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From cell culture to cynomolgus macaque: infection models show lineage-specific virulence potential of Coxiella burnetii.

Metters G, Norville IH, Titball RW, Hemsley CM.

J Med Microbiol. 2019 Oct;68(10):1419-1430. doi: 10.1099/jmm.0.001064. Review.


Clostridium perfringens epsilon toxin vaccine candidate lacking toxicity to cells expressing myelin and lymphocyte protein.

Morcrette H, Bokori-Brown M, Ong S, Bennett L, Wren BW, Lewis N, Titball RW.

NPJ Vaccines. 2019 Jul 30;4:32. doi: 10.1038/s41541-019-0128-2. eCollection 2019.


Quantitative Proteomics Reveals Differences in the Response of Neutrophils Isolated from Healthy or Diabetic Subjects to Infection with Capsule-Variant Burkholderia thailandensis.

Withatanung P, Kurian D, Tangjittipokin W, Plengvidhya N, Titball RW, Korbsrisate S, Stevens JM.

J Proteome Res. 2019 Jul 5;18(7):2848-2858. doi: 10.1021/acs.jproteome.9b00166. Epub 2019 Jun 21.


The pore structure of Clostridium perfringens epsilon toxin.

Savva CG, Clark AR, Naylor CE, Popoff MR, Moss DS, Basak AK, Titball RW, Bokori-Brown M.

Nat Commun. 2019 Jun 14;10(1):2641. doi: 10.1038/s41467-019-10645-8.


Extensive genome analysis of Coxiella burnetii reveals limited evolution within genomic groups.

Hemsley CM, O'Neill PA, Essex-Lopresti A, Norville IH, Atkins TP, Titball RW.

BMC Genomics. 2019 Jun 5;20(1):441. doi: 10.1186/s12864-019-5833-8.


Burkholderia thailandensis strain E555 is a surrogate for the investigation of Burkholderia pseudomallei replication and survival in macrophages.

Kovacs-Simon A, Hemsley CM, Scott AE, Prior JL, Titball RW.

BMC Microbiol. 2019 May 15;19(1):97. doi: 10.1186/s12866-019-1469-8.


Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model.

Adler D, Linden JR, Shetty SV, Ma Y, Bokori-Brown M, Titball RW, Vartanian T.

iScience. 2019 May 31;15:39-54. doi: 10.1016/j.isci.2019.04.016. Epub 2019 Apr 11.


Novel multi-component vaccine approaches for Burkholderia pseudomallei.

Morici L, Torres AG, Titball RW.

Clin Exp Immunol. 2019 May;196(2):178-188. doi: 10.1111/cei.13286. Epub 2019 Apr 8. Review.


Genome Resequencing of Laboratory Stocks of Burkholderia pseudomallei K96243.

Wagley S, Scott AE, Ireland PM, Prior JL, Atkins TP, Bancroft GJ, Studholme DJ, Titball RW.

Microbiol Resour Announc. 2019 Feb 28;8(9). pii: e01529-18. doi: 10.1128/MRA.01529-18. eCollection 2019 Feb.


Global Analysis of Genes Essential for Francisella tularensis Schu S4 Growth In Vitro and for Fitness during Competitive Infection of Fischer 344 Rats.

Ireland PM, Bullifent HL, Senior NJ, Southern SJ, Yang ZR, Ireland RE, Nelson M, Atkins HS, Titball RW, Scott AE.

J Bacteriol. 2019 Mar 13;201(7). pii: e00630-18. doi: 10.1128/JB.00630-18. Print 2019 Apr 1.


Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy.

Bokori-Brown M, Metz J, Petrov PG, Mussai F, De Santo C, Smart NJ, Saunders S, Knight B, Pastan I, Titball RW, Winlove CP.

Front Oncol. 2018 Nov 27;8:553. doi: 10.3389/fonc.2018.00553. eCollection 2018.


The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA.

Winter AJ, Williams C, Isupov MN, Crocker H, Gromova M, Marsh P, Wilkinson OJ, Dillingham MS, Harmer NJ, Titball RW, Crump MP.

J Biol Chem. 2018 Dec 14;293(50):19429-19440. doi: 10.1074/jbc.RA118.005173. Epub 2018 Oct 18.


Standardization of G. mellonella Larvae to Provide Reliable and Reproducible Results in the Study of Fungal Pathogens.

Champion OL, Titball RW, Bates S.

J Fungi (Basel). 2018 Sep 6;4(3). pii: E108. doi: 10.3390/jof4030108. Review.


The Culture Environment Influences Both Gene Regulation and Phenotypic Heterogeneity in Escherichia coli.

Smith A, Kaczmar A, Bamford RA, Smith C, Frustaci S, Kovacs-Simon A, O'Neill P, Moore K, Paszkiewicz K, Titball RW, Pagliara S.

Front Microbiol. 2018 Aug 15;9:1739. doi: 10.3389/fmicb.2018.01739. eCollection 2018.


Genome Sequence of Staphylococcus aureus Ex1, Isolated from a Patient with Spinal Osteomyelitis.

Morcrette H, Morgan MS, Farbos A, O'Neill P, Moore K, Titball RW, Studholme DJ.

Genome Announc. 2018 Jun 28;6(26). pii: e00623-18. doi: 10.1128/genomeA.00623-18.


Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory.

Burton BR, Tennant RK, Love J, Titball RW, Wraith DC, White HN.

Elife. 2018 May 1;7. pii: e26832. doi: 10.7554/eLife.26832.


Evidence of Clostridium perfringens epsilon toxin associated with multiple sclerosis.

Wagley S, Bokori-Brown M, Morcrette H, Malaspina A, D'Arcy C, Gnanapavan S, Lewis N, Popoff MR, Raciborska D, Nicholas R, Turner B, Titball RW.

Mult Scler. 2019 Apr;25(5):653-660. doi: 10.1177/1352458518767327. Epub 2018 Apr 21.


Galleria mellonella larvae allow the discrimination of toxic and non-toxic chemicals.

Allegra E, Titball RW, Carter J, Champion OL.

Chemosphere. 2018 May;198:469-472. doi: 10.1016/j.chemosphere.2018.01.175. Epub 2018 Feb 6.


Investigating the physiology of viable but non-culturable bacteria by microfluidics and time-lapse microscopy.

Bamford RA, Smith A, Metz J, Glover G, Titball RW, Pagliara S.

BMC Biol. 2017 Dec 21;15(1):121. doi: 10.1186/s12915-017-0465-4.


Galleria mellonella as an infection model to investigate virulence of Vibrio parahaemolyticus.

Wagley S, Borne R, Harrison J, Baker-Austin C, Ottaviani D, Leoni F, Vuddhakul V, Titball RW.

Virulence. 2018 Jan 1;9(1):197-207. doi: 10.1080/21505594.2017.1384895. Epub 2017 Nov 27.


Use of Reverse Vaccinology in the Design and Construction of Nanoglycoconjugate Vaccines against Burkholderia pseudomallei.

Muruato LA, Tapia D, Hatcher CL, Kalita M, Brett PJ, Gregory AE, Samuel JE, Titball RW, Torres AG.

Clin Vaccine Immunol. 2017 Nov 6;24(11). pii: e00206-17. doi: 10.1128/CVI.00206-17. Print 2017 Nov.


An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions.

Senior NJ, Sasidharan K, Saint RJ, Scott AE, Sarkar-Tyson M, Ireland PM, Bullifent HL, Rong Yang Z, Moore K, Oyston PCF, Atkins TP, Atkins HS, Soyer OS, Titball RW.

BMC Microbiol. 2017 Jul 21;17(1):163. doi: 10.1186/s12866-017-1073-8.


Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?

Titball RW, Burtnick MN, Bancroft GJ, Brett P.

Vaccine. 2017 Oct 20;35(44):5981-5989. doi: 10.1016/j.vaccine.2017.03.022. Epub 2017 Mar 21. Review.


A proteasome inhibitor produced by Burkholderia pseudomallei modulates intracellular growth.

Wagley S, Vanaporn M, Rinchai D, Conejero L, Lertmemongkolchai G, Bancroft GJ, Titball RW.

Microb Pathog. 2017 Jun;107:175-180. doi: 10.1016/j.micpath.2017.03.015. Epub 2017 Mar 18.


A Noise Trimming and Positional Significance of Transposon Insertion System to Identify Essential Genes in Yersinia pestis.

Yang ZR, Bullifent HL, Moore K, Paszkiewicz K, Saint RJ, Southern SJ, Champion OL, Senior NJ, Sarkar-Tyson M, Oyston PC, Atkins TP, Titball RW.

Sci Rep. 2017 Feb 6;7:41923. doi: 10.1038/srep41923.


A Bioluminescent Francisella tularensis SCHU S4 Strain Enables Noninvasive Tracking of Bacterial Dissemination and the Evaluation of Antibiotics in an Inhalational Mouse Model of Tularemia.

Hall CA, Flick-Smith HC, Harding SV, Atkins HS, Titball RW.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7206-7215. Print 2016 Dec.


Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection.

Cizmeci D, Dempster EL, Champion OL, Wagley S, Akman OE, Prior JL, Soyer OS, Mill J, Titball RW.

Sci Rep. 2016 Aug 3;6:30861. doi: 10.1038/srep30861.


Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts.

Vanaporn M, Sarkar-Tyson M, Kovacs-Simon A, Ireland PM, Pumirat P, Korbsrisate S, Titball RW, Butt A.

Virulence. 2017 Jan 2;8(1):30-40. doi: 10.1080/21505594.2016.1199316. Epub 2016 Jul 1.


Galleria mellonella as a model host for microbiological and toxin research.

Champion OL, Wagley S, Titball RW.

Virulence. 2016 Oct 2;7(7):840-5. doi: 10.1080/21505594.2016.1203486. Epub 2016 Jun 30.


Protection against Experimental Melioidosis with a Synthetic manno-Heptopyranose Hexasaccharide Glycoconjugate.

Scott AE, Christ WJ, George AJ, Stokes MG, Lohman GJ, Guo Y, Jones M, Titball RW, Atkins TP, Campbell AS, Prior JL.

Bioconjug Chem. 2016 Jun 15;27(6):1435-46. doi: 10.1021/acs.bioconjchem.5b00525. Epub 2016 May 17.


Cryo-EM structure of lysenin pore elucidates membrane insertion by an aerolysin family protein.

Bokori-Brown M, Martin TG, Naylor CE, Basak AK, Titball RW, Savva CG.

Nat Commun. 2016 Apr 6;7:11293. doi: 10.1038/ncomms11293.



Bokori-Brown M, Petrov PG, Khafaji MA, Mughal MK, Naylor CE, Shore AC, Gooding KM, Casanova F, Mitchell TJ, Titball RW, Winlove CP.

J Biol Chem. 2016 May 6;291(19):10210-27. doi: 10.1074/jbc.M115.691899. Epub 2016 Mar 16.


Immunisation with proteins expressed during chronic murine melioidosis provides enhanced protection against disease.

Champion OL, Gourlay LJ, Scott AE, Lassaux P, Conejero L, Perletti L, Hemsley C, Prior J, Bancroft G, Bolognesi M, Titball RW.

Vaccine. 2016 Mar 29;34(14):1665-71. doi: 10.1016/j.vaccine.2016.02.038. Epub 2016 Feb 23.


Variable protection against experimental broiler necrotic enteritis after immunization with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant.

Fernandes da Costa SP, Mot D, Geeraerts S, Bokori-Brown M, Van Immerseel F, Titball RW.

Avian Pathol. 2016 Jun;45(3):381-8. doi: 10.1080/03079457.2015.1129663.


Burkholderia pseudomallei kynB plays a role in AQ production, biofilm formation, bacterial swarming and persistence.

Butt A, Halliday N, Williams P, Atkins HS, Bancroft GJ, Titball RW.

Res Microbiol. 2016 Apr;167(3):159-67. doi: 10.1016/j.resmic.2015.11.002. Epub 2015 Nov 30.


Draft Genome Sequence of the Enteropathogenic Bacterium Campylobacter jejuni Strain cj255.

Siddiqui FM, Ibrahim M, Noureen N, Noreen Z, Titball RW, Champion OL, Wren BW, Studholme D, Bokhari H.

Genome Announc. 2015 Oct 22;3(5). pii: e01223-15. doi: 10.1128/genomeA.01223-15.


Functional Analysis of the Role of Toxin-Antitoxin (TA) Loci in Bacterial Persistence.

Butt AT, Titball RW.

Methods Mol Biol. 2016;1333:121-9. doi: 10.1007/978-1-4939-2854-5_11.


Evaluation of antibiotic efficacy against infections caused by planktonic or biofilm cultures of Pseudomonas aeruginosa and Klebsiella pneumoniae in Galleria mellonella.

Benthall G, Touzel RE, Hind CK, Titball RW, Sutton JM, Thomas RJ, Wand ME.

Int J Antimicrob Agents. 2015 Nov;46(5):538-45. doi: 10.1016/j.ijantimicag.2015.07.014. Epub 2015 Aug 31.


Clostridium perfringensα-toxin interaction with red cells and model membranes.

Jewell SA, Titball RW, Huyet J, Naylor CE, Basak AK, Gologan P, Winlove CP, Petrov PG.

Soft Matter. 2015 Oct 21;11(39):7748-61. doi: 10.1039/c5sm00876j. Epub 2015 Aug 25.


Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils.

Rinchai D, Riyapa D, Buddhisa S, Utispan K, Titball RW, Stevens MP, Stevens JM, Ogawa M, Tanida I, Koike M, Uchiyama Y, Ato M, Lertmemongkolchai G.

Autophagy. 2015;11(5):748-55. doi: 10.1080/15548627.2015.1040969.


Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine.

Torres AG, Gregory AE, Hatcher CL, Vinet-Oliphant H, Morici LA, Titball RW, Roy CJ.

Vaccine. 2015 Jan 29;33(5):686-92. doi: 10.1016/j.vaccine.2014.11.057. Epub 2014 Dec 19.


Differences in carbon source utilisation distinguish Campylobacter jejuni from Campylobacter coli.

Wagley S, Newcombe J, Laing E, Yusuf E, Sambles CM, Studholme DJ, La Ragione RM, Titball RW, Champion OL.

BMC Microbiol. 2014 Oct 28;14:262. doi: 10.1186/s12866-014-0262-y.


Transcriptional profiles of Burkholderia pseudomallei reveal the direct and indirect roles of Sigma E under oxidative stress conditions.

Jitprasutwit S, Ong C, Juntawieng N, Ooi WF, Hemsley CM, Vattanaviboon P, Titball RW, Tan P, Korbsrisate S.

BMC Genomics. 2014 Sep 12;15:787. doi: 10.1186/1471-2164-15-787.


A gold nanoparticle-linked glycoconjugate vaccine against Burkholderia mallei.

Gregory AE, Judy BM, Qazi O, Blumentritt CA, Brown KA, Shaw AM, Torres AG, Titball RW.

Nanomedicine. 2015 Feb;11(2):447-56. doi: 10.1016/j.nano.2014.08.005. Epub 2014 Sep 3.


Bacterial drug tolerance under clinical conditions is governed by anaerobic adaptation but not anaerobic respiration.

Hemsley CM, Luo JX, Andreae CA, Butler CS, Soyer OS, Titball RW.

Antimicrob Agents Chemother. 2014 Oct;58(10):5775-83. doi: 10.1128/AAC.02793-14. Epub 2014 Jul 21.


Protection against experimental melioidosis following immunisation with a lipopolysaccharide-protein conjugate.

Scott AE, Ngugi SA, Laws TR, Corser D, Lonsdale CL, D'Elia RV, Titball RW, Williamson ED, Atkins TP, Prior JL.

J Immunol Res. 2014;2014:392170. doi: 10.1155/2014/392170. Epub 2014 May 7.


Identification of possible virulence marker from Campylobacter jejuni isolates.

Harrison JW, Dung TT, Siddiqui F, Korbrisate S, Bukhari H, Tra MP, Hoang NV, Carrique-Mas J, Bryant J, Campbell JI, Studholme DJ, Wren BW, Baker S, Titball RW, Champion OL.

Emerg Infect Dis. 2014 Jun;20(6):1026-9. doi: 10.3201/eid2006.130635.


Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia.

Bokori-Brown M, Hall CA, Vance C, Fernandes da Costa SP, Savva CG, Naylor CE, Cole AR, Basak AK, Moss DS, Titball RW.

Vaccine. 2014 May 13;32(23):2682-7. doi: 10.1016/j.vaccine.2014.03.079. Epub 2014 Apr 5.


Identification of a key residue for oligomerisation and pore-formation of Clostridium perfringens NetB.

Fernandes da Costa SP, Savva CG, Bokori-Brown M, Naylor CE, Moss DS, Basak AK, Titball RW.

Toxins (Basel). 2014 Mar 12;6(3):1049-61. doi: 10.3390/toxins6031049.


Genome-wide saturation mutagenesis of Burkholderia pseudomallei K96243 predicts essential genes and novel targets for antimicrobial development.

Moule MG, Hemsley CM, Seet Q, Guerra-Assunção JA, Lim J, Sarkar-Tyson M, Clark TG, Tan PB, Titball RW, Cuccui J, Wren BW.

mBio. 2014 Feb 11;5(1):e00926-13. doi: 10.1128/mBio.00926-13.

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