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Items: 1 to 50 of 89

1.

The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency.

Gennari A, Rios de la Rosa JM, Hohn E, Pelliccia M, Lallana E, Donno R, Tirella A, Tirelli N.

Beilstein J Nanotechnol. 2019 Dec 30;10:2594-2608. doi: 10.3762/bjnano.10.250. eCollection 2019.

2.

20 Years of Biopolymers, Biomaterials, and Biomimetics.

Tirelli N, Pfisterer A, Mayer C.

Macromol Biosci. 2020 Jan;20(1):e1900421. doi: 10.1002/mabi.201900421. No abstract available.

PMID:
31943752
3.

"Tandem" Nanomedicine Approach against Osteoclastogenesis: Polysulfide Micelles Synergically Scavenge ROS and Release Rapamycin.

El Mohtadi F, d'Arcy R, Burke J, Rios De La Rosa JM, Gennari A, Marotta R, Francini N, Donno R, Tirelli N.

Biomacromolecules. 2020 Feb 10;21(2):305-318. doi: 10.1021/acs.biomac.9b01348. Epub 2019 Dec 17.

PMID:
31793790
4.

Fibrin Matrices as (Injectable) Biomaterials: Formation, Clinical Use, and Molecular Engineering.

Roberts IV, Bukhary D, Valdivieso CYL, Tirelli N.

Macromol Biosci. 2020 Jan;20(1):e1900283. doi: 10.1002/mabi.201900283. Epub 2019 Nov 18. Review.

PMID:
31769933
5.

Binding and Internalization in Receptor-Targeted Carriers: The Complex Role of CD44 in the Uptake of Hyaluronic Acid-Based Nanoparticles (siRNA Delivery).

Rios de la Rosa JM, Pingrajai P, Pelliccia M, Spadea A, Lallana E, Gennari A, Stratford IJ, Rocchia W, Tirella A, Tirelli N.

Adv Healthc Mater. 2019 Dec;8(24):e1901182. doi: 10.1002/adhm.201901182. Epub 2019 Nov 18.

PMID:
31738017
6.

Main Chain Polysulfoxides as Active 'Stealth' Polymers with Additional Antioxidant and Anti-Inflammatory Behaviour.

El Mohtadi F, d'Arcy R, Yang X, Turhan ZY, Alshamsan A, Tirelli N.

Int J Mol Sci. 2019 Sep 17;20(18). pii: E4583. doi: 10.3390/ijms20184583.

7.

Enhanced Intraliposomal Metallic Nanoparticle Payload Capacity Using Microfluidic-Assisted Self-Assembly.

Al-Ahmady ZS, Donno R, Gennari A, Prestat E, Marotta R, Mironov A, Newman L, Lawrence MJ, Tirelli N, Ashford M, Kostarelos K.

Langmuir. 2019 Oct 15;35(41):13318-13331. doi: 10.1021/acs.langmuir.9b00579. Epub 2019 Oct 2.

PMID:
31478662
8.

Angiogenesis and tissue formation driven by an arteriovenous loop in the mouse.

Wong R, Donno R, Leon-Valdivieso CY, Roostalu U, Derby B, Tirelli N, Wong JK.

Sci Rep. 2019 Jul 19;9(1):10478. doi: 10.1038/s41598-019-46571-4.

9.

Disulfide-Mediated Bioconjugation: Disulfide Formation and Restructuring on the Surface of Nanomanufactured (Microfluidics) Nanoparticles.

Geven M, Luo H, Koo D, Panambur G, Donno R, Gennari A, Marotta R, Grimaldi B, Tirelli N.

ACS Appl Mater Interfaces. 2019 Jul 31;11(30):26607-26618. doi: 10.1021/acsami.9b07972. Epub 2019 Jul 18.

PMID:
31282644
10.

Fibroblast migration correlates with matrix softness. A study in knob-hole engineered fibrin.

Leon-Valdivieso CY, Wedgwood J, Lallana E, Donno R, Roberts I, Ghibaudi M, Tirella A, Tirelli N.

APL Bioeng. 2018 Jul 17;2(3):036102. doi: 10.1063/1.5022841. eCollection 2018 Sep.

11.

Evaluating the Efficiency of Hyaluronic Acid for Tumor Targeting via CD44.

Spadea A, Rios de la Rosa JM, Tirella A, Ashford MB, Williams KJ, Stratford IJ, Tirelli N, Mehibel M.

Mol Pharm. 2019 Jun 3;16(6):2481-2493. doi: 10.1021/acs.molpharmaceut.9b00083. Epub 2019 May 1.

PMID:
31013093
12.

CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment.

Tirella A, Kloc-Muniak K, Good L, Ridden J, Ashford M, Puri S, Tirelli N.

Int J Pharm. 2019 Apr 20;561:114-123. doi: 10.1016/j.ijpharm.2019.02.032. Epub 2019 Feb 26.

PMID:
30822503
13.

Oxidation-Responsive Materials: Biological Rationale, State of the Art, Multiple Responsiveness, and Open Issues.

El-Mohtadi F, d'Arcy R, Tirelli N.

Macromol Rapid Commun. 2019 Jan;40(1):e1800699. doi: 10.1002/marc.201800699. Epub 2018 Nov 26. Review.

PMID:
30474897
14.

Cellular responses of hyaluronic acid-coated chitosan nanoparticles.

Almalik A, Alradwan I, Majrashi MA, Alsaffar BA, Algarni AT, Alsuabeyl MS, Alrabiah H, Tirelli N, Alhasan AH.

Toxicol Res (Camb). 2018 May 23;7(5):942-950. doi: 10.1039/c8tx00041g. eCollection 2018 Sep 1.

15.

Chitosan/β-glycerophosphate-based microparticles manufactured by laminar jet break-up technology.

Benamer W, Cellesi F, Tirelli N.

J Microencapsul. 2018 Aug;35(5):407-420. doi: 10.1080/02652048.2018.1515996. Epub 2018 Oct 9.

PMID:
30134755
16.

Microfluidic-assisted nanoprecipitation of (PEGylated) poly (d,l-lactic acid-co-caprolactone): Effect of macromolecular and microfluidic parameters on particle size and paclitaxel encapsulation.

Lallana E, Donno R, Magrì D, Barker K, Nazir Z, Treacher K, Lawrence MJ, Ashford M, Tirelli N.

Int J Pharm. 2018 Sep 5;548(1):530-539. doi: 10.1016/j.ijpharm.2018.07.031. Epub 2018 Jul 17.

PMID:
30009983
17.

Tyrosinase-Mediated Bioconjugation. A Versatile Approach to Chimeric Macromolecules.

Montanari E, Gennari A, Pelliccia M, Manzi L, Donno R, Oldham NJ, MacDonald A, Tirelli N.

Bioconjug Chem. 2018 Aug 15;29(8):2550-2560. doi: 10.1021/acs.bioconjchem.8b00227. Epub 2018 Jul 19.

PMID:
29975838
18.

Amphiphilic polysaccharides as building blocks for self-assembled nanosystems: molecular design and application in cancer and inflammatory diseases.

Yang X, Shi X, D'arcy R, Tirelli N, Zhai G.

J Control Release. 2018 Feb 28;272:114-144. doi: 10.1016/j.jconrel.2017.12.033. Epub 2017 Dec 30. Review.

PMID:
29292037
19.

Selective Targeting of a Novel Vasodilator to the Uterine Vasculature to Treat Impaired Uteroplacental Perfusion in Pregnancy.

Cureton N, Korotkova I, Baker B, Greenwood S, Wareing M, Kotamraju VR, Teesalu T, Cellesi F, Tirelli N, Ruoslahti E, Aplin JD, Harris LK.

Theranostics. 2017 Aug 29;7(15):3715-3731. doi: 10.7150/thno.19678. eCollection 2017.

20.

Nanomanufacturing through microfluidic-assisted nanoprecipitation: Advanced analytics and structure-activity relationships.

Donno R, Gennari A, Lallana E, De La Rosa JMR, d'Arcy R, Treacher K, Hill K, Ashford M, Tirelli N.

Int J Pharm. 2017 Dec 20;534(1-2):97-107. doi: 10.1016/j.ijpharm.2017.10.006. Epub 2017 Oct 7.

PMID:
29017804
21.

Hyaluronic Acid Coated Chitosan Nanoparticles Reduced the Immunogenicity of the Formed Protein Corona.

Almalik A, Benabdelkamel H, Masood A, Alanazi IO, Alradwan I, Majrashi MA, Alfadda AA, Alghamdi WM, Alrabiah H, Tirelli N, Alhasan AH.

Sci Rep. 2017 Sep 5;7(1):10542. doi: 10.1038/s41598-017-10836-7.

22.

Chitosan/Hyaluronic Acid Nanoparticles: Rational Design Revisited for RNA Delivery.

Lallana E, Rios de la Rosa JM, Tirella A, Pelliccia M, Gennari A, Stratford IJ, Puri S, Ashford M, Tirelli N.

Mol Pharm. 2017 Jul 3;14(7):2422-2436. doi: 10.1021/acs.molpharmaceut.7b00320. Epub 2017 Jun 19.

PMID:
28597662
23.

Polymeric micelles with dual thermal and reactive oxygen species (ROS)-responsiveness for inflammatory cancer cell delivery.

Tang M, Hu P, Zheng Q, Tirelli N, Yang X, Wang Z, Wang Y, Tang Q, He Y.

J Nanobiotechnology. 2017 May 16;15(1):39. doi: 10.1186/s12951-017-0275-4.

24.

Revisiting Boronate/Diol Complexation as a Double Stimulus-Responsive Bioconjugation.

Gennari A, Gujral C, Hohn E, Lallana E, Cellesi F, Tirelli N.

Bioconjug Chem. 2017 May 17;28(5):1391-1402. doi: 10.1021/acs.bioconjchem.7b00080. Epub 2017 Apr 18.

PMID:
28381085
25.

The CD44-Mediated Uptake of Hyaluronic Acid-Based Carriers in Macrophages.

Rios de la Rosa JM, Tirella A, Gennari A, Stratford IJ, Tirelli N.

Adv Healthc Mater. 2017 Feb;6(4). doi: 10.1002/adhm.201601012. Epub 2016 Dec 19.

PMID:
27990775
26.

Self-Replicating RNA Vaccine Delivery to Dendritic Cells.

Démoulins T, Englezou PC, Milona P, Ruggli N, Tirelli N, Pichon C, Sapet C, Ebensen T, Guzmán CA, McCullough KC.

Methods Mol Biol. 2017;1499:37-75. Review.

PMID:
27987142
27.

The Effect of Branching (Star Architecture) on Poly(d,l-lactide) (PDLLA) Degradation and Drug Delivery.

Burke J, Donno R, d'Arcy R, Cartmell S, Tirelli N.

Biomacromolecules. 2017 Mar 13;18(3):728-739. doi: 10.1021/acs.biomac.6b01524. Epub 2017 Feb 16.

PMID:
27930884
28.

Hyaluronan/Tannic Acid Nanoparticles Via Catechol/Boronate Complexation as a Smart Antibacterial System.

Montanari E, Gennari A, Pelliccia M, Gourmel C, Lallana E, Matricardi P, McBain AJ, Tirelli N.

Macromol Biosci. 2016 Dec;16(12):1815-1823. doi: 10.1002/mabi.201600311. Epub 2016 Oct 13.

PMID:
27735135
29.

Linear, Star, and Comb Oxidation-Responsive Polymers: Effect of Branching Degree and Topology on Aggregation and Responsiveness.

d'Arcy R, Gennari A, Donno R, Tirelli N.

Macromol Rapid Commun. 2016 Dec;37(23):1918-1925. doi: 10.1002/marc.201600481. Epub 2016 Sep 27.

PMID:
27676076
30.

Tumor-homing peptides as tools for targeted delivery of payloads to the placenta.

King A, Ndifon C, Lui S, Widdows K, Kotamraju VR, Agemy L, Teesalu T, Glazier JD, Cellesi F, Tirelli N, Aplin JD, Ruoslahti E, Harris LK.

Sci Adv. 2016 May 6;2(5):e1600349. doi: 10.1126/sciadv.1600349. eCollection 2016 May.

31.

Branched polyesters: Preparative strategies and applications.

d'Arcy R, Burke J, Tirelli N.

Adv Drug Deliv Rev. 2016 Dec 15;107:60-81. doi: 10.1016/j.addr.2016.05.005. Epub 2016 May 14. Review.

PMID:
27189232
32.

Mannosylation Allows for Synergic (CD44/C-Type Lectin) Uptake of Hyaluronic Acid Nanoparticles in Dendritic Cells, but Only upon Correct Ligand Presentation.

Gennari A, Pelliccia M, Donno R, Kimber I, Tirelli N.

Adv Healthc Mater. 2016 Apr 20;5(8):966-76. doi: 10.1002/adhm.201500941. Epub 2016 Feb 10.

PMID:
26865006
33.

Mitsunobu Reaction: A Versatile Tool for PEG End Functionalization.

d'Arcy R, Tirelli N.

Macromol Rapid Commun. 2015 Oct;36(20):1829-35. doi: 10.1002/marc.201500380. Epub 2015 Aug 21.

PMID:
26296426
34.

Fibronectin localization and fibrillization are affected by the presence of serum in culture media.

Siani A, Khaw RR, Manley OW, Tirella A, Cellesi F, Donno R, Tirelli N.

Sci Rep. 2015 Mar 23;5:9278. doi: 10.1038/srep09278.

35.

Enhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration.

Cai H, Wen X, Wen L, Tirelli N, Zhang X, Zhang Y, Su H, Yang F, Chen G.

Int J Nanomedicine. 2014 Dec 1;9:5591-601. doi: 10.2147/IJN.S72555. eCollection 2014.

36.

Binary behaviour of an oxidation-responsive MRI nano contrast agent.

Jeanmaire D, Timco GA, Gennari A, Sproules S, Williams KJ, Winpenny RE, Tirelli N.

Chem Commun (Camb). 2015 Jan 21;51(6):1074-6. doi: 10.1039/c4cc08024f.

PMID:
25447319
37.

An orthogonal click-chemistry approach to design poly(glycerol monomethacrylate)-based nanomaterials for controlled immunostimulation.

Ragupathy L, Millar DG, Tirelli N, Cellesi F.

Macromol Biosci. 2014 Nov;14(11):1528-38. doi: 10.1002/mabi.201400146. Epub 2014 Aug 18.

PMID:
25130689
38.

Myofibroblast differentiation: main features, biomedical relevance, and the role of reactive oxygen species.

Siani A, Tirelli N.

Antioxid Redox Signal. 2014 Aug 10;21(5):768-85. doi: 10.1089/ars.2013.5724. Epub 2014 Feb 6. Review.

PMID:
24279926
39.

HA-coated chitosan nanoparticles for CD44-mediated nucleic acid delivery.

Almalik A, Day PJ, Tirelli N.

Macromol Biosci. 2013 Dec;13(12):1671-80. doi: 10.1002/mabi.201300302. Epub 2013 Sep 17.

PMID:
24106105
40.

Hyaluronic acid-coated chitosan nanoparticles: molecular weight-dependent effects on morphology and hyaluronic acid presentation.

Almalik A, Donno R, Cadman CJ, Cellesi F, Day PJ, Tirelli N.

J Control Release. 2013 Dec 28;172(3):1142-50. doi: 10.1016/j.jconrel.2013.09.032. Epub 2013 Oct 6.

PMID:
24103813
41.

Hyaluronic acid (HA) presentation as a tool to modulate and control the receptor-mediated uptake of HA-coated nanoparticles.

Almalik A, Karimi S, Ouasti S, Donno R, Wandrey C, Day PJ, Tirelli N.

Biomaterials. 2013 Jul;34(21):5369-80. doi: 10.1016/j.biomaterials.2013.03.065. Epub 2013 Apr 21.

PMID:
23615561
42.

The antibiofilm effects of Byotrol™ G32.

Govindji N, Wills P, Upton M, Tirelli N, Yeates S, Webb M.

J Appl Microbiol. 2013 May;114(5):1285-93. doi: 10.1111/jam.12162. Epub 2013 Mar 1.

43.

Combination of episulfide ring-opening polymerization with ATRP for the preparation of amphiphilic block copolymers.

Vo CD, Cadman CJ, Donno R, Goos JA, Tirelli N.

Macromol Rapid Commun. 2013 Jan 25;34(2):156-62. doi: 10.1002/marc.201200636.

PMID:
23319175
44.

Quantitative descriptors for the effect of nature/mechanical properties of solid substrates on fibroblast morphology.

Siani A, Robert-Nicoud G, Cellesi F, Tirelli N.

J Appl Biomater Funct Mater. 2012;10(3):265-72. doi: 10.5301/JABFM.2012.10355.

PMID:
23242875
45.

Advantages of surface-initiated ATRP (SI-ATRP) for the functionalization of electrospun materials.

Gualandi C, Vo CD, Focarete ML, Scandola M, Pollicino A, Di Silvestro G, Tirelli N.

Macromol Rapid Commun. 2013 Jan 11;34(1):51-6. doi: 10.1002/marc.201200648. Epub 2012 Oct 26.

PMID:
23109133
46.

End-group rearrangements in poly(propylene sulfide) matrix-assisted laser desorption/ionization time-of-flight analysis. Experimental evidence and possible mechanisms.

Lallana E, Ferreri T, Carroccio SC, Puga AM, Tirelli N.

Rapid Commun Mass Spectrom. 2012 Sep 30;26(18):2158-64. doi: 10.1002/rcm.6337.

PMID:
22886812
47.

PEGylation of nanosubstrates (titania) with multifunctional reagents: at the crossroads between nanoparticles and nanocomposites.

Kotsokechagia T, Zaki NM, Syres K, de Leonardis P, Thomas A, Cellesi F, Tirelli N.

Langmuir. 2012 Aug 7;28(31):11490-501. doi: 10.1021/la3012958. Epub 2012 Jul 25.

PMID:
22746328
48.

Yeast cells as microcapsules. Analytical tools and process variables in the encapsulation of hydrophobes in S. cerevisiae.

Ciamponi F, Duckham C, Tirelli N.

Appl Microbiol Biotechnol. 2012 Sep;95(6):1445-56. doi: 10.1007/s00253-012-4127-8. Epub 2012 May 13.

PMID:
22581037
49.

Scavenging ROS: superoxide dismutase/catalase mimetics by the use of an oxidation-sensitive nanocarrier/enzyme conjugate.

Hu P, Tirelli N.

Bioconjug Chem. 2012 Mar 21;23(3):438-49. doi: 10.1021/bc200449k. Epub 2012 Feb 14.

PMID:
22292618
50.

The CD44/integrins interplay and the significance of receptor binding and re-presentation in the uptake of RGD-functionalized hyaluronic acid.

Ouasti S, Kingham PJ, Terenghi G, Tirelli N.

Biomaterials. 2012 Feb;33(4):1120-34. doi: 10.1016/j.biomaterials.2011.10.009. Epub 2011 Nov 8.

PMID:
22071098

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