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Items: 1 to 50 of 88

1.

Neuralized family member NEURL1 is a ubiquitin ligase for the cGMP-specific phosphodiesterase 9A.

Taal K, Tuvikene J, Rullinkov G, Piirsoo M, Sepp M, Neuman T, Tamme R, Timmusk T.

Sci Rep. 2019 May 8;9(1):7104. doi: 10.1038/s41598-019-43069-x.

2.

Glucocorticoid Receptor Stimulation Resulting from Early Life Stress Affects Expression of DNA Methyltransferases in Rat Prefrontal Cortex.

Urb M, Anier K, Matsalu T, Aonurm-Helm A, Tasa G, Koppel I, Zharkovsky A, Timmusk T, Kalda A.

J Mol Neurosci. 2019 May;68(1):99-110. doi: 10.1007/s12031-019-01286-z. Epub 2019 Mar 9.

PMID:
30852742
3.

The role of DNA methyltransferase activity in cocaine treatment and withdrawal in the nucleus accumbens of mice.

Urb M, Niinep K, Matsalu T, Kipper K, Herodes K, Zharkovsky A, Timmusk T, Anier K, Kalda A.

Addict Biol. 2019 Feb 7. doi: 10.1111/adb.12720. [Epub ahead of print]

PMID:
30730091
4.

Cocaine-induced epigenetic DNA modification in mouse addiction-specific and non-specific tissues.

Anier K, Urb M, Kipper K, Herodes K, Timmusk T, Zharkovsky A, Kalda A.

Neuropharmacology. 2018 Sep 1;139:13-25. doi: 10.1016/j.neuropharm.2018.06.036. Epub 2018 Jun 28.

PMID:
29964092
5.

Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients.

Karis K, Eskla KL, Kaare M, Täht K, Tuusov J, Visnapuu T, Innos J, Jayaram M, Timmusk T, Weickert CS, Väli M, Vasar E, Philips MA.

Front Mol Neurosci. 2018 Jan 29;11:8. doi: 10.3389/fnmol.2018.00008. eCollection 2018.

6.

Dopamine cross-reacts with adrenoreceptors in cortical astrocytes to induce BDNF expression, CREB signaling and morphological transformation.

Koppel I, Jaanson K, Klasche A, Tuvikene J, Tiirik T, Pärn A, Timmusk T.

Glia. 2018 Jan;66(1):206-216. doi: 10.1002/glia.23238. Epub 2017 Oct 6.

PMID:
28983964
7.

The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A.

Sepp M, Vihma H, Nurm K, Urb M, Page SC, Roots K, Hark A, Maher BJ, Pruunsild P, Timmusk T.

J Neurosci. 2017 Oct 25;37(43):10516-10527. doi: 10.1523/JNEUROSCI.1151-17.2017. Epub 2017 Sep 26.

8.

Sumoylation regulates the transcriptional activity of different human NFAT isoforms in neurons.

Vihma H, Timmusk T.

Neurosci Lett. 2017 Jul 13;653:302-307. doi: 10.1016/j.neulet.2017.05.074.

PMID:
28595951
9.

Rat NEURL1 3'UTR is alternatively spliced and targets mRNA to dendrites.

Jaagura M, Taal K, Koppel I, Tuvikene J, Timmusk T, Tamme R.

Neurosci Lett. 2016 Dec 2;635:71-76. doi: 10.1016/j.neulet.2016.10.041. Epub 2016 Oct 22.

PMID:
27780737
10.

Indole-like Trk receptor antagonists.

Tammiku-Taul J, Park R, Jaanson K, Luberg K, Dobchev DA, Kananovich D, Noole A, Mandel M, Kaasik A, Lopp M, Timmusk T, Karelson M.

Eur J Med Chem. 2016 Oct 4;121:541-552. doi: 10.1016/j.ejmech.2016.06.003. Epub 2016 Jun 4.

PMID:
27318978
11.

Partial deletion of TCF4 in three generation family with non-syndromic intellectual disability, without features of Pitt-Hopkins syndrome.

Kharbanda M, Kannike K, Lampe A, Berg J, Timmusk T, Sepp M.

Eur J Med Genet. 2016 Jun;59(6-7):310-4. doi: 10.1016/j.ejmg.2016.04.003. Epub 2016 Apr 28.

PMID:
27132474
12.

Nucleolar Enrichment of Brain Proteins with Critical Roles in Human Neurodevelopment.

Slomnicki LP, Malinowska A, Kistowski M, Palusinski A, Zheng JJ, Sepp M, Timmusk T, Dadlez M, Hetman M.

Mol Cell Proteomics. 2016 Jun;15(6):2055-75. doi: 10.1074/mcp.M115.051920. Epub 2016 Apr 6.

13.

Regulation of different human NFAT isoforms by neuronal activity.

Vihma H, Luhakooder M, Pruunsild P, Timmusk T.

J Neurochem. 2016 May;137(3):394-408. doi: 10.1111/jnc.13568. Epub 2016 Mar 1.

14.

AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons.

Tuvikene J, Pruunsild P, Orav E, Esvald EE, Timmusk T.

J Neurosci. 2016 Jan 27;36(4):1290-305. doi: 10.1523/JNEUROSCI.3360-15.2016.

15.

Introducing Pitt-Hopkins syndrome-associated mutations of TCF4 to Drosophila daughterless.

Tamberg L, Sepp M, Timmusk T, Palgi M.

Biol Open. 2015 Nov 30;4(12):1762-71. doi: 10.1242/bio.014696.

16.

Novel transcripts reveal a complex structure of the human TRKA gene and imply the presence of multiple protein isoforms.

Luberg K, Park R, Aleksejeva E, Timmusk T.

BMC Neurosci. 2015 Nov 18;16:78. doi: 10.1186/s12868-015-0215-x.

17.

GLI2 cell-specific activity is controlled at the level of transcription and RNA processing: Consequences to cancer metastasis.

Sadam H, Liivas U, Kazantseva A, Pruunsild P, Kazantseva J, Timmusk T, Neuman T, Palm K.

Biochim Biophys Acta. 2016 Jan;1862(1):46-55. doi: 10.1016/j.bbadis.2015.10.008. Epub 2015 Oct 14.

18.

Efficient use of a translation start codon in BDNF exon I.

Koppel I, Tuvikene J, Lekk I, Timmusk T.

J Neurochem. 2015 Sep;134(6):1015-25. doi: 10.1111/jnc.13124. Epub 2015 Apr 27.

19.

The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.

Blázquez C, Chiarlone A, Bellocchio L, Resel E, Pruunsild P, García-Rincón D, Sendtner M, Timmusk T, Lutz B, Galve-Roperh I, Guzmán M.

Cell Death Differ. 2015 Oct;22(10):1618-29. doi: 10.1038/cdd.2015.11. Epub 2015 Feb 20.

20.

Neuronal-activity regulated gene expression: emphasis on BDNF.

Timmusk T.

Springerplus. 2015 Jun 12;4(Suppl 1):L38. doi: 10.1186/2193-1801-4-S1-L38. eCollection 2015. No abstract available.

21.

Forkhead transcription factor FOXO3a levels are increased in Huntington disease because of overactivated positive autofeedback loop.

Kannike K, Sepp M, Zuccato C, Cattaneo E, Timmusk T.

J Biol Chem. 2014 Nov 21;289(47):32845-57. doi: 10.1074/jbc.M114.612424. Epub 2014 Sep 30.

22.

BAC-based cellular model for screening regulators of BDNF gene transcription.

Jaanson K, Sepp M, Aid-Pavlidis T, Timmusk T.

BMC Neurosci. 2014 Jun 18;15:75. doi: 10.1186/1471-2202-15-75.

23.

Neurotrophins: transcription and translation.

West AE, Pruunsild P, Timmusk T.

Handb Exp Pharmacol. 2014;220:67-100. doi: 10.1007/978-3-642-45106-5_4. Review.

PMID:
24668470
24.

Differential regulation of Bdnf expression in cortical neurons by class-selective histone deacetylase inhibitors.

Koppel I, Timmusk T.

Neuropharmacology. 2013 Dec;75:106-15. doi: 10.1016/j.neuropharm.2013.07.015. Epub 2013 Aug 2.

PMID:
23916482
26.

Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects.

Sepp M, Pruunsild P, Timmusk T.

Hum Mol Genet. 2012 Jul 1;21(13):2873-88. doi: 10.1093/hmg/dds112. Epub 2012 Mar 28.

PMID:
22460224
27.

Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing.

Sepp M, Kannike K, Eesmaa A, Urb M, Timmusk T.

PLoS One. 2011;6(7):e22138. doi: 10.1371/journal.pone.0022138. Epub 2011 Jul 15.

28.

Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms.

Kask M, Pruunsild P, Timmusk T.

Biochem Biophys Res Commun. 2011 Jul 22;411(1):56-61. doi: 10.1016/j.bbrc.2011.06.085. Epub 2011 Jun 17.

PMID:
21708131
29.

Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene.

Pruunsild P, Sepp M, Orav E, Koppel I, Timmusk T.

J Neurosci. 2011 Mar 2;31(9):3295-308. doi: 10.1523/JNEUROSCI.4540-10.2011.

30.

Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development.

Luberg K, Wong J, Weickert CS, Timmusk T.

J Neurochem. 2010 May;113(4):952-64. doi: 10.1111/j.1471-4159.2010.06662.x. Epub 2010 Feb 27.

31.

BAC transgenic mice reveal distal cis-regulatory elements governing BDNF gene expression.

Koppel I, Aid-Pavlidis T, Jaanson K, Sepp M, Palm K, Timmusk T.

Genesis. 2010 Apr;48(4):214-9. doi: 10.1002/dvg.20606.

32.

Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons.

Vashishta A, Habas A, Pruunsild P, Zheng JJ, Timmusk T, Hetman M.

J Neurosci. 2009 Dec 2;29(48):15331-40. doi: 10.1523/JNEUROSCI.4873-09.2009.

33.

Expression of NGF and GDNF family members and their receptors during peripheral nerve development and differentiation of Schwann cells in vitro.

Piirsoo M, Kaljas A, Tamm K, Timmusk T.

Neurosci Lett. 2010 Jan 18;469(1):135-40. doi: 10.1016/j.neulet.2009.11.060. Epub 2009 Nov 26.

34.
35.

NF-kappaB-dependent regulation of brain-derived neurotrophic factor in hippocampal neurons by X-linked inhibitor of apoptosis protein.

Kairisalo M, Korhonen L, Sepp M, Pruunsild P, Kukkonen JP, Kivinen J, Timmusk T, Blomgren K, Lindholm D.

Eur J Neurosci. 2009 Sep;30(6):958-66. doi: 10.1111/j.1460-9568.2009.06898.x. Epub 2009 Sep 4.

PMID:
19735291
36.

Neuralized-2: expression in human and rodents and interaction with Delta-like ligands.

Rullinkov G, Tamme R, Sarapuu A, Laurén J, Sepp M, Palm K, Timmusk T.

Biochem Biophys Res Commun. 2009 Nov 20;389(3):420-5. doi: 10.1016/j.bbrc.2009.08.147. Epub 2009 Aug 31.

PMID:
19723503
37.

Tissue-specific and neural activity-regulated expression of human BDNF gene in BAC transgenic mice.

Koppel I, Aid-Pavlidis T, Jaanson K, Sepp M, Pruunsild P, Palm K, Timmusk T.

BMC Neurosci. 2009 Jun 25;10:68. doi: 10.1186/1471-2202-10-68.

38.

N-terminally truncated BAF57 isoforms contribute to the diversity of SWI/SNF complexes in neurons.

Kazantseva A, Sepp M, Kazantseva J, Sadam H, Pruunsild P, Timmusk T, Neuman T, Palm K.

J Neurochem. 2009 May;109(3):807-18. doi: 10.1111/j.1471-4159.2009.06005.x. Epub 2009 Feb 20.

39.

Expression analysis of the CLCA gene family in mouse and human with emphasis on the nervous system.

Piirsoo M, Meijer D, Timmusk T.

BMC Dev Biol. 2009 Feb 11;9:10. doi: 10.1186/1471-213X-9-10.

40.

Long-lasting behavioural and molecular alterations induced by early postnatal fluoxetine exposure are restored by chronic fluoxetine treatment in adult mice.

Karpova NN, Lindholm J, Pruunsild P, Timmusk T, Castrén E.

Eur Neuropsychopharmacol. 2009 Feb;19(2):97-108. doi: 10.1016/j.euroneuro.2008.09.002. Epub 2008 Oct 29.

PMID:
18973993
41.

MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain.

Lindholm P, Peränen J, Andressoo JO, Kalkkinen N, Kokaia Z, Lindvall O, Timmusk T, Saarma M.

Mol Cell Neurosci. 2008 Nov;39(3):356-71. doi: 10.1016/j.mcn.2008.07.016. Epub 2008 Jul 30.

PMID:
18718866
42.

Alternative splicing and expression of human and mouse NFAT genes.

Vihma H, Pruunsild P, Timmusk T.

Genomics. 2008 Nov;92(5):279-91. doi: 10.1016/j.ygeno.2008.06.011. Epub 2008 Aug 26.

43.

Regulation of extracellular serotonin levels and brain-derived neurotrophic factor in rats with high and low exploratory activity.

Mällo T, Kõiv K, Koppel I, Raudkivi K, Uustare A, Rinken A, Timmusk T, Harro J.

Brain Res. 2008 Feb 15;1194:110-7. doi: 10.1016/j.brainres.2007.11.041. Epub 2007 Dec 4.

44.

A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2.

Uvarov P, Ludwig A, Markkanen M, Pruunsild P, Kaila K, Delpire E, Timmusk T, Rivera C, Airaksinen MS.

J Biol Chem. 2007 Oct 19;282(42):30570-6. Epub 2007 Aug 22.

45.

LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia.

Francks C, Maegawa S, Laurén J, Abrahams BS, Velayos-Baeza A, Medland SE, Colella S, Groszer M, McAuley EZ, Caffrey TM, Timmusk T, Pruunsild P, Koppel I, Lind PA, Matsumoto-Itaba N, Nicod J, Xiong L, Joober R, Enard W, Krinsky B, Nanba E, Richardson AJ, Riley BP, Martin NG, Strittmatter SM, Möller HJ, Rujescu D, St Clair D, Muglia P, Roos JL, Fisher SE, Wade-Martins R, Rouleau GA, Stein JF, Karayiorgou M, Geschwind DH, Ragoussis J, Kendler KS, Airaksinen MS, Oshimura M, DeLisi LE, Monaco AP.

Mol Psychiatry. 2007 Dec;12(12):1129-39, 1057. Epub 2007 Jul 31.

46.

Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters.

Pruunsild P, Kazantseva A, Aid T, Palm K, Timmusk T.

Genomics. 2007 Sep;90(3):397-406. Epub 2007 Jul 12.

47.

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.

Lindholm P, Voutilainen MH, Laurén J, Peränen J, Leppänen VM, Andressoo JO, Lindahl M, Janhunen S, Kalkkinen N, Timmusk T, Tuominen RK, Saarma M.

Nature. 2007 Jul 5;448(7149):73-7.

PMID:
17611540
48.

Mouse and rat BDNF gene structure and expression revisited.

Aid T, Kazantseva A, Piirsoo M, Palm K, Timmusk T.

J Neurosci Res. 2007 Feb 15;85(3):525-35.

50.

Structure, alternative splicing, and expression of the human and mouse KCNIP gene family.

Pruunsild P, Timmusk T.

Genomics. 2005 Nov;86(5):581-93. Epub 2005 Aug 19.

PMID:
16112838

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