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Items: 30

1.

Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma.

Zhuang J, Shirazi F, Singh RK, Kuiatse I, Wang H, Lee HC, Berkova Z, Berger A, Hyer M, Chattopadhyay N, Syed S, Shi JQ, Yu J, Shinde V, Tirrell S, Jones RJ, Wang Z, Davis RE, Orlowski RZ.

Blood. 2019 Apr 4;133(14):1572-1584. doi: 10.1182/blood-2018-06-859686. Epub 2019 Feb 8.

PMID:
30737236
2.

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.

Hyer ML, Milhollen MA, Ciavarri J, Fleming P, Traore T, Sappal D, Huck J, Shi J, Gavin J, Brownell J, Yang Y, Stringer B, Griffin R, Bruzzese F, Soucy T, Duffy J, Rabino C, Riceberg J, Hoar K, Lublinsky A, Menon S, Sintchak M, Bump N, Pulukuri SM, Langston S, Tirrell S, Kuranda M, Veiby P, Newcomb J, Li P, Wu JT, Powe J, Dick LR, Greenspan P, Galvin K, Manfredi M, Claiborne C, Amidon BS, Bence NF.

Nat Med. 2018 Feb;24(2):186-193. doi: 10.1038/nm.4474. Epub 2018 Jan 15.

PMID:
29334375
3.

The beagle dog MicroRNA tissue atlas: identifying translatable biomarkers of organ toxicity.

Koenig EM, Fisher C, Bernard H, Wolenski FS, Gerrein J, Carsillo M, Gallacher M, Tse A, Peters R, Smith A, Meehan A, Tirrell S, Kirby P.

BMC Genomics. 2016 Aug 17;17:649. doi: 10.1186/s12864-016-2958-x.

4.

A Sensitive IHC Method for Monitoring Autophagy-Specific Markers in Human Tumor Xenografts.

He H, Yang Y, Xiang Z, Yu L, Chouitar J, Yu J, D'Amore NR, Li P, Li Z, Bowman D, Theisen M, Brownell JE, Tirrell S.

J Biomark. 2016;2016:1274603. doi: 10.1155/2016/1274603. Epub 2016 May 10.

5.

KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism.

Chattopadhyay N, Berger AJ, Koenig E, Bannerman B, Garnsey J, Bernard H, Hales P, Maldonado Lopez A, Yang Y, Donelan J, Jordan K, Tirrell S, Stringer B, Xia C, Hather G, Galvin K, Manfredi M, Rhodes N, Amidon B.

PLoS One. 2015 Dec 28;10(12):e0144825. doi: 10.1371/journal.pone.0144825. eCollection 2015.

6.

Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma.

Shah JJ, Jakubowiak AJ, O'Connor OA, Orlowski RZ, Harvey RD, Smith MR, Lebovic D, Diefenbach C, Kelly K, Hua Z, Berger AJ, Mulligan G, Faessel HM, Tirrell S, Dezube BJ, Lonial S.

Clin Cancer Res. 2016 Jan 1;22(1):34-43. doi: 10.1158/1078-0432.CCR-15-1237. Epub 2015 Nov 11.

7.

Phase 1 study of ixazomib, an investigational proteasome inhibitor, in advanced non-hematologic malignancies.

Smith DC, Kalebic T, Infante JR, Siu LL, Sullivan D, Vlahovic G, Kauh JS, Gao F, Berger AJ, Tirrell S, Gupta N, Di Bacco A, Berg D, Liu G, Lin J, Hui AM, Thompson JA.

Invest New Drugs. 2015 Jun;33(3):652-63. doi: 10.1007/s10637-015-0230-x. Epub 2015 Mar 18.

8.

Comparative genome analysis of non-toxigenic non-O1 versus toxigenic O1 Vibrio cholerae.

Mukherjee M, Kakarla P, Kumar S, Gonzalez E, Floyd JT, Inupakutika M, Devireddy AR, Tirrell SR, Bruns M, He G, Lindquist IE, Sundararajan A, Schilkey FD, Mudge J, Varela MF.

Genom Discov. 2014;2(1):1-15.

9.

Applications of pathology-assisted image analysis of immunohistochemistry-based biomarkers in oncology.

Shinde V, Burke KE, Chakravarty A, Fleming M, McDonald AA, Berger A, Ecsedy J, Blakemore SJ, Tirrell SM, Bowman D.

Vet Pathol. 2014 Jan;51(1):292-303. doi: 10.1177/0300985813511124. Epub 2013 Nov 14.

PMID:
24232190
10.

Reply to "Phenotypic identification of Staphylococcus intermedius may be inaccurate".

Hatch S, Sree A, Tirrell S, Torres B, Rothman AL.

J Clin Microbiol. 2013 Feb;51(2):735. doi: 10.1128/JCM.02767-12. No abstract available.

11.

Metastatic complications from Staphylococcus intermedius, a zoonotic pathogen.

Hatch S, Sree A, Tirrell S, Torres B, Rothman AL.

J Clin Microbiol. 2012 Mar;50(3):1099-101. doi: 10.1128/JCM.05170-11. Epub 2011 Dec 14.

12.

Phase I assessment of new mechanism-based pharmacodynamic biomarkers for MLN8054, a small-molecule inhibitor of Aurora A kinase.

Chakravarty A, Shinde V, Tabernero J, Cervantes A, Cohen RB, Dees EC, Burris H, Infante JR, Macarulla T, Elez E, Andreu J, Rodriguez-Braun E, Rosello S, von Mehren M, Meropol NJ, Langer CJ, ONeil B, Bowman D, Zhang M, Danaee H, Faron-Yowe L, Gray G, Liu H, Pappas J, Silverman L, Simpson C, Stringer B, Tirrell S, Veiby OP, Venkatakrishnan K, Galvin K, Manfredi M, Ecsedy JA.

Cancer Res. 2011 Feb 1;71(3):675-85. doi: 10.1158/0008-5472.CAN-10-1030. Epub 2010 Dec 10.

13.

Transcriptional responses to estrogen and progesterone in mammary gland identify networks regulating p53 activity.

Lu S, Becker KA, Hagen MJ, Yan H, Roberts AL, Mathews LA, Schneider SS, Siegelmann HT, MacBeth KJ, Tirrell SM, Blanchard JL, Jerry DJ.

Endocrinology. 2008 Oct;149(10):4809-20. doi: 10.1210/en.2008-0035. Epub 2008 Jun 12.

14.

Diarrheagenic Escherichia coli infection in Baltimore, Maryland, and New Haven, Connecticut.

Nataro JP, Mai V, Johnson J, Blackwelder WC, Heimer R, Tirrell S, Edberg SC, Braden CR, Glenn Morris J Jr, Hirshon JM.

Clin Infect Dis. 2006 Aug 15;43(4):402-7. Epub 2006 Jul 11.

PMID:
16838226
15.

Reproducibility of gene expression signature-based predictions in replicate experiments.

Anderson K, Hess KR, Kapoor M, Tirrell S, Courtemanche J, Wang B, Wu Y, Gong Y, Hortobagyi GN, Symmans WF, Pusztai L.

Clin Cancer Res. 2006 Mar 15;12(6):1721-7.

16.

Comparison of the predictive accuracy of DNA array-based multigene classifiers across cDNA arrays and Affymetrix GeneChips.

Stec J, Wang J, Coombes K, Ayers M, Hoersch S, Gold DL, Ross JS, Hess KR, Tirrell S, Linette G, Hortobagyi GN, Fraser Symmans W, Pusztai L.

J Mol Diagn. 2005 Aug;7(3):357-67.

17.
18.

Isolation of West Nile virus from mosquitoes, crows, and a Cooper's hawk in Connecticut.

Anderson JF, Andreadis TG, Vossbrinck CR, Tirrell S, Wakem EM, French RA, Garmendia AE, Van Kruiningen HJ.

Science. 1999 Dec 17;286(5448):2331-3.

19.

Japanese encephalitis vaccine (inactivated, BIKEN) in U.S. soldiers: immunogenicity and safety of vaccine administered in two dosing regimens.

Defraites RF, Gambel JM, Hoke CH Jr, Sanchez JL, Withers BG, Karabatsos N, Shope RE, Tirrell S, Yoshida I, Takagi M, Meschievitz CK, Tsai TF.

Am J Trop Med Hyg. 1999 Aug;61(2):288-93.

PMID:
10463681
20.
21.

Serologic evidence of Jamestown Canyon virus infection in white-tailed deer populations from Connecticut.

Zamparo JM, Andreadis TG, Shope RE, Tirrell SJ.

J Wildl Dis. 1997 Jul;33(3):623-7.

PMID:
9249710
22.

Stabilising oral poliovaccine at high ambient temperatures.

Newman JF, Tirrell S, Ullman C, Piatti PG, Brown F.

Dev Biol Stand. 1996;87:103-11. Review.

PMID:
8854007
23.

Stabilising oral poliovaccine at high ambient temperatures.

Newman JF, Tirrell S, Ullman C, Piatti PG, Brown F.

Vaccine. 1995;13(15):1431-5.

PMID:
8578821
24.

Mosquito and arbovirus surveillance in Connecticut, 1991-1992.

Andreadis TG, Capotosto PM, Shope RE, Tirrell SJ.

J Am Mosq Control Assoc. 1994 Dec;10(4):556-64.

PMID:
7707064
25.

Necrotizing panencephalitis in puppies infected with La Crosse virus.

Black SS, Harrison LR, Pursell AR, Cole JR Jr, Appel MJ, Shope RE, Tirrell SJ.

J Vet Diagn Invest. 1994 Apr;6(2):250-4. No abstract available.

PMID:
8068759
26.
27.

Anti-idiotypic antibodies that protect cells against the action of diphtheria toxin.

Rolf JM, Gaudin HM, Tirrell SM, MacDonald AB, Eidels L.

Proc Natl Acad Sci U S A. 1989 Mar;86(6):2036-9.

28.

The angiogenic properties of the rat vibrissa hair follicle associate with the bulb.

Stenn KS, Fernandez LA, Tirrell SJ.

J Invest Dermatol. 1988 Mar;90(3):409-11.

29.

Characterization of an antigen secreted by Chlamydia-infected cell culture.

Stuart ES, Tirrell SM, MacDonald AB.

Immunology. 1987 Aug;61(4):527-33.

30.

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