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Microphysiological systems modeling acute respiratory distress syndrome that capture mechanical force-induced injury-inflammation-repair.

Viola H, Chang J, Grunwell JR, Hecker L, Tirouvanziam R, Grotberg JB, Takayama S.

APL Bioeng. 2019 Nov 22;3(4):041503. doi: 10.1063/1.5111549. eCollection 2019 Dec. Review.


Neutrophil-targeted, protease-activated pulmonary drug delivery blocks airway and systemic inflammation.

Mejías JC, Forrest OA, Margaroli C, Frey Rubio DA, Viera L, Li J, Xu X, Gaggar A, Tirouvanziam R, Roy K.

JCI Insight. 2019 Dec 5;4(23). pii: 131468. doi: 10.1172/jci.insight.131468.


MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients.

Dwir D, Giangreco B, Xin L, Tenenbaum L, Cabungcal JH, Steullet P, Goupil A, Cleusix M, Jenni R, Baumann PS, Klauser P, Conus P, Tirouvanziam R, Cuenod M, Do KQ.

Mol Psychiatry. 2019 Mar 25. doi: 10.1038/s41380-019-0393-5. [Epub ahead of print]


Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections.

Grunwell JR, Giacalone VD, Stephenson S, Margaroli C, Dobosh BS, Brown MR, Fitzpatrick AM, Tirouvanziam R.

Sci Rep. 2019 Feb 27;9(1):2874. doi: 10.1038/s41598-019-39726-w.


Vitamin D for the Immune System in Cystic Fibrosis (DISC): a double-blind, multicenter, randomized, placebo-controlled clinical trial.

Tangpricha V, Lukemire J, Chen Y, Binongo JNG, Judd SE, Michalski ES, Lee MJ, Walker S, Ziegler TR, Tirouvanziam R, Zughaier SM, Chesdachai S, Hermes WA, Chmiel JF, Grossmann RE, Gaggar A, Joseph PM, Alvarez JA.

Am J Clin Nutr. 2019 Mar 1;109(3):544-553. doi: 10.1093/ajcn/nqy291.


Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung.

Genschmer KR, Russell DW, Lal C, Szul T, Bratcher PE, Noerager BD, Abdul Roda M, Xu X, Rezonzew G, Viera L, Dobosh BS, Margaroli C, Abdalla TH, King RW, McNicholas CM, Wells JM, Dransfield MT, Tirouvanziam R, Gaggar A, Blalock JE.

Cell. 2019 Jan 10;176(1-2):113-126.e15. doi: 10.1016/j.cell.2018.12.002.


Elastase Exocytosis by Airway Neutrophils Is Associated with Early Lung Damage in Children with Cystic Fibrosis.

Margaroli C, Garratt LW, Horati H, Dittrich AS, Rosenow T, Montgomery ST, Frey DL, Brown MR, Schultz C, Guglani L, Kicic A, Peng L, Scholte BJ, Mall MA, Janssens HM, Stick SM, Tirouvanziam R.

Am J Respir Crit Care Med. 2019 Apr 1;199(7):873-881. doi: 10.1164/rccm.201803-0442OC.


Children with Neutrophil-Predominant Severe Asthma Have Proinflammatory Neutrophils With Enhanced Survival and Impaired Clearance.

Grunwell JR, Stephenson ST, Tirouvanziam R, Brown LAS, Brown MR, Fitzpatrick AM.

J Allergy Clin Immunol Pract. 2019 Feb;7(2):516-525.e6. doi: 10.1016/j.jaip.2018.08.024. Epub 2018 Sep 5.


Myeloperoxidase oxidation of methionine associates with early cystic fibrosis lung disease.

Chandler JD, Margaroli C, Horati H, Kilgore MB, Veltman M, Liu HK, Taurone AJ, Peng L, Guglani L, Uppal K, Go YM, Tiddens HAWM, Scholte BJ, Tirouvanziam R, Jones DP, Janssens HM.

Eur Respir J. 2018 Oct 10;52(4). pii: 1801118. doi: 10.1183/13993003.01118-2018. Print 2018 Oct.


Determination of thiocyanate in exhaled breath condensate.

Chandler JD, Horati H, Walker DI, Pagliano E, Tirouvanziam R, Veltman M, Scholte BJ, Janssens HM, Go YM, Jones DP.

Free Radic Biol Med. 2018 Oct;126:334-340. doi: 10.1016/j.freeradbiomed.2018.08.012. Epub 2018 Aug 22.


Resistin is elevated in cystic fibrosis sputum and correlates negatively with lung function.

Forrest OA, Chopyk DM, Gernez Y, Brown MR, Conrad CK, Moss RB, Tangpricha V, Peng L, Tirouvanziam R.

J Cyst Fibros. 2019 Jan;18(1):64-70. doi: 10.1016/j.jcf.2018.05.018. Epub 2018 Jun 21.


Frontline Science: Pathological conditioning of human neutrophils recruited to the airway milieu in cystic fibrosis.

Forrest OA, Ingersoll SA, Preininger MK, Laval J, Limoli DH, Brown MR, Lee FE, Bedi B, Sadikot RT, Goldberg JB, Tangpricha V, Gaggar A, Tirouvanziam R.

J Leukoc Biol. 2018 Oct;104(4):665-675. doi: 10.1002/JLB.5HI1117-454RR. Epub 2018 May 9.


Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine.

Hartl D, Tirouvanziam R, Laval J, Greene CM, Habiel D, Sharma L, Yildirim AÖ, Dela Cruz CS, Hogaboam CM.

J Innate Immun. 2018;10(5-6):487-501. doi: 10.1159/000487057. Epub 2018 Feb 13. Review.


Adenosine Production by Biomaterial-Supported Mesenchymal Stromal Cells Reduces the Innate Inflammatory Response in Myocardial Ischemia/Reperfusion Injury.

Shin EY, Wang L, Zemskova M, Deppen J, Xu K, Strobel F, García AJ, Tirouvanziam R, Levit RD.

J Am Heart Assoc. 2018 Jan 13;7(2). pii: e006949. doi: 10.1161/JAHA.117.006949.


Leukocyte and plasma activation profiles in chronically transfused patients with a history of allergic reactions.

Fontaine MJ, Shih H, Schubert R, Wong W, Andrews J, Jeng M, Tirouvanziam R.

Transfusion. 2017 Nov;57(11):2639-2648. doi: 10.1111/trf.14275. Epub 2017 Sep 6.


The Vitamin D for Enhancing the Immune System in Cystic Fibrosis (DISC) trial: Rationale and design of a multi-center, double-blind, placebo-controlled trial of high dose bolus administration of vitamin D3 during acute pulmonary exacerbation of cystic fibrosis.

Tangpricha V, Smith EM, Binongo J, Judd SE, Ziegler TR, Walker S, Tirouvanziam R, Zughaier SM, Lee MJ, Chesdachai S, Hermes WA, Chmiel JF, Gaggar A, Grossmann RE, Joseph PM, Alvarez JA.

Contemp Clin Trials Commun. 2017 Jun;6:39-45. doi: 10.1016/j.conctc.2017.02.010. Epub 2017 Mar 9.


Corrigendum to "Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration" [Metabolism vol. 70, May 2017, pages 31-41].

Alvarez JA, Chong EY, Walker DI, Chandler JD, Michalski ES, Grossmann RE, Uppal K, Li S, Frediani JK, Tirouvanziam R, Tran VT, Tangpricha V, Jones DP, Ziegler TR.

Metabolism. 2017 Sep;74:41-42. doi: 10.1016/j.metabol.2017.04.009. Epub 2017 Apr 26. No abstract available.


Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration.

Alvarez JA, Chong EY, Walker DI, Chandler JD, Michalski ES, Grossmann RE, Uppal K, Li S, Frediani JK, Tirouvanziam R, Tran VT, Tangpricha V, Jones DP, Ziegler TR.

Metabolism. 2017 May;70:31-41. doi: 10.1016/j.metabol.2017.02.006. Epub 2017 Feb 11. Erratum in: Metabolism. 2017 Sep;74:41-42.


Basophil activation test determination of CD63 combined with CD203c is not superior to CD203c alone in identifying allergic bronchopulmonary aspergillosis in cystic fibrosis.

Gernez Y, Waters J, Tirouvanziam R, Herzenberg L, Moss R.

J Allergy Clin Immunol. 2016 Oct;138(4):1195-1196. doi: 10.1016/j.jaci.2016.04.002. Epub 2016 Apr 22. No abstract available.


High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial.

Johnson K, McEvoy CE, Naqvi S, Wendt C, Reilkoff RA, Kunisaki KM, Wetherbee EE, Nelson D, Tirouvanziam R, Niewoehner DE.

Int J Chron Obstruct Pulmon Dis. 2016 Apr 21;11:799-807. doi: 10.2147/COPD.S102375. eCollection 2016.


Blood basophil activation is a reliable biomarker of allergic bronchopulmonary aspergillosis in cystic fibrosis.

Gernez Y, Waters J, Mirković B, Lavelle GM, Dunn CE, Davies ZA, Everson C, Tirouvanziam R, Silver E, Wallenstein S, Chotirmall SH, McElvaney NG, Herzenberg LA, Moss RB.

Eur Respir J. 2016 Jan;47(1):177-85. doi: 10.1183/13993003.01068-2015. Epub 2015 Nov 19. Erratum in: Eur Respir J. 2016 Jun;47(6):1892.


Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes.

Szul T, Bratcher PE, Fraser KB, Kong M, Tirouvanziam R, Ingersoll S, Sztul E, Rangarajan S, Blalock JE, Xu X, Gaggar A.

Am J Respir Cell Mol Biol. 2016 Mar;54(3):359-69. doi: 10.1165/rcmb.2015-0108OC.


Mature cystic fibrosis airway neutrophils suppress T cell function: evidence for a role of arginase 1 but not programmed death-ligand 1.

Ingersoll SA, Laval J, Forrest OA, Preininger M, Brown MR, Arafat D, Gibson G, Tangpricha V, Tirouvanziam R.

J Immunol. 2015 Jun 1;194(11):5520-8. doi: 10.4049/jimmunol.1500312. Epub 2015 Apr 29.


Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity.

Napier RJ, Norris BA, Swimm A, Giver CR, Harris WA, Laval J, Napier BA, Patel G, Crump R, Peng Z, Bornmann W, Pulendran B, Buller RM, Weiss DS, Tirouvanziam R, Waller EK, Kalman D.

PLoS Pathog. 2015 Mar 30;11(3):e1004770. doi: 10.1371/journal.ppat.1004770. eCollection 2015 Mar.


Alterations in blood leukocytes of G551D-bearing cystic fibrosis patients undergoing treatment with ivacaftor.

Bratcher PE, Rowe SM, Reeves G, Roberts T, Szul T, Harris WT, Tirouvanziam R, Gaggar A.

J Cyst Fibros. 2016 Jan;15(1):67-73. doi: 10.1016/j.jcf.2015.02.010. Epub 2015 Mar 11.


Long-term treatment with oral N-acetylcysteine: affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial.

Conrad C, Lymp J, Thompson V, Dunn C, Davies Z, Chatfield B, Nichols D, Clancy J, Vender R, Egan ME, Quittell L, Michelson P, Antony V, Spahr J, Rubenstein RC, Moss RB, Herzenberg LA, Goss CH, Tirouvanziam R.

J Cyst Fibros. 2015 Mar;14(2):219-27. doi: 10.1016/j.jcf.2014.08.008. Epub 2014 Sep 13.


PET imaging of stroke-induced neuroinflammation in mice using [18F]PBR06.

Lartey FM, Ahn GO, Shen B, Cord KT, Smith T, Chua JY, Rosenblum S, Liu H, James ML, Chernikova S, Lee SW, Pisani LJ, Tirouvanziam R, Chen JW, Palmer TD, Chin FT, Guzman R, Graves EE, Loo BW Jr.

Mol Imaging Biol. 2014 Feb;16(1):109-17. doi: 10.1007/s11307-013-0664-5. Epub 2013 Jul 9.


Metabolic adaptation of neutrophils in cystic fibrosis airways involves distinct shifts in nutrient transporter expression.

Laval J, Touhami J, Herzenberg LA, Conrad C, Taylor N, Battini JL, Sitbon M, Tirouvanziam R.

J Immunol. 2013 Jun 15;190(12):6043-50. doi: 10.4049/jimmunol.1201755. Epub 2013 May 20.


The long-term impact of early adversity on late-life psychiatric disorders.

Gershon A, Sudheimer K, Tirouvanziam R, Williams LM, O'Hara R.

Curr Psychiatry Rep. 2013 Apr;15(4):352. doi: 10.1007/s11920-013-0352-9. Review.


Blood basophils from cystic fibrosis patients with allergic bronchopulmonary aspergillosis are primed and hyper-responsive to stimulation by aspergillus allergens.

Gernez Y, Dunn CE, Everson C, Mitsunaga E, Gudiputi L, Krasinska K, Davies ZA, Herzenberg LA, Tirouvanziam R, Moss RB.

J Cyst Fibros. 2012 Dec;11(6):502-10. doi: 10.1016/j.jcf.2012.04.008. Epub 2012 May 16.


Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients.

Gernez Y, Tirouvanziam R, Reshamwala N, Yu G, Weldon BC, Galli SJ, Herzenberg LA, Nadeau KC.

J Clin Immunol. 2012 Jun;32(3):565-73. doi: 10.1007/s10875-012-9651-x. Epub 2012 Feb 21.


A randomized controlled pilot trial of oral N-acetylcysteine in children with autism.

Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA, Frazier TW, Tirouvanziam R.

Biol Psychiatry. 2012 Jun 1;71(11):956-61. doi: 10.1016/j.biopsych.2012.01.014. Epub 2012 Feb 18.


Distinct plasma profile of polar neutral amino acids, leucine, and glutamate in children with Autism Spectrum Disorders.

Tirouvanziam R, Obukhanych TV, Laval J, Aronov PA, Libove R, Banerjee AG, Parker KJ, O'Hara R, Herzenberg LA, Herzenberg LA, Hardan AY.

J Autism Dev Disord. 2012 May;42(5):827-36. doi: 10.1007/s10803-011-1314-x.


Immunophenotyping of peripheral eosinophils demonstrates activation in eosinophilic esophagitis.

Nguyen T, Gernez Y, Fuentebella J, Patel A, Tirouvanziam R, Reshamwala N, Bass D, Berquist WE, Cox KL, Kerner JA, Nadeau KC.

J Pediatr Gastroenterol Nutr. 2011 Jul;53(1):40-7. doi: 10.1097/MPG.0b013e318212647a.


Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy.

Gernez Y, Tirouvanziam R, Yu G, Ghosn EE, Reshamwala N, Nguyen T, Tsai M, Galli SJ, Herzenberg LA, Herzenberg LA, Nadeau KC.

Int Arch Allergy Immunol. 2011;154(4):318-27. doi: 10.1159/000321824. Epub 2010 Oct 25.


Neutrophils in chronic inflammatory airway diseases: can we target them and how?

Gernez Y, Tirouvanziam R, Chanez P.

Eur Respir J. 2010 Mar;35(3):467-9. doi: 10.1183/09031936.00186109. No abstract available.


Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs.

Makam M, Diaz D, Laval J, Gernez Y, Conrad CK, Dunn CE, Davies ZA, Moss RB, Herzenberg LA, Herzenberg LA, Tirouvanziam R.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5779-83. doi: 10.1073/pnas.0813410106. Epub 2009 Mar 17.


Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways.

Tirouvanziam R, Gernez Y, Conrad CK, Moss RB, Schrijver I, Dunn CE, Davies ZA, Herzenberg LA, Herzenberg LA.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4335-9. doi: 10.1073/pnas.0712386105. Epub 2008 Mar 11.


[Phospho-FACS: a powerful tool for exploring intracellular transduction cascades].

Gernez Y, Herzenberg LA, Herzenberg LA, Tirouvanziam R.

Rev Mal Respir. 2007 Oct;24(8):955-64. Review. French.


Altered phosphorylated signal transducer and activator of transcription profile of CD4+CD161+ T cells in asthma: modulation by allergic status and oral corticosteroids.

Gernez Y, Tirouvanziam R, Nguyen KD, Herzenberg LA, Krensky AM, Nadeau KC.

J Allergy Clin Immunol. 2007 Dec;120(6):1441-8. Epub 2007 Oct 24.


Modern flow cytometry: a practical approach.

Tung JW, Heydari K, Tirouvanziam R, Sahaf B, Parks DR, Herzenberg LA, Herzenberg LA.

Clin Lab Med. 2007 Sep;27(3):453-68, v. Review.


Neutrophilic inflammation as a major determinant in the progression of cystic fibrosis.

Tirouvanziam R.

Drug News Perspect. 2006 Dec;19(10):609-14. Review.


High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis.

Tirouvanziam R, Conrad CK, Bottiglieri T, Herzenberg LA, Moss RB, Herzenberg LA.

Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4628-33. Epub 2006 Mar 13.


Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes.

Davidson CJ, Tirouvanziam R, Herzenberg LA, Lipsick JS.

Genetics. 2005 Jan;169(1):215-29. Epub 2004 Oct 16.


Fluorescence-activated cell sorting (FACS) of Drosophila hemocytes reveals important functional similarities to mammalian leukocytes.

Tirouvanziam R, Davidson CJ, Lipsick JS, Herzenberg LA.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2912-7. Epub 2004 Feb 19.


Primary inflammation in human cystic fibrosis small airways.

Tirouvanziam R, Khazaal I, Péault B.

Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L445-51.


Ex vivo development of functional human lymph node and bronchus-associated lymphoid tissue.

Tirouvanziam R, Khazaal I, N'Sondé V, Peyrat MA, Lim A, de Bentzmann S, Fournié JJ, Bonneville M, Péault B.

Blood. 2002 Apr 1;99(7):2483-9.


Inflammation and infection in naive human cystic fibrosis airway grafts.

Tirouvanziam R, de Bentzmann S, Hubeau C, Hinnrasky J, Jacquot J, Péault B, Puchelle E.

Am J Respir Cell Mol Biol. 2000 Aug;23(2):121-7.


Epithelial stem cell-mediated development of the human respiratory mucosa in SCID mice.

Delplanque A, Coraux C, Tirouvanziam R, Khazaal I, Puchelle E, Ambros P, Gaillard D, Péault B.

J Cell Sci. 2000 Mar;113 ( Pt 5):767-78.

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