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Items: 1 to 50 of 65

1.

Associations of pathogen-specific and host-specific characteristics with disease outcome in patients with Staphylococcus aureus bacteremic pneumonia.

Sharma-Kuinkel BK, Tkaczyk C, Bonnell J, Yu L, Tovchigrechko A, Tabor DE, Park LP, Ruffin F, Esser MT, Sellman BR, Fowler VG Jr, Ruzin A.

Clin Transl Immunology. 2019 Jul 19;8(7):e01070. doi: 10.1002/cti2.1070. eCollection 2019.

2.

Candida albicans Augments Staphylococcus aureus Virulence by Engaging the Staphylococcal agr Quorum Sensing System.

Todd OA, Fidel PL Jr, Harro JM, Hilliard JJ, Tkaczyk C, Sellman BR, Noverr MC, Peters BM.

MBio. 2019 Jun 4;10(3). pii: e00910-19. doi: 10.1128/mBio.00910-19.

3.

Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice.

Ortines RV, Wang Y, Liu H, Dikeman DA, Pinsker BL, Miller RJ, Kim SE, Ackerman NE, Rizkallah JF, Marcello LT, Cohen TS, Tkaczyk C, Sellman BR, Miller LS.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00346-19. doi: 10.1128/AAC.00346-19. Print 2019 Aug.

PMID:
31138566
4.

Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets.

Thompson JM, Miller RJ, Ashbaugh AG, Dillen CA, Pickett JE, Wang Y, Ortines RV, Sterling RS, Francis KP, Bernthal NM, Cohen TS, Tkaczyk C, Yu L, Stover CK, DiGiandomenico A, Sellman BR, Thorek DL, Miller LS.

JCI Insight. 2018 Sep 6;3(17). pii: 121737. doi: 10.1172/jci.insight.121737. eCollection 2018 Sep 6.

5.

Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity In Vitro and Staphylococcus aureus Fitness in Infection Models.

Tkaczyk C, Semenova E, Shi YY, Rosenthal K, Oganesyan V, Warrener P, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01033-18. doi: 10.1128/AAC.01033-18. Print 2018 Nov.

6.

α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis.

Surewaard BGJ, Thanabalasuriar A, Zeng Z, Tkaczyk C, Cohen TS, Bardoel BW, Jorch SK, Deppermann C, Bubeck Wardenburg J, Davis RP, Jenne CN, Stover KC, Sellman BR, Kubes P.

Cell Host Microbe. 2018 Aug 8;24(2):271-284.e3. doi: 10.1016/j.chom.2018.06.017. Epub 2018 Jul 19.

7.

Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone.

Pickett JE, Thompson JM, Sadowska A, Tkaczyk C, Sellman BR, Minola A, Corti D, Lanzavecchia A, Miller LS, Thorek DL.

Bone Res. 2018 Apr 25;6:13. doi: 10.1038/s41413-018-0014-y. eCollection 2018.

8.

Alpha-Toxin Contributes to Biofilm Formation among Staphylococcus aureus Wound Isolates.

Anderson MJ, Schaaf E, Breshears LM, Wallis HW, Johnson JR, Tkaczyk C, Sellman BR, Sun J, Peterson ML.

Toxins (Basel). 2018 Apr 16;10(4). pii: E157. doi: 10.3390/toxins10040157.

9.

S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking.

Cohen TS, Boland ML, Boland BB, Takahashi V, Tovchigrechko A, Lee Y, Wilde AD, Mazaitis MJ, Jones-Nelson O, Tkaczyk C, Raja R, Stover CK, Sellman BR.

Cell Rep. 2018 Feb 27;22(9):2431-2441. doi: 10.1016/j.celrep.2018.02.027.

10.

Characterisation of anti-alpha toxin antibody levels and colonisation status after administration of an investigational human monoclonal antibody, MEDI4893, against Staphylococcus aureus alpha toxin.

Ruzin A, Wu Y, Yu L, Yu XQ, Tabor DE, Mok H, Tkaczyk C, Jensen K, Bellamy T, Roskos L, Esser MT, Jafri HS.

Clin Transl Immunology. 2018 Jan 23;7(1):e1009. doi: 10.1002/cti2.1009. eCollection 2018.

11.

Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus aureus-Infected Wounds in Nondiabetic and Diabetic Mice.

Ortines RV, Liu H, Cheng LI, Cohen TS, Lawlor H, Gami A, Wang Y, Dillen CA, Archer NK, Miller RJ, Ashbaugh AG, Pinsker BL, Marchitto MC, Tkaczyk C, Stover CK, Sellman BR, Miller LS.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02288-17. doi: 10.1128/AAC.02288-17. Print 2018 Mar.

12.

Adherence and dosing interval of subcutaneous antitumour necrosis factor biologics among patients with inflammatory arthritis: analysis from a Canadian administrative database.

Bhoi P, Bessette L, Bell MJ, Tkaczyk C, Nantel F, Maslova K.

BMJ Open. 2017 Sep 18;7(9):e015872. doi: 10.1136/bmjopen-2017-015872.

13.

Real-world validation of the minimal disease activity index in psoriatic arthritis: an analysis from a prospective, observational, biological treatment registry.

Rahman P, Zummer M, Bessette L, Baer P, Haraoui B, Chow A, Kelsall J, Kapur S, Rampakakis E, Psaradellis E, Lehman AJ, Nantel F, Osborne B, Tkaczyk C.

BMJ Open. 2017 Aug 30;7(8):e016619. doi: 10.1136/bmjopen-2017-016619.

14.

Mouse model of hematogenous implant-related Staphylococcus aureus biofilm infection reveals therapeutic targets.

Wang Y, Cheng LI, Helfer DR, Ashbaugh AG, Miller RJ, Tzomides AJ, Thompson JM, Ortines RV, Tsai AS, Liu H, Dillen CA, Archer NK, Cohen TS, Tkaczyk C, Stover CK, Sellman BR, Miller LS.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5094-E5102. doi: 10.1073/pnas.1703427114. Epub 2017 Jun 12.

15.

Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach.

Tkaczyk C, Kasturirangan S, Minola A, Jones-Nelson O, Gunter V, Shi YY, Rosenthal K, Aleti V, Semenova E, Warrener P, Tabor D, Stover CK, Corti D, Rainey G, Sellman BR.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00629-17. doi: 10.1128/AAC.00629-17. Print 2017 Aug.

16.

Effects of Tedizolid Phosphate on Survival Outcomes and Suppression of Production of Staphylococcal Toxins in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia.

Le VT, Le HN, Pinheiro MG, Hahn KJ, Dinh ML, Larson KB, Flanagan SD, Badiou C, Lina G, Tkaczyk C, Sellman BR, Diep BA.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02734-16. doi: 10.1128/AAC.02734-16. Print 2017 Apr.

17.

Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia.

Diep BA, Hilliard JJ, Le VT, Tkaczyk C, Le HN, Tran VG, Rao RL, Dip EC, Pereira-Franchi EP, Cha P, Jacobson S, Broome R, Cheng LI, Weiss W, Prokai L, Nguyen V, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02456-16. doi: 10.1128/AAC.02456-16. Print 2017 Apr.

18.

IVIG-mediated protection against necrotizing pneumonia caused by MRSA.

Diep BA, Le VT, Badiou C, Le HN, Pinheiro MG, Duong AH, Wang X, Dip EC, Aguiar-Alves F, Basuino L, Marbach H, Mai TT, Sarda MN, Kajikawa O, Matute-Bello G, Tkaczyk C, Rasigade JP, Sellman BR, Chambers HF, Lina G.

Sci Transl Med. 2016 Sep 21;8(357):357ra124. doi: 10.1126/scitranslmed.aag1153.

PMID:
27655850
19.

Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections.

Le VT, Tkaczyk C, Chau S, Rao RL, Dip EC, Pereira-Franchi EP, Cheng L, Lee S, Koelkebeck H, Hilliard JJ, Yu XQ, Datta V, Nguyen V, Weiss W, Prokai L, O'Day T, Stover CK, Sellman BR, Diep BA.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5640-8. doi: 10.1128/AAC.00710-16. Print 2016 Oct.

20.

Targeting Alpha Toxin and ClfA with a Multimechanistic Monoclonal-Antibody-Based Approach for Prophylaxis of Serious Staphylococcus aureus Disease.

Tkaczyk C, Hamilton MM, Sadowska A, Shi Y, Chang CS, Chowdhury P, Buonapane R, Xiao X, Warrener P, Mediavilla J, Kreiswirth B, Suzich J, Stover CK, Sellman BR.

MBio. 2016 Jun 28;7(3). pii: e00528-16. doi: 10.1128/mBio.00528-16.

21.

Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893.

Tabor DE, Yu L, Mok H, Tkaczyk C, Sellman BR, Wu Y, Oganesyan V, Slidel T, Jafri H, McCarthy M, Bradford P, Esser MT.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5312-21. doi: 10.1128/AAC.00357-16. Print 2016 Sep.

22.

Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections.

Cohen TS, Hilliard JJ, Jones-Nelson O, Keller AE, O'Day T, Tkaczyk C, DiGiandomenico A, Hamilton M, Pelletier M, Wang Q, Diep BA, Le VT, Cheng L, Suzich J, Stover CK, Sellman BR.

Sci Transl Med. 2016 Mar 9;8(329):329ra31. doi: 10.1126/scitranslmed.aad9922.

PMID:
26962155
23.

A Novel Dual Expression Platform for High Throughput Functional Screening of Phage Libraries in Product like Format.

Xiao X, Chen Y, Mugabe S, Gao C, Tkaczyk C, Mazor Y, Pavlik P, Wu H, Dall'Acqua W, Chowdhury PS.

PLoS One. 2015 Oct 15;10(10):e0140691. doi: 10.1371/journal.pone.0140691. eCollection 2015.

24.

MEDI4893* Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model.

Hua L, Cohen TS, Shi Y, Datta V, Hilliard JJ, Tkaczyk C, Suzich J, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2015 Aug;59(8):4526-32. doi: 10.1128/AAC.00510-15. Epub 2015 May 18.

25.

Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.

Hilliard JJ, Datta V, Tkaczyk C, Hamilton M, Sadowska A, Jones-Nelson O, O'Day T, Weiss WJ, Szarka S, Nguyen V, Prokai L, Suzich J, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2015 Jan;59(1):299-309. doi: 10.1128/AAC.03918-14. Epub 2014 Oct 27.

26.

Mechanisms of neutralization of a human anti-α-toxin antibody.

Oganesyan V, Peng L, Damschroder MM, Cheng L, Sadowska A, Tkaczyk C, Sellman BR, Wu H, Dall'Acqua WF.

J Biol Chem. 2014 Oct 24;289(43):29874-80. doi: 10.1074/jbc.M114.601328. Epub 2014 Sep 10.

27.

Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia.

Hua L, Hilliard JJ, Shi Y, Tkaczyk C, Cheng LI, Yu X, Datta V, Ren S, Feng H, Zinsou R, Keller A, O'Day T, Du Q, Cheng L, Damschroder M, Robbie G, Suzich J, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2014;58(2):1108-17. doi: 10.1128/AAC.02190-13. Epub 2013 Dec 2.

28.

Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model.

Tkaczyk C, Hamilton MM, Datta V, Yang XP, Hilliard JJ, Stephens GL, Sadowska A, Hua L, O'Day T, Suzich J, Stover CK, Sellman BR.

PLoS One. 2013 Oct 2;8(10):e75103. doi: 10.1371/journal.pone.0075103. eCollection 2013.

29.

Characterization and biocompatibility studies of new degradable poly(urea)urethanes prepared with arginine, glycine or aspartic acid as chain extenders.

Chan-Chan LH, Tkaczyk C, Vargas-Coronado RF, Cervantes-Uc JM, Tabrizian M, Cauich-Rodriguez JV.

J Mater Sci Mater Med. 2013 Jul;24(7):1733-44. doi: 10.1007/s10856-013-4931-4. Epub 2013 Apr 25.

PMID:
23615787
30.

Effects of linezolid on suppressing in vivo production of staphylococcal toxins and improving survival outcomes in a rabbit model of methicillin-resistant Staphylococcus aureus necrotizing pneumonia.

Diep BA, Afasizheva A, Le HN, Kajikawa O, Matute-Bello G, Tkaczyk C, Sellman B, Badiou C, Lina G, Chambers HF.

J Infect Dis. 2013 Jul;208(1):75-82. doi: 10.1093/infdis/jit129. Epub 2013 Mar 26.

31.

Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-alpha toxin antibody fragment and alpha toxin.

Oganesyan V, Barnes A, Tkaczyk C, Ferguson A, Wu H, Dall'Acqua WF.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Mar 1;69(Pt 3):302-5. doi: 10.1107/S1744309113002881. Epub 2013 Feb 23.

32.

Identification of anti-alpha toxin monoclonal antibodies that reduce the severity of Staphylococcus aureus dermonecrosis and exhibit a correlation between affinity and potency.

Tkaczyk C, Hua L, Varkey R, Shi Y, Dettinger L, Woods R, Barnes A, MacGill RS, Wilson S, Chowdhury P, Stover CK, Sellman BR.

Clin Vaccine Immunol. 2012 Mar;19(3):377-85. doi: 10.1128/CVI.05589-11. Epub 2012 Jan 11.

33.

Significance of Elevated Blood Metal Ion Levels in Patients with Metal-on-Metal Prostheses: An Evaluation of Oxidative Stress Markers.

Tkaczyk C, Petit A, Antoniou J, Zukor DJ, Tabrizian M, Huk OL.

Open Orthop J. 2010 Jul 2;4:221-7. doi: 10.2174/1874325001004010221.

34.

Effect of chromium and cobalt ions on the expression of antioxidant enzymes in human U937 macrophage-like cells.

Tkaczyk C, Huk OL, Mwale F, Antoniou J, Zukor DJ, Petit A, Tabrizian M.

J Biomed Mater Res A. 2010 Aug;94(2):419-25. doi: 10.1002/jbm.a.32688.

PMID:
20186739
35.

Investigation of the binding of Cr(III) complexes to bovine and human serum proteins: a proteomic approach.

Tkaczyk C, Huk OL, Mwale F, Antoniou J, Zukor DJ, Petit A, Tabrizian M.

J Biomed Mater Res A. 2010 Jul;94(1):214-22. doi: 10.1002/jbm.a.32700.

PMID:
20166223
36.

No.39, Paychex. Lowering health-care costs.

Tkaczyk C.

Fortune. 2009 Nov 23;160(10):26. No abstract available.

PMID:
19968060
37.

The molecular structure of complexes formed by chromium or cobalt ions in simulated physiological fluids.

Tkaczyk C, Huk OL, Mwale F, Antoniou J, Zukor DJ, Petit A, Tabrizian M.

Biomaterials. 2009 Feb;30(4):460-7. doi: 10.1016/j.biomaterials.2008.09.055. Epub 2008 Oct 30.

PMID:
18976808
38.

Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells.

Iwaki S, Spicka J, Tkaczyk C, Jensen BM, Furumoto Y, Charles N, Kovarova M, Rivera J, Horejsi V, Metcalfe DD, Gilfillan AM.

Cell Signal. 2008 Jan;20(1):195-205. Epub 2007 Oct 16.

39.

Adaptive and innate immune reactions regulating mast cell activation: from receptor-mediated signaling to responses.

Tkaczyk C, Jensen BM, Iwaki S, Gilfillan AM.

Immunol Allergy Clin North Am. 2006 Aug;26(3):427-50. Review.

PMID:
16931287
40.

Cobalt and chromium ions induce nitration of proteins in human U937 macrophages in vitro.

Petit A, Mwale F, Tkaczyk C, Antoniou J, Zukor DJ, Huk OL.

J Biomed Mater Res A. 2006 Dec 1;79(3):599-605.

PMID:
16817215
41.

Integrated signalling pathways for mast-cell activation.

Gilfillan AM, Tkaczyk C.

Nat Rev Immunol. 2006 Mar;6(3):218-30. Review.

PMID:
16470226
42.

Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit.

Iwaki S, Tkaczyk C, Satterthwaite AB, Halcomb K, Beaven MA, Metcalfe DD, Gilfillan AM.

J Biol Chem. 2005 Dec 2;280(48):40261-70. Epub 2005 Sep 21.

43.

Roles of adaptor molecules in mast cell activation.

Tkaczyk C, Iwaki S, Metcalfe DD, Gilfillan AM.

Chem Immunol Allergy. 2005;87:43-58. doi: 10.1159/000087570. Review.

PMID:
16107762
44.

Induction of protein oxidation by cobalt and chromium ions in human U937 macrophages.

Petit A, Mwale F, Tkaczyk C, Antoniou J, Zukor DJ, Huk OL.

Biomaterials. 2005 Jul;26(21):4416-22.

PMID:
15701370
45.

Delivery platform for hydrophobic drugs: prodrug approach combined with self-assembled multilayers.

Thierry B, Kujawa P, Tkaczyk C, Winnik FM, Bilodeau L, Tabrizian M.

J Am Chem Soc. 2005 Feb 16;127(6):1626-7.

PMID:
15700982
46.

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.

Ali K, Bilancio A, Thomas M, Pearce W, Gilfillan AM, Tkaczyk C, Kuehn N, Gray A, Giddings J, Peskett E, Fox R, Bruce I, Walker C, Sawyer C, Okkenhaug K, Finan P, Vanhaesebroeck B.

Nature. 2004 Oct 21;431(7011):1007-11.

47.

Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells.

Hundley TR, Gilfillan AM, Tkaczyk C, Andrade MV, Metcalfe DD, Beaven MA.

Blood. 2004 Oct 15;104(8):2410-7. Epub 2004 Jun 24.

PMID:
15217825
48.

Fcgamma receptors on mast cells: activatory and inhibitory regulation of mediator release.

Tkaczyk C, Okayama Y, Metcalfe DD, Gilfillan AM.

Int Arch Allergy Immunol. 2004 Mar;133(3):305-15. Epub 2004 Mar 10. Review.

PMID:
15017113
49.

NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation.

Tkaczyk C, Horejsi V, Iwaki S, Draber P, Samelson LE, Satterthwaite AB, Nahm DH, Metcalfe DD, Gilfillan AM.

Blood. 2004 Jul 1;104(1):207-14. Epub 2004 Mar 9.

PMID:
15010370
50.

Identification of Fyn-binding proteins in MC/9 mast cells using mass spectrometry.

Nahm DH, Tkaczyk C, Fukuishi N, Colucci-Guyon E, Gilfillan AM, Metcalfe DD.

Biochem Biophys Res Commun. 2003 Oct 10;310(1):202-8.

PMID:
14511671

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