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Putting the brakes on a myosin motor.

Eddington C, Titus MA.

J Biol Chem. 2020 Mar 20;295(12):3757-3758. doi: 10.1074/jbc.H120.013153.


A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer.

Corn PG, Zhang M, Nogueras-Gonzalez GM, Xiao L, Zurita AJ, Subudhi SK, Tu SM, Aparicio AM, Coarfa C, Rajapakshe K, Huang S, Navone NM, Lin SH, Wang G, Ramachandran S, Titus MA, Panaretakis T, Gallick GE, Efstathiou E, Troncoso P, Logothetis C.

Clin Cancer Res. 2020 Mar 1;26(5):990-999. doi: 10.1158/1078-0432.CCR-19-2389. Epub 2020 Jan 15.


Basic-hydrophobic sites are localized in conserved positions inside and outside of PH domains and affect localization of Dictyostelium myosin 1s.

Brzeska H, Gonzalez J, Korn ED, Titus MA.

Mol Biol Cell. 2020 Jan 15;31(2):101-117. doi: 10.1091/mbc.E19-08-0475. Epub 2019 Nov 27.


Optimized filopodia formation requires myosin tail domain cooperation.

Arthur AL, Songster LD, Sirkia H, Bhattacharya A, Kikuti C, Borrega FP, Houdusse A, Titus MA.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22196-22204. doi: 10.1073/pnas.1901527116. Epub 2019 Oct 14.


Developing Evolutionary Cell Biology.

Titus MA, Goodson HV.

Dev Cell. 2018 Nov 19;47(4):395-396. doi: 10.1016/j.devcel.2018.11.006.


Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo.

Zacharias N, Lee J, Ramachandran S, Shanmugavelandy S, McHenry J, Dutta P, Millward S, Gammon S, Efstathiou E, Troncoso P, Frigo DE, Piwnica-Worms D, Logothetis CJ, Maity SN, Titus MA, Bhattacharya P.

Mol Imaging Biol. 2019 Feb;21(1):86-94. doi: 10.1007/s11307-018-1199-6.


Therapeutic Targeting of Sunitinib-Induced AR Phosphorylation in Renal Cell Carcinoma.

Adelaiye-Ogala R, Damayanti NP, Orillion AR, Arisa S, Chintala S, Titus MA, Kao C, Pili R.

Cancer Res. 2018 Jun 1;78(11):2886-2896. doi: 10.1158/0008-5472.CAN-17-3386. Epub 2018 Mar 23.


Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II.

Yu G, Cheng CJ, Lin SC, Lee YC, Frigo DE, Yu-Lee LY, Gallick GE, Titus MA, Nutt LK, Lin SH.

Cancer Res. 2018 May 15;78(10):2490-2502. doi: 10.1158/0008-5472.CAN-17-2392. Epub 2018 Mar 13.


Myosin-Driven Intracellular Transport.

Titus MA.

Cold Spring Harb Perspect Biol. 2018 Mar 1;10(3). pii: a021972. doi: 10.1101/cshperspect.a021972. Review.


Cabozantinib-induced osteoblast secretome promotes survival and migration of metastatic prostate cancer cells in bone.

Yu KJ, Li JK, Lee YC, Yu G, Lin SC, Pan T, Satcher RL, Titus MA, Yu-Lee LY, Weng WH, Gallick GE, Lin SH.

Oncotarget. 2017 Aug 24;8(43):74987-75006. doi: 10.18632/oncotarget.20489. eCollection 2017 Sep 26.


Myosin 7 and its adaptors link cadherins to actin.

Yu IM, Planelles-Herrero VJ, Sourigues Y, Moussaoui D, Sirkia H, Kikuti C, Stroebel D, Titus MA, Houdusse A.

Nat Commun. 2017 Jun 29;8:15864. doi: 10.1038/ncomms15864.


An evolutionary perspective on cell migration: Digging for the roots of amoeboid motility.

Titus MA, Goodson HV.

J Cell Biol. 2017 Jun 5;216(6):1509-1511. doi: 10.1083/jcb.201704112. Epub 2017 May 24.


Growing, splitting and stacking myosin II filaments.

Titus MA.

Nat Cell Biol. 2017 Jan 31;19(2):77-79. doi: 10.1038/ncb3468.


MyTH4-FERM myosins have an ancient and conserved role in filopod formation.

Petersen KJ, Goodson HV, Arthur AL, Luxton GW, Houdusse A, Titus MA.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8059-E8068. Epub 2016 Nov 23.


The Efflux Transporter ABCG2 Maintains Prostate Stem Cells.

Sabnis NG, Miller A, Titus MA, Huss WJ.

Mol Cancer Res. 2017 Feb;15(2):128-140. doi: 10.1158/1541-7786.MCR-16-0270-T. Epub 2016 Nov 17.


Targeting of CYP17A1 Lyase by VT-464 Inhibits Adrenal and Intratumoral Androgen Biosynthesis and Tumor Growth of Castration Resistant Prostate Cancer.

Maity SN, Titus MA, Gyftaki R, Wu G, Lu JF, Ramachandran S, Li-Ning-Tapia EM, Logothetis CJ, Araujo JC, Efstathiou E.

Sci Rep. 2016 Oct 17;6:35354. doi: 10.1038/srep35354.


Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes.

Pylypenko O, Welz T, Tittel J, Kollmar M, Chardon F, Malherbe G, Weiss S, Michel CI, Samol-Wolf A, Grasskamp AT, Hume A, Goud B, Baron B, England P, Titus MA, Schwille P, Weidemann T, Houdusse A, Kerkhoff E.

Elife. 2016 Sep 13;5. pii: e17523. doi: 10.7554/eLife.17523.


Myosin MyTH4-FERM structures highlight important principles of convergent evolution.

Planelles-Herrero VJ, Blanc F, Sirigu S, Sirkia H, Clause J, Sourigues Y, Johnsrud DO, Amigues B, Cecchini M, Gilbert SP, Houdusse A, Titus MA.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2906-15. doi: 10.1073/pnas.1600736113. Epub 2016 May 10.


Selective localization of myosin-I proteins in macropinosomes and actin waves.

Brzeska H, Koech H, Pridham KJ, Korn ED, Titus MA.

Cytoskeleton (Hoboken). 2016 Feb;73(2):68-82. doi: 10.1002/cm.21275. Epub 2016 Feb 22.


Recent Advances in Metabolic Profiling And Imaging of Prostate Cancer.

Thapar R, Titus MA.

Curr Metabolomics. 2014 Apr;2(1):53-69.


The association of myosin IB with actin waves in dictyostelium requires both the plasma membrane-binding site and actin-binding region in the myosin tail.

Brzeska H, Pridham K, Chery G, Titus MA, Korn ED.

PLoS One. 2014 Apr 18;9(4):e94306. doi: 10.1371/journal.pone.0094306. eCollection 2014.


The prolyl isomerase pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteins.

Krishnan N, Titus MA, Thapar R.

PLoS One. 2014 Jan 9;9(1):e85427. doi: 10.1371/journal.pone.0085427. eCollection 2014.


Structural basis of myosin V Rab GTPase-dependent cargo recognition.

Pylypenko O, Attanda W, Gauquelin C, Lahmani M, Coulibaly D, Baron B, Hoos S, Titus MA, England P, Houdusse AM.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20443-8. doi: 10.1073/pnas.1314329110. Epub 2013 Nov 18.


5α-reductase type 3 enzyme in benign and malignant prostate.

Titus MA, Li Y, Kozyreva OG, Maher V, Godoy A, Smith GJ, Mohler JL.

Prostate. 2014 Feb;74(3):235-49. doi: 10.1002/pros.22745. Epub 2013 Oct 22.


Mechanism of androgen receptor corepression by CKβBP2/CRIF1, a multifunctional transcription factor coregulator expressed in prostate cancer.

Tan JA, Bai S, Grossman G, Titus MA, Harris Ford O, Pop EA, Smith GJ, Mohler JL, Wilson EM, French FS.

Mol Cell Endocrinol. 2014 Jan 25;382(1):302-313. doi: 10.1016/j.mce.2013.09.036. Epub 2013 Oct 5.


Allosteric communication in Dictyostelium myosin II.

Guhathakurta P, Prochniewicz E, Muretta JM, Titus MA, Thomas DD.

J Muscle Res Cell Motil. 2012 Oct;33(5):305-12. doi: 10.1007/s10974-012-9304-y. Epub 2012 Jul 1.


Molecular basis of dynamic relocalization of Dictyostelium myosin IB.

Brzeska H, Guag J, Preston GM, Titus MA, Korn ED.

J Biol Chem. 2012 Apr 27;287(18):14923-36. doi: 10.1074/jbc.M111.318667. Epub 2012 Feb 24.


Dominant-negative androgen receptor inhibition of intracrine androgen-dependent growth of castration-recurrent prostate cancer.

Titus MA, Zeithaml B, Kantor B, Li X, Haack K, Moore DT, Wilson EM, Mohler JL, Kafri T.

PLoS One. 2012;7(1):e30192. doi: 10.1371/journal.pone.0030192. Epub 2012 Jan 17.


Structural and functional impact of site-directed methionine oxidation in myosin.

Klein JC, Moen RJ, Smith EA, Titus MA, Thomas DD.

Biochemistry. 2011 Nov 29;50(47):10318-27. doi: 10.1021/bi201279u. Epub 2011 Nov 8.


Characterization of a myosin VII MyTH/FERM domain.

Moen RJ, Johnsrud DO, Thomas DD, Titus MA.

J Mol Biol. 2011 Oct 14;413(1):17-23. doi: 10.1016/j.jmb.2011.08.036. Epub 2011 Aug 22.


Potential prostate cancer drug target: bioactivation of androstanediol by conversion to dihydrotestosterone.

Mohler JL, Titus MA, Wilson EM.

Clin Cancer Res. 2011 Sep 15;17(18):5844-9. doi: 10.1158/1078-0432.CCR-11-0644. Epub 2011 Jun 24.


5α-reductase type 3 expression in human benign and malignant tissues: a comparative analysis during prostate cancer progression.

Godoy A, Kawinski E, Li Y, Oka D, Alexiev B, Azzouni F, Titus MA, Mohler JL.

Prostate. 2011 Jul;71(10):1033-46. doi: 10.1002/pros.21318. Epub 2010 Dec 28.


Cytoskeletons by the sea.

Titus MA.

EMBO Rep. 2011 Mar;12(3):185-7. doi: 10.1038/embor.2011.26. Epub 2011 Feb 25.


Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer.

Mohler JL, Titus MA, Bai S, Kennerley BJ, Lih FB, Tomer KB, Wilson EM.

Cancer Res. 2011 Feb 15;71(4):1486-96. doi: 10.1158/0008-5472.CAN-10-1343. Epub 2011 Feb 8.


Structural kinetics of myosin by transient time-resolved FRET.

Nesmelov YE, Agafonov RV, Negrashov IV, Blakely SE, Titus MA, Thomas DD.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1891-6. doi: 10.1073/pnas.1012320108. Epub 2011 Jan 18.


Atmospheric pressure photoionization tandem mass spectrometry of androgens in prostate cancer.

Lih FB, Titus MA, Mohler JL, Tomer KB.

Anal Chem. 2010 Jul 15;82(14):6000-7. doi: 10.1021/ac100460x.


An unconventional myosin required for cell polarization and chemotaxis.

Breshears LM, Wessels D, Soll DR, Titus MA.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6918-23. doi: 10.1073/pnas.0909796107. Epub 2010 Mar 29.


Motors: unleashing mitochondria.

Titus MA.

Curr Biol. 2009 Dec 15;19(23):R1076-8. doi: 10.1016/j.cub.2009.10.053.


14-3-3{eta} Amplifies Androgen Receptor Actions in Prostate Cancer.

Titus MA, Tan JA, Gregory CW, Ford OH, Subramanian RR, Fu H, Wilson EM, Mohler JL, French FS.

Clin Cancer Res. 2009 Dec 15;15(24):7571-7581.


Structural dynamics of the myosin relay helix by time-resolved EPR and FRET.

Agafonov RV, Negrashov IV, Tkachev YV, Blakely SE, Titus MA, Thomas DD, Nesmelov YE.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21625-30. doi: 10.1073/pnas.0909757106. Epub 2009 Dec 4.


The Dictyostelium type V myosin MyoJ is responsible for the cortical association and motility of contractile vacuole membranes.

Jung G, Titus MA, Hammer JA 3rd.

J Cell Biol. 2009 Aug 24;186(4):555-70. doi: 10.1083/jcb.200810147. Epub 2009 Aug 17.


Thioredoxin Reductase 1 Expression and Castration-recurrent Growth of Prostate Cancer.

Singh SS, Li Y, Ford OH, Wrzosek CS, Mehedint DC, Titus MA, Mohler JL.

Transl Oncol. 2008 Sep;1(3):153-7.


Muscle and nonmuscle myosins probed by a spin label at equivalent sites in the force-generating domain.

Agafonov RV, Nesmelov YE, Titus MA, Thomas DD.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13397-402. doi: 10.1073/pnas.0801342105. Epub 2008 Sep 2.


Actin-binding cleft closure in myosin II probed by site-directed spin labeling and pulsed EPR.

Klein JC, Burr AR, Svensson B, Kennedy DJ, Allingham J, Titus MA, Rayment I, Thomas DD.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12867-72. doi: 10.1073/pnas.0802286105. Epub 2008 Aug 25.


Motor Proteins: tightening your belt with myosin VI.

Breshears LM, Titus MA.

Curr Biol. 2007 Nov 6;17(21):R915-7.


Talin influences the dynamics of the myosin VII-membrane interaction.

Galdeen SA, Stephens S, Thomas DD, Titus MA.

Mol Biol Cell. 2007 Oct;18(10):4074-84. Epub 2007 Aug 1.


The SH3 domain of a M7 interacts with its C-terminal proline-rich region.

Wang Q, Deloia MA, Kang Y, Litchke C, Zhang N, Titus MA, Walters KJ.

Protein Sci. 2007 Feb;16(2):189-96. Epub 2006 Dec 22.


Myosin I and actin dynamics: the frogs weigh in.

Titus MA.

Dev Cell. 2006 Nov;11(5):594-5.

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