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Development and evaluation of a conventional RT-PCR for differentiating emerging influenza B/Victoria lineage viruses with hemagglutinin amino acid deletion from B/Yamagata lineage viruses.

Chan WM, Wong LH, So CF, Chen LL, Wu WL, Ip JD, Lam AH, Yip CCY, Yuen KY, To KKW.

J Med Virol. 2019 Oct 14. doi: 10.1002/jmv.25607. [Epub ahead of print]


Activation of C-type lectin receptor and (RIG)-I-like receptors contributes to proinflammatory response in MERS coronavirus infected macrophages.

Zhao X, Chu H, Wong BH, Chiu MC, Wang D, Li C, Liu X, Yang D, Poon VK, Cai J, Chan JF, To KK, Zhou J, Yuen KY.

J Infect Dis. 2019 Sep 28. pii: jiz483. doi: 10.1093/infdis/jiz483. [Epub ahead of print]


Assessment of population susceptibility to upcoming seasonal influenza epidemic strain using interepidemic emerging influenza virus strains.

Chen LL, Wu WL, Chan WM, Fong CHY, Ng ACK, Ip JD, Lu L, Dissanayake TK, Ding X, Cai JP, Zhang AJX, Tam S, Hung IFN, Chan KH, Yuen KY, To KKW.

Epidemiol Infect. 2019 Sep 26;147:e279. doi: 10.1017/S0950268819001717.


Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines.

Wang P, Zheng M, Lau SY, Chen P, Mok BW, Liu S, Liu H, Huang X, Cremin CJ, Song W, Chen Y, Wong YC, Huang H, To KK, Chen Z, Xia N, Yuen KY, Chen H.

MBio. 2019 Sep 17;10(5). pii: e02180-19. doi: 10.1128/mBio.02180-19.


H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses.

Lee ACY, Zhang AJX, Chu H, Li C, Zhu H, Mak WWN, Chen Y, Kok KH, To KKW, Yuen KY.

Cell Death Dis. 2019 Jun 5;10(6):442. doi: 10.1038/s41419-019-1684-0.


Drug repurposing to overcome resistance to various therapies for colorectal cancer.

Fong W, To KKW.

Cell Mol Life Sci. 2019 Sep;76(17):3383-3406. doi: 10.1007/s00018-019-03134-0. Epub 2019 May 13. Review.


SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection.

Lui WY, Yuen CK, Li C, Wong WM, Lui PY, Lin CH, Chan KH, Zhao H, Chen H, To KKW, Zhang AJX, Yuen KY, Kok KH.

Emerg Microbes Infect. 2019;8(1):662-674. doi: 10.1080/22221751.2019.1611346.


Biodegradable Thermosensitive PLGA-PEG-PLGA Polymer for Non-irritating and Sustained Ophthalmic Drug Delivery.

Chan PS, Xian JW, Li Q, Chan CW, Leung SSY, To KKW.

AAPS J. 2019 Apr 24;21(4):59. doi: 10.1208/s12248-019-0326-x.


Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study.

To KKW, Chan KH, Ho J, Pang PKP, Ho DTY, Chang ACH, Seng CW, Yip CCY, Cheng VCC, Hung IFN, Yuen KY.

Clin Microbiol Infect. 2019 Apr 18. pii: S1198-743X(19)30183-1. doi: 10.1016/j.cmi.2019.04.012. [Epub ahead of print]


Improving the specific diagnosis of trematode, cestode and nematode infections by a multiplex single-tube real-time PCR assay.

Wong SSY, Poon RWS, To KKW, Chan JFW, Lu G, Xing F, Cheng VCC, Yuen KY.

J Clin Pathol. 2019 Jul;72(7):487-492. doi: 10.1136/jclinpath-2018-205590. Epub 2019 Apr 5.


Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice.

Ling L, Wu T, To KKW, Cheung KW, Lui KOL, Niu M, Lam KS, Wang CC, Li J, Wang H, Yuen KY, Chen Z.

AIDS. 2019 Mar 15;33(4):F1-F12. doi: 10.1097/QAD.0000000000002149.


Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment.

Rosa Duque JS, To KKW, Chiang AKS, Chan GCF, Poon RWS, Yuen KY, Ha SY, Cheuk DKL.

Int J Infect Dis. 2019 Apr;81:110-113. doi: 10.1016/j.ijid.2019.02.002. Epub 2019 Feb 14.


SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.

Yuan S, Chu H, Chan JF, Ye ZW, Wen L, Yan B, Lai PM, Tee KM, Huang J, Chen D, Li C, Zhao X, Yang D, Chiu MC, Yip C, Poon VK, Chan CC, Sze KH, Zhou J, Chan IH, Kok KH, To KK, Kao RY, Lau JY, Jin DY, Perlman S, Yuen KY.

Nat Commun. 2019 Jan 10;10(1):120. doi: 10.1038/s41467-018-08015-x.


Identification and characterization of GLDC as host susceptibility gene to severe influenza.

Zhou J, Wang D, Wong BH, Li C, Poon VK, Wen L, Zhao X, Chiu MC, Liu X, Ye Z, Yuan S, Sze KH, Chan JF, Chu H, To KK, Yuen KY.

EMBO Mol Med. 2019 Jan;11(1). pii: e9528. doi: 10.15252/emmm.201809528.


The Accuracy of Self-Screening of Group B Streptococcus in Pregnant Women-A Randomized Crossover Study.

Seto MTY, Ko JKY, Cheung KW, To KKW, Hui PW, Lao TT, Lee CP.

J Obstet Gynaecol Can. 2019 Jun;41(6):792-797. doi: 10.1016/j.jogc.2018.08.003. Epub 2018 Nov 2.


The RNA Binding Protein HuR: A Promising Drug Target for Anticancer Therapy.

Wu M, Tong CWS, Yan W, To KKW, Cho WCS.

Curr Cancer Drug Targets. 2019;19(5):382-399. doi: 10.2174/1568009618666181031145953.


Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production.

Li C, To KKW, Zhang AJX, Lee ACY, Zhu H, Mak WWN, Hung IFN, Yuen KY.

Front Immunol. 2018 Oct 12;9:2370. doi: 10.3389/fimmu.2018.02370. eCollection 2018.


Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups.

Lau SKP, Zhao PSH, Sridhar S, Yip CCY, Aw-Yong KL, Chow EYY, Cheung KCM, Hui RWH, Leung RYH, Lai YSK, Wu AKL, To KKW, Woo PCY, Yuen KY.

J Clin Virol. 2018 Nov;108:43-49. doi: 10.1016/j.jcv.2018.09.002. Epub 2018 Sep 8.


Prostaglandin E2-Mediated Impairment of Innate Immune Response to A(H1N1)pdm09 Infection in Diet-Induced Obese Mice Could Be Restored by Paracetamol.

Zhang AJX, Zhu H, Chen Y, Li C, Li C, Chu H, Gozali L, Lee ACY, To KKW, Hung IFN, Yuen KY.

J Infect Dis. 2019 Feb 15;219(5):795-807. doi: 10.1093/infdis/jiy527.


PCI29732, a Bruton's Tyrosine Kinase Inhibitor, Enhanced the Efficacy of Conventional Chemotherapeutic Agents in ABCG2-Overexpressing Cancer Cells.

Ge C, Wang F, Cui C, Su X, To KKW, Wang X, Zhang H, Song X, Fu L.

Cell Physiol Biochem. 2018;48(6):2302-2317. doi: 10.1159/000492647. Epub 2018 Aug 16.


Olmutinib (HM61713) reversed multidrug resistance by inhibiting the activity of ATP-binding cassette subfamily G member 2 in vitro and in vivo.

Zhang Z, Guo X, To KKW, Chen Z, Fang X, Luo M, Ma C, Xu J, Yan S, Fu L.

Acta Pharm Sin B. 2018 Jul;8(4):563-574. doi: 10.1016/j.apsb.2018.06.002. Epub 2018 Jun 15.


MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside.

To KK, Tong CW, Wu M, Cho WC.

World J Gastroenterol. 2018 Jul 21;24(27):2949-2973. doi: 10.3748/wjg.v24.i27.2949. Review.


Recent Advances in the Treatment of Breast Cancer.

Tong CWS, Wu M, Cho WCS, To KKW.

Front Oncol. 2018 Jun 14;8:227. doi: 10.3389/fonc.2018.00227. eCollection 2018. Review.


Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza.

Zhao H, To KKW, Chu H, Ding Q, Zhao X, Li C, Shuai H, Yuan S, Zhou J, Kok KH, Jiang S, Yuen KY.

Nat Commun. 2018 Jun 15;9(1):2358. doi: 10.1038/s41467-018-04792-7.


Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study.

To KKW, Yip CCY, Lai CYW, Wong CKH, Ho DTY, Pang PKP, Ng ACK, Leung KH, Poon RWS, Chan KH, Cheng VCC, Hung IFN, Yuen KY.

Clin Microbiol Infect. 2019 Mar;25(3):372-378. doi: 10.1016/j.cmi.2018.06.009. Epub 2018 Jun 12.


Differentiated human airway organoids to assess infectivity of emerging influenza virus.

Zhou J, Li C, Sachs N, Chiu MC, Wong BH, Chu H, Poon VK, Wang D, Zhao X, Wen L, Song W, Yuan S, Wong KK, Chan JF, To KK, Chen H, Clevers H, Yuen KY.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6822-6827. doi: 10.1073/pnas.1806308115. Epub 2018 Jun 11.


Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice.

Lee ACY, To KKW, Zhang AJX, Zhu H, Li C, Zhang RR, Hung IFN, Kao RYT, Chan KH, Yuen KY.

Arch Virol. 2018 Sep;163(9):2349-2358. doi: 10.1007/s00705-018-3852-4. Epub 2018 May 7.


Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017.

Zhu H, Lee ACY, Li C, Mak WWN, Chen YY, Chan KH, Zhang AJX, Fung WF, Zhang RQ, Fung YF, Poon RWS, Lam JY, Tam S, Hung IFN, Chen H, Yuen KY, To KKW.

Emerg Microbes Infect. 2018 Mar 6;7(1):23. doi: 10.1038/s41426-018-0041-1.


Dacomitinib potentiates the efficacy of conventional chemotherapeutic agents via inhibiting the drug efflux function of ABCG2 in vitro and in vivo.

Guo X, To KKW, Chen Z, Wang X, Zhang J, Luo M, Wang F, Yan S, Fu L.

J Exp Clin Cancer Res. 2018 Feb 20;37(1):31. doi: 10.1186/s13046-018-0690-x.


Rhinovirus respiratory tract infection in hospitalized adult patients is associated with TH2 response irrespective of asthma.

To KKW, Lu L, Fong CHY, Wu AKL, Mok KY, Yip CCY, Ke YH, Sze KH, Lau SKP, Hung IFN, Yuen KY.

J Infect. 2018 May;76(5):465-474. doi: 10.1016/j.jinf.2018.02.005. Epub 2018 Feb 15.


Impact of inter-genotypic recombination and probe cross-reactivity on the performance of the Abbott RealTime HCV Genotype II assay for hepatitis C genotyping.

Sridhar S, Yip CCY, Chan JFW, To KKW, Cheng VCC, Yuen KY.

Diagn Microbiol Infect Dis. 2018 May;91(1):34-37. doi: 10.1016/j.diagmicrobio.2017.12.024. Epub 2018 Jan 11.


PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy.

To KKW, Wu WKK, Loong HHF.

Eur J Pharmacol. 2018 Mar 15;823:19-26. doi: 10.1016/j.ejphar.2018.01.036. Epub 2018 Jan 31.


Identification of Clinically Approved Drugs Indacaterol and Canagliflozin for Repurposing to Treat Epidermal Growth Factor Tyrosine Kinase Inhibitor-Resistant Lung Cancer.

Li H, Tong CW, Leung Y, Wong MH, To KK, Leung KS.

Front Oncol. 2017 Nov 29;7:288. doi: 10.3389/fonc.2017.00288. eCollection 2017.


Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus.

Zhou J, Li C, Zhao G, Chu H, Wang D, Yan HH, Poon VK, Wen L, Wong BH, Zhao X, Chiu MC, Yang D, Wang Y, Au-Yeung RKH, Chan IH, Sun S, Chan JF, To KK, Memish ZA, Corman VM, Drosten C, Hung IF, Zhou Y, Leung SY, Yuen KY.

Sci Adv. 2017 Nov 15;3(11):eaao4966. doi: 10.1126/sciadv.aao4966. eCollection 2017 Nov.


CUDC-907, a dual HDAC and PI3K inhibitor, reverses platinum drug resistance.

To KKW, Fu LW.

Invest New Drugs. 2018 Feb;36(1):10-19. doi: 10.1007/s10637-017-0501-9. Epub 2017 Aug 17.


Drug combination approach to overcome resistance to EGFR tyrosine kinase inhibitors in lung cancer.

Tong CWS, Wu WKK, Loong HHF, Cho WCS, To KKW.

Cancer Lett. 2017 Oct 1;405:100-110. doi: 10.1016/j.canlet.2017.07.023. Epub 2017 Jul 31. Review.


Candidatus Dirofilaria hongkongensis as Causative Agent of Human Ocular Filariosis after Travel to India.

Winkler S, Pollreisz A, Georgopoulos M, Bagò-Horvath Z, Auer H, To KK, Krücken J, Poppert S, Walochnik J.

Emerg Infect Dis. 2017 Aug;23(8):1428-1431. doi: 10.3201/eid2308.170423.


Additional molecular testing of saliva specimens improves the detection of respiratory viruses.

To KK, Lu L, Yip CC, Poon RW, Fung AM, Cheng A, Lui DH, Ho DT, Hung IF, Chan KH, Yuen KY.

Emerg Microbes Infect. 2017 Jun 7;6(6):e49. doi: 10.1038/emi.2017.35.


Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes.

Lee ACY, To KKW, Zhu H, Chu H, Li C, Mak WWN, Zhang AJX, Yuen KY.

J Gen Virol. 2017 May;98(5):922-934. doi: 10.1099/jgv.0.000751. Epub 2017 May 30.


High prevalence of four novel astrovirus genotype species identified from rodents in China.

To KKW, Chan WM, Li KSM, Lam CSF, Chen Z, Tse H, Lau SKP, Woo PCY, Yuen KY.

J Gen Virol. 2017 May;98(5):1004-1015. doi: 10.1099/jgv.0.000766. Epub 2017 May 25.


Rhinovirus - From bench to bedside.

To KKW, Yip CCY, Yuen KY.

J Formos Med Assoc. 2017 Jul;116(7):496-504. doi: 10.1016/j.jfma.2017.04.009. Epub 2017 May 8. Review.


Reversal of multidrug resistance by Marsdenia tenacissima and its main active ingredients polyoxypregnanes.

To KKW, Wu X, Yin C, Chai S, Yao S, Kadioglu O, Efferth T, Ye Y, Lin G.

J Ethnopharmacol. 2017 May 5;203:110-119. doi: 10.1016/j.jep.2017.03.051. Epub 2017 Mar 28.


Alectinib (CH5424802) antagonizes ABCB1- and ABCG2-mediated multidrug resistance in vitro, in vivo and ex vivo.

Yang K, Chen Y, To KK, Wang F, Li D, Chen L, Fu L.

Exp Mol Med. 2017 Mar 17;49(3):e303. doi: 10.1038/emm.2016.168.


Infection after fracture osteosynthesis - Part II.

Fang C, Wong TM, To KK, Wong SS, Lau TW, Leung F.

J Orthop Surg (Hong Kong). 2017 Jan;25(1):2309499017692714. doi: 10.1177/2309499017692714. Review.


Infection after fracture osteosynthesis - Part I.

Fang C, Wong TM, Lau TW, To KK, Wong SS, Leung F.

J Orthop Surg (Hong Kong). 2017 Jan;25(1):2309499017692712. doi: 10.1177/2309499017692712. Review.


New Pt-NNSO core anticancer agents: Structural optimization and investigation of their anticancer activity.

Chong SX, Jin Y, Au-Yeung SC, To KK.

J Inorg Biochem. 2017 May;170:34-45. doi: 10.1016/j.jinorgbio.2017.02.002. Epub 2017 Feb 12.


Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection.

Hung IF, Zhang AJ, To KK, Chan JF, Zhu SH, Zhang R, Chan TC, Chan KH, Yuen KY.

Int J Mol Sci. 2017 Jan 26;18(2). pii: E259. doi: 10.3390/ijms18020259.


Reversal of platinum drug resistance by the histone deacetylase inhibitor belinostat.

To KK, Tong WS, Fu LW.

Lung Cancer. 2017 Jan;103:58-65. doi: 10.1016/j.lungcan.2016.11.019. Epub 2016 Nov 28.


Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: An Open-label Randomized, Controlled, Phase IIb/III Trial.

Hung IFN, To KKW, Chan JFW, Cheng VCC, Liu KSH, Tam A, Chan TC, Zhang AJ, Li P, Wong TL, Zhang R, Cheung MKS, Leung W, Lau JYN, Fok M, Chen H, Chan KH, Yuen KY.

Chest. 2017 May;151(5):1069-1080. doi: 10.1016/j.chest.2016.11.012. Epub 2016 Nov 22.


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