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H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses.

Lee ACY, Zhang AJX, Chu H, Li C, Zhu H, Mak WWN, Chen Y, Kok KH, To KKW, Yuen KY.

Cell Death Dis. 2019 Jun 5;10(6):442. doi: 10.1038/s41419-019-1684-0.


Letter to the editor on the article "Virtual reality simulator versus box-trainer to teach minimally invasive procedures: A meta-analysis".

Bojanic C, To K.

Int J Surg. 2019 May 21. pii: S1743-9191(19)30110-4. doi: 10.1016/j.ijsu.2019.03.025. [Epub ahead of print] No abstract available.


Drug repurposing to overcome resistance to various therapies for colorectal cancer.

Fong W, To KKW.

Cell Mol Life Sci. 2019 May 13. doi: 10.1007/s00018-019-03134-0. [Epub ahead of print] Review.


SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection.

Lui WY, Yuen CK, Li C, Wong WM, Lui PY, Lin CH, Chan KH, Zhao H, Chen H, To KKW, Zhang AJX, Yuen KY, Kok KH.

Emerg Microbes Infect. 2019;8(1):662-674. doi: 10.1080/22221751.2019.1611346.


Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma.

Liu M, Zhou J, Liu X, Feng Y, Yang W, Wu F, Cheung OK, Sun H, Zeng X, Tang W, Mok MTS, Wong J, Yeung PC, Lai PBS, Chen Z, Jin H, Chen J, Chan SL, Chan AWH, To KF, Sung JJY, Chen M, Cheng AS.

Gut. 2019 May 10. pii: gutjnl-2018-317257. doi: 10.1136/gutjnl-2018-317257. [Epub ahead of print]


Biodegradable Thermosensitive PLGA-PEG-PLGA Polymer for Non-irritating and Sustained Ophthalmic Drug Delivery.

Chan PS, Xian JW, Li Q, Chan CW, Leung SSY, To KKW.

AAPS J. 2019 Apr 24;21(4):59. doi: 10.1208/s12248-019-0326-x.


TTPAL promotes colorectal tumorigenesis by stabilizing TRIP6 to activate Wnt/β-catenin signaling.

Gou H, Liang JQ, Zhang L, Chen H, Zhang Y, Li R, Wang X, Ji J, Tong JH, To KF, Sung JJ, Chan FK, Fang JY, Yu J.

Cancer Res. 2019 Apr 24. pii: canres.2986.2018. doi: 10.1158/0008-5472.CAN-18-2986. [Epub ahead of print]


PRRX-NCOA1/2 rearrangement characterizes a distinctive fibroblastic neoplasm.

Lacambra MD, Weinreb I, Demicco EG, Chow C, Sung YS, Swanson D, To KF, Wong KC, Antonescu CR, Dickson BC.

Genes Chromosomes Cancer. 2019 Apr 22. doi: 10.1002/gcc.22762. [Epub ahead of print]


Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study.

To KKW, Chan KH, Ho J, Pang PKP, Ho DTY, Chang ACH, Seng CW, Yip CCY, Cheng VCC, Hung IFN, Yuen KY.

Clin Microbiol Infect. 2019 Apr 18. pii: S1198-743X(19)30183-1. doi: 10.1016/j.cmi.2019.04.012. [Epub ahead of print]


Effect of hopper angle on granular clogging.

López-Rodríguez D, Gella D, To K, Maza D, Garcimartín A, Zuriguel I.

Phys Rev E. 2019 Mar;99(3-1):032901. doi: 10.1103/PhysRevE.99.032901.


The Landscape of Actionable Molecular Alterations in Immunomarker-Defined Large-Cell Carcinoma of the Lung.

Chan AW, Chau SL, Tong JH, Chow C, Kwan JSH, Chung LY, Lung RW, Tong CY, Tin EK, Law PP, Law WT, Ng CSH, Wan IYP, Mok TSK, To KF.

J Thorac Oncol. 2019 Apr 9. pii: S1556-0864(19)30277-1. doi: 10.1016/j.jtho.2019.03.021. [Epub ahead of print]


Improving the specific diagnosis of trematode, cestode and nematode infections by a multiplex single-tube real-time PCR assay.

Wong SSY, Poon RWS, To KKW, Chan JFW, Lu G, Xing F, Cheng VCC, Yuen KY.

J Clin Pathol. 2019 Apr 5. pii: jclinpath-2018-205590. doi: 10.1136/jclinpath-2018-205590. [Epub ahead of print]


Author Correction: A randomized controlled trial of an ambulatory approach versus the hospital-based approach in managing suspected obstructive sleep apnea syndrome.

Hui DS, Ng SS, To KW, Ko FW, Ngai J, Chan KKP, Yip WH, Chan TO, Yiu K, Tam WWS.

Sci Rep. 2019 Apr 2;9(1):5595. doi: 10.1038/s41598-019-41389-6.


Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish.

Truong L, Zaikova T, Baldock BL, Balik-Meisner M, To K, Reif DM, Kennedy ZC, Hutchison JE, Tanguay RL.

Nanotoxicology. 2019 Apr 2:1-15. doi: 10.1080/17435390.2019.1592259. [Epub ahead of print]


Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis.

Zhang J, Zhou Y, Tang PMK, Cheng ASL, Yu J, To KF, Kang W.

Int J Mol Sci. 2019 Mar 29;20(7). pii: E1576. doi: 10.3390/ijms20071576. Review.


Correction: Hsa-miRNA-765 as a Key Mediator for Inhibiting Growth, Migration and Invasion in Fulvestrant-Treated Prostate Cancer.

Leung YK, Chan QK, Ng CF, Ma FM, Tse HM, To KF, Maranchie J, Ho SM, Lau KM.

PLoS One. 2019 Mar 18;14(3):e0214184. doi: 10.1371/journal.pone.0214184. eCollection 2019.


The effectiveness of acupressure in the management of depressive symptoms and in improving quality of life in older people living in the community: a randomised sham-controlled trial.

Molassiotis A, Suen L, Lai C, Chan B, Wat KHY, Tang J, To KL, Leung CO, Lee S, Lee P, Chien WT.

Aging Ment Health. 2019 Mar 14:1-9. doi: 10.1080/13607863.2019.1584789. [Epub ahead of print]


Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice.

Ling L, Wu T, To KKW, Cheung KW, Lui KOL, Niu M, Lam KS, Wang CC, Li J, Wang H, Yuen KY, Chen Z.

AIDS. 2019 Mar 15;33(4):F1-F12. doi: 10.1097/QAD.0000000000002149.


Long-term outcome after Lambrinudi arthrodesis: How they're doing after three decades.

So LWN, Kuong EE, To KM, Leong JCY, Chow W.

J Orthop Surg (Hong Kong). 2019 Jan-Apr;27(1):2309499019826492. doi: 10.1177/2309499019826492.


Use of Berlin questionnaire in comparison to polysomnography and home sleep study in patients with obstructive sleep apnea.

Ng SS, Tam W, Chan TO, To KW, Ngai J, Chan KKP, Yip WH, Lo RL, Yiu K, Ko FW, Hui DS.

Respir Res. 2019 Feb 22;20(1):40. doi: 10.1186/s12931-019-1009-y.


Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment.

Rosa Duque JS, To KKW, Chiang AKS, Chan GCF, Poon RWS, Yuen KY, Ha SY, Cheuk DKL.

Int J Infect Dis. 2019 Apr;81:110-113. doi: 10.1016/j.ijid.2019.02.002. Epub 2019 Feb 14.


Evaluation of matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) for the Identification of Group B Streptococcus.

To KN, Cornwell E, Daniel R, Goonesekera S, Jauneikaite E, Chalker V, Le Doare K.

BMC Res Notes. 2019 Feb 14;12(1):85. doi: 10.1186/s13104-019-4119-1.


The interaction between hypertension and obstructive sleep apnea on subjective daytime sleepiness.

Tam W, Ng SS, To KW, Ko FW, Hui DS.

J Clin Hypertens (Greenwich). 2019 Mar;21(3):390-396. doi: 10.1111/jch.13485. Epub 2019 Feb 6.


Quality of life, depression and correlates in HIV+ people at An Hoa Clinic, Ho Chi Minh City.

Huynh VN, To QG, Do DV, Nguyen MT, To KG.

AIDS Care. 2019 May;31(5):582-588. doi: 10.1080/09540121.2019.1576846. Epub 2019 Feb 5.


Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming.

Xiong L, Wu F, Wu Q, Xu L, Cheung OK, Kang W, Mok MT, Szeto LLM, Lun CY, Lung RW, Zhang J, Yu KH, Lee SD, Huang G, Wang CM, Liu J, Yu Z, Yu DY, Chou JL, Huang WH, Feng B, Cheung YS, Lai PB, Tan P, Wong N, Chan MW, Huang TH, Yip KY, Cheng AS, To KF.

Nat Commun. 2019 Jan 18;10(1):335. doi: 10.1038/s41467-018-08245-z.


Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after cART interruption in humanized mice.

Ling L, Wu T, To KKW, Cheung KW, Lui KO, Niu M, Lam KS, Wang CC, Li J, Wang H, Yuen KY, Chen Z.

AIDS. 2019 Jan 14. doi: 10.1097/QAD.0000000000002149. [Epub ahead of print]


Targeting the miR-630/YAP1/ERK feedback loop in epidermal growth factor receptor-mutated lung adenocarcinomas.

Zhang J, Cheng ASL, Yu J, To KF, Kang W.

J Thorac Dis. 2018 Nov;10(Suppl 33):S4017-S4020. doi: 10.21037/jtd.2018.10.16. No abstract available.


SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.

Yuan S, Chu H, Chan JF, Ye ZW, Wen L, Yan B, Lai PM, Tee KM, Huang J, Chen D, Li C, Zhao X, Yang D, Chiu MC, Yip C, Poon VK, Chan CC, Sze KH, Zhou J, Chan IH, Kok KH, To KK, Kao RY, Lau JY, Jin DY, Perlman S, Yuen KY.

Nat Commun. 2019 Jan 10;10(1):120. doi: 10.1038/s41467-018-08015-x.


The Legionella effector LtpM is a new type of phosphoinositide-activated glucosyltransferase.

Levanova N, Mattheis C, Carson D, To KN, Jank T, Frankel G, Aktories K, Schroeder GN.

J Biol Chem. 2019 Feb 22;294(8):2862-2879. doi: 10.1074/jbc.RA118.005952. Epub 2018 Dec 20.


A Neuroendocrine Tumor of Unknown Primary Origin that Responded to Treatment Based on Tumor Grade Progression.

Hamano Y, Moriwaki T, To K, Watahiki T, Yamada T, Sakashita S, Hyodo I.

Intern Med. 2019 Apr 15;58(8):1087-1091. doi: 10.2169/internalmedicine.1809-18. Epub 2018 Dec 18.


An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma.

Sun H, Yang W, Tian Y, Zeng X, Zhou J, Mok MTS, Tang W, Feng Y, Xu L, Chan AWH, Tong JH, Cheung YS, Lai PBS, Wang HKS, Tsang SW, Chow KL, Hu M, Liu R, Huang L, Yang B, Yang P, To KF, Sung JJY, Wong GLH, Wong VWS, Cheng ASL.

Nat Commun. 2018 Dec 6;9(1):5214. doi: 10.1038/s41467-018-07402-8.


Mismatch repair deficiency is implicated in carcinoma arising from ovarian teratoma.

Cheung AH, Chow C, Yu MY, Law WW, Law PP, Choi PC, Kang W, To KF.

Pathology. 2019 Jan;51(1):67-73. doi: 10.1016/j.pathol.2018.09.061. Epub 2018 Nov 28.


Identification and characterization of GLDC as host susceptibility gene to severe influenza.

Zhou J, Wang D, Wong BH, Li C, Poon VK, Wen L, Zhao X, Chiu MC, Liu X, Ye Z, Yuan S, Sze KH, Chan JF, Chu H, To KK, Yuen KY.

EMBO Mol Med. 2019 Jan;11(1). pii: e9528. doi: 10.15252/emmm.201809528.


Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam.

Baptissart M, Lamb HE, To K, Bradish C, Tehrani J, Reif D, Cowley M.

Proc Biol Sci. 2018 Nov 14;285(1891). pii: 20181237. doi: 10.1098/rspb.2018.1237.


HIV pre-exposure prophylaxis in South East Asia: A focused review on present situation.

To KW, Lee SS.

Int J Infect Dis. 2018 Dec;77:113-117. doi: 10.1016/j.ijid.2018.10.027. Epub 2018 Nov 3. Review.


The Accuracy of Self-Screening of Group B Streptococcus in Pregnant Women-A Randomized Crossover Study.

Seto MTY, Ko JKY, Cheung KW, To KKW, Hui PW, Lao TT, Lee CP.

J Obstet Gynaecol Can. 2019 Jun;41(6):792-797. doi: 10.1016/j.jogc.2018.08.003. Epub 2018 Nov 2.


The RNA Binding Protein HuR: A Promising Drug Target for Anticancer Therapy.

Wu M, Tong CWS, Yan W, To KKW, Cho WCS.

Curr Cancer Drug Targets. 2019;19(5):382-399. doi: 10.2174/1568009618666181031145953.


Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production.

Li C, To KKW, Zhang AJX, Lee ACY, Zhu H, Mak WWN, Hung IFN, Yuen KY.

Front Immunol. 2018 Oct 12;9:2370. doi: 10.3389/fimmu.2018.02370. eCollection 2018.


Acute Care Surgery Model and Outcomes in Emergency General Surgery.

To KB, Kamdar NS, Patil P, Collins SD, Seese E, Krapohl GL, Campbell DS Jr, Englesbe MJ, Hemmila MR, Napolitano LM; Michigan Surgical Quality Collaborative (MSQC) Emergency General Surgery Study Group and the MSQC Research Advisory Group.

J Am Coll Surg. 2019 Jan;228(1):21-28.e7. doi: 10.1016/j.jamcollsurg.2018.07.664. Epub 2018 Oct 22.


Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups.

Lau SKP, Zhao PSH, Sridhar S, Yip CCY, Aw-Yong KL, Chow EYY, Cheung KCM, Hui RWH, Leung RYH, Lai YSK, Wu AKL, To KKW, Woo PCY, Yuen KY.

J Clin Virol. 2018 Nov;108:43-49. doi: 10.1016/j.jcv.2018.09.002. Epub 2018 Sep 8.


Oncogenes expand during evolution to withstand somatic amplification.

Wang X, Li X, Zhang L, Wong SH, Wang MHT, Tse G, Dai RZW, Nakatsu G, Coker OO, Chen Z, Ko H, Chan JYK, Liu T, Cheng CHK, Cheng ASL, To KF, Plewczynski D, Sung JJY, Yu J, Gin T, Chan MTV, Wu WKK.

Ann Oncol. 2018 Nov 1;29(11):2254-2260. doi: 10.1093/annonc/mdy397.


Prostaglandin E2-Mediated Impairment of Innate Immune Response to A(H1N1)pdm09 Infection in Diet-Induced Obese Mice Could Be Restored by Paracetamol.

Zhang AJX, Zhu H, Chen Y, Li C, Li C, Chu H, Gozali L, Lee ACY, To KKW, Hung IFN, Yuen KY.

J Infect Dis. 2019 Feb 15;219(5):795-807. doi: 10.1093/infdis/jiy527.


EXOSC4 functions as a potential oncogene in development and progression of colorectal cancer.

Pan Y, Tong JHM, Kang W, Lung RWM, Chak WP, Chung LY, Wu F, Li H, Yu J, Chan AWH, To KF.

Mol Carcinog. 2018 Dec;57(12):1780-1791. doi: 10.1002/mc.22896. Epub 2018 Sep 21.


The Clinical Value of PELP1 for Breast Cancer: A Comparison with Multiple Cancers and Analysis in Breast Cancer Subtypes.

Wang X, Tsang JYS, Lee MA, Ni YB, Tong JH, Chan SK, Cheung SY, To KF, Tse GM.

Cancer Res Treat. 2019 Apr;51(2):706-717. doi: 10.4143/crt.2018.316. Epub 2018 Aug 23.


PCI29732, a Bruton's Tyrosine Kinase Inhibitor, Enhanced the Efficacy of Conventional Chemotherapeutic Agents in ABCG2-Overexpressing Cancer Cells.

Ge C, Wang F, Cui C, Su X, To KKW, Wang X, Zhang H, Song X, Fu L.

Cell Physiol Biochem. 2018;48(6):2302-2317. doi: 10.1159/000492647. Epub 2018 Aug 16.


Olmutinib (HM61713) reversed multidrug resistance by inhibiting the activity of ATP-binding cassette subfamily G member 2 in vitro and in vivo.

Zhang Z, Guo X, To KKW, Chen Z, Fang X, Luo M, Ma C, Xu J, Yan S, Fu L.

Acta Pharm Sin B. 2018 Jul;8(4):563-574. doi: 10.1016/j.apsb.2018.06.002. Epub 2018 Jun 15.


Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes.

Wu H, Rahman HNA, Dong Y, Liu X, Lee Y, Wen A, To KH, Xiao L, Birsner AE, Bazinet L, Wong S, Song K, Brophy ML, Mahamud MR, Chang B, Cai X, Pasula S, Kwak S, Yang W, Bischoff J, Xu J, Bielenberg DR, Dixon JB, D'Amato RJ, Srinivasan RS, Chen H.

J Clin Invest. 2018 Aug 31;128(9):4025-4043. doi: 10.1172/JCI96063. Epub 2018 Aug 13.


FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p.

Zhang J, Zhou Y, Huang T, Wu F, Pan Y, Dong Y, Wang Y, Chan AKY, Liu L, Kwan JSH, Cheung AHK, Wong CC, Lo AKF, Cheng ASL, Yu J, Lo KW, Kang W, To KF.

Oncogene. 2019 Jan;38(1):33-46. doi: 10.1038/s41388-018-0430-x. Epub 2018 Aug 6.


MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside.

To KK, Tong CW, Wu M, Cho WC.

World J Gastroenterol. 2018 Jul 21;24(27):2949-2973. doi: 10.3748/wjg.v24.i27.2949. Review.

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