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Items: 11


Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.

Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA.

Science. 2019 Jul 26;365(6451):386-392. doi: 10.1126/science.aav3722. Epub 2019 Jul 4.


The ceramide ratio: a predictor of cardiometabolic risk.

Tippetts TS, Holland WL, Summers SA.

J Lipid Res. 2018 Sep;59(9):1549-1550. doi: 10.1194/jlr.C088377. Epub 2018 Jul 9. No abstract available.


Insulin selectively reduces mitochondrial uncoupling in brown adipose tissue in mice.

Dallon BW, Parker BA, Hodson AE, Tippetts TS, Harrison ME, Appiah MMA, Witt JE, Gibbs JL, Gray HM, Sant TM, Bikman BT.

Biochem J. 2018 Feb 9;475(3):561-569. doi: 10.1042/BCJ20170736.


High-Mobility Group Box 1 Disrupts Metabolic Function with Cigarette Smoke Exposure in a Ceramide-Dependent Manner.

Taylor OJ, Thatcher MO, Carr ST, Gibbs JL, Trumbull AM, Harrison ME, Winden DR, Pearson MJ, Tippetts TS, Holland WL, Reynolds PR, Bikman BT.

Int J Mol Sci. 2017 May 20;18(5). pii: E1099. doi: 10.3390/ijms18051099.


Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis.

Holland WL, Xia JY, Johnson JA, Sun K, Pearson MJ, Sharma AX, Quittner-Strom E, Tippetts TS, Gordillo R, Scherer PE.

Mol Metab. 2017 Jan 12;6(3):267-275. doi: 10.1016/j.molmet.2017.01.002. eCollection 2017 Mar.


Insulin treatment increases myocardial ceramide accumulation and disrupts cardiometabolic function.

Hodson AE, Tippetts TS, Bikman BT.

Cardiovasc Diabetol. 2015 Dec 18;14:153. doi: 10.1186/s12933-015-0316-y.


Lipopolysaccharide Disrupts Mitochondrial Physiology in Skeletal Muscle via Disparate Effects on Sphingolipid Metabolism.

Hansen ME, Simmons KJ, Tippetts TS, Thatcher MO, Saito RR, Hubbard ST, Trumbull AM, Parker BA, Taylor OJ, Bikman BT.

Shock. 2015 Dec;44(6):585-92. doi: 10.1097/SHK.0000000000000468.


Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration.

Tippetts TS, Winden DR, Swensen AC, Nelson MB, Thatcher MO, Saito RR, Condie TB, Simmons KJ, Judd AM, Reynolds PR, Bikman BT.

BMC Cardiovasc Disord. 2014 Nov 22;14:165. doi: 10.1186/1471-2261-14-165.


Ceramides mediate cigarette smoke-induced metabolic disruption in mice.

Thatcher MO, Tippetts TS, Nelson MB, Swensen AC, Winden DR, Hansen ME, Anderson MC, Johnson IE, Porter JP, Reynolds PR, Bikman BT.

Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E919-27. doi: 10.1152/ajpendo.00258.2014. Epub 2014 Sep 30.


Insulin increases ceramide synthesis in skeletal muscle.

Hansen ME, Tippetts TS, Anderson MC, Holub ZE, Moulton ER, Swensen AC, Prince JT, Bikman BT.

J Diabetes Res. 2014;2014:765784. doi: 10.1155/2014/765784. Epub 2014 May 18.


Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle.

Smith ME, Tippetts TS, Brassfield ES, Tucker BJ, Ockey A, Swensen AC, Anthonymuthu TS, Washburn TD, Kane DA, Prince JT, Bikman BT.

Biochem J. 2013 Dec 15;456(3):427-39. doi: 10.1042/BJ20130807.


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