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Items: 1 to 50 of 141

1.

Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity.

Megarity CF, Timson DJ.

Biosci Rep. 2019 Aug 20. pii: BSR20191874. doi: 10.1042/BSR20191874. [Epub ahead of print]

PMID:
31431515
2.

Negative cooperativity in NAD(P)H quinone oxidoreductase 1 (NQO1).

Megarity CF, Abdel-Aal Bettley H, Caraher MC, Scott KA, Whitehead RA, Jowitt TA, Gutierrez A, Bryce RA, Nolan KA, Stratford IJ, Timson DJ.

Chembiochem. 2019 Jun 5. doi: 10.1002/cbic.201900313. [Epub ahead of print]

PMID:
31165578
3.

NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms.

Beaver SK, Mesa-Torres N, Pey AL, Timson DJ.

Biochim Biophys Acta Proteins Proteom. 2019 Jul - Aug;1867(7-8):663-676. doi: 10.1016/j.bbapap.2019.05.002. Epub 2019 May 12. Review.

PMID:
31091472
4.

Myosin Va and spermine synthase: partners in exosome transport.

Timson DJ.

Biosci Rep. 2019 Apr 30;39(4). pii: BSR20190326. doi: 10.1042/BSR20190326. Print 2019 Apr 30.

5.

Phosphorylation Mechanism of N-Acetyl-l-glutamate Kinase, a QM/MM Study.

McClory J, Hu GX, Zou JW, Timson DJ, Huang M.

J Phys Chem B. 2019 Apr 4;123(13):2844-2852. doi: 10.1021/acs.jpcb.9b00547. Epub 2019 Mar 21.

PMID:
30848915
6.

Fructose 1,6-bisphosphatase: getting the message across.

Timson DJ.

Biosci Rep. 2019 Mar 6;39(3). pii: BSR20190124. doi: 10.1042/BSR20190124. Print 2019 Mar 29.

7.

Catalytic mechanism of mevalonate kinase revisited, a QM/MM study.

McClory J, Lin JT, Timson DJ, Zhang J, Huang M.

Org Biomol Chem. 2019 Feb 27;17(9):2423-2431. doi: 10.1039/c8ob03197e.

PMID:
30735219
8.

Characterization of Calcium-Binding Proteins from Parasitic Worms.

Thomas CM, Timson DJ.

Methods Mol Biol. 2019;1929:615-641. doi: 10.1007/978-1-4939-9030-6_39.

PMID:
30710301
9.

NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places.

Pey AL, Megarity CF, Timson DJ.

Biosci Rep. 2019 Jan 3;39(1). pii: BSR20180459. doi: 10.1042/BSR20180459. Print 2019 Jan 31. Review.

10.

Type IV galactosemia.

Timson DJ.

Genet Med. 2019 Jun;21(6):1283-1285. doi: 10.1038/s41436-018-0359-z. Epub 2018 Nov 21. No abstract available.

PMID:
30459459
11.

The Mechanism of Action of Praziquantel: Six Hypotheses.

Thomas CM, Timson DJ.

Curr Top Med Chem. 2018;18(18):1575-1584. doi: 10.2174/1568026618666181029143214. Review.

PMID:
30370849
12.

The mechanism of action of praziquantel: can new drugs exploit similar mechanisms?

Thomas CM, Timson D.

Curr Med Chem. 2018 Sep 26. doi: 10.2174/0929867325666180926145537. [Epub ahead of print]

PMID:
30259811
13.

Modulation of the mobility of a key region in human galactokinase: Impacts on catalysis and stability.

McAuley M, Huang M, Timson DJ.

Bioorg Chem. 2018 Dec;81:649-657. doi: 10.1016/j.bioorg.2018.09.002. Epub 2018 Sep 19.

PMID:
30253338
14.

Water-mediated network in the resistance mechanism of fosfomycin.

McClory J, Lin JT, Timson DJ, Zhang J, Huang M.

Phys Chem Chem Phys. 2018 Aug 22;20(33):21660-21667. doi: 10.1039/c8cp02860e.

PMID:
30101239
15.

A galactokinase-like protein from the liver fluke Fasciola hepatica.

Zinsser VL, Cox C, McAuley M, Hoey EM, Trudgett A, Timson DJ.

Exp Parasitol. 2018 Sep;192:65-72. doi: 10.1016/j.exppara.2018.07.013. Epub 2018 Jul 21.

PMID:
30040960
16.

Calmodulins from Schistosoma mansoni: Biochemical analysis and interaction with IQ-motifs from voltage-gated calcium channels.

Thomas CM, Timson DJ.

Cell Calcium. 2018 Sep;74:1-13. doi: 10.1016/j.ceca.2018.05.006. Epub 2018 May 17.

PMID:
29802931
17.

Improving the Activity and Stability of Human Galactokinase for Therapeutic and Biotechnological Applications.

McAuley M, Mesa-Torres N, McFall A, Morris S, Huang M, Pey AL, Timson DJ.

Chembiochem. 2018 May 18;19(10):1088-1095. doi: 10.1002/cbic.201800025. Epub 2018 Apr 26.

PMID:
29505688
18.

The tegumental allergen-like proteins of Schistosoma mansoni: A biochemical study of SmTAL4-TAL13.

Carson J, Thomas CM, McGinty A, Takata G, Timson DJ.

Mol Biochem Parasitol. 2018 Apr;221:14-22. doi: 10.1016/j.molbiopara.2018.02.002. Epub 2018 Feb 14.

PMID:
29453993
19.

Reaction Mechanism of Isopentenyl Phosphate Kinase: A QM/MM Study.

McClory J, Timson DJ, Singh W, Zhang J, Huang M.

J Phys Chem B. 2017 Dec 14;121(49):11062-11071. doi: 10.1021/acs.jpcb.7b08770. Epub 2017 Nov 30.

PMID:
29155589
20.

Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer.

Betancor-Fernández I, Timson DJ, Salido E, Pey AL.

Handb Exp Pharmacol. 2018;245:155-190. doi: 10.1007/164_2017_55. Review.

PMID:
28993836
21.

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution.

Medina-Carmona E, Fuchs JE, Gavira JA, Mesa-Torres N, Neira JL, Salido E, Palomino-Morales R, Burgos M, Timson DJ, Pey AL.

Hum Mol Genet. 2017 Sep 15;26(18):3531-3544. doi: 10.1093/hmg/ddx238.

PMID:
28911204
22.

LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.

Carmon KS, Gong X, Yi J, Wu L, Thomas A, Moore CM, Masuho I, Timson DJ, Martemyanov KA, Liu QJ.

J Biol Chem. 2017 Sep 8;292(36):14989-15001. doi: 10.1074/jbc.M117.786798. Epub 2017 Jul 24.

23.

Characterisation of eppin function: expression and activity in the lung.

Scott A, Glasgow A, Small D, Carlile S, McCrudden M, McLean D, Brown R, Doherty D, Lundy FT, Hamid UI, O'Kane CM, McAuley DF, Brodlie M, Tunney M, Elborn JS, Irwin CR, Timson DJ, Taggart CC, Weldon S.

Eur Respir J. 2017 Jul 13;50(1). pii: 1601937. doi: 10.1183/13993003.01937-2016. Print 2017 Jul.

24.

New model for the interaction of IQGAP1 with CDC42 and RAC1.

Nouri K, Timson DJ, Ahmadian MR.

Small GTPases. 2017 Jun 16:1-7. doi: 10.1080/21541248.2017.1321169. [Epub ahead of print]

PMID:
28622072
25.

In silico prediction of the effects of mutations in the human triose phosphate isomerase gene: Towards a predictive framework for TPI deficiency.

Oliver C, Timson DJ.

Eur J Med Genet. 2017 Jun;60(6):289-298. doi: 10.1016/j.ejmg.2017.03.008. Epub 2017 Mar 21.

PMID:
28341520
26.

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.

Medina-Carmona E, Neira JL, Salido E, Fuchs JE, Palomino-Morales R, Timson DJ, Pey AL.

Sci Rep. 2017 Mar 14;7:44532. doi: 10.1038/srep44532.

27.

Different specificities of two aldehyde dehydrogenases from Saccharomyces cerevisiae var. boulardii.

Datta S, Annapure US, Timson DJ.

Biosci Rep. 2017 Mar 2;37(2). pii: BSR20160529. doi: 10.1042/BSR20160529. Print 2017 Apr 30.

28.

Antioxidant properties and global metabolite screening of the probiotic yeast Saccharomyces cerevisiae var. boulardii.

Datta S, Timson DJ, Annapure US.

J Sci Food Agric. 2017 Jul;97(9):3039-3049. doi: 10.1002/jsfa.8147. Epub 2017 Jan 19.

PMID:
27868205
29.

IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.

Nouri K, Fansa EK, Amin E, Dvorsky R, Gremer L, Willbold D, Schmitt L, Timson DJ, Ahmadian MR.

J Biol Chem. 2016 Dec 16;291(51):26364-26376. Epub 2016 Nov 4.

30.

Insight into the mechanism of galactokinase: Role of a critical glutamate residue and helix/coil transitions.

McAuley M, Huang M, Timson DJ.

Biochim Biophys Acta Proteins Proteom. 2017 Mar;1865(3):321-328. doi: 10.1016/j.bbapap.2016.10.012. Epub 2016 Oct 24.

PMID:
27789348
31.

FhCaBP1 (FH22): A Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains.

Cheung S, Thomas CM, Timson DJ.

Exp Parasitol. 2016 Nov;170:109-115. doi: 10.1016/j.exppara.2016.09.013. Epub 2016 Sep 28.

PMID:
27693219
32.

Phosphorylation Mechanism of Phosphomevalonate Kinase: Implications for Rational Engineering of Isoprenoid Biosynthetic Pathway Enzymes.

Huang M, Wei K, Li X, McClory J, Hu G, Zou JW, Timson D.

J Phys Chem B. 2016 Oct 20;120(41):10714-10722. doi: 10.1021/acs.jpcb.6b08480. Epub 2016 Oct 11.

PMID:
27676321
33.
34.

Glycerol enhances fungal germination at the water-activity limit for life.

Stevenson A, Hamill PG, Medina Á, Kminek G, Rummel JD, Dijksterhuis J, Timson DJ, Magan N, Leong SL, Hallsworth JE.

Environ Microbiol. 2017 Mar;19(3):947-967. doi: 10.1111/1462-2920.13530. Epub 2016 Nov 13.

35.

A mysterious family of calcium-binding proteins from parasitic worms.

Thomas CM, Timson DJ.

Biochem Soc Trans. 2016 Aug 15;44(4):1005-10. doi: 10.1042/BST20150270. Review.

PMID:
27528745
36.

Modulating Mobility: a Paradigm for Protein Engineering?

McAuley M, Timson DJ.

Appl Biochem Biotechnol. 2017 Jan;181(1):83-90. doi: 10.1007/s12010-016-2200-y. Epub 2016 Jul 23. Review.

PMID:
27449223
37.

Fasciola hepatica calcium-binding protein FhCaBP2: structure of the dynein light chain-like domain.

Nguyen TH, Thomas CM, Timson DJ, van Raaij MJ.

Parasitol Res. 2016 Jul;115(7):2879-86. doi: 10.1007/s00436-016-5046-x. Epub 2016 Apr 16.

PMID:
27083189
38.

Metabolic Enzymes of Helminth Parasites: Potential as Drug Targets.

Timson DJ.

Curr Protein Pept Sci. 2016;17(3):280-95. Review.

PMID:
26983888
39.

Erratum: Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.

Medina-Carmona E, Palomino-Morales RJ, Fuchs JE, Padín-Gonzalez E, Mesa-Torres N, Salido E, Timson DJ, Pey AL.

Sci Rep. 2016 Mar 4;6:21939. doi: 10.1038/srep21939. No abstract available.

40.

Galactokinase promiscuity: a question of flexibility?

McAuley M, Kristiansson H, Huang M, Pey AL, Timson DJ.

Biochem Soc Trans. 2016 Feb;44(1):116-22. doi: 10.1042/BST20150188. Review.

PMID:
26862196
41.

On the Interaction Between Human IQGAP1 and Actin.

Magill DJ, Hamilton E, Shirran SL, Botting CH, Timson DJ.

Protein Pept Lett. 2016;23(4):386-95.

PMID:
26845769
42.

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.

Medina-Carmona E, Palomino-Morales RJ, Fuchs JE, Padín-Gonzalez E, Mesa-Torres N, Salido E, Timson DJ, Pey AL.

Sci Rep. 2016 Feb 3;6:20331. doi: 10.1038/srep20331. Erratum in: Sci Rep. 2016;6:21939.

43.

Calmodulin disruption impacts growth and motility in juvenile liver fluke.

McCammick EM, McVeigh P, McCusker P, Timson DJ, Morphew RM, Brophy PM, Marks NJ, Mousley A, Maule AG.

Parasit Vectors. 2016 Jan 27;9:46. doi: 10.1186/s13071-016-1324-9.

44.

Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms.

Pey AL, Megarity CF, Medina-Carmona E, Timson DJ.

Curr Drug Targets. 2016;17(13):1506-14. Review.

PMID:
26721407
45.
46.

Dicoumarol: A Drug which Hits at Least Two Very Different Targets in Vitamin K Metabolism.

Timson DJ.

Curr Drug Targets. 2017;18(5):500-510. doi: 10.2174/1389450116666150722141906. Review.

PMID:
26201483
47.

FhCaBP2: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains.

Thomas CM, Timson DJ.

Parasitology. 2015 Sep;142(11):1375-86. doi: 10.1017/S0031182015000736. Epub 2015 Jul 8.

PMID:
26152524
48.

The molecular basis of galactosemia - Past, present and future.

Timson DJ.

Gene. 2016 Sep 10;589(2):133-41. doi: 10.1016/j.gene.2015.06.077. Epub 2015 Jul 2. Review.

PMID:
26143117
49.

Chaotropicity: a key factor in product tolerance of biofuel-producing microorganisms.

Cray JA, Stevenson A, Ball P, Bankar SB, Eleutherio EC, Ezeji TC, Singhal RS, Thevelein JM, Timson DJ, Hallsworth JE.

Curr Opin Biotechnol. 2015 Jun;33:228-59. doi: 10.1016/j.copbio.2015.02.010. Epub 2015 Apr 2. Review.

PMID:
25841213
50.

Is there a common water-activity limit for the three domains of life?

Stevenson A, Cray JA, Williams JP, Santos R, Sahay R, Neuenkirchen N, McClure CD, Grant IR, Houghton JD, Quinn JP, Timson DJ, Patil SV, Singhal RS, Antón J, Dijksterhuis J, Hocking AD, Lievens B, Rangel DE, Voytek MA, Gunde-Cimerman N, Oren A, Timmis KN, McGenity TJ, Hallsworth JE.

ISME J. 2015 Jun;9(6):1333-51. doi: 10.1038/ismej.2014.219. Epub 2014 Dec 12.

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