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Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

Frankowski KJ, Wang C, Patnaik S, Schoenen FJ, Southall N, Li D, Teper Y, Sun W, Kandela I, Hu D, Dextras C, Knotts Z, Bian Y, Norton J, Titus S, Lewandowska MA, Wen Y, Farley KI, Griner LM, Sultan J, Meng Z, Zhou M, Vilimas T, Powers AS, Kozlov S, Nagashima K, Quadri HS, Fang M, Long C, Khanolkar O, Chen W, Kang J, Huang H, Chow E, Goldberg E, Feldman C, Xi R, Kim HR, Sahagian G, Baserga SJ, Mazar A, Ferrer M, Zheng W, Shilatifard A, Aubé J, Rudloff U, Marugan JJ, Huang S.

Sci Transl Med. 2018 May 16;10(441). pii: eaap8307. doi: 10.1126/scitranslmed.aap8307.


Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

Yasgar A, Titus SA, Wang Y, Danchik C, Yang SM, Vasiliou V, Jadhav A, Maloney DJ, Simeonov A, Martinez NJ.

PLoS One. 2018 May 15;13(5):e0197292. doi: 10.1371/journal.pone.0197292. eCollection 2018.


Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses.

Sima N, Li R, Huang W, Xu M, Beers J, Zou J, Titus S, Ottinger EA, Marugan JJ, Xie X, Zheng W.

Orphanet J Rare Dis. 2018 Apr 10;13(1):54. doi: 10.1186/s13023-018-0798-2.


Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.

Pei F, Li H, Henderson MJ, Titus SA, Jadhav A, Simeonov A, Cobanoglu MC, Mousavi SH, Shun T, McDermott L, Iyer P, Fioravanti M, Carlisle D, Friedlander RM, Bahar I, Taylor DL, Lezon TR, Stern AM, Schurdak ME.

Sci Rep. 2017 Dec 19;7(1):17803. doi: 10.1038/s41598-017-17378-y.


Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.

Al-Ramahi I, Panapakkam Giridharan SS, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ.

Elife. 2017 Dec 26;6. pii: e29123. doi: 10.7554/eLife.29123.


Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.

Urban DJ, Martinez NJ, Davis MI, Brimacombe KR, Cheff DM, Lee TD, Henderson MJ, Titus SA, Pragani R, Rohde JM, Liu L, Fang Y, Karavadhi S, Shah P, Lee OW, Wang A, McIver A, Zheng H, Wang X, Xu X, Jadhav A, Simeonov A, Shen M, Boxer MB, Hall MD.

Sci Rep. 2017 Oct 6;7(1):12758. doi: 10.1038/s41598-017-12630-x.


Ovarian Aging in Women With BRCA Germline Mutations.

Lin W, Titus S, Moy F, Ginsburg ES, Oktay K.

J Clin Endocrinol Metab. 2017 Oct 1;102(10):3839-3847. doi: 10.1210/jc.2017-00765.


Ethics: More research won't crack misconduct.

Kornfeld DS, Titus SL.

Nature. 2017 Aug 2;548(7665):31. doi: 10.1038/548031a. No abstract available.


Exploring Drug Dosing Regimens In Vitro Using Real-Time 3D Spheroid Tumor Growth Assays.

Lal-Nag M, McGee L, Titus SA, Brimacombe K, Michael S, Sittampalam G, Ferrer M.

SLAS Discov. 2017 Jun;22(5):537-546. doi: 10.1177/2472555217698818. Epub 2017 Mar 15.


Cellular and molecular defects in a patient with Hermansky-Pudlak syndrome type 5.

Stephen J, Yokoyama T, Tolman NJ, O'Brien KJ, Nicoli ER, Brooks BP, Huryn L, Titus SA, Adams DR, Chen D, Gahl WA, Gochuico BR, Malicdan MC.

PLoS One. 2017 Mar 15;12(3):e0173682. doi: 10.1371/journal.pone.0173682. eCollection 2017.


RNAi High-Throughput Screening of Single- and Multi-Cell-Type Tumor Spheroids: A Comprehensive Analysis in Two and Three Dimensions.

Fu J, Fernandez D, Ferrer M, Titus SA, Buehler E, Lal-Nag MA.

SLAS Discov. 2017 Jun;22(5):525-536. doi: 10.1177/2472555217696796. Epub 2017 Mar 9.


A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

Yasgar A, Titus SA, Wang Y, Danchik C, Yang SM, Vasiliou V, Jadhav A, Maloney DJ, Simeonov A, Martinez NJ.

PLoS One. 2017 Jan 27;12(1):e0170937. doi: 10.1371/journal.pone.0170937. eCollection 2017. Erratum in: PLoS One. 2018 May 15;13(5):e0197292.


Large-scale pharmacological profiling of 3D tumor models of cancer cells.

Mathews Griner LA, Zhang X, Guha R, McKnight C, Goldlust IS, Lal-Nag M, Wilson K, Michael S, Titus S, Shinn P, Thomas CJ, Ferrer M.

Cell Death Dis. 2016 Dec 1;7(12):e2492. doi: 10.1038/cddis.2016.360.


ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice.

Abera MB, Xiao J, Nofziger J, Titus S, Southall N, Zheng W, Moritz KE, Ferrer M, Cherry JJ, Androphy EJ, Wang A, Xu X, Austin C, Fischbeck KH, Marugan JJ, Burnett BG.

JCI Insight. 2016 Nov 17;1(19):e88427.


One-Step Seeding of Neural Stem Cells with Vitronectin-Supplemented Medium for High-Throughput Screening Assays.

Dai S, Li R, Long Y, Titus S, Zhao J, Huang R, Xia M, Zheng W.

J Biomol Screen. 2016 Dec;21(10):1112-1124. doi: 10.1177/1087057116670068. Epub 2016 Sep 26.


Stop ignoring misconduct.

Kornfeld DS, Titus SL.

Nature. 2016 Sep 1;537(7618):29-30. doi: 10.1038/537029a. No abstract available.


Murine uterine decidualization is a novel function of autoimmune regulator-beyond immune tolerance.

Soumya V, Padmanabhan RA, Titus S, Laloraya M.

Am J Reprod Immunol. 2016 Sep;76(3):224-34. doi: 10.1111/aji.12538. Epub 2016 Jul 19.


Neurochemical correlation between major depressive disorder and neurodegenerative diseases.

Réus GZ, Titus SE, Abelaira HM, Freitas SM, Tuon T, Quevedo J, Budni J.

Life Sci. 2016 Aug 1;158:121-9. doi: 10.1016/j.lfs.2016.06.027. Epub 2016 Jun 28. Review.


Glutamatergic NMDA Receptor as Therapeutic Target for Depression.

Réus GZ, Abelaira HM, Tuon T, Titus SE, Ignácio ZM, Rodrigues AL, Quevedo J.

Adv Protein Chem Struct Biol. 2016;103:169-202. doi: 10.1016/bs.apcsb.2015.10.003. Epub 2015 Dec 17. Review.


Enriched Flavonoid Fraction from Cecropia pachystachya Trécul Leaves Exerts Antidepressant-like Behavior and Protects Brain Against Oxidative Stress in Rats Subjected to Chronic Mild Stress.

Ortmann CF, Réus GZ, Ignácio ZM, Abelaira HM, Titus SE, de Carvalho P, Arent CO, Dos Santos MA, Matias BI, Martins MM, de Campos AM, Petronilho F, Teixeira LJ, Morais MO, Streck EL, Quevedo J, Reginatto FH.

Neurotox Res. 2016 May;29(4):469-83. doi: 10.1007/s12640-016-9596-6. Epub 2016 Jan 13.


Effects of ketamine administration on the phosphorylation levels of CREB and TrKB and on oxidative damage after infusion of MEK inhibitor.

Réus GZ, Abaleira HM, Titus SE, Arent CO, Michels M, da Luz JR, dos Santos MA, Carlessi AS, Matias BI, Bruchchen L, Steckert AV, Ceretta LB, Dal-Pizzol F, Quevedo J.

Pharmacol Rep. 2016 Feb;68(1):177-84. doi: 10.1016/j.pharep.2015.08.010. Epub 2015 Aug 28.


Impaired DNA Repair as a Mechanism for Oocyte Aging: Is It Epigenetically Determined?

Titus S, Stobezki R, Oktay K.

Semin Reprod Med. 2015 Nov;33(6):384-8. doi: 10.1055/s-0035-1567824. Epub 2015 Nov 12. Review.


Reflecting on Carlos: Unique and Homeless.

Bowera L, Titus S.

Imprint. 2015 Apr-May;62(3):42-3. No abstract available.


Antioxidant treatment ameliorates experimental diabetes-induced depressive-like behaviour and reduces oxidative stress in brain and pancreas.

Réus GZ, Dos Santos MA, Abelaira HM, Titus SE, Carlessi AS, Matias BI, Bruchchen L, Florentino D, Vieira A, Petronilho F, Ceretta LB, Zugno AI, Quevedo J.

Diabetes Metab Res Rev. 2016 Mar;32(3):278-88. doi: 10.1002/dmrr.2732. Epub 2015 Nov 11.


Methylphenidate increases glucose uptake in the brain of young and adult rats.

Réus GZ, Scaini G, Titus SE, Furlanetto CB, Wessler LB, Ferreira GK, Gonçalves CL, Jeremias GC, Quevedo J, Streck EL.

Pharmacol Rep. 2015 Oct;67(5):1033-40. doi: 10.1016/j.pharep.2015.03.005. Epub 2015 Mar 23.


High-throughput fluorescence imaging approaches for drug discovery using in vitro and in vivo three-dimensional models.

Martinez NJ, Titus SA, Wagner AK, Simeonov A.

Expert Opin Drug Discov. 2015 Dec;10(12):1347-61. doi: 10.1517/17460441.2015.1091814. Epub 2015 Sep 22. Review.


BRCA Mutations, DNA Repair Deficiency, and Ovarian Aging.

Oktay K, Turan V, Titus S, Stobezki R, Liu L.

Biol Reprod. 2015 Sep;93(3):67. doi: 10.1095/biolreprod.115.132290. Epub 2015 Jul 29. Review.



Titus S.

Account Res. 2015;22(6):307-11. doi: 10.1080/08989621.2015.1047710. No abstract available.


Acute and Chronic Treatments with Quetiapine Increase Mitochondrial Respiratory Chain Complex Activity in the Rat Brain.

Ignácio ZM, Réus GZ, Abelaira HM, Titus SE, Carlessi AS, da Luz JR, Matias BI, Bruchchen L, Carvalho-Silva M, Gomes LM, Rebelo J, Streck EL, Quevedo J.

Curr Neurovasc Res. 2015;12(3):283-92.


Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies.

Réus GZ, Jansen K, Titus S, Carvalho AF, Gabbay V, Quevedo J.

J Psychiatr Res. 2015 Sep;68:316-28. doi: 10.1016/j.jpsychires.2015.05.007. Epub 2015 May 19. Review.


Polyarthritis and massive small bowel bleed: An unusual combination in scrub typhus.

Iqbal N, Titus S, Basheer A, George S, George S, Mookkappan S, Nair S, Alexander T, Ramdas A, Periyasamy S, Anitha P, Kanungo R.

Australas Med J. 2015 Mar 31;8(3):89-95. doi: 10.4066/AMJ.2015.2299. eCollection 2015.


A single dose of S-ketamine induces long-term antidepressant effects and decreases oxidative stress in adulthood rats following maternal deprivation.

Réus GZ, Carlessi AS, Titus SE, Abelaira HM, Ignácio ZM, da Luz JR, Matias BI, Bruchchen L, Florentino D, Vieira A, Petronilho F, Quevedo J.

Dev Neurobiol. 2015 Nov;75(11):1268-81. doi: 10.1002/dneu.22283. Epub 2015 Mar 19.


Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial.

Cudkowicz ME, Titus S, Kearney M, Yu H, Sherman A, Schoenfeld D, Hayden D, Shui A, Brooks B, Conwit R, Felsenstein D, Greenblatt DJ, Keroack M, Kissel JT, Miller R, Rosenfeld J, Rothstein JD, Simpson E, Tolkoff-Rubin N, Zinman L, Shefner JM; Ceftriaxone Study Investigators.

Lancet Neurol. 2014 Nov;13(11):1083-1091. doi: 10.1016/S1474-4422(14)70222-4. Epub 2014 Oct 5.


Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates.

Lawrence SA, Titus SA, Ferguson J, Heineman AL, Taylor SM, Moran RG.

J Biol Chem. 2014 Oct 17;289(42):29386-96. doi: 10.1074/jbc.M114.593244. Epub 2014 Aug 27.


Severe euvolemic hyponatremia with urinary retention: a case report.

Lax JW, Kinderknecht KJ, Titus SJ.

J Am Geriatr Soc. 2014 Jun;62(6):1199-200. doi: 10.1111/jgs.12854. No abstract available.


Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor.

Free RB, Chun LS, Moritz AE, Miller BN, Doyle TB, Conroy JL, Padron A, Meade JA, Xiao J, Hu X, Dulcey AE, Han Y, Duan L, Titus S, Bryant-Genevier M, Barnaeva E, Ferrer M, Javitch JA, Beuming T, Shi L, Southall NT, Marugan JJ, Sibley DR.

Mol Pharmacol. 2014 Jul;86(1):96-105. doi: 10.1124/mol.113.090563. Epub 2014 Apr 22.


Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists.

Xiao J, Free RB, Barnaeva E, Conroy JL, Doyle T, Miller B, Bryant-Genevier M, Taylor MK, Hu X, Dulcey AE, Southall N, Ferrer M, Titus S, Zheng W, Sibley DR, Marugan JJ.

J Med Chem. 2014 Apr 24;57(8):3450-63. doi: 10.1021/jm500126s. Epub 2014 Apr 10.


Student experiences in transcultural nursing: monsoon style.

Titus SK.

Imprint. 2013 Nov-Dec;60(5):42-4. No abstract available.


A panel of diverse assays to interrogate the interaction between glucokinase and glucokinase regulatory protein, two vital proteins in human disease.

Rees MG, Davis MI, Shen M, Titus S, Raimondo A, Barrett A, Gloyn AL, Collins FS, Simeonov A.

PLoS One. 2014 Feb 19;9(2):e89335. doi: 10.1371/journal.pone.0089335. eCollection 2014.


Age-related decline in DNA repair function explains diminished ovarian reserve, earlier menopause, and possible oocyte vulnerability to chemotherapy in women with BRCA mutations.

Oktay K, Moy F, Titus S, Stobezki R, Turan V, Dickler M, Goswami S.

J Clin Oncol. 2014 Apr 1;32(10):1093-4. doi: 10.1200/JCO.2013.53.5369. Epub 2014 Feb 18. No abstract available.


STAT3 and MCL-1 associate to cause a mesenchymal epithelial transition.

Renjini AP, Titus S, Narayan P, Murali M, Jha RK, Laloraya M.

J Cell Sci. 2014 Apr 15;127(Pt 8):1738-50. doi: 10.1242/jcs.138214. Epub 2014 Jan 30.


Discovery, optimization, and characterization of a novel series of dopamine D2 versus D3 receptor selective antagonists.

Xiao J, Free RB, Barnaeva E, Conroy J, Doyle T, Bryant-Genevier M, Taylor MK, Southall N, Hu X, Ferrer M, Titus S, Zheng W, Sibley DR, Marugan JJ.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 25 [updated 2013 Sep 3].


In reply.

Titus SJ.

Am Fam Physician. 2013 Jul 1;88(1):Online. No abstract available.


A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis.

Samie M, Wang X, Zhang X, Goschka A, Li X, Cheng X, Gregg E, Azar M, Zhuo Y, Garrity AG, Gao Q, Slaugenhaupt S, Pickel J, Zolov SN, Weisman LS, Lenk GM, Titus S, Bryant-Genevier M, Southall N, Juan M, Ferrer M, Xu H.

Dev Cell. 2013 Sep 16;26(5):511-24. doi: 10.1016/j.devcel.2013.08.003. Epub 2013 Aug 29.


Discovery and Development of Small Molecules That Reduce PNC Prevalence.

Frankowski K, Patnaik S, Schoenen F, Huang S, Norton J, Wang C, Titus S, Ferrer M, Zheng W, Southall N, Day VW, Aubé J, Marugan JJ.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.


Ensuring PhD development of responsible conduct of research behaviors: who's responsible?

Titus SL, Ballou JM.

Sci Eng Ethics. 2014 Mar;20(1):221-35. doi: 10.1007/s11948-013-9437-4. Epub 2013 May 18.


Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists.

Huang W, Englund E, Titus S, Southall N, Zheng W, Ferrer M, Marugan J, Neumann S, Gershengorn M.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Mar 31 [updated 2013 Feb 28].


Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans.

Titus S, Li F, Stobezki R, Akula K, Unsal E, Jeong K, Dickler M, Robson M, Moy F, Goswami S, Oktay K.

Sci Transl Med. 2013 Feb 13;5(172):172ra21. doi: 10.1126/scitranslmed.3004925.


High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model.

Titus SA, Southall N, Marugan J, Austin CP, Zheng W.

Curr Chem Genomics. 2012;6:79-86. doi: 10.2174/1875397301206010079. Epub 2012 Dec 28.

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