvong C, Wang S, Autran C, Bode L, Fitzgerald D, Kuhn L, Aldrovandi GM.

Sci Transl Med. 2016 Jul 27;8(349):349ra100. doi: 10.1126/scitranslmed.aaf5103. Erratum in: Sci Transl Med. 2016 Aug 10;8(351):351er6.

28.

Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages.

Wallerius M, Wallmann T, Bartish M, Östling J, Mezheyeuski A, Tobin NP, Nygren E, Pangigadde P, Pellegrini P, Squadrito ML, Pontén F, Hartman J, Bergh J, De Milito A, De Palma M, Östman A, Andersson J, Rolny C.

Cancer Res. 2016 Jun 1;76(11):3166-78. doi: 10.1158/0008-5472.CAN-15-2596. Epub 2016 Apr 6.

29.

Digital image analysis outperforms manual biomarker assessment in breast cancer.

Stålhammar G, Fuentes Martinez N, Lippert M, Tobin NP, Mølholm I, Kis L, Rosin G, Rantalainen M, Pedersen L, Bergh J, Grunkin M, Hartman J.

Mod Pathol. 2016 Apr;29(4):318-29. doi: 10.1038/modpathol.2016.34. Epub 2016 Feb 26.

30.

Brief Report: Macrophage Activation in HIV-Infected Adolescent Males Contributes to Differential Bone Loss by Sex: Adolescent Trials Network Study 021.

Ruan A, Tobin NH, Mulligan K, Rollie A, Li F, Sleasman J, Aldrovandi GM.

J Acquir Immune Defic Syndr. 2016 Aug 1;72(4):372-5. doi: 10.1097/QAI.0000000000000953.

31.

An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors.

Tobin NP, Wennmalm K, Lindström LS, Foukakis T, He L, Genové G, Östman A, Landberg G, Betsholtz C, Bergh J.

Clin Cancer Res. 2016 May 15;22(10):2417-26. doi: 10.1158/1078-0432.CCR-15-1691. Epub 2016 Jan 14.

32.

Intrinsic subtypes and genomic signatures of primary breast cancer and prognosis after systemic relapse.

Falato C, Tobin NP, Lorent J, Lindström LS, Bergh J, Foukakis T.

Mol Oncol. 2016 Apr;10(4):517-25. doi: 10.1016/j.molonc.2015.11.004. Epub 2015 Nov 18.

33.

Contrasting breast cancer molecular subtypes across serial tumor progression stages: biological and prognostic implications.

Kimbung S, Kovács A, Danielsson A, Bendahl PO, Lövgren K, Frostvik Stolt M, Tobin NP, Lindström L, Bergh J, Einbeigi Z, Fernö M, Hatschek T, Hedenfalk I.

Oncotarget. 2015 Oct 20;6(32):33306-18. doi: 10.18632/oncotarget.5089.

34.

The importance of molecular markers for diagnosis and selection of targeted treatments in patients with cancer.

Tobin NP, Foukakis T, De Petris L, Bergh J.

J Intern Med. 2015 Dec;278(6):545-70. doi: 10.1111/joim.12429. Epub 2015 Sep 16. Review.

35.

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells.

Hong J, Tobin NP, Rundqvist H, Li T, Lavergne M, García-Ibáñez Y, Qin H, Paulsson J, Zeitelhofer M, Adzemovic MZ, Nilsson I, Roswall P, Hartman J, Johnson RS, Östman A, Bergh J, Poljakovic M, Genové G.

J Natl Cancer Inst. 2015 Aug 21;107(10). pii: djv209. doi: 10.1093/jnci/djv209. Print 2015 Oct. Erratum in: J Natl Cancer Inst. 2016 Mar;108(3). pii: djv434. doi: 10.1093/jnci/djv434.

36.

A Conserved Glycan in the C2 Domain of HIV-1 Envelope Acts as a Molecular Switch to Control X4 Utilization by Clonal Variants with Identical V3 Loops.

Lombardi F, Nakamura KJ, Chen T, Sobrera ER, Tobin NH, Aldrovandi GM.

PLoS One. 2015 Jun 17;10(6):e0128116. doi: 10.1371/journal.pone.0128116. eCollection 2015.

37.

Molecular subtype and tumor characteristics of breast cancer metastases as assessed by gene expression significantly influence patient post-relapse survival.

Tobin NP, Harrell JC, Lövrot J, Egyhazi Brage S, Frostvik Stolt M, Carlsson L, Einbeigi Z, Linderholm B, Loman N, Malmberg M, Walz T, Fernö M, Perou CM, Bergh J, Hatschek T, Lindström LS; TEX Trialists Group.

Ann Oncol. 2015 Jan;26(1):81-8. doi: 10.1093/annonc/mdu498. Epub 2014 Oct 31.

38.

Multi-level gene expression signatures, but not binary, outperform Ki67 for the long term prognostication of breast cancer patients.

Tobin NP, Lindström LS, Carlson JW, Bjöhle J, Bergh J, Wennmalm K.

Mol Oncol. 2014 May;8(3):741-52. doi: 10.1016/j.molonc.2014.02.007. Epub 2014 Feb 28. Erratum in: Mol Oncol. 2014 Sep 12;8(6):1159.

39.

Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response.

Lehn S, Tobin NP, Sims AH, Stål O, Jirström K, Axelson H, Landberg G.

BMC Cancer. 2014 Feb 22;14:119. doi: 10.1186/1471-2407-14-119.

40.

Are infants unique in their ability to be "functionally cured" of HIV-1?

Tobin NH, Aldrovandi GM.

Curr HIV/AIDS Rep. 2014 Mar;11(1):1-10. doi: 10.1007/s11904-013-0189-1.

PMID:
24390641
41.

Clinical instability of breast cancer markers is reflected in long-term in vitro estrogen deprivation studies.

Milosevic J, Klinge J, Borg AL, Foukakis T, Bergh J, Tobin NP.

BMC Cancer. 2013 Oct 11;13:473. doi: 10.1186/1471-2407-13-473.

42.

Immunology of pediatric HIV infection.

Tobin NH, Aldrovandi GM.

Immunol Rev. 2013 Jul;254(1):143-69. doi: 10.1111/imr.12074. Review.

43.

Prognostic significance in breast cancer of a gene signature capturing stromal PDGF signaling.

Frings O, Augsten M, Tobin NP, Carlson J, Paulsson J, Pena C, Olsson E, Veerla S, Bergh J, Ostman A, Sonnhammer EL.

Am J Pathol. 2013 Jun;182(6):2037-47. doi: 10.1016/j.ajpath.2013.02.018. Epub 2013 Apr 10.

PMID:
23583284
44.

An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells.

Wagner TA, McKernan JL, Tobin NH, Tapia KA, Mullins JI, Frenkel LM.

J Virol. 2013 Feb;87(3):1770-8. doi: 10.1128/JVI.01985-12. Epub 2012 Nov 21.

45.

Quantification of mitochondrial toxicity in HIV-infected individuals by quantitative PCR compared to flow cytometry.

Wagner TA, Lin CH, Tobin NH, Côté HC, Sloan DD, Jerome KR, Frenkel LM.

Cytometry B Clin Cytom. 2013 Jan-Feb;84(1):55-8. doi: 10.1002/cyto.b.21045. Epub 2012 Oct 8.

46.

Analysis of Cyclin D1 in Breast Cancer: A Call to Arms.

Tobin NP, Bergh J.

Curr Breast Cancer Rep. 2012 Sep;4(3):171-173. Epub 2012 Jun 22.

47.

Automated image analysis of cyclin D1 protein expression in invasive lobular breast carcinoma provides independent prognostic information.

Tobin NP, Lundgren KL, Conway C, Anagnostaki L, Costello S, Landberg G.

Hum Pathol. 2012 Nov;43(11):2053-61. doi: 10.1016/j.humpath.2012.02.015. Epub 2012 May 29.

PMID:
22647349
48.

Cyclin D1, Id1 and EMT in breast cancer.

Tobin NP, Sims AH, Lundgren KL, Lehn S, Landberg G.

BMC Cancer. 2011 Sep 28;11:417. doi: 10.1186/1471-2407-11-417.

49.

Stromal expression of β-arrestin-1 predicts clinical outcome and tamoxifen response in breast cancer.

Lundgren K, Tobin NP, Lehn S, Stål O, Rydén L, Jirström K, Landberg G.

J Mol Diagn. 2011 May;13(3):340-51. doi: 10.1016/j.jmoldx.2011.01.009.

50.

Down-regulation of the oncogene cyclin D1 increases migratory capacity in breast cancer and is linked to unfavorable prognostic features.

Lehn S, Tobin NP, Berglund P, Nilsson K, Sims AH, Jirström K, Härkönen P, Lamb R, Landberg G.

Am J Pathol. 2010 Dec;177(6):2886-97. doi: 10.2353/ajpath.2010.100303. Epub 2010 Oct 22.

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