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Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in mice.

Jiang X, Jiang L, Shan A, Su Y, Cheng Y, Song D, Ji H, Ning G, Wang W, Cao Y.

EBioMedicine. 2018 Oct 10. pii: S2352-3964(18)30408-0. doi: 10.1016/j.ebiom.2018.09.051. [Epub ahead of print]


Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules.

Boussadia Z, Lamberti J, Mattei F, Pizzi E, Puglisi R, Zanetti C, Pasquini L, Fratini F, Fantozzi L, Felicetti F, Fecchi K, Raggi C, Sanchez M, D'Atri S, Carè A, Sargiacomo M, Parolini I.

J Exp Clin Cancer Res. 2018 Oct 5;37(1):245. doi: 10.1186/s13046-018-0915-z.


TIMP3 and TIMP1 are risk genes for bicuspid aortic valve and aortopathy in Turner syndrome.

Corbitt H, Morris SA, Gravholt CH, Mortensen KH, Tippner-Hedges R, Silberbach M, Maslen CL; GenTAC Registry Investigators.

PLoS Genet. 2018 Oct 3;14(10):e1007692. doi: 10.1371/journal.pgen.1007692. eCollection 2018 Oct.


Multipotent adult progenitor cells, but not TIMP3, increase tissue sparing and reduce urological complications following spinal cord injury.

Jones JM, DePaul M, Gregory CR, Lang BT, Xie H, Zhu M, Rutten M, Mays R, Busch S, Pati S, Gregory K.

J Neurotrauma. 2018 Sep 25. doi: 10.1089/neu.2018.5727. [Epub ahead of print]


Comprehensive molecular characterization of microneedling therapy in a human three-dimensional skin model.

Schmitt L, Marquardt Y, Amann P, Heise R, Huth L, Wagner-Schiffler S, Huth S, Baron JM.

PLoS One. 2018 Sep 20;13(9):e0204318. doi: 10.1371/journal.pone.0204318. eCollection 2018.


Negative correlation of cytoplasm TIMP3 with miR-222 indicates a good prognosis for NSCLC.

Lei Y, Liu Z, Yang W.

Onco Targets Ther. 2018 Sep 6;11:5551-5557. doi: 10.2147/OTT.S172522. eCollection 2018.


Predicting cervical intraepithelial neoplasia recurrence in HIV-infected and -noninfected women by detecting aberrant promoter methylation in the CDH1, TIMP3, and MGMT genes.

Teixeira da Costa Lodi C, Michelin MA, Miranda Lima MI, Murta EFC, Braga LDC, Montes L, Melo VH.

Arch Gynecol Obstet. 2018 Sep 14. doi: 10.1007/s00404-018-4899-x. [Epub ahead of print]


TIMP Loss Activates Metalloproteinase-TNFα-DKK1 Axis To Compromise Wnt Signaling and Bone Mass.

Chen Y, Aiken A, Saw S, Weiss A, Fang H, Khokha R.

J Bone Miner Res. 2018 Sep 14. doi: 10.1002/jbmr.3585. [Epub ahead of print]


Correction: Increasing TIMP3 expression by hypomethylating agents diminishes soluble MICA, MICB and ULBP2 shedding in acute myeloid leukemia, facilitating NK cell-mediated immune recognition.

Raneros AB, Minguela A, Rodriguez RM, Colado E, Bernal T, Anguita E, Mogorron AV, Gil AC, Vidal-Castiñeira JR, Márquez-Kisinousky L, Bulnes PD, Marin AM, García Garay MC, Suarez-Alvarez B, Lopez-Larrea C.

Oncotarget. 2018 Aug 28;9(67):32881. doi: 10.18632/oncotarget.26079. eCollection 2018 Aug 28.


Down-regulation of microRNA-21 reduces inflammation and podocyte apoptosis in diabetic nephropathy by relieving the repression of TIMP3 expression.

Chen X, Zhao L, Xing Y, Lin B.

Biomed Pharmacother. 2018 Sep 10;108:7-14. doi: 10.1016/j.biopha.2018.09.007. [Epub ahead of print]


Quercetin is able to alleviate TGF-β-induced fibrosis in renal tubular epithelial cells by suppressing miR-21.

Cao Y, Hu J, Sui J, Jiang L, Cong Y, Ren G.

Exp Ther Med. 2018 Sep;16(3):2442-2448. doi: 10.3892/etm.2018.6489. Epub 2018 Jul 20.


Correlating blood-based DNA methylation markers and prostate cancer risk in African-American men.

Moses-Fynn E, Tang W, Beyene D, Apprey V, Copeland R, Kanaan Y, Kwabi-Addo B.

PLoS One. 2018 Sep 11;13(9):e0203322. doi: 10.1371/journal.pone.0203322. eCollection 2018.


CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases.

Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB.

Cancer Res. 2018 Sep 5. pii: canres.1583.2018. doi: 10.1158/0008-5472.CAN-18-1583. [Epub ahead of print]


Temporal Changes in Myocardial Collagen, Matrix Metalloproteinases and their Inhibitors in Experimental Chronic Mitral Regurgitation in Rodents.

Corporan D, Onohara D, Hernandez-Merlo R, Sielicka A, Padala M.

Am J Physiol Heart Circ Physiol. 2018 Aug 24. doi: 10.1152/ajpheart.00099.2018. [Epub ahead of print]


Sorsby fundus dystrophy: Insights from the past and looking to the future.

Anand-Apte B, Chao JR, Singh R, Stöhr H.

J Neurosci Res. 2018 Aug 21. doi: 10.1002/jnr.24317. [Epub ahead of print]


Perturbations of BMP/TGF-β and VEGF/VEGFR signalling pathways in non-syndromic sporadic brain arteriovenous malformations (BAVM).

Wang K, Zhao S, Liu B, Zhang Q, Li Y, Liu J, Shen Y, Ding X, Lin J, Wu Y, Yan Z, Chen J, Li X, Song X, Niu Y, Liu J, Chen W, Ming Y, Du R, Chen C, Long B, Zhang Y, Tong X, Zhang S, Posey JE, Zhang B, Wu Z, Wythe JD, Liu P, Lupski JR, Yang X, Wu N.

J Med Genet. 2018 Oct;55(10):675-684. doi: 10.1136/jmedgenet-2017-105224. Epub 2018 Aug 17.


A Novel Class of tRNA-Derived Small Non-Coding RNAs Respond to Myocardial Hypertrophy and Contribute to Intergenerational Inheritance.

Shen L, Gan M, Tan Z, Jiang D, Jiang Y, Li M, Wang J, Li X, Zhang S, Zhu L.

Biomolecules. 2018 Jul 16;8(3). pii: E54. doi: 10.3390/biom8030054.


Lung Cancer Therapy Targeting Histone Methylation: Opportunities and Challenges.

Chen Y, Liu X, Li Y, Quan C, Zheng L, Huang K.

Comput Struct Biotechnol J. 2018 Jun 20;16:211-223. doi: 10.1016/j.csbj.2018.06.001. eCollection 2018. Review.


Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion.

Laheri S, Ashary N, Bhatt P, Modi D.

J Assist Reprod Genet. 2018 Aug;35(8):1419-1429. doi: 10.1007/s10815-018-1231-4. Epub 2018 Jun 30.


The stress response gene ATF3 is a direct target of the Wnt/β-catenin pathway and inhibits the invasion and migration of HCT116 human colorectal cancer cells.

Inoue M, Uchida Y, Edagawa M, Hirata M, Mitamura J, Miyamoto D, Taketani K, Sekine S, Kawauchi J, Kitajima S.

PLoS One. 2018 Jul 2;13(7):e0194160. doi: 10.1371/journal.pone.0194160. eCollection 2018.

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