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Items: 18


Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.

Huard K, Londregan AT, Tesz G, Bahnck KB, Magee TV, Hepworth D, Polivkova J, Coffey SB, Pabst BA, Gosset JR, Nigam A, Kou K, Sun H, Lee K, Herr M, Boehm M, Carpino PA, Goodwin B, Perreault C, Li Q, Jorgensen CC, Tkalcevic GT, Subashi TA, Ahn K.

J Med Chem. 2015 Sep 24;58(18):7164-72. doi: 10.1021/acs.jmedchem.5b01008. Epub 2015 Sep 8.


Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors.

Arcari JT, Beebe JS, Berliner MA, Bernardo V, Boehm M, Borzillo GV, Clark T, Cohen BD, Connell RD, Frost HN, Gordon DA, Hungerford WM, Kakar SM, Kanter A, Keene NF, Knauth EA, Lagreca SD, Lu Y, Martinez-Alsina L, Marx MA, Morris J, Patel NC, Savage D, Soderstrom CI, Thompson C, Tkalcevic G, Tom NJ, Vajdos FF, Valentine JJ, Vincent PW, Wessel MD, Chen JM.

Bioorg Med Chem Lett. 2013 May 15;23(10):3059-63. doi: 10.1016/j.bmcl.2013.03.012. Epub 2013 Mar 21.


Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened.

Munchhof MJ, Li Q, Shavnya A, Borzillo GV, Boyden TL, Jones CS, LaGreca SD, Martinez-Alsina L, Patel N, Pelletier K, Reiter LA, Robbins MD, Tkalcevic GT.

ACS Med Chem Lett. 2011 Dec 21;3(2):106-11. doi: 10.1021/ml2002423. eCollection 2012 Feb 9.


Assessment of cholesteryl ester transfer protein inhibitors for interaction with proteins involved in the immune response to infection.

Clark RW, Cunningham D, Cong Y, Subashi TA, Tkalcevic GT, Lloyd DB, Boyd JG, Chrunyk BA, Karam GA, Qiu X, Wang IK, Francone OL.

J Lipid Res. 2010 May;51(5):967-74. doi: 10.1194/jlr.M002295. Epub 2009 Oct 21.


Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.

Cohen BD, Baker DA, Soderstrom C, Tkalcevic G, Rossi AM, Miller PE, Tengowski MW, Wang F, Gualberto A, Beebe JS, Moyer JD.

Clin Cancer Res. 2005 Mar 1;11(5):2063-73.


Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451.

Roberts WG, Whalen PM, Soderstrom E, Moraski G, Lyssikatos JP, Wang HF, Cooper B, Baker DA, Savage D, Dalvie D, Atherton JA, Ralston S, Szewc R, Kath JC, Lin J, Soderstrom C, Tkalcevic G, Cohen BD, Pollack V, Barth W, Hungerford W, Ung E.

Cancer Res. 2005 Feb 1;65(3):957-66.


Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass.

Gowen LC, Petersen DN, Mansolf AL, Qi H, Stock JL, Tkalcevic GT, Simmons HA, Crawford DT, Chidsey-Frink KL, Ke HZ, McNeish JD, Brown TA.

J Biol Chem. 2003 Jan 17;278(3):1998-2007. Epub 2002 Nov 5.


Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene.

Rosati RL, Da Silva Jardine P, Cameron KO, Thompson DD, Ke HZ, Toler SM, Brown TA, Pan LC, Ebbinghaus CF, Reinhold AR, Elliott NC, Newhouse BN, Tjoa CM, Sweetnam PM, Cole MJ, Arriola MW, Gauthier JW, Crawford DT, Nickerson DF, Pirie CM, Qi H, Simmons HA, Tkalcevic GT.

J Med Chem. 1998 Jul 30;41(16):2928-31. No abstract available.


Estrogen-induced genes in the uterus of ovariectomized rats and their regulation by droloxifene and tamoxifen.

Rivera-Gonzalez R, Petersen DN, Tkalcevic G, Thompson DD, Brown TA.

J Steroid Biochem Mol Biol. 1998 Jan;64(1-2):13-24.


Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues.

Petersen DN, Tkalcevic GT, Koza-Taylor PH, Turi TG, Brown TA.

Endocrinology. 1998 Mar;139(3):1082-92.


Potentiation of tamoxifen activity by verapamil in a human breast cancer cell line.

Gupta V, Kamath N, Tkalcevic GT, Singh SV.

Biochem Pharmacol. 1994 Apr 29;47(9):1701-4.


Glutathione-linked detoxification pathway in normal and malignant human bladder tissue.

Singh SV, Xu BH, Tkalcevic GT, Gupta V, Roberts B, Ruiz P.

Cancer Lett. 1994 Feb 28;77(1):15-24.


Molecular cloning of mouse hepatic triacylglycerol lipase: gene expression in combined lipase-deficient (cld/cld) mice.

Oka K, Nakano T, Tkalcevic GT, Scow RO, Brown WV.

Biochim Biophys Acta. 1991 May 2;1089(1):13-20.


Structure and polymorphic map of human lipoprotein lipase gene.

Oka K, Tkalcevic GT, Nakano T, Tucker H, Ishimura-Oka K, Brown WV.

Biochim Biophys Acta. 1990 May 24;1049(1):21-6. Erratum in: Biochim Biophys Acta 1991 Nov 11;1090(3):357.


Nucleotide sequence of PvuII polymorphic site at the human lipoprotein lipase gene locus.

Oka K, Tkalcevic GT, Stocks J, Galton DJ, Brown WV.

Nucleic Acids Res. 1989 Aug 25;17(16):6752. No abstract available.


Genetic studies of kanamycin resistance in Campylobacter jejuni.

Kotarski SF, Merriwether TL, Tkalcevic GT, Gemski P.

Antimicrob Agents Chemother. 1986 Aug;30(2):225-30.

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