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Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.

Brehm MA, Kenney LL, Wiles MV, Low BE, Tisch RM, Burzenski L, Mueller C, Greiner DL, Shultz LD.

FASEB J. 2019 Mar;33(3):3137-3151. doi: 10.1096/fj.201800636R. Epub 2018 Nov 1.


Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes.

Kroger CJ, Clark M, Ke Q, Tisch RM.

Front Immunol. 2018 Aug 16;9:1891. doi: 10.3389/fimmu.2018.01891. eCollection 2018. Review.


Prevention of Type 1 Diabetes with Acetalated Dextran Microparticles Containing Rapamycin and Pancreatic Peptide P31.

Chen N, Kroger CJ, Tisch RM, Bachelder EM, Ainslie KM.

Adv Healthc Mater. 2018 Sep;7(18):e1800341. doi: 10.1002/adhm.201800341. Epub 2018 Jul 26.


Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response.

Clark M, Kroger CJ, Tisch RM.

Front Immunol. 2017 Dec 22;8:1898. doi: 10.3389/fimmu.2017.01898. eCollection 2017. Review.


Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice.

Durost PA, Aryee KE, Manzoor F, Tisch RM, Mueller C, Jurczyk A, Shultz LD, Brehm MA.

Hum Gene Ther. 2018 Mar;29(3):352-365. doi: 10.1089/hum.2017.072. Epub 2017 Oct 3.


Staphylococcus aureus Protein A Disrupts Immunity Mediated by Long-Lived Plasma Cells.

Keener AB, Thurlow LT, Kang S, Spidale NA, Clarke SH, Cunnion KM, Tisch R, Richardson AR, Vilen BJ.

J Immunol. 2017 Feb 1;198(3):1263-1273. doi: 10.4049/jimmunol.1600093. Epub 2016 Dec 28.


Thymic Dendritic Cell Subsets Display Distinct Efficiencies and Mechanisms of Intercellular MHC Transfer.

Kroger CJ, Spidale NA, Wang B, Tisch R.

J Immunol. 2017 Jan 1;198(1):249-256. Epub 2016 Nov 28.


β-cell-specific IL-35 therapy suppresses ongoing autoimmune diabetes in NOD mice.

Manzoor F, Johnson MC, Li C, Samulski RJ, Wang B, Tisch R.

Eur J Immunol. 2017 Jan;47(1):144-154. doi: 10.1002/eji.201646493. Epub 2016 Nov 25.


Anti-coreceptor therapy drives selective T cell egress by suppressing inflammation-dependent chemotactic cues.

Martin AJ, Clark M, Gojanovich G, Manzoor F, Miller K, Kline DE, Morillon YM, Wang B, Tisch R.

JCI Insight. 2016 Oct 20;1(17):e87636. doi: 10.1172/jci.insight.87636.


Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration.

Morillon YM 2nd, Lessey-Morillon EC, Clark M, Zhang R, Wang B, Burridge K, Tisch R.

J Immunol. 2016 Nov 1;197(9):3504-3511. doi: 10.4049/jimmunol.1501600. Epub 2016 Sep 30.


Temporal increase in thymocyte negative selection parallels enhanced thymic SIRPα+ DC function.

Kroger CJ, Wang B, Tisch R.

Eur J Immunol. 2016 Oct;46(10):2352-2362. doi: 10.1002/eji.201646354. Epub 2016 Sep 6.


Adiponectin-SOGA Dissociation in Type 1 Diabetes.

Combs TP, Snell-Bergeon JK, Maahs DM, Bergman BC, Lamarche M, Iberkleid L, AbdelBaky O, Tisch R, Scherer PE, Marliss EB.

J Clin Endocrinol Metab. 2015 Aug;100(8):E1065-73. doi: 10.1210/jc.2015-1275. Epub 2015 Jun 8.


Isolation and transplantation of different aged murine thymic grafts.

Morillon YM 2nd, Manzoor F, Wang B, Tisch R.

J Vis Exp. 2015 May 13;(99):e52709. doi: 10.3791/52709.


Reestablishing T Cell Tolerance by Antibody-Based Therapy in Type 1 Diabetes.

Maurice Morillon Y 2nd, Martin A, Gojanovich G, Wang B, Tisch R.

Arch Immunol Ther Exp (Warsz). 2015 Aug;63(4):239-50. doi: 10.1007/s00005-015-0336-z. Epub 2015 Mar 20. Review.


IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells.

Mizui M, Koga T, Lieberman LA, Beltran J, Yoshida N, Johnson MC, Tisch R, Tsokos GC.

J Immunol. 2014 Sep 1;193(5):2168-77. doi: 10.4049/jimmunol.1400977. Epub 2014 Jul 25.


Cutting edge: Antigen-specific thymocyte feedback regulates homeostatic thymic conventional dendritic cell maturation.

Spidale NA, Wang B, Tisch R.

J Immunol. 2014 Jul 1;193(1):21-5. doi: 10.4049/jimmunol.1400321. Epub 2014 Jun 2.


Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner.

He Q, Morillon YM 2nd, Spidale NA, Kroger CJ, Liu B, Sartor RB, Wang B, Tisch R.

J Immunol. 2013 Dec 15;191(12):5858-66. doi: 10.4049/jimmunol.1302273. Epub 2013 Nov 6.


Evidence for the role of EPHX2 gene variants in anorexia nervosa.

Scott-Van Zeeland AA, Bloss CS, Tewhey R, Bansal V, Torkamani A, Libiger O, Duvvuri V, Wineinger N, Galvez L, Darst BF, Smith EN, Carson A, Pham P, Phillips T, Villarasa N, Tisch R, Zhang G, Levy S, Murray S, Chen W, Srinivasan S, Berenson G, Brandt H, Crawford S, Crow S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB, Bulik CM, Keel P, Klump KL, Lilenfeld L, Plotnicov K, Topol EJ, Shih PB, Magistretti P, Bergen AW, Berrettini W, Kaye W, Schork NJ.

Mol Psychiatry. 2014 Jun;19(6):724-32. doi: 10.1038/mp.2013.91. Epub 2013 Sep 3.


β-cell-specific IL-2 therapy increases islet Foxp3+Treg and suppresses type 1 diabetes in NOD mice.

Johnson MC, Garland AL, Nicolson SC, Li C, Samulski RJ, Wang B, Tisch R.

Diabetes. 2013 Nov;62(11):3775-84. doi: 10.2337/db13-0669. Epub 2013 Jul 24.


Manipulating T cell-mediated pathology: targets and functions of monoclonal antibody immunotherapy.

Martin A, Tisch RM, Getts DR.

Clin Immunol. 2013 Jul;148(1):136-47. doi: 10.1016/j.clim.2013.04.011. Epub 2013 Apr 28. Review.


Kinetics of adeno-associated virus serotype 2 (AAV2) and AAV8 capsid antigen presentation in vivo are identical.

He Y, Weinberg MS, Hirsch M, Johnson MC, Tisch R, Samulski RJ, Li C.

Hum Gene Ther. 2013 May;24(5):545-53. doi: 10.1089/hum.2013.065. Epub 2013 May 2.


Family-centered interventions for substance abuse in Hispanic communities.

Sparks SN, Tisch R, Gardner M.

J Ethn Subst Abuse. 2013;12(1):68-81. doi: 10.1080/15332640.2013.759785.


Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usage.

Diz R, Garland A, Vincent BG, Johnson MC, Spidale N, Wang B, Tisch R.

PLoS One. 2012;7(12):e52054. doi: 10.1371/journal.pone.0052054. Epub 2012 Dec 14.


IFN-γ receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells.

Yi Z, Li L, Garland A, He Q, Wang H, Katz JD, Tisch R, Wang B.

Eur J Immunol. 2012 Aug;42(8):2010-8. doi: 10.1002/eji.201142374.


Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies.

Yi Z, Diz R, Martin AJ, Morillon YM, Kline DE, Li L, Wang B, Tisch R.

Diabetes. 2012 Nov;61(11):2871-80. doi: 10.2337/db12-0098. Epub 2012 Jun 29.


Influence of genetic polymorphisms on the effect of high- and standard-dose clopidogrel after percutaneous coronary intervention: the GIFT (Genotype Information and Functional Testing) study.

Price MJ, Murray SS, Angiolillo DJ, Lillie E, Smith EN, Tisch RL, Schork NJ, Teirstein PS, Topol EJ; GIFT Investigators.

J Am Coll Cardiol. 2012 May 29;59(22):1928-37. doi: 10.1016/j.jacc.2011.11.068.


Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.

Goudy KS, Johnson MC, Garland A, Li C, Samulski RJ, Wang B, Tisch R.

Eur J Immunol. 2011 May;41(5):1480-1490. doi: 10.1002/eji.201040890. Epub 2011 Apr 20.


Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes.

Goudy KS, Johnson MC, Garland A, Li C, Samulski RJ, Wang B, Tisch R.

J Immunol. 2011 Mar 15;186(6):3779-86. doi: 10.4049/jimmunol.1001422. Epub 2011 Feb 11.


Cumulative autoimmunity: T cell clones recognizing several self-epitopes exhibit enhanced pathogenicity.

Liblau RS, Wekerle H, Tisch RM.

Front Immunol. 2011 Oct 5;2:47. doi: 10.3389/fimmu.2011.00047. eCollection 2011.


Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes.

Johnson MC, Wang B, Tisch R.

Hum Vaccin. 2011 Jan 1;7(1):27-36. Epub 2011 Jan 1. Review.


Dysregulation of thymic clonal deletion and the escape of autoreactive T cells.

Kroger CJ, Flores RR, Morillon M, Wang B, Tisch R.

Arch Immunol Ther Exp (Warsz). 2010 Dec;58(6):449-57. doi: 10.1007/s00005-010-0100-3. Epub 2010 Sep 26. Review.


Adiponectin lowers glucose production by increasing SOGA.

Cowherd RB, Asmar MM, Alderman JM, Alderman EA, Garland AL, Busby WH, Bodnar WM, Rusyn I, Medoff BD, Tisch R, Mayer-Davis E, Swenberg JA, Zeisel SH, Combs TP.

Am J Pathol. 2010 Oct;177(4):1936-45. doi: 10.2353/ajpath.2010.100363. Epub 2010 Sep 2. Erratum in: Am J Pathol. 2011 Mar;178(3):1406. Cowerd, Rachael B [corrected to Cowherd, Rachael B].


Immunogenic versus tolerogenic dendritic cells: a matter of maturation.

Tisch R.

Int Rev Immunol. 2010 Apr;29(2):111-8. doi: 10.3109/08830181003602515. Review. No abstract available.


Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells.

Burton AR, Baquet Z, Eisenbarth GS, Tisch R, Smeyne R, Workman CJ, Vignali DA.

J Immunol. 2010 May 1;184(9):4863-70. doi: 10.4049/jimmunol.0903728. Epub 2010 Mar 26.


Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice.

Vincent BG, Young EF, Buntzman AS, Stevens R, Kepler TB, Tisch RM, Frelinger JA, Hess PR.

J Immunol. 2010 Apr 15;184(8):4196-204. doi: 10.4049/jimmunol.0903931. Epub 2010 Mar 10.


beta cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct.

Li L, He Q, Garland A, Yi Z, Aybar LT, Kepler TB, Frelinger JA, Wang B, Tisch R.

J Immunol. 2009 Dec 1;183(11):7585-91. doi: 10.4049/jimmunol.0901587. Epub 2009 Nov 16.


Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct.

Young EF, Hess PR, Arnold LW, Tisch R, Frelinger JA.

Autoimmunity. 2009;42(8):678-91. doi: 10.3109/08916930903213993.


Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination.

Li L, Yi Z, Wang B, Tisch R.

J Immunol. 2009 Oct 1;183(7):4809-16. doi: 10.4049/jimmunol.0901616. Epub 2009 Sep 14.


A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells.

Yi Z, Li L, Matsushima GK, Earp HS, Wang B, Tisch R.

Blood. 2009 Oct 8;114(15):3191-8. doi: 10.1182/blood-2009-03-207522. Epub 2009 Aug 10.


CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice.

Pang S, Zhang L, Wang H, Yi Z, Li L, Gao L, Zhao J, Tisch R, Katz JD, Wang B.

Eur J Immunol. 2009 Oct;39(10):2716-24. doi: 10.1002/eji.200939408.


Cellular immune response to cryptic epitopes during therapeutic gene transfer.

Li C, Goudy K, Hirsch M, Asokan A, Fan Y, Alexander J, Sun J, Monahan P, Seiber D, Sidney J, Sette A, Tisch R, Frelinger J, Samulski RJ.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10770-4. doi: 10.1073/pnas.0902269106. Epub 2009 Jun 16.


Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo.

Li C, Hirsch M, DiPrimio N, Asokan A, Goudy K, Tisch R, Samulski RJ.

J Virol. 2009 Jul;83(13):6817-24. doi: 10.1128/JVI.00278-09. Epub 2009 Apr 15.


The receptor tyrosine kinase MerTK regulates dendritic cell production of BAFF.

Gohlke PR, Williams JC, Vilen BJ, Dillon SR, Tisch R, Matsushima GK.

Autoimmunity. 2009 Mar;42(3):183-97. doi: 10.1080/08916930802668586.


MerTK regulates thymic selection of autoreactive T cells.

Wallet MA, Flores RR, Wang Y, Yi Z, Kroger CJ, Mathews CE, Earp HS, Matsushima G, Wang B, Tisch R.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4810-5. doi: 10.1073/pnas.0900683106. Epub 2009 Feb 27.


Role of plasmacytoid dendritic cells in type 1 diabetes: friend or foe?

Tisch R, Wang B.

Diabetes. 2009 Jan;58(1):12-3. doi: 10.2337/db08-1341. No abstract available.


Dysrulation of T cell peripheral tolerance in type 1 diabetes.

Tisch R, Wang B.

Adv Immunol. 2008;100:125-49. doi: 10.1016/S0065-2776(08)00805-5. Review.


Parameters influencing antigen-specific immunotherapy for Type 1 diabetes.

Wang B, Tisch R.

Immunol Res. 2008;42(1-3):246-58. doi: 10.1007/s12026-008-8090-5.


Immunotherapy of type 1 diabetes.

Li L, Yi Z, Tisch R, Wang B.

Arch Immunol Ther Exp (Warsz). 2008 Jul-Aug;56(4):227-36. doi: 10.1007/s00005-008-0025-2. Epub 2008 Jul 29. Review.


ANCA patients have T cells responsive to complementary PR-3 antigen.

Yang J, Bautz DJ, Lionaki S, Hogan SL, Chin H, Tisch RM, Schmitz JL, Pressler BM, Jennette JC, Falk RJ, Preston GA.

Kidney Int. 2008 Nov;74(9):1159-69. doi: 10.1038/ki.2008.309. Epub 2008 Jul 2.

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