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Items: 36

1.

GLP-1 secretion is regulated by IL-6 signalling: a randomised, placebo-controlled study.

Ellingsgaard H, Seelig E, Timper K, Coslovsky M, Soederlund L, Lyngbaek MP, Wewer Albrechtsen NJ, Schmidt-Trucksäss A, Hanssen H, Frey WO, Karstoft K, Pedersen BK, Böni-Schnetzler M, Donath MY.

Diabetologia. 2020 Feb;63(2):362-373. doi: 10.1007/s00125-019-05045-y. Epub 2019 Dec 3.

PMID:
31796986
2.

Exercise upregulates copeptin levels which is not regulated by interleukin-1.

Popovic M, Timper K, Seelig E, Nordmann T, Erlanger TE, Donath MY, Christ-Crain M.

PLoS One. 2019 May 31;14(5):e0217800. doi: 10.1371/journal.pone.0217800. eCollection 2019.

3.

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance.

Turpin-Nolan SM, Hammerschmidt P, Chen W, Jais A, Timper K, Awazawa M, Brodesser S, Brüning JC.

Cell Rep. 2019 Jan 2;26(1):1-10.e7. doi: 10.1016/j.celrep.2018.12.031.

4.

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity.

Timper K, Paeger L, Sánchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik JA, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, Brüning JC.

Cell Rep. 2018 Oct 9;25(2):383-397.e10. doi: 10.1016/j.celrep.2018.09.034.

5.

The role of IL-1 in postprandial fatigue.

Lehrskov LL, Dorph E, Widmer AM, Hepprich M, Siegenthaler J, Timper K, Donath MY.

Mol Metab. 2018 Jun;12:107-112. doi: 10.1016/j.molmet.2018.04.001. Epub 2018 Apr 12.

6.

IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis.

Theurich S, Tsaousidou E, Hanssen R, Lempradl AM, Mauer J, Timper K, Schilbach K, Folz-Donahue K, Heilinger C, Sexl V, Pospisilik JA, Wunderlich FT, Brüning JC.

Cell Metab. 2017 Jul 5;26(1):171-184.e6. doi: 10.1016/j.cmet.2017.05.018.

7.

Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity.

Timper K, Brüning JC.

Dis Model Mech. 2017 Jun 1;10(6):679-689. doi: 10.1242/dmm.026609. Review.

8.

IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling.

Timper K, Denson JL, Steculorum SM, Heilinger C, Engström-Ruud L, Wunderlich CM, Rose-John S, Wunderlich FT, Brüning JC.

Cell Rep. 2017 Apr 11;19(2):267-280. doi: 10.1016/j.celrep.2017.03.043.

9.

Inhibition of P2Y6 Signaling in AgRP Neurons Reduces Food Intake and Improves Systemic Insulin Sensitivity in Obesity.

Steculorum SM, Timper K, Engström Ruud L, Evers N, Paeger L, Bremser S, Kloppenburg P, Brüning JC.

Cell Rep. 2017 Feb 14;18(7):1587-1597. doi: 10.1016/j.celrep.2017.01.047.

10.

Copeptin for risk stratification in non-traumatic headache in the emergency setting: a prospective multicenter observational cohort study.

Blum CA, Winzeler B, Nigro N, Schuetz P, Biethahn S, Kahles T, Mueller C, Timper K, Haaf K, Tepperberg J, Amort M, Huber A, Bingisser R, Sándor PS, Nedeltchev K, Müller B, Katan M, Christ-Crain M.

J Headache Pain. 2017 Dec;18(1):21. doi: 10.1186/s10194-017-0733-2. Epub 2017 Feb 13.

11.

Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation.

Dror E, Dalmas E, Meier DT, Wueest S, Thévenet J, Thienel C, Timper K, Nordmann TM, Traub S, Schulze F, Item F, Vallois D, Pattou F, Kerr-Conte J, Lavallard V, Berney T, Thorens B, Konrad D, Böni-Schnetzler M, Donath MY.

Nat Immunol. 2017 Mar;18(3):283-292. doi: 10.1038/ni.3659. Epub 2017 Jan 16.

12.

Metformin prevents metabolic side effects during systemic glucocorticoid treatment.

Seelig E, Meyer S, Timper K, Nigro N, Bally M, Pernicova I, Schuetz P, Müller B, Korbonits M, Christ-Crain M.

Eur J Endocrinol. 2017 Mar;176(3):349-358. doi: 10.1530/EJE-16-0653. Epub 2017 Jan 10.

PMID:
28073907
13.

Interleukin-1 antagonism in type 1 diabetes of long duration.

Seelig E, Timper K, Falconnier C, Stoeckli R, Bilz S, Oram R, McDonald TJ, Donath MY.

Diabetes Metab. 2016 Dec;42(6):453-456. doi: 10.1016/j.diabet.2016.08.005. Epub 2016 Oct 5. No abstract available.

PMID:
27720360
14.

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue.

Steculorum SM, Ruud J, Karakasilioti I, Backes H, Engström Ruud L, Timper K, Hess ME, Tsaousidou E, Mauer J, Vogt MC, Paeger L, Bremser S, Klein AC, Morgan DA, Frommolt P, Brinkkötter PT, Hammerschmidt P, Benzing T, Rahmouni K, Wunderlich FT, Kloppenburg P, Brüning JC.

Cell. 2016 Mar 24;165(1):125-138. doi: 10.1016/j.cell.2016.02.044.

15.

Glucose-Dependent Insulinotropic Peptide Stimulates Glucagon-Like Peptide 1 Production by Pancreatic Islets via Interleukin 6, Produced by α Cells.

Timper K, Dalmas E, Dror E, Rütti S, Thienel C, Sauter NS, Bouzakri K, Bédat B, Pattou F, Kerr-Conte J, Böni-Schnetzler M, Donath MY.

Gastroenterology. 2016 Jul;151(1):165-79. doi: 10.1053/j.gastro.2016.03.003. Epub 2016 Mar 10.

PMID:
26971825
16.

Plasma Apelin Concentrations in Patients With Polyuria-Polydipsia Syndrome.

Urwyler SA, Timper K, Fenske W, de Mota N, Blanchard A, Kühn F, Frech N, Arici B, Rutishauser J, Kopp P, Stettler C, Müller B, Katan M, Llorens-Cortes C, Christ-Crain M.

J Clin Endocrinol Metab. 2016 May;101(5):1917-23. doi: 10.1210/jc.2016-1158. Epub 2016 Mar 11.

PMID:
26967692
17.

Development of an Interleukin-1β Vaccine in Patients with Type 2 Diabetes.

Cavelti-Weder C, Timper K, Seelig E, Keller C, Osranek M, Lässing U, Spohn G, Maurer P, Müller P, Jennings GT, Willers J, Saudan P, Donath MY, Bachmann MF.

Mol Ther. 2016 May;24(5):1003-12. doi: 10.1038/mt.2015.227. Epub 2015 Dec 21.

18.

Muscle-Derived IL-6 Is Not Regulated by IL-1 during Exercise. A Double Blind, Placebo-Controlled, Randomized Crossover Study.

Nordmann TM, Seelig E, Timper K, Cordes M, Coslovsky M, Hanssen H, Schmidt-Trucksäss A, Donath MY.

PLoS One. 2015 Oct 8;10(10):e0139662. doi: 10.1371/journal.pone.0139662. eCollection 2015.

19.

Safety, pharmacokinetics, and preliminary efficacy of a specific anti-IL-1alpha therapeutic antibody (MABp1) in patients with type 2 diabetes mellitus.

Timper K, Seelig E, Tsakiris DA, Donath MY.

J Diabetes Complications. 2015 Sep-Oct;29(7):955-60. doi: 10.1016/j.jdiacomp.2015.05.019. Epub 2015 Jun 3.

PMID:
26139558
20.

Diagnostic Accuracy of Copeptin in the Differential Diagnosis of the Polyuria-polydipsia Syndrome: A Prospective Multicenter Study.

Timper K, Fenske W, Kühn F, Frech N, Arici B, Rutishauser J, Kopp P, Allolio B, Stettler C, Müller B, Katan M, Christ-Crain M.

J Clin Endocrinol Metab. 2015 Jun;100(6):2268-74. doi: 10.1210/jc.2014-4507. Epub 2015 Mar 13.

PMID:
25768671
21.

Fractalkine (CX3CL1), a new factor protecting β-cells against TNFα.

Rutti S, Arous C, Schvartz D, Timper K, Sanchez JC, Dermitzakis E, Donath MY, Halban PA, Bouzakri K.

Mol Metab. 2014 Aug 11;3(7):731-41. doi: 10.1016/j.molmet.2014.07.007. eCollection 2014 Oct.

22.

Angiotensin II induces interleukin-1β-mediated islet inflammation and β-cell dysfunction independently of vasoconstrictive effects.

Sauter NS, Thienel C, Plutino Y, Kampe K, Dror E, Traub S, Timper K, Bédat B, Pattou F, Kerr-Conte J, Jehle AW, Böni-Schnetzler M, Donath MY.

Diabetes. 2015 Apr;64(4):1273-83. doi: 10.2337/db14-1282. Epub 2014 Oct 28.

23.

Interleukin-6 contributes to early fasting-induced free fatty acid mobilization in mice.

Wueest S, Item F, Boyle CN, Jirkof P, Cesarovic N, Ellingsgaard H, Böni-Schnetzler M, Timper K, Arras M, Donath MY, Lutz TA, Schoenle EJ, Konrad D.

Am J Physiol Regul Integr Comp Physiol. 2014 Jun 1;306(11):R861-7. doi: 10.1152/ajpregu.00533.2013. Epub 2014 Apr 2.

24.

Infliximab in the treatment of Crohn disease and type 1 diabetes.

Timper K, Hruz P, Beglinger C, Donath MY.

Diabetes Care. 2013 Jul;36(7):e90-1. doi: 10.2337/dc13-0199. No abstract available.

25.

Identification of a SIRT1 mutation in a family with type 1 diabetes.

Biason-Lauber A, Böni-Schnetzler M, Hubbard BP, Bouzakri K, Brunner A, Cavelti-Weder C, Keller C, Meyer-Böni M, Meier DT, Brorsson C, Timper K, Leibowitz G, Patrignani A, Bruggmann R, Boily G, Zulewski H, Geier A, Cermak JM, Elliott P, Ellis JL, Westphal C, Knobel U, Eloranta JJ, Kerr-Conte J, Pattou F, Konrad D, Matter CM, Fontana A, Rogler G, Schlapbach R, Regairaz C, Carballido JM, Glaser B, McBurney MW, Pociot F, Sinclair DA, Donath MY.

Cell Metab. 2013 Mar 5;17(3):448-455. doi: 10.1016/j.cmet.2013.02.001.

26.

Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes.

Timper K, Grisouard J, Sauter NS, Herzog-Radimerski T, Dembinski K, Peterli R, Frey DM, Zulewski H, Keller U, Müller B, Christ-Crain M.

Am J Physiol Endocrinol Metab. 2013 Jan 1;304(1):E1-13. doi: 10.1152/ajpendo.00100.2012. Epub 2012 Oct 23.

27.

Diabetes mellitus Type 2--the new face of an old lady.

Timper K, Donath MY.

Swiss Med Wkly. 2012 Jul 16;142:w13635. doi: 10.4414/smw.2012.13635. eCollection 2012. Review.

28.

Metformin counters both lipolytic/inflammatory agents-decreased hormone sensitive lipase phosphorylation at Ser-554 and -induced lipolysis in human adipocytes.

Grisouard J, Timper K, Bouillet E, Radimerski T, Dembinski K, Frey DM, Peterli R, Zulewski H, Keller U, Müller B, Christ-Crain M.

Arch Physiol Biochem. 2011 Oct;117(4):209-14. doi: 10.3109/13813455.2010.550925. Epub 2011 Feb 22.

PMID:
21338323
29.

Glucose-dependent insulinotropic polypeptide (GIP) induces calcitonin gene-related peptide (CGRP)-I and procalcitonin (Pro-CT) production in human adipocytes.

Timper K, Grisouard J, Radimerski T, Dembinski K, Peterli R, Häring A, Frey DM, Zulewski H, Keller U, Müller B, Christ-Crain M.

J Clin Endocrinol Metab. 2011 Feb;96(2):E297-303. doi: 10.1210/jc.2010-1324. Epub 2010 Nov 24.

PMID:
21106708
30.

Both inflammatory and classical lipolytic pathways are involved in lipopolysaccharide-induced lipolysis in human adipocytes.

Grisouard J, Bouillet E, Timper K, Radimerski T, Dembinski K, Frey DM, Peterli R, Zulewski H, Keller U, Müller B, Christ-Crain M.

Innate Immun. 2012 Feb;18(1):25-34. doi: 10.1177/1753425910386632. Epub 2010 Nov 18.

PMID:
21088047
31.

Mechanisms of metformin action on glucose transport and metabolism in human adipocytes.

Grisouard J, Timper K, Radimerski TM, Frey DM, Peterli R, Kola B, Korbonits M, Herrmann P, Krähenbühl S, Zulewski H, Keller U, Müller B, Christ-Crain M.

Biochem Pharmacol. 2010 Dec 1;80(11):1736-45. doi: 10.1016/j.bcp.2010.08.021. Epub 2010 Sep 8.

PMID:
20816671
32.

Role of calcium in lipopolysaccharide-induced calcitonin gene expression in human adipocytes.

Radimerski TM, Grisouard J, Timper K, Zulewski H, Christ-Crain M, Keller U, Müller B.

Innate Immun. 2011 Aug;17(4):403-13. doi: 10.1177/1753425910377100. Epub 2010 Aug 3.

PMID:
20682585
33.

Metformin induces glucose uptake in human preadipocyte-derived adipocytes from various fat depots.

Fischer M, Timper K, Radimerski T, Dembinski K, Frey DM, Zulewski H, Keller U, Müller B, Christ-Crain M, Grisouard J.

Diabetes Obes Metab. 2010 Apr;12(4):356-9. doi: 10.1111/j.1463-1326.2009.01169.x.

PMID:
20380657
34.

Lead poisoning due to adulterated marijuana.

Busse F, Omidi L, Timper K, Leichtle A, Windgassen M, Kluge E, Stumvoll M.

N Engl J Med. 2008 Apr 10;358(15):1641-2. doi: 10.1056/NEJMc0707784. No abstract available. Erratum in: N Engl J Med. 2008 Jul 24;359(4):440. Timper, Katharina [added].

PMID:
18403778
35.

Bone marrow derived mesenchymal stem cells isolated from patients with diabetes mellitus type 1 are able to induce a pancreatic endocrine genes in vitro.

Sebok D, Eberhardt M, Barbero A, Linscheid P, Timper K, Martin I, Keller U, Muller B, Zulewski H.

J Stem Cells Regen Med. 2007 May 16;2(1):102-3. eCollection 2007. No abstract available.

PMID:
24692931
36.

Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells.

Timper K, Seboek D, Eberhardt M, Linscheid P, Christ-Crain M, Keller U, Müller B, Zulewski H.

Biochem Biophys Res Commun. 2006 Mar 24;341(4):1135-40. Epub 2006 Jan 26.

PMID:
16460677

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