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Items: 1 to 50 of 110

1.

STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation.

Nepal S, Tiruppathi C, Tsukasaki Y, Farahany J, Mittal M, Rehman J, Prockop DJ, Malik AB.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16513-16518. doi: 10.1073/pnas.1821601116. Epub 2019 Jul 30.

2.

Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury.

Ebenezer DL, Berdyshev EV, Bronova IA, Liu Y, Tiruppathi C, Komarova Y, Benevolenskaya EV, Suryadevara V, Ha AW, Harijith A, Tuder RM, Natarajan V, Fu P.

Thorax. 2019 Jun;74(6):579-591. doi: 10.1136/thoraxjnl-2018-212378. Epub 2019 Feb 5.

3.

Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury.

Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C.

Cell Death Discov. 2018 May 16;4:60. doi: 10.1038/s41420-018-0056-3. eCollection 2018.

4.

Response by Mittal et al to Letter Regarding Article, "Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury".

Mittal M, Nepal S, Tsukasaki Y, Hecquet CM, Soni D, Tiruppathi C, Malik AB, Rehman J.

Circ Res. 2017 Dec 8;121(12):e87. doi: 10.1161/CIRCRESAHA.117.312146. No abstract available.

5.

Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury.

Mittal M, Nepal S, Tsukasaki Y, Hecquet CM, Soni D, Rehman J, Tiruppathi C, Malik AB.

Circ Res. 2017 Oct 13;121(9):1081-1091. doi: 10.1161/CIRCRESAHA.117.311747. Epub 2017 Aug 8.

6.

Aberrant caveolin-1-mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension.

Marsboom G, Chen Z, Yuan Y, Zhang Y, Tiruppathi C, Loyd JE, Austin ED, Machado RF, Minshall RD, Rehman J, Malik AB.

Mol Biol Cell. 2017 May 1;28(9):1177-1185. doi: 10.1091/mbc.E16-11-0790.

7.

Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca2+ entry regulates disassembly of adherens junctions.

Soni D, Regmi SC, Wang DM, DebRoy A, Zhao YY, Vogel SM, Malik AB, Tiruppathi C.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L1003-L1017. doi: 10.1152/ajplung.00008.2017. Epub 2017 Apr 6.

8.

Aberrant Caveolin-1-Mediated Smad Signaling and Proliferation Identified by Analysis of Adenine 474 Deletion Mutation (c.474delA) in Patient Fibroblasts: A New Perspective in the Mechanism of Pulmonary Hypertension.

Marsboom G, Chen Z, Yuan Y, Zhang Y, Tiruppathi C, Loyd JE, Austin ED, Machado RF, Minshall RD, Rehman J, Malik AB.

Mol Biol Cell. 2017 Mar 15. pii: mbc.E16-06-0380. doi: 10.1091/mbc.E16-06-0380. [Epub ahead of print]

PMID:
28298490
9.

Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids.

Ayee MAA, LeMaster E, Shentu TP, Singh DK, Barbera N, Soni D, Tiruppathi C, Subbaiah PV, Berdyshev E, Bronova I, Cho M, Akpa BS, Levitan I.

Biophys J. 2017 Jan 24;112(2):325-338. doi: 10.1016/j.bpj.2016.12.002.

10.

TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury.

Mittal M, Tiruppathi C, Nepal S, Zhao YY, Grzych D, Soni D, Prockop DJ, Malik AB.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8151-E8158. Epub 2016 Nov 28.

11.

Oxidant Sensing by TRPM2 Inhibits Neutrophil Migration and Mitigates Inflammation.

Wang G, Cao L, Liu X, Sieracki NA, Di A, Wen X, Chen Y, Taylor S, Huang X, Tiruppathi C, Zhao YY, Song Y, Gao X, Jin T, Bai C, Malik AB, Xu J.

Dev Cell. 2016 Sep 12;38(5):453-62. doi: 10.1016/j.devcel.2016.07.014. Epub 2016 Aug 25.

12.

Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae.

Zimnicka AM, Husain YS, Shajahan AN, Sverdlov M, Chaga O, Chen Z, Toth PT, Klomp J, Karginov AV, Tiruppathi C, Malik AB, Minshall RD.

Mol Biol Cell. 2016 Jul 1;27(13):2090-106. doi: 10.1091/mbc.E15-11-0756. Epub 2016 May 11.

13.

Cooperative signaling via transcription factors NF-κB and AP1/c-Fos mediates endothelial cell STIM1 expression and hyperpermeability in response to endotoxin.

DebRoy A, Vogel SM, Soni D, Sundivakkam PC, Malik AB, Tiruppathi C.

J Biol Chem. 2014 Aug 29;289(35):24188-201. doi: 10.1074/jbc.M114.570051. Epub 2014 Jul 11.

14.

Endothelial FoxM1 mediates bone marrow progenitor cell-induced vascular repair and resolution of inflammation following inflammatory lung injury.

Zhao YD, Huang X, Yi F, Dai Z, Qian Z, Tiruppathi C, Tran K, Zhao YY.

Stem Cells. 2014 Jul;32(7):1855-64. doi: 10.1002/stem.1690.

15.

The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation.

Tiruppathi C, Soni D, Wang DM, Xue J, Singh V, Thippegowda PB, Cheppudira BP, Mishra RK, Debroy A, Qian Z, Bachmaier K, Zhao YY, Christman JW, Vogel SM, Ma A, Malik AB.

Nat Immunol. 2014 Mar;15(3):239-47. doi: 10.1038/ni.2823. Epub 2014 Feb 2.

16.
17.

Dentin phosphophoryn activates Smad protein signaling through Ca2+-calmodulin-dependent protein kinase II in undifferentiated mesenchymal cells.

Eapen A, Kulkarni R, Ravindran S, Ramachandran A, Sundivakkam P, Tiruppathi C, George A.

J Biol Chem. 2013 Mar 22;288(12):8585-95. doi: 10.1074/jbc.M112.413997. Epub 2013 Jan 28.

18.

Role of nicotinamide adenine dinucleotide phosphate-reduced oxidase proteins in Pseudomonas aeruginosa-induced lung inflammation and permeability.

Fu P, Mohan V, Mansoor S, Tiruppathi C, Sadikot RT, Natarajan V.

Am J Respir Cell Mol Biol. 2013 Apr;48(4):477-88. doi: 10.1165/rcmb.2012-0242OC.

19.

Expression and distribution of grp-78/bip in mineralizing tissues and mesenchymal cells.

Ravindran S, Gao Q, Ramachandran A, Sundivakkam P, Tiruppathi C, George A.

Histochem Cell Biol. 2012 Jul;138(1):113-25. doi: 10.1007/s00418-012-0952-1. Epub 2012 Apr 17.

20.

Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress.

Yamada KH, Kozlowski DA, Seidl SE, Lance S, Wieschhaus AJ, Sundivakkam P, Tiruppathi C, Chishti I, Herman IM, Kuchay SM, Chishti AH.

J Biol Chem. 2012 Apr 13;287(16):13182-93. doi: 10.1074/jbc.M111.302612. Epub 2012 Feb 24.

21.

The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells.

Sundivakkam PC, Freichel M, Singh V, Yuan JP, Vogel SM, Flockerzi V, Malik AB, Tiruppathi C.

Mol Pharmacol. 2012 Apr;81(4):510-26. doi: 10.1124/mol.111.074658. Epub 2011 Dec 30.

22.

Delivery of nanoparticle: complexed drugs across the vascular endothelial barrier via caveolae.

Wang Z, Tiruppathi C, Cho J, Minshall RD, Malik AB.

IUBMB Life. 2011 Aug;63(8):659-67. doi: 10.1002/iub.485. Epub 2011 Jul 15. Review.

23.

A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt.

Mehta RR, Yamada T, Taylor BN, Christov K, King ML, Majumdar D, Lekmine F, Tiruppathi C, Shilkaitis A, Bratescu L, Green A, Beattie CW, Das Gupta TK.

Angiogenesis. 2011 Sep;14(3):355-69. doi: 10.1007/s10456-011-9220-6. Epub 2011 Jun 11.

PMID:
21667138
24.

Calcium-mediated stress kinase activation by DMP1 promotes osteoblast differentiation.

Eapen A, Sundivakkam P, Song Y, Ravindran S, Ramachandran A, Tiruppathi C, George A.

J Biol Chem. 2010 Nov 19;285(47):36339-51. doi: 10.1074/jbc.M110.145607. Epub 2010 Sep 14.

25.

Role of protein kinase Czeta in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers.

Minshall RD, Vandenbroucke EE, Holinstat M, Place AT, Tiruppathi C, Vogel SM, van Nieuw Amerongen GP, Mehta D, Malik AB.

Microvasc Res. 2010 Sep;80(2):240-9. doi: 10.1016/j.mvr.2010.04.007. Epub 2010 Apr 24.

26.

Caveolin-1 deficiency dampens Toll-like receptor 4 signaling through eNOS activation.

Mirza MK, Yuan J, Gao XP, Garrean S, Brovkovych V, Malik AB, Tiruppathi C, Zhao YY.

Am J Pathol. 2010 May;176(5):2344-51. doi: 10.2353/ajpath.2010.091088. Epub 2010 Mar 19.

27.

Ca2+ influx via TRPC channels induces NF-kappaB-dependent A20 expression to prevent thrombin-induced apoptosis in endothelial cells.

Thippegowda PB, Singh V, Sundivakkam PC, Xue J, Malik AB, Tiruppathi C.

Am J Physiol Cell Physiol. 2010 Mar;298(3):C656-64. doi: 10.1152/ajpcell.00456.2009. Epub 2009 Dec 23.

28.

Size and dynamics of caveolae studied using nanoparticles in living endothelial cells.

Wang Z, Tiruppathi C, Minshall RD, Malik AB.

ACS Nano. 2009 Dec 22;3(12):4110-6. doi: 10.1021/nn9012274.

29.

NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene.

Xue J, Thippegowda PB, Hu G, Bachmaier K, Christman JW, Malik AB, Tiruppathi C.

Physiol Genomics. 2009 Jun 10;38(1):42-53. doi: 10.1152/physiolgenomics.00012.2009. Epub 2009 Apr 7.

30.

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells.

Sundivakkam PC, Kwiatek AM, Sharma TT, Minshall RD, Malik AB, Tiruppathi C.

Am J Physiol Cell Physiol. 2009 Mar;296(3):C403-13. doi: 10.1152/ajpcell.00470.2008. Epub 2008 Dec 3.

31.

Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-kappaB activation in endothelial cells through AMP-activated protein kinase and protein kinase Cdelta.

Bair AM, Thippegowda PB, Freichel M, Cheng N, Ye RD, Vogel SM, Yu Y, Flockerzi V, Malik AB, Tiruppathi C.

J Biol Chem. 2009 Jan 2;284(1):563-74. doi: 10.1074/jbc.M803984200. Epub 2008 Nov 6.

32.

Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation.

Welch EJ, Naikawadi RP, Li Z, Lin P, Ishii S, Shimizu T, Tiruppathi C, Du X, Subbaiah PV, Ye RD.

Mol Pharmacol. 2009 Jan;75(1):227-34. doi: 10.1124/mol.108.051003. Epub 2008 Oct 17.

33.

Characterization of isoprostane signaling: evidence for a unique coordination profile of 8-iso-PGF(2alpha) with the thromboxane A(2) receptor, and activation of a separate cAMP-dependent inhibitory pathway in human platelets.

Khasawneh FT, Huang JS, Mir F, Srinivasan S, Tiruppathi C, Le Breton GC.

Biochem Pharmacol. 2008 Jun 15;75(12):2301-15. doi: 10.1016/j.bcp.2008.03.014. Epub 2008 Mar 30.

34.

Role of NF-kappaB-dependent caveolin-1 expression in the mechanism of increased endothelial permeability induced by lipopolysaccharide.

Tiruppathi C, Shimizu J, Miyawaki-Shimizu K, Vogel SM, Bair AM, Minshall RD, Predescu D, Malik AB.

J Biol Chem. 2008 Feb 15;283(7):4210-8. Epub 2007 Dec 11.

35.

E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury.

Bachmaier K, Toya S, Gao X, Triantafillou T, Garrean S, Park GY, Frey RS, Vogel S, Minshall R, Christman JW, Tiruppathi C, Malik AB.

Nat Med. 2007 Aug;13(8):920-6. Epub 2007 Jul 8.

PMID:
17618294
36.

Ca2+ signaling, TRP channels, and endothelial permeability.

Tiruppathi C, Ahmmed GU, Vogel SM, Malik AB.

Microcirculation. 2006 Dec;13(8):693-708. Review.

PMID:
17085428
37.

Novel mechanism of endothelial nitric oxide synthase activation mediated by caveolae internalization in endothelial cells.

Maniatis NA, Brovkovych V, Allen SE, John TA, Shajahan AN, Tiruppathi C, Vogel SM, Skidgel RA, Malik AB, Minshall RD.

Circ Res. 2006 Oct 13;99(8):870-7. Epub 2006 Sep 14.

PMID:
16973909
38.

Caveolin-1 regulates store-operated Ca2+ influx by binding of its scaffolding domain to transient receptor potential channel-1 in endothelial cells.

Kwiatek AM, Minshall RD, Cool DR, Skidgel RA, Malik AB, Tiruppathi C.

Mol Pharmacol. 2006 Oct;70(4):1174-83. Epub 2006 Jul 5.

PMID:
16822931
39.

Ca2+ influx induced by protease-activated receptor-1 activates a feed-forward mechanism of TRPC1 expression via nuclear factor-kappaB activation in endothelial cells.

Paria BC, Bair AM, Xue J, Yu Y, Malik AB, Tiruppathi C.

J Biol Chem. 2006 Jul 28;281(30):20715-27. Epub 2006 May 18.

40.

Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2 influx.

Jho D, Mehta D, Ahmmed G, Gao XP, Tiruppathi C, Broman M, Malik AB.

Circ Res. 2005 Jun 24;96(12):1282-90. Epub 2005 May 26. Erratum in: Circ Res. 2009 May 8;104(9):e58.

PMID:
15920022
41.

Tumor necrosis factor-alpha-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability.

Paria BC, Vogel SM, Ahmmed GU, Alamgir S, Shroff J, Malik AB, Tiruppathi C.

Am J Physiol Lung Cell Mol Physiol. 2004 Dec;287(6):L1303-13. Epub 2004 Sep 3. Erratum in: Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L204.

42.

Gbetagamma activation of Src induces caveolae-mediated endocytosis in endothelial cells.

Shajahan AN, Tiruppathi C, Smrcka AV, Malik AB, Minshall RD.

J Biol Chem. 2004 Nov 12;279(46):48055-62. Epub 2004 Sep 2.

43.

Albumin mediates the transcytosis of myeloperoxidase by means of caveolae in endothelial cells.

Tiruppathi C, Naqvi T, Wu Y, Vogel SM, Minshall RD, Malik AB.

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7699-704. Epub 2004 May 10.

44.

Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells.

Ahmmed GU, Mehta D, Vogel S, Holinstat M, Paria BC, Tiruppathi C, Malik AB.

J Biol Chem. 2004 May 14;279(20):20941-9. Epub 2004 Mar 10. Erratum in: J Biol Chem. 2011 Oct 14;286(41):36162.

45.

Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells.

Shajahan AN, Timblin BK, Sandoval R, Tiruppathi C, Malik AB, Minshall RD.

J Biol Chem. 2004 May 7;279(19):20392-400. Epub 2004 Mar 8.

46.

Tumor necrosis factor-alpha induces nuclear factor-kappaB-dependent TRPC1 expression in endothelial cells.

Paria BC, Malik AB, Kwiatek AM, Rahman A, May MJ, Ghosh S, Tiruppathi C.

J Biol Chem. 2003 Sep 26;278(39):37195-203. Epub 2003 Jul 10.

47.

RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability.

Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB.

J Biol Chem. 2003 Aug 29;278(35):33492-500. Epub 2003 May 22.

48.

Role of Ca2+ signaling in the regulation of endothelial permeability.

Tiruppathi C, Minshall RD, Paria BC, Vogel SM, Malik AB.

Vascul Pharmacol. 2002 Nov;39(4-5):173-85. Review.

PMID:
12747958
49.

Quantitative analysis of albumin uptake and transport in the rat microvessel endothelial monolayer.

John TA, Vogel SM, Tiruppathi C, Malik AB, Minshall RD.

Am J Physiol Lung Cell Mol Physiol. 2003 Jan;284(1):L187-96.

50.

Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability.

Tiruppathi C, Freichel M, Vogel SM, Paria BC, Mehta D, Flockerzi V, Malik AB.

Circ Res. 2002 Jul 12;91(1):70-6.

PMID:
12114324

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