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Items: 1 to 50 of 71

1.

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death.

Seijkens TTP, Poels K, Meiler S, van Tiel CM, Kusters PJH, Reiche M, Atzler D, Winkels H, Tjwa M, Poelman H, Slütter B, Kuiper J, Gijbels M, Kuivenhoven JA, Matic LP, Paulsson-Berne G, Hedin U, Hansson GK, Nicolaes GAF, Daemen MJAP, Weber C, Gerdes N, de Winther MPJ, Lutgens E.

Eur Heart J. 2019 Jan 21;40(4):372-382. doi: 10.1093/eurheartj/ehy714.

2.

Decreased microglial numbers in Vav1-Cre+:dicer knock-out mice suggest a second source of microglia beyond yolk sac macrophages.

Fehrenbach MK, Tjwa M, Bechmann I, Krueger M.

Ann Anat. 2018 Jul;218:190-198. doi: 10.1016/j.aanat.2018.03.004. Epub 2018 Apr 26.

PMID:
29704636
3.

Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment.

Ridder K, Sevko A, Heide J, Dams M, Rupp AK, Macas J, Starmann J, Tjwa M, Plate KH, Sültmann H, Altevogt P, Umansky V, Momma S.

Oncoimmunology. 2015 Mar 19;4(6):e1008371. eCollection 2015 Jun.

4.

The role of RNA interference in the developmental separation of blood and lymphatic vasculature.

Gauvrit S, Philippe J, Lesage M, Tjwa M, Godin I, Germain S.

Vasc Cell. 2014 Apr 1;6(1):9. doi: 10.1186/2045-824X-6-9.

5.

Supporting roles of platelet thrombospondin-1 and CD36 in thrombus formation on collagen.

Kuijpers MJ, de Witt S, Nergiz-Unal R, van Kruchten R, Korporaal SJ, Verhamme P, Febbraio M, Tjwa M, Voshol PJ, Hoylaerts MF, Cosemans JM, Heemskerk JW.

Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1187-92. doi: 10.1161/ATVBAHA.113.302917. Epub 2014 Mar 27.

PMID:
24675658
6.

Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis.

Seijkens T, Hoeksema MA, Beckers L, Smeets E, Meiler S, Levels J, Tjwa M, de Winther MP, Lutgens E.

FASEB J. 2014 May;28(5):2202-13. doi: 10.1096/fj.13-243105. Epub 2014 Jan 30.

PMID:
24481967
7.

Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1.

Albiero M, Poncina N, Tjwa M, Ciciliot S, Menegazzo L, Ceolotto G, Vigili de Kreutzenberg S, Moura R, Giorgio M, Pelicci P, Avogaro A, Fadini GP.

Diabetes. 2014 Apr;63(4):1353-65. doi: 10.2337/db13-0894. Epub 2013 Nov 22.

8.

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.

Bono F, De Smet F, Herbert C, De Bock K, Georgiadou M, Fons P, Tjwa M, Alcouffe C, Ny A, Bianciotto M, Jonckx B, Murakami M, Lanahan AA, Michielsen C, Sibrac D, Dol-Gleizes F, Mazzone M, Zacchigna S, Herault JP, Fischer C, Rigon P, Ruiz de Almodovar C, Claes F, Blanc I, Poesen K, Zhang J, Segura I, Gueguen G, Bordes MF, Lambrechts D, Broussy R, van de Wouwer M, Michaux C, Shimada T, Jean I, Blacher S, Noel A, Motte P, Rom E, Rakic JM, Katsuma S, Schaeffer P, Yayon A, Van Schepdael A, Schwalbe H, Gervasio FL, Carmeliet G, Rozensky J, Dewerchin M, Simons M, Christopoulos A, Herbert JM, Carmeliet P.

Cancer Cell. 2013 Apr 15;23(4):477-88. doi: 10.1016/j.ccr.2013.02.019.

9.

Circulating apoptotic endothelial cells and apoptotic endothelial microparticles independently predict the presence of cardiac allograft vasculopathy.

Singh N, Van Craeyveld E, Tjwa M, Ciarka A, Emmerechts J, Droogne W, Gordts SC, Carlier V, Jacobs F, Fieuws S, Vanhaecke J, Van Cleemput J, De Geest B.

J Am Coll Cardiol. 2012 Jul 24;60(4):324-31. doi: 10.1016/j.jacc.2012.02.065.

10.

PlGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of myo-angiogenic competent marrow progenitors.

Iwasaki H, Kawamoto A, Tjwa M, Horii M, Hayashi S, Oyamada A, Matsumoto T, Suehiro S, Carmeliet P, Asahara T.

PLoS One. 2011;6(9):e24872. doi: 10.1371/journal.pone.0024872. Epub 2011 Sep 28.

11.

Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin.

Kaluza D, Kroll J, Gesierich S, Yao TP, Boon RA, Hergenreider E, Tjwa M, Rössig L, Seto E, Augustin HG, Zeiher AM, Dimmeler S, Urbich C.

EMBO J. 2011 Aug 16;30(20):4142-56. doi: 10.1038/emboj.2011.298.

12.

Another angiogenesis-independent role for VEGF: SDF1-dependent cardiac repair via cardiac stem cells.

Claes F, Vandevelde W, Moons L, Tjwa M.

Cardiovasc Res. 2011 Aug 1;91(3):369-70. doi: 10.1093/cvr/cvr184. Epub 2011 Jun 23. No abstract available.

PMID:
21705348
13.

Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia.

Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P.

Cancer Cell. 2011 Jun 14;19(6):740-53. doi: 10.1016/j.ccr.2011.05.007.

14.

Hepatocyte growth factor mobilizes non-bone marrow-derived circulating mesoangioblasts.

Iwasaki M, Koyanagi M, Kossmann H, Monsefi N, Rupp S, Trauth J, Paulus P, Goetz R, Momma S, Tjwa M, Ohtani K, Henschler R, Schranz D, Cossu G, Zacharowski K, Martens S, Zeiher AM, Dimmeler S.

Eur Heart J. 2011 Mar;32(5):627-36. doi: 10.1093/eurheartj/ehq442. Epub 2010 Dec 29.

PMID:
21193434
15.

Platelets suppress Treg recruitment.

Moura R, Tjwa M.

Blood. 2010 Nov 18;116(20):4035-7. doi: 10.1182/blood-2010-09-303396. No abstract available.

PMID:
21088138
16.

The role of CD154 in haematopoietic development.

Seijkens T, Engel D, Tjwa M, Lutgens E.

Thromb Haemost. 2010 Oct;104(4):693-701. doi: 10.1160/TH10-03-0174. Epub 2010 Aug 5. Review.

PMID:
20694278
17.

Long-term diabetes impairs repopulation of hematopoietic progenitor cells and dysregulates the cytokine expression in the bone marrow microenvironment in mice.

Orlandi A, Chavakis E, Seeger F, Tjwa M, Zeiher AM, Dimmeler S.

Basic Res Cardiol. 2010 Nov;105(6):703-12. doi: 10.1007/s00395-010-0109-0. Epub 2010 Jul 22.

PMID:
20652278
18.

Induced pluripotent stem (iPS) cells and endothelial cell generation: SIRT-ainly a good idea!

Moura R, Fadini GP, Tjwa M.

Atherosclerosis. 2010 Sep;212(1):36-9. doi: 10.1016/j.atherosclerosis.2010.06.031. Epub 2010 Jun 26. No abstract available.

PMID:
20638064
19.

A role for TGF-beta in transforming endothelial progenitor cells into neointimal smooth muscle cells.

Fadini GP, Tjwa M.

Atherosclerosis. 2010 Jul;211(1):32-5. doi: 10.1016/j.atherosclerosis.2010.03.025. Epub 2010 Apr 7. No abstract available.

PMID:
20427045
20.

Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones.

Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, Moermans K, Nyabi O, Haigh K, Naessens M, Haenebalcke L, Tuckermann JP, Tjwa M, Carmeliet P, Mandic V, David JP, Behrens A, Nagy A, Carmeliet G, Haigh JJ.

EMBO J. 2010 Jan 20;29(2):424-41. doi: 10.1038/emboj.2009.361. Epub 2009 Dec 10.

21.

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.

Loges S, Schmidt T, Tjwa M, van Geyte K, Lievens D, Lutgens E, Vanhoutte D, Borgel D, Plaisance S, Hoylaerts M, Luttun A, Dewerchin M, Jonckx B, Carmeliet P.

Blood. 2010 Mar 18;115(11):2264-73. doi: 10.1182/blood-2009-06-228684. Epub 2009 Nov 20.

PMID:
19965679
22.

Pleiotropic role of growth arrest-specific gene 6 in atherosclerosis.

Tjwa M, Moons L, Lutgens E.

Curr Opin Lipidol. 2009 Oct;20(5):386-92. doi: 10.1097/MOL.0b013e328330982e. Review.

PMID:
19644365
23.

MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice.

Bonauer A, Carmona G, Iwasaki M, Mione M, Koyanagi M, Fischer A, Burchfield J, Fox H, Doebele C, Ohtani K, Chavakis E, Potente M, Tjwa M, Urbich C, Zeiher AM, Dimmeler S.

Science. 2009 Jun 26;324(5935):1710-3. doi: 10.1126/science.1174381. Epub 2009 May 21.

24.

Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences.

Tintu A, Rouwet E, Verlohren S, Brinkmann J, Ahmad S, Crispi F, van Bilsen M, Carmeliet P, Staff AC, Tjwa M, Cetin I, Gratacos E, Hernandez-Andrade E, Hofstra L, Jacobs M, Lamers WH, Morano I, Safak E, Ahmed A, le Noble F.

PLoS One. 2009;4(4):e5155. doi: 10.1371/journal.pone.0005155. Epub 2009 Apr 9.

25.

Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells.

Tjwa M, Sidenius N, Moura R, Jansen S, Theunissen K, Andolfo A, De Mol M, Dewerchin M, Moons L, Blasi F, Verfaillie C, Carmeliet P.

J Clin Invest. 2009 Apr;119(4):1008-18. doi: 10.1172/JCI36010. Epub 2009 Mar 9.

26.

Antibiotics may impair hematopoietic recovery after cytotoxic myeloablation.

Tjwa M, Moons L, Verfaillie C, Carmeliet P.

Blood. 2009 Feb 12;113(7):1608-9. doi: 10.1182/blood-2008-10-185694. No abstract available.

PMID:
19221044
27.

Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation.

Tjwa M, Moura R, Moons L, Plaisance S, De Mol M, Jansen S, Dewerchin M, Verfaillie C, Carmeliet P.

J Cell Mol Med. 2009 Nov-Dec;13(11-12):4587-95. doi: 10.1111/j.1582-4934.2008.00521.x. Epub 2008 Nov 22.

28.

Better regenerative output after cellular input: healing hearts by combining basic fibroblast factor and cell-based therapy.

Dimmeler S, Tjwa M.

J Am Coll Cardiol. 2008 Dec 2;52(23):1866-1868. doi: 10.1016/j.jacc.2008.07.065. No abstract available.

29.

Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration.

Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P.

J Neurosci. 2008 Oct 15;28(42):10451-9. doi: 10.1523/JNEUROSCI.1092-08.2008.

30.

Critical role of scavenger receptor-BI-expressing bone marrow-derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo A-I transfer.

Feng Y, van Eck M, Van Craeyveld E, Jacobs F, Carlier V, Van Linthout S, Erdel M, Tjwa M, De Geest B.

Blood. 2009 Jan 15;113(3):755-64. doi: 10.1182/blood-2008-06-161794. Epub 2008 Sep 29.

PMID:
18824596
31.

Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/- mice.

Moura R, Tjwa M, Vandervoort P, Van Kerckhoven S, Holvoet P, Hoylaerts MF.

Circ Res. 2008 Nov 7;103(10):1181-9. doi: 10.1161/CIRCRESAHA.108.185645. Epub 2008 Sep 25.

PMID:
18818405
32.

Plasmin therapy enhances mobilization of HPCs after G-CSF.

Tjwa M, Janssens S, Carmeliet P.

Blood. 2008 Nov 15;112(10):4048-50. doi: 10.1182/blood-2008-07-166587. Epub 2008 Aug 22. Erratum in: Blood. 2009 May 21;113(21):5368.

33.

A nucleolar weapon in our fight for regenerating adult hearts: nucleostemin and cardiac stem cells.

Tjwa M, Dimmeler S.

Circ Res. 2008 Jul 3;103(1):4-6. doi: 10.1161/CIRCRESAHA.108.179994. No abstract available.

PMID:
18596260
34.

Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway.

Vidal B, Serrano AL, Tjwa M, Suelves M, Ardite E, De Mori R, Baeza-Raja B, Martínez de Lagrán M, Lafuste P, Ruiz-Bonilla V, Jardí M, Gherardi R, Christov C, Dierssen M, Carmeliet P, Degen JL, Dewerchin M, Muñoz-Cánoves P.

Genes Dev. 2008 Jul 1;22(13):1747-52. doi: 10.1101/gad.465908.

35.

Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis.

Lutgens E, Tjwa M, Garcia de Frutos P, Wijnands E, Beckers L, Dahlbäck B, Daemen MJ, Carmeliet P, Moons L.

J Pathol. 2008 Sep;216(1):55-63. doi: 10.1002/path.2381.

PMID:
18570189
36.

Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.

Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Juan TD, Sievers RE, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, von Degenfeld G, Dewerchin M, Blau HM, Alitalo K, Eriksson U, Carmeliet P, Moons L.

Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1614-20. doi: 10.1161/ATVBAHA.107.158725. Epub 2008 May 29.

37.

Role of Gas6 in erythropoiesis and anemia in mice.

Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish RJ, Tjwa M, Plaisance S, Sugamele R, DeMol M, Martinez-Soria E, Maxwell PH, Lemke G, Goff SP, Matsushima GK, Earp HS, Chanson M, Collen D, Izui S, Schapira M, Conway EM, Carmeliet P.

J Clin Invest. 2008 Feb;118(2):583-96. doi: 10.1172/JCI30375.

38.

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.

Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P.

Nat Genet. 2008 Feb;40(2):170-80. doi: 10.1038/ng.2007.62. Epub 2008 Jan 6.

PMID:
18176562
39.

Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes.

Tjwa M, Bellido-Martin L, Lin Y, Lutgens E, Plaisance S, Bono F, Delesque-Touchard N, Hervé C, Moura R, Billiau AD, Aparicio C, Levi M, Daemen M, Dewerchin M, Lupu F, Arnout J, Herbert JM, Waer M, García de Frutos P, Dahlbäck B, Carmeliet P, Hoylaerts MF, Moons L.

Blood. 2008 Apr 15;111(8):4096-105. Epub 2007 Dec 21.

40.

Human ApoA-I transfer attenuates transplant arteriosclerosis via enhanced incorporation of bone marrow-derived endothelial progenitor cells.

Feng Y, Jacobs F, Van Craeyveld E, Brunaud C, Snoeys J, Tjwa M, Van Linthout S, De Geest B.

Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):278-83. Epub 2007 Dec 6.

PMID:
18063807
41.

Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice.

Tirziu D, Chorianopoulos E, Moodie KL, Palac RT, Zhuang ZW, Tjwa M, Roncal C, Eriksson U, Fu Q, Elfenbein A, Hall AE, Carmeliet P, Moons L, Simons M.

J Clin Invest. 2007 Nov;117(11):3188-97.

42.

uPA deficiency exacerbates muscular dystrophy in MDX mice.

Suelves M, Vidal B, Serrano AL, Tjwa M, Roma J, López-Alemany R, Luttun A, de Lagrán MM, Díaz-Ramos A, Jardí M, Roig M, Dierssen M, Dewerchin M, Carmeliet P, Muñoz-Cánoves P.

J Cell Biol. 2007 Sep 10;178(6):1039-51. Epub 2007 Sep 4. Erratum in: J Cell Biol. 2007 Oct 8;179(1):165. Díaz, Maria Angels [corrected to Díaz-Ramos, Angels].

43.

Thrombospondin-1 activates medial smooth muscle cells and triggers neointima formation upon mouse carotid artery ligation.

Moura R, Tjwa M, Vandervoort P, Cludts K, Hoylaerts MF.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2163-9. Epub 2007 Aug 30.

PMID:
17761938
44.

Tumoral and choroidal vascularization: differential cellular mechanisms involving plasminogen activator inhibitor type I.

Jost M, Maillard C, Lecomte J, Lambert V, Tjwa M, Blaise P, Alvarez Gonzalez ML, Bajou K, Blacher S, Motte P, Humblet C, Defresne MP, Thiry M, Frankenne F, Gothot A, Carmeliet P, Rakic JM, Foidart JM, Noël A.

Am J Pathol. 2007 Oct;171(4):1369-80. Epub 2007 Aug 23.

45.

Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis.

Umans L, Cox L, Tjwa M, Bito V, Vermeire L, Laperre K, Sipido K, Moons L, Huylebroeck D, Zwijsen A.

Am J Pathol. 2007 May;170(5):1460-72.

46.

Impaired adipose tissue development in mice with inactivation of placental growth factor function.

Lijnen HR, Christiaens V, Scroyen I, Voros G, Tjwa M, Carmeliet P, Collen D.

Diabetes. 2006 Oct;55(10):2698-704.

47.

A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span.

Vangheluwe P, Tjwa M, Van Den Bergh A, Louch WE, Beullens M, Dode L, Carmeliet P, Kranias E, Herijgers P, Sipido KR, Raeymaekers L, Wuytack F.

J Mol Cell Cardiol. 2006 Aug;41(2):308-17. Epub 2006 Jun 30.

PMID:
16814319
48.

Novel transgenic rabbit model sheds light on the puzzling role of matrix metalloproteinase-12 in atherosclerosis.

Tjwa M, Carmeliet P, Moons L.

Circulation. 2006 Apr 25;113(16):1929-32. No abstract available.

PMID:
16636186
49.

Genetic evidence for a tumor suppressor role of HIF-2alpha.

Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P.

Cancer Cell. 2005 Aug;8(2):131-41.

50.

A surrogate marker to monitor angiogenesis at last.

Schneider M, Tjwa M, Carmeliet P.

Cancer Cell. 2005 Jan;7(1):3-4.

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