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Items: 25

1.

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy.

Li JY, Perry SR, Muniz-Medina V, Wang X, Wetzel LK, Rebelatto MC, Masson Hinrichs MJ, Bezabeh BZ, Fleming RL, Dimasi N, Feng H, Toader D, Yuan AQ, Xu L, Lin J, Gao C, Wu H, Dixit R, Osbourn JK, Coats SR.

Cancer Cell. 2019 Jun 10;35(6):948-949. doi: 10.1016/j.ccell.2019.05.010. No abstract available.

PMID:
31185215
2.

A rare cause of ischemic stroke: cardiac myxoma. Case report and review of literature.

Mustafa ER, Tudoraşcu DR, Giucă A, Toader DM, Foarfă MC, Puiu I, Istrate-Ofiţeru AM.

Rom J Morphol Embryol. 2018;59(3):903-909. Review.

3.

Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.

Grimster NP, Anderson E, Alimzhanov M, Bebernitz G, Bell K, Chuaqui C, Deegan T, Ferguson AD, Gero T, Harsch A, Huszar D, Kawatkar A, Kettle JG, Lyne P, Read JA, Rivard Costa C, Ruston L, Schroeder P, Shi J, Su Q, Throner S, Toader D, Vasbinder M, Woessner R, Wang H, Wu A, Ye M, Zheng W, Zinda M.

J Med Chem. 2018 Jun 28;61(12):5235-5244. doi: 10.1021/acs.jmedchem.8b00076. Epub 2018 Jun 13.

PMID:
29856615
4.

Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.

Yang B, Vasbinder MM, Hird AW, Su Q, Wang H, Yu Y, Toader D, Lyne PD, Read JA, Breed J, Ioannidis S, Deng C, Grondine M, DeGrace N, Whitston D, Brassil P, Janetka JW.

J Med Chem. 2018 Feb 8;61(3):1061-1073. doi: 10.1021/acs.jmedchem.7b01490. Epub 2018 Jan 19.

PMID:
29301085
5.

miR-31a-5p promotes postnatal cardiomyocyte proliferation by targeting RhoBTB1.

Xiao J, Liu H, Cretoiu D, Toader DO, Suciu N, Shi J, Shen S, Bei Y, Sluijter JP, Das S, Kong X, Li X.

Exp Mol Med. 2017 Oct 20;49(10):e386. doi: 10.1038/emm.2017.150.

6.

Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4.

Harper J, Lloyd C, Dimasi N, Toader D, Marwood R, Lewis L, Bannister D, Jovanovic J, Fleming R, D'Hooge F, Mao S, Marrero AM, Korade M 3rd, Strout P, Xu L, Chen C, Wetzel L, Breen S, van Vlerken-Ysla L, Jalla S, Rebelatto M, Zhong H, Hurt EM, Hinrichs MJ, Huang K, Howard PW, Tice DA, Hollingsworth RE, Herbst R, Kamal A.

Mol Cancer Ther. 2017 Aug;16(8):1576-1587. doi: 10.1158/1535-7163.MCT-16-0825. Epub 2017 May 18.

7.

Straightforward Glycoengineering Approach to Site-Specific Antibody-Pyrrolobenzodiazepine Conjugates.

Thompson P, Ezeadi E, Hutchinson I, Fleming R, Bezabeh B, Lin J, Mao S, Chen C, Masterson L, Zhong H, Toader D, Howard P, Wu H, Gao C, Dimasi N.

ACS Med Chem Lett. 2016 Sep 20;7(11):1005-1008. eCollection 2016 Nov 10.

8.

Structure-Cytotoxicity Relationships of Analogues of N14-Desacetoxytubulysin H.

Toader D, Wang F, Gingipalli L, Vasbinder M, Roth M, Mao S, Block M, Harper J, Thota S, Su M, Ma J, Bedian V, Kamal A.

J Med Chem. 2016 Dec 8;59(23):10781-10787. Epub 2016 Nov 16.

PMID:
27809515
9.

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy.

Li JY, Perry SR, Muniz-Medina V, Wang X, Wetzel LK, Rebelatto MC, Hinrichs MJ, Bezabeh BZ, Fleming RL, Dimasi N, Feng H, Toader D, Yuan AQ, Xu L, Lin J, Gao C, Wu H, Dixit R, Osbourn JK, Coats SR.

Cancer Cell. 2016 Jan 11;29(1):117-29. doi: 10.1016/j.ccell.2015.12.008. Erratum in: Cancer Cell. 2019 Jun 10;35(6):948-949.

10.

Identification of azabenzimidazoles as potent JAK1 selective inhibitors.

Vasbinder MM, Alimzhanov M, Augustin M, Bebernitz G, Bell K, Chuaqui C, Deegan T, Ferguson AD, Goodwin K, Huszar D, Kawatkar A, Kawatkar S, Read J, Shi J, Steinbacher S, Steuber H, Su Q, Toader D, Wang H, Woessner R, Wu A, Ye M, Zinda M.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):60-7. doi: 10.1016/j.bmcl.2015.11.031. Epub 2015 Nov 12.

PMID:
26614408
11.

Experimental demonstration of Martian soil simulant removal from a surface using a pulsed plasma jet.

Ticoş CM, Scurtu A, Toader D, Banu N.

Rev Sci Instrum. 2015 Mar;86(3):033509. doi: 10.1063/1.4915498.

PMID:
25832231
12.

Collimated electron beam accelerated at 12 kV from a Penning discharge.

Toader D, Oane M, Ticoş CM.

Rev Sci Instrum. 2015 Jan;86(1):013301. doi: 10.1063/1.4905683.

PMID:
25638079
13.

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol.

Wu J, Powell F, Larsen NA, Lai Z, Byth KF, Read J, Gu RF, Roth M, Toader D, Saeh JC, Chen H.

ACS Chem Biol. 2013 Mar 15;8(3):643-50. doi: 10.1021/cb3005897. Epub 2013 Jan 7.

PMID:
23272696
14.

Essential role of TAK1 in regulating mantle cell lymphoma survival.

Buglio D, Palakurthi S, Byth K, Vega F, Toader D, Saeh J, Neelapu SS, Younes A.

Blood. 2012 Jul 12;120(2):347-55. doi: 10.1182/blood-2011-07-369397. Epub 2012 May 30. Erratum in: Blood. 2014 Jul 17;124(3):463.

15.

Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.

Oza V, Ashwell S, Almeida L, Brassil P, Breed J, Deng C, Gero T, Grondine M, Horn C, Ioannidis S, Liu D, Lyne P, Newcombe N, Pass M, Read J, Ready S, Rowsell S, Su M, Toader D, Vasbinder M, Yu D, Yu Y, Xue Y, Zabludoff S, Janetka J.

J Med Chem. 2012 Jun 14;55(11):5130-42. doi: 10.1021/jm300025r. Epub 2012 Jun 4.

PMID:
22551018
16.

Structural approaches to obtain kinase selectivity.

Norman RA, Toader D, Ferguson AD.

Trends Pharmacol Sci. 2012 May;33(5):273-8. doi: 10.1016/j.tips.2012.03.005. Epub 2012 Apr 11. Review.

PMID:
22503441
17.

Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors.

Oza V, Ashwell S, Brassil P, Breed J, Ezhuthachan J, Deng C, Grondine M, Horn C, Liu D, Lyne P, Newcombe N, Pass M, Read J, Su M, Toader D, Yu D, Yu Y, Zabludoff S.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2330-7. doi: 10.1016/j.bmcl.2012.01.043. Epub 2012 Feb 1.

PMID:
22342147
18.

Discovery of a novel class of triazolones as checkpoint kinase inhibitors--hit to lead exploration.

Oza V, Ashwell S, Brassil P, Breed J, Deng C, Ezhuthachan J, Haye H, Horn C, Janetka J, Lyne P, Newcombe N, Otterbien L, Pass M, Read J, Roswell S, Su M, Toader D, Yu D, Yu Y, Valentine A, Webborn P, White A, Zabludoff S, Zheng X.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5133-8. doi: 10.1016/j.bmcl.2010.07.015. Epub 2010 Jul 29.

PMID:
20673630
19.

Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.

Janetka JW, Almeida L, Ashwell S, Brassil PJ, Daly K, Deng C, Gero T, Glynn RE, Horn CL, Ioannidis S, Lyne P, Newcombe NJ, Oza VB, Pass M, Springer SK, Su M, Toader D, Vasbinder MM, Yu D, Yu Y, Zabludoff SD.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):4242-8. doi: 10.1016/j.bmcl.2008.05.016. Epub 2008 May 6.

PMID:
18547806
20.

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J.

Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7.

PMID:
15863305
21.

A Four-Carbon Unit Reagent for the Regiospecific Synthesis of 2-Alkyl-Substituted 1,3-Butadienes.

Katritzky AR, Serdyuk L, Toader D, Wang X.

J Org Chem. 1999 Mar 19;64(6):1888-1892.

PMID:
11674278
22.

Syntheses of 2-alkylamino- and 2-dialkylamino-4,6-diarylpyridines and 2,4,6-trisubstituted pyrimidines using solid-phase-bound chalcones.

Katritzky AR, Serdyuk L, Chassaing C, Toader D, Wang X, Forood B, Flatt B, Sun C, Vo K.

J Comb Chem. 2000 Mar-Apr;2(2):182-5.

PMID:
10757097
23.

[Preeclampsia in a twin pregnancy. Influence of the "immune burden" of the fetal allograft].

Riethmuller D, Toader D, Schaal JP, Maillet R, Colette C.

J Gynecol Obstet Biol Reprod (Paris). 1997;26(3 Suppl):154-7. French. No abstract available.

PMID:
9471448
24.
25.

[The role of the auxilliary health personnel in the prevention of iatrogenic quadriceps contracture].

Horghidan S, Toader D, Luciu R.

Viata Med Rev Inf Prof Stiint Cadrelor Medii Sanit. 1979 Dec;27(12):271-2. Romanian. No abstract available.

PMID:
120064

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