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Items: 1 to 50 of 439

1.

Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.

Lee YY, Mok MT, Kang W, Yang W, Tang W, Wu F, Xu L, Yan M, Yu Z, Lee SD, Tong JH, Cheung YS, Lai PB, Yu DY, Wang Q, Wong GL, Chan AM, Yip KY, To KF, Cheng AS.

Nucleic Acids Res. 2018 Jul 10. doi: 10.1093/nar/gky589. [Epub ahead of print]

PMID:
29992318
2.

Activation of SREBP1-mediated lipogenesis by the Epstein-Barr Virus-encoded LMP1 promotes cell proliferation and progression of nasopharyngeal carcinoma.

Lo AK, Lung RW, Dawson CW, Young LS, Ko CW, Yeung WW, Kang W, To KF, Lo KW.

J Pathol. 2018 Jul 3. doi: 10.1002/path.5130. [Epub ahead of print]

PMID:
29968360
3.

Enhanced cancer immunotherapy with Smad3-slilencing NK-92 cells.

Wang QM, Tang PM, Lian GY, Li C, Li J, Huang XR, To KF, Lan HY.

Cancer Immunol Res. 2018 Jun 18. pii: canimm.0491.2017. doi: 10.1158/2326-6066.CIR-17-0491. [Epub ahead of print]

PMID:
29915022
4.

Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway.

Pan Y, Cheung ST, Tong JHM, Tin KY, Kang W, Lung RWM, Wu F, Li H, Ng SSM, Mak TWC, To KF, Chan AWH.

J Transl Med. 2018 Jun 4;16(1):150. doi: 10.1186/s12967-018-1530-7.

5.

Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9.

Cheung AH, Chow C, Zhang J, Zhou Y, Huang T, Ng KC, Or TC, Yao YY, Dong Y, Fung JM, Xiong L, Chan AK, Lung WR, Kang W, To KF.

Lab Invest. 2018 May 10. doi: 10.1038/s41374-018-0056-1. [Epub ahead of print]

PMID:
29748615
6.

Assessment of programmed cell death ligand-1 expression by 4 diagnostic assays and its clinicopathological correlation in a large cohort of surgical resected non-small cell lung carcinoma.

Chan AWH, Tong JHM, Kwan JSH, Chow C, Chung LY, Chau SL, Lung RWM, Ng CSH, Wan IYP, Mok TSK, To KF.

Mod Pathol. 2018 Apr 30. doi: 10.1038/s41379-018-0053-3. [Epub ahead of print]

PMID:
29713040
7.

PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis.

Zhang J, Zhou Y, Huang T, Wu F, Liu L, Kwan JSH, Cheng ASL, Yu J, To KF, Kang W.

Mol Carcinog. 2018 Apr 23. doi: 10.1002/mc.22831. [Epub ahead of print]

PMID:
29683214
8.

Emerging roles of Hippo signaling in inflammation and YAP-driven tumor immunity.

Zhou Y, Huang T, Zhang J, Cheng ASL, Yu J, Kang W, To KF.

Cancer Lett. 2018 Jul 10;426:73-79. doi: 10.1016/j.canlet.2018.04.004. Epub 2018 Apr 11.

PMID:
29654891
9.

The physiological role of Motin family and its dysregulation in tumorigenesis.

Huang T, Zhou Y, Zhang J, Cheng ASL, Yu J, To KF, Kang W.

J Transl Med. 2018 Apr 12;16(1):98. doi: 10.1186/s12967-018-1466-y. Review.

10.

Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742).

Ma BBY, Lim WT, Goh BC, Hui EP, Lo KW, Pettinger A, Foster NR, Riess JW, Agulnik M, Chang AYC, Chopra A, Kish JA, Chung CH, Adkins DR, Cullen KJ, Gitlitz BJ, Lim DW, To KF, Chan KCA, Lo YMD, King AD, Erlichman C, Yin J, Costello BA, Chan ATC.

J Clin Oncol. 2018 May 10;36(14):1412-1418. doi: 10.1200/JCO.2017.77.0388. Epub 2018 Mar 27.

PMID:
29584545
11.

CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation.

Zhang Y, Wang S, Kang W, Liu C, Dong Y, Ren F, Wang Y, Zhang J, Wang G, To KF, Zhang X, Sung JJ, Chang Z, Yu J.

Oncogene. 2018 Jun;37(26):3485-3500. doi: 10.1038/s41388-018-0161-z. Epub 2018 Mar 22.

12.

Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features.

Li X, Xu W, Kang W, Wong SH, Wang M, Zhou Y, Fang X, Zhang X, Yang H, Wong CH, To KF, Chan SL, Chan MTV, Sung JJY, Wu WKK, Yu J.

Theranostics. 2018 Feb 12;8(6):1740-1751. doi: 10.7150/thno.22010. eCollection 2018.

13.

The role of human papillomavirus in laryngeal cancer in Southern China.

Lam EWH, Chan MMH, Wai CKC, Ngai CM, Chen Z, Wong MCS, Yeung ACM, Tong JHM, Chan ABW, To KF, Chan PKS.

J Med Virol. 2018 Jun;90(6):1150-1159. doi: 10.1002/jmv.25058. Epub 2018 Mar 6.

PMID:
29446476
14.

miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis.

Kang W, Huang T, Zhou Y, Zhang J, Lung RWM, Tong JHM, Chan AWH, Zhang B, Wong CC, Wu F, Dong Y, Wang S, Yang W, Pan Y, Chak WP, Cheung AHK, Pang JCS, Yu J, Cheng ASL, To KF.

Cell Death Dis. 2018 Jan 24;9(2):92. doi: 10.1038/s41419-017-0134-0.

15.

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro.

Tang PM, Tang PC, Chung JY, Hung JSC, Wang QM, Lian GY, Sheng J, Huang XR, To KF, Lan HY.

J Vis Exp. 2018 Jan 9;(131). doi: 10.3791/56785.

PMID:
29364233
16.

GATA-3 is superior to GCDFP-15 and mammaglobin to identify primary and metastatic breast cancer.

Ni YB, Tsang JYS, Shao MM, Chan SK, Cheung SY, Tong J, To KF, Tse GM.

Breast Cancer Res Treat. 2018 May;169(1):25-32. doi: 10.1007/s10549-017-4645-2. Epub 2018 Jan 16.

PMID:
29340880
17.

Molecular and functional characterization of tumor-induced factor (TIF): Hamster homolog of CXCL3 (GROγ) displays tumor suppressive activity.

Jin L, Li ZF, Wang DK, Sun M, Qi W, Ma Q, Zhang L, Chu C, Chan EYM, Lee SST, Wise H, To KF, Shi Y, Zhou N, Cheung WT.

Cytokine. 2018 Feb;102:62-75. doi: 10.1016/j.cyto.2017.12.019. Epub 2017 Dec 23.

PMID:
29276973
18.

SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis.

Huang T, Zhou Y, Zhang J, Wong CC, Li W, Kwan JSH, Yang R, Chan AKY, Dong Y, Wu F, Zhang B, Cheung AHK, Wu WKK, Cheng ASL, Yu J, Wong N, Kang W, To KF.

Oncogene. 2018 Mar;37(9):1159-1174. doi: 10.1038/s41388-017-0029-7. Epub 2017 Dec 13.

19.

EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma.

Lung RW, Hau PM, Yu KH, Yip KY, Tong JH, Chak WP, Chan AW, Lam KH, Lo AK, Tin EK, Chau SL, Pang JC, Kwan JS, Busson P, Young LS, Yap LF, Tsao SW, To KF, Lo KW.

J Pathol. 2018 Apr;244(4):394-407. doi: 10.1002/path.5018. Epub 2018 Feb 16.

20.

Genomic profiles of nasopharyngeal carcinoma: The importance of histological subtyping and Epstein-Barr virus in situ assays.

Lui VWY, To KF, Lo KW.

Cancer. 2018 Jan 15;124(2):434-435. doi: 10.1002/cncr.31131. Epub 2017 Nov 22. No abstract available.

PMID:
29165785
21.

The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring.

Tang PM, Zhou S, Li CJ, Liao J, Xiao J, Wang QM, Lian GY, Li J, Huang XR, To KF, Ng CF, Chong CC, Ma RC, Lee TL, Lan HY.

Kidney Int. 2018 Jan;93(1):173-187. doi: 10.1016/j.kint.2017.07.026. Epub 2017 Oct 14.

PMID:
29042082
22.

The oncogenic role of Epstein-Barr virus-encoded microRNAs in Epstein-Barr virus-associated gastric carcinoma.

Zhang J, Huang T, Zhou Y, Cheng ASL, Yu J, To KF, Kang W.

J Cell Mol Med. 2018 Jan;22(1):38-45. doi: 10.1111/jcmm.13354. Epub 2017 Oct 9. Review.

23.

Epstein-Barr virus-driven promoter hypermethylated genes in gastric cancer.

Yu J, To KF, Liang QY.

Hong Kong Med J. 2017 Aug;23 Suppl 5(4):17-22. No abstract available.

24.

Human papillomavirus infection and squamous cell carcinoma in Hong Kong: a case-control study.

Chan PK, To KF, Tsang SH, Lau CH, Kwong WH, Chan YH.

Hong Kong Med J. 2017 Aug;23 Suppl 5(4):8-11. No abstract available.

25.

Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.

Zhou J, Liu M, Sun H, Feng Y, Xu L, Chan AWH, Tong JH, Wong J, Chong CCN, Lai PBS, Wang HK, Tsang SW, Goodwin T, Liu R, Huang L, Chen Z, Sung JJ, Chow KL, To KF, Cheng AS.

Gut. 2018 May;67(5):931-944. doi: 10.1136/gutjnl-2017-314032. Epub 2017 Sep 22.

PMID:
28939663
26.

The CCCTC-binding factor (CTCF)-forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma.

Zhang B, Zhang Y, Zou X, Chan AW, Zhang R, Lee TK, Liu H, Lau EY, Ho NP, Lai PB, Cheung YS, To KF, Wong HK, Choy KW, Keng VW, Chow LM, Chan KK, Cheng AS, Ko BC.

J Pathol. 2017 Dec;243(4):418-430. doi: 10.1002/path.4976. Epub 2017 Oct 27.

27.

Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis.

Wang X, Zhang X, Chu ESH, Chen X, Kang W, Wu F, To KF, Wong VWS, Chan HLY, Chan MTV, Sung JJY, Wu WKK, Yu J.

FASEB J. 2018 Jan;32(1):37-51. doi: 10.1096/fj.201601393R. Epub 2017 Aug 25.

PMID:
28842428
28.

The large tumor suppressor family: friend or foe?

Kang W, Zhou Y, To KF.

J Thorac Dis. 2017 Jul;9(7):1748-1751. doi: 10.21037/jtd.2017.06.26. No abstract available.

29.

Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics.

Tsang JCH, Vong JSL, Ji L, Poon LCY, Jiang P, Lui KO, Ni YB, To KF, Cheng YKY, Chiu RWK, Lo YMD.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7786-E7795. doi: 10.1073/pnas.1710470114. Epub 2017 Aug 22.

30.

Albumin-bilirubin grade predicts the outcomes of liver resection versus radiofrequency ablation for very early/early stage of hepatocellular carcinoma.

Chong CC, Chan AW, Wong J, Chu CM, Chan SL, Lee KF, Yu SC, To KF, Johnson P, Lai PB.

Surgeon. 2018 Jun;16(3):163-170. doi: 10.1016/j.surge.2017.07.003. Epub 2017 Aug 12.

PMID:
28807570
31.

TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis.

Zhou Y, Huang T, Zhang J, Wong CC, Zhang B, Dong Y, Wu F, Tong JHM, Wu WKK, Cheng ASL, Yu J, Kang W, To KF.

Oncogene. 2017 Nov 23;36(47):6518-6530. doi: 10.1038/onc.2017.257. Epub 2017 Jul 31.

32.

Topical Application of Mesenchymal Stromal Cells Ameliorated Liver Parenchyma Damage After Ischemia-Reperfusion Injury in an Animal Model.

Lam PK, Chong CCN, Lo AWI, Chan AWH, Tong CSW, Chin DWC, Wong KHK, Choy RKW, Fung AK, Wang YX, To KF, Lai PBS.

Transplant Direct. 2017 May 11;3(6):e160. doi: 10.1097/TXD.0000000000000675. eCollection 2017 Jun.

33.

Congenital intestinal fibrosarcoma with rapid recurrence requiring adjuvant chemotherapy.

See WSQ, Cheuk DKL, To KF, Ip PP, Chiang AKS, Ha SY, Chan GCF.

Pediatr Int. 2017 Jun;59(6):733-736. doi: 10.1111/ped.13252. Epub 2017 Apr 24.

PMID:
28436622
34.

Clinical heterogeneity in children with gonadal dysgenesis associated with non-mosaic 46,XY karyotype.

Wong YS, Tam YH, Pang KKY, To KF, Chan SSC, Chan KW, Lee KH.

J Pediatr Urol. 2017 Oct;13(5):508.e1-508.e6. doi: 10.1016/j.jpurol.2017.03.021. Epub 2017 Apr 10.

PMID:
28434637
35.

IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis.

Zhou Y, Huang T, Siu HL, Wong CC, Dong Y, Wu F, Zhang B, Wu WK, Cheng AS, Yu J, To KF, Kang W.

Mol Cancer. 2017 Apr 11;16(1):77. doi: 10.1186/s12943-017-0647-2.

36.

Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development.

Tang PM, Zhou S, Meng XM, Wang QM, Li CJ, Lian GY, Huang XR, Tang YJ, Guan XY, Yan BP, To KF, Lan HY.

Nat Commun. 2017 Mar 6;8:14677. doi: 10.1038/ncomms14677.

37.

Prenatal Diagnosis of a Retroesophageal Left Brachiocephalic Vein: Two Case Reports.

Cheng YKY, Law KM, Chak PK, To KF, Chan YM, Leung TY.

J Ultrasound Med. 2017 May;36(5):1065-1069. doi: 10.7863/ultra.16.05003. Epub 2017 Mar 4.

PMID:
28258609
38.

The Interplay of LncRNA-H19 and Its Binding Partners in Physiological Process and Gastric Carcinogenesis.

Zhang L, Zhou Y, Huang T, Cheng AS, Yu J, Kang W, To KF.

Int J Mol Sci. 2017 Feb 20;18(2). pii: E450. doi: 10.3390/ijms18020450. Review.

39.

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury.

Wang YY, Jiang H, Pan J, Huang XR, Wang YC, Huang HF, To KF, Nikolic-Paterson DJ, Lan HY, Chen JH.

J Am Soc Nephrol. 2017 Jul;28(7):2053-2067. doi: 10.1681/ASN.2016050573. Epub 2017 Feb 16.

40.

Elevated PRC1 in gastric carcinoma exerts oncogenic function and is targeted by piperlongumine in a p53-dependent manner.

Zhang B, Shi X, Xu G, Kang W, Zhang W, Zhang S, Cao Y, Qian L, Zhan P, Yan H, To KF, Wang L, Zou X.

J Cell Mol Med. 2017 Jul;21(7):1329-1341. doi: 10.1111/jcmm.13063. Epub 2017 Feb 12.

41.

Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations.

Li YY, Chung GT, Lui VW, To KF, Ma BB, Chow C, Woo JK, Yip KY, Seo J, Hui EP, Mak MK, Rusan M, Chau NG, Or YY, Law MH, Law PP, Liu ZW, Ngan HL, Hau PM, Verhoeft KR, Poon PH, Yoo SK, Shin JY, Lee SD, Lun SW, Jia L, Chan AW, Chan JY, Lai PB, Fung CY, Hung ST, Wang L, Chang AM, Chiosea SI, Hedberg ML, Tsao SW, van Hasselt AC, Chan AT, Grandis JR, Hammerman PS, Lo KW.

Nat Commun. 2017 Jan 18;8:14121. doi: 10.1038/ncomms14121.

42.

NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?

Huang T, Zhou Y, Cheng AS, Yu J, To KF, Kang W.

Mol Cancer. 2016 Dec 9;15(1):80. Review.

43.

Activation of GPR30 stimulates GTP-binding of Gαi1 protein to sustain activation of Erk1/2 in inhibition of prostate cancer cell growth and modulates metastatic properties.

Lau KM, Ma FM, Xia JT, Chan QKY, Ng CF, To KF.

Exp Cell Res. 2017 Jan 1;350(1):199-209. doi: 10.1016/j.yexcr.2016.11.022. Epub 2016 Nov 28.

PMID:
27908592
44.

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis.

Meng XM, Wang S, Huang XR, Yang C, Xiao J, Zhang Y, To KF, Nikolic-Paterson DJ, Lan HY.

Cell Death Dis. 2016 Dec 1;7(12):e2495. doi: 10.1038/cddis.2016.402.

45.

Applicability of albumin-bilirubin-based Japan integrated staging score in hepatitis B-associated hepatocellular carcinoma.

Chan AW, Chong CC, Mo FK, Wong J, Yeo W, Johnson PJ, Yu S, Lai PB, Chan AT, To KF, Chan SL.

J Gastroenterol Hepatol. 2016 Oct;31(10):1766-1772. doi: 10.1111/jgh.13339.

PMID:
26992142
46.

Downregulation of long non-coding RNA MEG3 in nasopharyngeal carcinoma.

Chak WP, Lung RW, Tong JH, Chan SY, Lun SW, Tsao SW, Lo KW, To KF.

Mol Carcinog. 2017 Mar;56(3):1041-1054. doi: 10.1002/mc.22569. Epub 2016 Oct 20.

PMID:
27597634
47.

Is there significance in identification of non-predominant micropapillary or solid components in early-stage lung adenocarcinoma?

Zhao ZR, To KF, Mok TS, Ng CS.

Interact Cardiovasc Thorac Surg. 2017 Jan;24(1):121-125. doi: 10.1093/icvts/ivw283. Epub 2016 Sep 5. Review.

PMID:
27600912
48.

EZH2 coupled with HOTAIR to silence MicroRNA-34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma.

Li CH, Xiao Z, Tong JH, To KF, Fang X, Cheng AS, Chen Y.

Int J Cancer. 2017 Jan 1;140(1):120-129. doi: 10.1002/ijc.30414. Epub 2016 Sep 19.

49.

Importance of Estrogenic Signaling and Its Mediated Receptors in Prostate Cancer.

Lau KM, To KF.

Int J Mol Sci. 2016 Aug 31;17(9). pii: E1434. doi: 10.3390/ijms17091434. Review.

50.

Concurrent fatty liver increases risk of hepatocellular carcinoma among patients with chronic hepatitis B.

Chan AW, Wong GL, Chan HY, Tong JH, Yu YH, Choi PC, Chan HL, To KF, Wong VW.

J Gastroenterol Hepatol. 2017 Mar;32(3):667-676. doi: 10.1111/jgh.13536.

PMID:
27547913

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