Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 224


Co-temporal Force and Fluorescence Measurements Reveal a Ribosomal Gear Shift Mechanism of Translation Regulation by Structured mRNAs.

Desai VP, Frank F, Lee A, Righini M, Lancaster L, Noller HF, Tinoco I Jr, Bustamante C.

Mol Cell. 2019 Sep 5;75(5):1007-1019.e5. doi: 10.1016/j.molcel.2019.07.024. Epub 2019 Aug 27.


Productive performance and surface temperatures of Japanese quail exposed to different environment conditions at start of lay.

Santos TC, Gates RS, Tinôco IFF, Zolnier S, Rocha KSO, Freitas LCSR.

Poult Sci. 2019 Jul 1;98(7):2830-2839. doi: 10.3382/ps/pez068.


Effects of carbon dioxide on turkey poult performance and behavior.

Cândido MGL, Xiong Y, Gates RS, Tinôco IFF, Koelkebeck KW.

Poult Sci. 2018 Aug 1;97(8):2768-2774. doi: 10.3382/ps/pey128.


Full molecular trajectories of RNA polymerase at single base-pair resolution.

Righini M, Lee A, Cañari-Chumpitaz C, Lionberger T, Gabizon R, Coello Y, Tinoco I Jr, Bustamante C.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1286-1291. doi: 10.1073/pnas.1719906115. Epub 2018 Jan 19.


Unconjugated bilirubin and acute schizophrenia: a probable correlation?

Gama-Marques J, Tinoco I, Pedro I, Leote F, Silva R, Ouakinin S.

Actas Esp Psiquiatr. 2017 Mar;45(2):79-88. Epub 2017 Mar 1. No abstract available.


EF-G catalyzed translocation dynamics in the presence of ribosomal frameshifting stimulatory signals.

Kim HK, Tinoco I Jr.

Nucleic Acids Res. 2017 Mar 17;45(5):2865-2874. doi: 10.1093/nar/gkw1020.


Ribosome. Mechanical force releases nascent chain-mediated ribosome arrest in vitro and in vivo.

Goldman DH, Kaiser CM, Milin A, Righini M, Tinoco I Jr, Bustamante C.

Science. 2015 Apr 24;348(6233):457-60. doi: 10.1126/science.1261909. Epub 2015 Apr 23.


Ribosome excursions during mRNA translocation mediate broad branching of frameshift pathways.

Yan S, Wen JD, Bustamante C, Tinoco I Jr.

Cell. 2015 Feb 26;160(5):870-881. doi: 10.1016/j.cell.2015.02.003. Epub 2015 Feb 19.


The ethical scientist: An old-fashioned view.

Tinoco I Jr.

Biopolymers. 2015 Aug;103(8):424-31. doi: 10.1002/bip.22568.


Direct measurement of the mechanical work during translocation by the ribosome.

Liu T, Kaplan A, Alexander L, Yan S, Wen JD, Lancaster L, Wickersham CE, Fredrick K, Noller H, Tinoco I, Bustamante CJ.

Elife. 2014 Aug 11;3:e03406. doi: 10.7554/eLife.03406. Erratum in: Elife. 2014;3:e04563. Fredrik, Kurt [corrected to Fredrick, Kurt].


A frameshifting stimulatory stem loop destabilizes the hybrid state and impedes ribosomal translocation.

Kim HK, Liu F, Fei J, Bustamante C, Gonzalez RL Jr, Tinoco I Jr.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5538-43. doi: 10.1073/pnas.1403457111. Epub 2014 Mar 31.


Fun and games in Berkeley: the early years (1956-2013).

Tinoco I Jr.

Annu Rev Biophys. 2014;43:1-17. doi: 10.1146/annurev-biophys-051013-022708.


Probing the mechanisms of translation with force.

Kaiser CM, Tinoco I Jr.

Chem Rev. 2014 Mar 26;114(6):3266-80. doi: 10.1021/cr400313x. Epub 2014 Jan 9. Review. No abstract available.


Frameshifting dynamics.

Tinoco I Jr, Kim HK, Yan S.

Biopolymers. 2013 Dec;99(12):1147-66. doi: 10.1002/bip.22293. Review. Erratum in: Biopolymers. 2014 Mar;101(3):306.


Ribosomal protein S1 unwinds double-stranded RNA in multiple steps.

Qu X, Lancaster L, Noller HF, Bustamante C, Tinoco I Jr.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14458-63. doi: 10.1073/pnas.1208950109. Epub 2012 Aug 20.


The ribosome modulates nascent protein folding.

Kaiser CM, Goldman DH, Chodera JD, Tinoco I Jr, Bustamante C.

Science. 2011 Dec 23;334(6063):1723-7. doi: 10.1126/science.1209740.


Single-base pair unwinding and asynchronous RNA release by the hepatitis C virus NS3 helicase.

Cheng W, Arunajadai SG, Moffitt JR, Tinoco I Jr, Bustamante C.

Science. 2011 Sep 23;333(6050):1746-9. doi: 10.1126/science.1206023.


The ribosome uses two active mechanisms to unwind messenger RNA during translation.

Qu X, Wen JD, Lancaster L, Noller HF, Bustamante C, Tinoco I Jr.

Nature. 2011 Jul 6;475(7354):118-21. doi: 10.1038/nature10126.


Biological mechanisms, one molecule at a time.

Tinoco I Jr, Gonzalez RL Jr.

Genes Dev. 2011 Jun 15;25(12):1205-31. doi: 10.1101/gad.2050011. Review.


RNA reactions one molecule at a time.

Tinoco I, Chen G, Qu X.

Cold Spring Harb Perspect Biol. 2010 Nov;2(11):a003624. doi: 10.1101/cshperspect.a003624. Epub 2010 Apr 14. Review.


Triplex structures in an RNA pseudoknot enhance mechanical stability and increase efficiency of -1 ribosomal frameshifting.

Chen G, Chang KY, Chou MY, Bustamante C, Tinoco I Jr.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12706-11. doi: 10.1073/pnas.0905046106. Epub 2009 Jul 23.


Simulation and analysis of single-ribosome translation.

Tinoco I Jr, Wen JD.

Phys Biol. 2009 Jul 1;6(2):025006. doi: 10.1088/1478-3975/6/2/025006.


Mechanical unfolding of two DIS RNA kissing complexes from HIV-1.

Li PT, Tinoco I Jr.

J Mol Biol. 2009 Mar 13;386(5):1343-56.


[Infective endarteritis complicating aortic coarctation in a 66-year-old woman].

Tinoco I, López E, Gutiérrez JF, Gamaza S.

Enferm Infecc Microbiol Clin. 2010 Jan;28(1):68-9. doi: 10.1016/j.eimc.2008.12.011. Epub 2009 May 13. Spanish. No abstract available.


How RNA unfolds and refolds.

Li PT, Vieregg J, Tinoco I Jr.

Annu Rev Biochem. 2008;77:77-100. doi: 10.1146/annurev.biochem.77.061206.174353. Review.


Biophysical analysis of nucleic acids.

Tinoco I Jr.

Curr Protoc Nucleic Acid Chem. 2001 May;Chapter 7:Unit 7.1. doi: 10.1002/0471142700.nc0701s00. Review.


Following translation by single ribosomes one codon at a time.

Wen JD, Lancaster L, Hodges C, Zeri AC, Yoshimura SH, Noller HF, Bustamante C, Tinoco I.

Nature. 2008 Apr 3;452(7187):598-603. doi: 10.1038/nature06716. Epub 2008 Mar 9.


Characterization of the mechanical unfolding of RNA pseudoknots.

Green L, Kim CH, Bustamante C, Tinoco I Jr.

J Mol Biol. 2008 Jan 11;375(2):511-28. Epub 2007 May 26.


Measurement of the effect of monovalent cations on RNA hairpin stability.

Vieregg J, Cheng W, Bustamante C, Tinoco I Jr.

J Am Chem Soc. 2007 Dec 5;129(48):14966-73. Epub 2007 Nov 13.


Single-molecule mechanical unfolding and folding of a pseudoknot in human telomerase RNA.

Chen G, Wen JD, Tinoco I Jr.

RNA. 2007 Dec;13(12):2175-88. Epub 2007 Oct 24.


NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork.

Cheng W, Dumont S, Tinoco I Jr, Bustamante C.

Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13954-9. Epub 2007 Aug 20.


Real-time control of the energy landscape by force directs the folding of RNA molecules.

Li PT, Bustamante C, Tinoco I Jr.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7039-44. Epub 2007 Apr 16.


Force unfolding kinetics of RNA using optical tweezers. I. Effects of experimental variables on measured results.

Wen JD, Manosas M, Li PT, Smith SB, Bustamante C, Ritort F, Tinoco I Jr.

Biophys J. 2007 May 1;92(9):2996-3009. Epub 2007 Feb 9.


Force unfolding kinetics of RNA using optical tweezers. II. Modeling experiments.

Manosas M, Wen JD, Li PT, Smith SB, Bustamante C, Tinoco I Jr, Ritort F.

Biophys J. 2007 May 1;92(9):3010-21. Epub 2007 Feb 9.


Unusual mechanical stability of a minimal RNA kissing complex.

Li PT, Bustamante C, Tinoco I Jr.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15847-52. Epub 2006 Oct 16.


Determination of thermodynamics and kinetics of RNA reactions by force.

Tinoco I Jr, Li PT, Bustamante C.

Q Rev Biophys. 2006 Nov;39(4):325-60. Epub 2006 Oct 16. Review.


Modelling RNA folding under mechanical tension.

Vieregg JR, Tinoco I.

Mol Phys. 2006 Apr 20;104(8):1343-1352.


RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP.

Dumont S, Cheng W, Serebrov V, Beran RK, Tinoco I Jr, Pyle AM, Bustamante C.

Nature. 2006 Jan 5;439(7072):105-8.


Probing the mechanical folding kinetics of TAR RNA by hopping, force-jump, and force-ramp methods.

Li PT, Collin D, Smith SB, Bustamante C, Tinoco I Jr.

Biophys J. 2006 Jan 1;90(1):250-60. Epub 2005 Oct 7.


Verification of the Crooks fluctuation theorem and recovery of RNA folding free energies.

Collin D, Ritort F, Jarzynski C, Smith SB, Tinoco I Jr, Bustamante C.

Nature. 2005 Sep 8;437(7056):231-4.


Temperature control methods in a laser tweezers system.

Mao H, Arias-Gonzalez JR, Smith SB, Tinoco I Jr, Bustamante C.

Biophys J. 2005 Aug;89(2):1308-16. Epub 2005 May 27.


An appreciation of John D. Ferry and the mechanical properties of single molecules.

Tinoco I.

Biophys Chem. 2004 Dec 20;112(2-3):105-8. Review. No abstract available.


The effect of force on thermodynamics and kinetics: unfolding single RNA molecules.

Tinoco I Jr, Collin D, Li PT.

Biochem Soc Trans. 2004 Nov;32(Pt 5):757-60. Review.


RNA folding and unfolding.

Onoa B, Tinoco I Jr.

Curr Opin Struct Biol. 2004 Jun;14(3):374-9. Review.


Force as a useful variable in reactions: unfolding RNA.

Tinoco I Jr.

Annu Rev Biophys Biomol Struct. 2004;33:363-85. Review.


[A 65-year-old woman with mediastinal enlargement].

Ramos-García MC, Brun FM, Tinoco I, Japón F, Girón JA.

Rev Clin Esp. 2004 Mar;204(3):173-5. Spanish. No abstract available.


Efficacy of directly observed treatment of HIV infection: experience in AIDS welfare homes.

Tinoco I, Girón-González JA, González-González MT, Vergara de Campos A, Rodríguez-Félix L, Serrano A, Bascuñana A.

Eur J Clin Microbiol Infect Dis. 2004 Apr;23(4):331-5. Epub 2004 Mar 13.


Identifying kinetic barriers to mechanical unfolding of the T. thermophila ribozyme.

Onoa B, Dumont S, Liphardt J, Smith SB, Tinoco I Jr, Bustamante C.

Science. 2003 Mar 21;299(5614):1892-5.


The effect of force on thermodynamics and kinetics of single molecule reactions.

Tinoco I Jr, Bustamante C.

Biophys Chem. 2002 Dec 10;101-102:513-33.


A two-state kinetic model for the unfolding of single molecules by mechanical force.

Ritort F, Bustamante C, Tinoco I Jr.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13544-8. Epub 2002 Oct 8.

Supplemental Content

Loading ...
Support Center