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Items: 19


Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.

Guridi M, Tintignac LA, Lin S, Kupr B, Castets P, Rüegg MA.

Sci Signal. 2015 Nov 10;8(402):ra113. doi: 10.1126/scisignal.aab3715.


Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting.

Tintignac LA, Brenner HR, Rüegg MA.

Physiol Rev. 2015 Jul;95(3):809-52. doi: 10.1152/physrev.00033.2014. Review.


Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy.

Castets P, Lin S, Rion N, Di Fulvio S, Romanino K, Guridi M, Frank S, Tintignac LA, Sinnreich M, Rüegg MA.

Cell Metab. 2013 May 7;17(5):731-44. doi: 10.1016/j.cmet.2013.03.015. Epub 2013 Apr 18.


Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy.

Bentzinger CF, Lin S, Romanino K, Castets P, Guridi M, Summermatter S, Handschin C, Tintignac LA, Hall MN, Rüegg MA.

Skelet Muscle. 2013 Mar 6;3(1):6. doi: 10.1186/2044-5040-3-6.


The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse.

Csibi A, Cornille K, Leibovitch MP, Poupon A, Tintignac LA, Sanchez AM, Leibovitch SA.

PLoS One. 2010 Feb 1;5(2):e8994. doi: 10.1371/journal.pone.0008994.


The Carboxy-Terminal Modulator Protein (CTMP) regulates mitochondrial dynamics.

Parcellier A, Tintignac LA, Zhuravleva E, Dummler B, Brazil DP, Hynx D, Cron P, Schenk S, Olivieri V, Hemmings BA.

PLoS One. 2009;4(5):e5471. doi: 10.1371/journal.pone.0005471. Epub 2009 May 7.


Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis.

Parcellier A, Tintignac LA, Zhuravleva E, Cron P, Schenk S, Bozulic L, Hemmings BA.

Cell Signal. 2009 Apr;21(4):639-50. doi: 10.1016/j.cellsig.2009.01.016. Epub 2009 Jan 8.


MAFbx/Atrogin-1 controls the activity of the initiation factor eIF3-f in skeletal muscle atrophy by targeting multiple C-terminal lysines.

Csibi A, Leibovitch MP, Cornille K, Tintignac LA, Leibovitch SA.

J Biol Chem. 2009 Feb 13;284(7):4413-21. doi: 10.1074/jbc.M807641200. Epub 2008 Dec 10.


eIF3-f function in skeletal muscles: to stand at the crossroads of atrophy and hypertrophy.

Csibi A, Tintignac LA, Leibovitch MP, Leibovitch SA.

Cell Cycle. 2008 Jun 15;7(12):1698-701. Epub 2008 Jun 11.


The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy.

Lagirand-Cantaloube J, Offner N, Csibi A, Leibovitch MP, Batonnet-Pichon S, Tintignac LA, Segura CT, Leibovitch SA.

EMBO J. 2008 Apr 23;27(8):1266-76. doi: 10.1038/emboj.2008.52. Epub 2008 Mar 20.


PKB and the mitochondria: AKTing on apoptosis.

Parcellier A, Tintignac LA, Zhuravleva E, Hemmings BA.

Cell Signal. 2008 Jan;20(1):21-30. Epub 2007 Jul 25. Review.


Protein kinase B/Akt at a glance.

Fayard E, Tintignac LA, Baudry A, Hemmings BA.

J Cell Sci. 2005 Dec 15;118(Pt 24):5675-8. Review. No abstract available.


Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase.

Tintignac LA, Lagirand J, Batonnet S, Sirri V, Leibovitch MP, Leibovitch SA.

J Biol Chem. 2005 Jan 28;280(4):2847-56. Epub 2004 Nov 5.


Mutant MyoD lacking Cdc2 phosphorylation sites delays M-phase entry.

Tintignac LA, Sirri V, Leibovitch MP, Lécluse Y, Castedo M, Metivier D, Kroemer G, Leibovitch SA.

Mol Cell Biol. 2004 Feb;24(4):1809-21.


Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope.

Castedo M, Roumier T, Blanco J, Ferri KF, Barretina J, Tintignac LA, Andreau K, Perfettini JL, Amendola A, Nardacci R, Leduc P, Ingber DE, Druillennec S, Roques B, Leibovitch SA, Vilella-Bach M, Chen J, Este JA, Modjtahedi N, Piacentini M, Kroemer G.

EMBO J. 2002 Aug 1;21(15):4070-80.


Dephosphorylation and subcellular compartment change of the mitotic Bloom's syndrome DNA helicase in response to ionizing radiation.

Dutertre S, Sekhri R, Tintignac LA, Onclercq-Delic R, Chatton B, Jaulin C, Amor-Guéret M.

J Biol Chem. 2002 Feb 22;277(8):6280-6. Epub 2001 Dec 10.


[New insight into MyoD regulation: involvement in rhabdomyosarcoma pathway?].

Tintignac LA, Leibovitch MP, Leibovitch SA.

Bull Cancer. 2001 Jun;88(6):545-8. Review. French.


Cyclin E-cdk2 phosphorylation promotes late G1-phase degradation of MyoD in muscle cells.

Tintignac LA, Leibovitch MP, Kitzmann M, Fernandez A, Ducommun B, Meijer L, Leibovitch SA.

Exp Cell Res. 2000 Aug 25;259(1):300-7.


Stabilization of MyoD by direct binding to p57(Kip2).

Reynaud EG, Leibovitch MP, Tintignac LA, Pelpel K, Guillier M, Leibovitch SA.

J Biol Chem. 2000 Jun 23;275(25):18767-76.

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