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Items: 1 to 50 of 545

1.

Laminin-121--recombinant expression and interactions with integrins.

Sasaki T, Takagi J, Giudici C, Yamada Y, Arikawa-Hirasawa E, Deutzmann R, Timpl R, Sonnenberg A, Bächinger HP, Tonge D.

Matrix Biol. 2010 Jul;29(6):484-93. doi: 10.1016/j.matbio.2010.05.004. Epub 2010 May 23.

2.

Expression of ECM proteins fibulin-1 and -2 in acute and chronic liver disease and in cultured rat liver cells.

Piscaglia F, Dudás J, Knittel T, Di Rocco P, Kobold D, Saile B, Zocco MA, Timpl R, Ramadori G.

Cell Tissue Res. 2009 Sep;337(3):449-62. doi: 10.1007/s00441-009-0823-9. Epub 2009 Jul 17.

3.

Mapping of SPARC/BM-40/osteonectin-binding sites on fibrillar collagens.

Giudici C, Raynal N, Wiedemann H, Cabral WA, Marini JC, Timpl R, Bächinger HP, Farndale RW, Sasaki T, Tenni R.

J Biol Chem. 2008 Jul 11;283(28):19551-60. doi: 10.1074/jbc.M710001200. Epub 2008 May 16.

4.

Compositional differences between infant and adult human corneal basement membranes.

Kabosova A, Azar DT, Bannikov GA, Campbell KP, Durbeej M, Ghohestani RF, Jones JC, Kenney MC, Koch M, Ninomiya Y, Patton BL, Paulsson M, Sado Y, Sage EH, Sasaki T, Sorokin LM, Steiner-Champliaud MF, Sun TT, Sundarraj N, Timpl R, Virtanen I, Ljubimov AV.

Invest Ophthalmol Vis Sci. 2007 Nov;48(11):4989-99.

5.

A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization.

Kobayashi N, Kostka G, Garbe JH, Keene DR, Bächinger HP, Hanisch FG, Markova D, Tsuda T, Timpl R, Chu ML, Sasaki T.

J Biol Chem. 2007 Apr 20;282(16):11805-16. Epub 2007 Feb 26.

6.

Chondroitin sulfate perlecan enhances collagen fibril formation. Implications for perlecan chondrodysplasias.

Kvist AJ, Johnson AE, Mörgelin M, Gustafsson E, Bengtsson E, Lindblom K, Aszódi A, Fässler R, Sasaki T, Timpl R, Aspberg A.

J Biol Chem. 2006 Nov 3;281(44):33127-39. Epub 2006 Sep 5.

7.

Endostatin influences endothelial morphology via the activated ERK1/2-kinase endothelial morphology and signal transduction.

Schmidt A, Wenzel D, Thorey I, Sasaki T, Hescheler J, Timpl R, Addicks K, Werner S, Fleischmann BK, Bloch W.

Microvasc Res. 2006 May;71(3):152-62. Epub 2006 May 2.

PMID:
16650878
8.

WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan.

Allen JM, Bateman JF, Hansen U, Wilson R, Bruckner P, Owens RT, Sasaki T, Timpl R, Fitzgerald J.

J Biol Chem. 2006 Mar 17;281(11):7341-9. Epub 2006 Jan 6.

9.

Structural basis for Gas6-Axl signalling.

Sasaki T, Knyazev PG, Clout NJ, Cheburkin Y, Göhring W, Ullrich A, Timpl R, Hohenester E.

EMBO J. 2006 Jan 11;25(1):80-7. Epub 2005 Dec 15.

10.

Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis.

Kadoya K, Sasaki T, Kostka G, Timpl R, Matsuzaki K, Kumagai N, Sakai LY, Nishiyama T, Amano S.

Br J Dermatol. 2005 Sep;153(3):607-12.

PMID:
16120151
11.

Disruption of perlecan binding and matrix assembly by post-translational or genetic disruption of dystroglycan function.

Kanagawa M, Michele DE, Satz JS, Barresi R, Kusano H, Sasaki T, Timpl R, Henry MD, Campbell KP.

FEBS Lett. 2005 Aug 29;579(21):4792-6.

12.

Laminin gamma3 chain binds to nidogen and is located in murine basement membranes.

Gersdorff N, Kohfeldt E, Sasaki T, Timpl R, Miosge N.

J Biol Chem. 2005 Jun 10;280(23):22146-53. Epub 2005 Apr 11.

13.

Laminin alpha1 globular domains 4-5 induce fetal development but are not vital for embryonic basement membrane assembly.

Schéele S, Falk M, Franzén A, Ellin F, Ferletta M, Lonai P, Andersson B, Timpl R, Forsberg E, Ekblom P.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1502-6. Epub 2005 Jan 24.

14.

Microfibrils at basement membrane zones interact with perlecan via fibrillin-1.

Tiedemann K, Sasaki T, Gustafsson E, Göhring W, Bätge B, Notbohm H, Timpl R, Wedel T, Schlötzer-Schrehardt U, Reinhardt DP.

J Biol Chem. 2005 Mar 25;280(12):11404-12. Epub 2005 Jan 17.

15.

The minimal active domain of endostatin is a heparin-binding motif that mediates inhibition of tumor vascularization.

Olsson AK, Johansson I, Akerud H, Einarsson B, Christofferson R, Sasaki T, Timpl R, Claesson-Welsh L.

Cancer Res. 2004 Dec 15;64(24):9012-7.

16.

Influence of endostatin on embryonic vasculo- and angiogenesis.

Schmidt A, Wenzel D, Ferring I, Kazemi S, Sasaki T, Hescheler J, Timpl R, Addicks K, Fleischmann BK, Bloch W.

Dev Dyn. 2004 Jul;230(3):468-80.

17.

Alternative splicing in the aggrecan G3 domain influences binding interactions with tenascin-C and other extracellular matrix proteins.

Day JM, Olin AI, Murdoch AD, Canfield A, Sasaki T, Timpl R, Hardingham TE, Aspberg A.

J Biol Chem. 2004 Mar 26;279(13):12511-8. Epub 2004 Jan 13.

18.

Targeted inactivation of murine laminin gamma2-chain gene recapitulates human junctional epidermolysis bullosa.

Meng X, Klement JF, Leperi DA, Birk DE, Sasaki T, Timpl R, Uitto J, Pulkkinen L.

J Invest Dermatol. 2003 Oct;121(4):720-31.

19.

Distinct requirements for heparin and alpha-dystroglycan binding revealed by structure-based mutagenesis of the laminin alpha2 LG4-LG5 domain pair.

Wizemann H, Garbe JH, Friedrich MV, Timpl R, Sasaki T, Hohenester E.

J Mol Biol. 2003 Sep 19;332(3):635-42.

PMID:
12963372
20.

Mutations in COCH that result in non-syndromic autosomal dominant deafness (DFNA9) affect matrix deposition of cochlin.

Grabski R, Szul T, Sasaki T, Timpl R, Mayne R, Hicks B, Sztul E.

Hum Genet. 2003 Oct;113(5):406-16. Epub 2003 Aug 20.

PMID:
12928864
21.

Opposing roles of integrin alpha6Abeta1 and dystroglycan in laminin-mediated extracellular signal-regulated kinase activation.

Ferletta M, Kikkawa Y, Yu H, Talts JF, Durbeej M, Sonnenberg A, Timpl R, Campbell KP, Ekblom P, Genersch E.

Mol Biol Cell. 2003 May;14(5):2088-103. Epub 2003 Feb 6.

22.

Fibulins: a versatile family of extracellular matrix proteins.

Timpl R, Sasaki T, Kostka G, Chu ML.

Nat Rev Mol Cell Biol. 2003 Jun;4(6):479-89. Review.

PMID:
12778127
23.

Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene.

Markova D, Zou Y, Ringpfeil F, Sasaki T, Kostka G, Timpl R, Uitto J, Chu ML.

Am J Hum Genet. 2003 Apr;72(4):998-1004. Epub 2003 Feb 28.

24.

Homoassociation of VE-cadherin follows a mechanism common to "classical" cadherins.

Ahrens T, Lambert M, Pertz O, Sasaki T, Schulthess T, Mège RM, Timpl R, Engel J.

J Mol Biol. 2003 Jan 24;325(4):733-42.

PMID:
12507476
25.

Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice.

Miosge N, Sasaki T, Timpl R.

Matrix Biol. 2002 Nov;21(7):611-21.

PMID:
12475645
26.

Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function.

Kreuger J, Matsumoto T, Vanwildemeersch M, Sasaki T, Timpl R, Claesson-Welsh L, Spillmann D, Lindahl U.

EMBO J. 2002 Dec 2;21(23):6303-11.

27.

Biglycan organizes collagen VI into hexagonal-like networks resembling tissue structures.

Wiberg C, Heinegård D, Wenglén C, Timpl R, Mörgelin M.

J Biol Chem. 2002 Dec 20;277(51):49120-6. Epub 2002 Sep 26.

28.
29.

Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains.

Sasaki T, Knyazev PG, Cheburkin Y, Göhring W, Tisi D, Ullrich A, Timpl R, Hohenester E.

J Biol Chem. 2002 Nov 15;277(46):44164-70. Epub 2002 Sep 5.

30.

Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is not essential for basement membrane formation in mice.

Schymeinsky J, Nedbal S, Miosge N, Pöschl E, Rao C, Beier DR, Skarnes WC, Timpl R, Bader BL.

Mol Cell Biol. 2002 Oct;22(19):6820-30.

31.

Structure and function of collagen-derived endostatin inhibitors of angiogenesis.

Sasaki T, Hohenester E, Timpl R.

IUBMB Life. 2002 Feb;53(2):77-84. Review.

32.

Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development.

Willem M, Miosge N, Halfter W, Smyth N, Jannetti I, Burghart E, Timpl R, Mayer U.

Development. 2002 Jun;129(11):2711-22.

33.

The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link.

Than ME, Henrich S, Huber R, Ries A, Mann K, Kühn K, Timpl R, Bourenkov GP, Bartunik HD, Bode W.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6607-12.

34.

Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen.

Rattenholl A, Pappano WN, Koch M, Keene DR, Kadler KE, Sasaki T, Timpl R, Burgeson RE, Greenspan DS, Bruckner-Tuderman L.

J Biol Chem. 2002 Jul 19;277(29):26372-8. Epub 2002 May 1.

35.

Expression and distribution of laminin alpha1 and alpha2 chains in embryonic and adult mouse tissues: an immunochemical approach.

Sasaki T, Giltay R, Talts U, Timpl R, Talts JF.

Exp Cell Res. 2002 May 1;275(2):185-99.

PMID:
11969289
36.

The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin.

Tu H, Sasaki T, Snellman A, Göhring W, Pirilä P, Timpl R, Pihlajaniemi T.

J Biol Chem. 2002 Jun 21;277(25):23092-9. Epub 2002 Apr 15.

37.

Endostatin regulates endothelial cell adhesion and cytoskeletal organization.

Dixelius J, Cross M, Matsumoto T, Sasaki T, Timpl R, Claesson-Welsh L.

Cancer Res. 2002 Apr 1;62(7):1944-7.

38.

Functional studies on recombinant domains of Mac-2-binding protein.

Hellstern S, Sasaki T, Fauser C, Lustig A, Timpl R, Engel J.

J Biol Chem. 2002 May 3;277(18):15690-6. Epub 2002 Feb 26.

39.

Domain IV of mouse laminin beta1 and beta2 chains.

Sasaki T, Mann K, Miner JH, Miosge N, Timpl R.

Eur J Biochem. 2002 Jan;269(2):431-42.

40.

The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor.

Bengtsson E, Mörgelin M, Sasaki T, Timpl R, Heinegård D, Aspberg A.

J Biol Chem. 2002 Apr 26;277(17):15061-8. Epub 2002 Feb 14.

41.

Defective laminin 5 processing in cylindroma cells.

Tunggal L, Ravaux J, Pesch M, Smola H, Krieg T, Gaill F, Sasaki T, Timpl R, Mauch C, Aumailley M.

Am J Pathol. 2002 Feb;160(2):459-68.

42.
43.

Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells.

Doi M, Thyboll J, Kortesmaa J, Jansson K, Iivanainen A, Parvardeh M, Timpl R, Hedin U, Swedenborg J, Tryggvason K.

J Biol Chem. 2002 Apr 12;277(15):12741-8. Epub 2002 Jan 30.

44.

Endostatin reduces vascularization, blood flow, and growth in a rat gliosarcoma.

Sorensen DR, Read TA, Porwol T, Olsen BR, Timpl R, Sasaki T, Iversen PO, Benestad HB, Sim BK, Bjerkvig R.

Neuro Oncol. 2002 Jan;4(1):1-8. doi: 10.1093/neuonc/4.1.1.

45.

Chondrogenic activity of the heparan sulfate proteoglycan perlecan maps to the N-terminal domain I.

French MM, Gomes RR Jr, Timpl R, Höök M, Czymmek K, Farach-Carson MC, Carson DD.

J Bone Miner Res. 2002 Jan;17(1):48-55.

47.

Glucocorticoids down-regulate the extracellular matrix proteins fibronectin, fibulin-1 and fibulin-2 in bone marrow stroma.

Gu YC, Talts JF, Gullberg D, Timpl R, Ekblom M.

Eur J Haematol. 2001 Sep;67(3):176-84.

PMID:
11737251
48.

Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins.

Sasaki T, Göhring W, Mann K, Brakebusch C, Yamada Y, Fässler R, Timpl R.

J Mol Biol. 2001 Dec 7;314(4):751-63.

PMID:
11733994
49.

Recombinant domains of mouse nidogen-1 and their binding to basement membrane proteins and monoclonal antibodies.

Ries A, Göhring W, Fox JW, Timpl R, Sasaki T.

Eur J Biochem. 2001 Oct;268(19):5119-28.

50.

Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan.

Kvansakul M, Hopf M, Ries A, Timpl R, Hohenester E.

EMBO J. 2001 Oct 1;20(19):5342-6.

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