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The role of B-Cell Lymphoma-3 (BCL-3) in enabling the hallmarks of cancer: implications for the treatment of colorectal carcinogenesis.

Legge DN, Chambers AC, Parker CT, Timms P, Collard TJ, Williams AC.

Carcinogenesis. 2020 Jan 13. pii: bgaa003. doi: 10.1093/carcin/bgaa003. [Epub ahead of print]


Navigating to the most promising directions amid complex fields of vaccine development: a chlamydial case study.

Lizárraga D, Carver S, Timms P.

Expert Rev Vaccines. 2019 Dec;18(12):1323-1337. doi: 10.1080/14760584.2019.1698954. Epub 2019 Dec 10.


Longitudinal study of wild koalas (Phascolarctos cinereus) reveals chlamydial disease progression in two thirds of infected animals.

Robbins A, Hanger J, Jelocnik M, Quigley BL, Timms P.

Sci Rep. 2019 Sep 13;9(1):13194. doi: 10.1038/s41598-019-49382-9.


Antibody response against koala retrovirus (KoRV) in koalas harboring KoRV-A in the presence or absence of KoRV-B.

Olagoke O, Quigley BL, Eiden MV, Timms P.

Sci Rep. 2019 Aug 27;9(1):12416. doi: 10.1038/s41598-019-48880-0.


Antibiotic treatment of Chlamydia-induced cystitis in the koala is linked to expression of key inflammatory genes in reactive oxygen pathways.

Phillips S, Quigley BL, Aziz A, Bergen W, Booth R, Pyne M, Timms P.

PLoS One. 2019 Aug 15;14(8):e0221109. doi: 10.1371/journal.pone.0221109. eCollection 2019.


Chlamydia-infected macrophages are resistant to azithromycin treatment and are associated with chronic oviduct inflammation and hydrosalpinx development.

Harvie MC, Carey AJ, Armitage CW, O'Meara CP, Peet J, Phillips ZN, Timms P, Beagley KW.

Immunol Cell Biol. 2019 Nov;97(10):865-876. doi: 10.1111/imcb.12285. Epub 2019 Sep 11.


Changes in Endogenous and Exogenous Koala Retrovirus Subtype Expression over Time Reflect Koala Health Outcomes.

Quigley BL, Phillips S, Olagoke O, Robbins A, Hanger J, Timms P.

J Virol. 2019 Aug 28;93(18). pii: e00849-19. doi: 10.1128/JVI.00849-19. Print 2019 Sep 15.


Evaluation of a PGP3 ELISA for surveillance of the burden of Chlamydia infection in women from Australia and Samoa.

Mazraani R, Timms P, Hill PC, Suaalii-Sauni T, Niupulusu T, Temese SVA, Iosefa-Siitia L, Auvaa L, Tapelu SA, Motu MF, Righarts A, Walsh MS, Rombauts L, Allan JA, Horner P, Huston WM.

Pathog Dis. 2019 Apr 1;77(3). pii: ftz031. doi: 10.1093/femspd/ftz031.


Prevalence and clinical significance of koala retrovirus in two South Australian koala (Phascolarctos cinereus) populations.

Fabijan J, Miller D, Olagoke O, Woolford L, Boardman W, Timms P, Polkinghorne A, Simmons G, Hemmatzadeh F, Trott DJ, Speight KN.

J Med Microbiol. 2019 Jul;68(7):1072-1080. doi: 10.1099/jmm.0.001009. Epub 2019 Jun 4.


In vitro analysis of genetically distinct Chlamydia pecorum isolates reveals key growth differences in mammalian epithelial and immune cells.

Islam MM, Jelocnik M, Anstey S, Kaltenboeck B, Borel N, Timms P, Polkinghorne A.

Vet Microbiol. 2019 May;232:22-29. doi: 10.1016/j.vetmic.2019.03.024. Epub 2019 Mar 31.


Chlamydia pecorum prevalence in South Australian koala (Phascolarctos cinereus) populations: Identification and modelling of a population free from infection.

Fabijan J, Caraguel C, Jelocnik M, Polkinghorne A, Boardman WSJ, Nishimoto E, Johnsson G, Molsher R, Woolford L, Timms P, Simmons G, Hemmatzadeh F, Trott DJ, Speight N.

Sci Rep. 2019 Apr 18;9(1):6261. doi: 10.1038/s41598-019-42702-z.


High expression of IDO1 and TGF-β1 during recurrence and post infection clearance with Chlamydia trachomatis, are independent of host IFN-γ response.

Ziklo N, Huston WM, Taing K, Timms P.

BMC Infect Dis. 2019 Mar 4;19(1):218. doi: 10.1186/s12879-019-3843-4.


Seventy Years of Chlamydia Vaccine Research - Limitations of the Past and Directions for the Future.

Phillips S, Quigley BL, Timms P.

Front Microbiol. 2019 Jan 31;10:70. doi: 10.3389/fmicb.2019.00070. eCollection 2019. Review.


Therapeutic effect of a Chlamydia pecorum recombinant major outer membrane protein vaccine on ocular disease in koalas (Phascolarctos cinereus).

Nyari S, Booth R, Quigley BL, Waugh CA, Timms P.

PLoS One. 2019 Jan 7;14(1):e0210245. doi: 10.1371/journal.pone.0210245. eCollection 2019.


Optimising the short and long-term clinical outcomes for koalas (Phascolarctos cinereus) during treatment for chlamydial infection and disease.

Robbins A, Loader J, Timms P, Hanger J.

PLoS One. 2018 Dec 27;13(12):e0209679. doi: 10.1371/journal.pone.0209679. eCollection 2018.


Chlamydia pecorum gastrointestinal tract infection associations with urogenital tract infections in the koala (Phascolarctos cinereus).

Phillips S, Robbins A, Loader J, Hanger J, Booth R, Jelocnik M, Polkinghorne A, Timms P.

PLoS One. 2018 Nov 1;13(11):e0206471. doi: 10.1371/journal.pone.0206471. eCollection 2018.


The Genetic Transformation of Chlamydia pneumoniae.

Shima K, Wanker M, Skilton RJ, Cutcliffe LT, Schnee C, Kohl TA, Niemann S, Geijo J, Klinger M, Timms P, Rattei T, Sachse K, Clarke IN, Rupp J.

mSphere. 2018 Oct 10;3(5). pii: e00412-18. doi: 10.1128/mSphere.00412-18.


Detection of Chlamydia trachomatis mRNA using digital PCR as a more accurate marker of viable organism.

Phillips S, Vodstrcil LA, Huston WM, Lawerence A, Timms P, Chen MY, Worthington K, McIver R, Bradshaw CS, Garland SM, Tabrizi SN, Hocking JS.

Eur J Clin Microbiol Infect Dis. 2018 Nov;37(11):2117-2122. doi: 10.1007/s10096-018-3347-y. Epub 2018 Aug 14.


Induction of neutralizing antibody response against koala retrovirus (KoRV) and reduction in viral load in koalas following vaccination with recombinant KoRV envelope protein.

Olagoke O, Miller D, Hemmatzadeh F, Stephenson T, Fabijan J, Hutt P, Finch S, Speight N, Timms P.

NPJ Vaccines. 2018 Aug 2;3:30. doi: 10.1038/s41541-018-0066-4. eCollection 2018.


Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion.

Löber U, Hobbs M, Dayaram A, Tsangaras K, Jones K, Alquezar-Planas DE, Ishida Y, Meers J, Mayer J, Quedenau C, Chen W, Johnson RN, Timms P, Young PR, Roca AL, Greenwood AD.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):8609-8614. doi: 10.1073/pnas.1807598115. Epub 2018 Aug 6.


Adaptation and conservation insights from the koala genome.

Johnson RN, O'Meally D, Chen Z, Etherington GJ, Ho SYW, Nash WJ, Grueber CE, Cheng Y, Whittington CM, Dennison S, Peel E, Haerty W, O'Neill RJ, Colgan D, Russell TL, Alquezar-Planas DE, Attenbrow V, Bragg JG, Brandies PA, Chong AY, Deakin JE, Di Palma F, Duda Z, Eldridge MDB, Ewart KM, Hogg CJ, Frankham GJ, Georges A, Gillett AK, Govendir M, Greenwood AD, Hayakawa T, Helgen KM, Hobbs M, Holleley CE, Heider TN, Jones EA, King A, Madden D, Graves JAM, Morris KM, Neaves LE, Patel HR, Polkinghorne A, Renfree MB, Robin C, Salinas R, Tsangaras K, Waters PD, Waters SA, Wright B, Wilkins MR, Timms P, Belov K.

Nat Genet. 2018 Aug;50(8):1102-1111. doi: 10.1038/s41588-018-0153-5. Epub 2018 Jul 2.


Vaccination of koalas (Phascolarctos cinereus) against Chlamydia pecorum using synthetic peptides derived from the major outer membrane protein.

Nyari S, Khan SA, Rawlinson G, Waugh CA, Potter A, Gerdts V, Timms P.

PLoS One. 2018 Jun 28;13(6):e0200112. doi: 10.1371/journal.pone.0200112. eCollection 2018.


In silico characterisation of the two-component system regulators of Streptococcus pyogenes.

Buckley SJ, Timms P, Davies MR, McMillan DJ.

PLoS One. 2018 Jun 21;13(6):e0199163. doi: 10.1371/journal.pone.0199163. eCollection 2018.


The relative contribution of causal factors in the transition from infection to clinical chlamydial disease.

Quigley BL, Carver S, Hanger J, Vidgen ME, Timms P.

Sci Rep. 2018 Jun 11;8(1):8893. doi: 10.1038/s41598-018-27253-z.


Prevalence of Chlamydia pecorum in Juvenile Koalas ( Phascolarctos cinereus) and Evidence for Protection from Infection via Maternal Immunization.

Russell I, Timms P, Hanger J, Loader J, Gillett A, Waugh C.

J Wildl Dis. 2018 Oct;54(4):863-865. doi: 10.7589/2017-07-183. Epub 2018 May 7.


High-dose vitamin D3 in the treatment of severe acute malnutrition: a multicenter double-blind randomized controlled trial.

Saleem J, Zakar R, Zakar MZ, Belay M, Rowe M, Timms PM, Scragg R, Martineau AR.

Am J Clin Nutr. 2018 May 1;107(5):725-733. doi: 10.1093/ajcn/nqy027.


Understanding the health and production impacts of endemic Chlamydia pecorum infections in lambs.

Walker E, Jelocnik M, Bommana S, Timms P, Carver S, Polkinghorne A.

Vet Microbiol. 2018 Apr;217:90-96. doi: 10.1016/j.vetmic.2018.03.009. Epub 2018 Mar 10.


Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections.

Ziklo N, Vidgen ME, Taing K, Huston WM, Timms P.

Front Cell Infect Microbiol. 2018 Jan 18;8:1. doi: 10.3389/fcimb.2018.00001. eCollection 2018.


Koala immunology and infectious diseases: How much can the koala bear?

Madden D, Whaite A, Jones E, Belov K, Timms P, Polkinghorne A.

Dev Comp Immunol. 2018 May;82:177-185. doi: 10.1016/j.dci.2018.01.017. Epub 2018 Jan 31. Review.


Molecular and serological dynamics of Chlamydia pecorum infection in a longitudinal study of prime lamb production.

Bommana S, Walker E, Desclozeaux M, Jelocnik M, Timms P, Polkinghorne A, Carver S.

PeerJ. 2018 Jan 25;6:e4296. doi: 10.7717/peerj.4296. eCollection 2018.


Characterization of the In Vitro Chlamydia pecorum Response to Gamma Interferon.

Islam MM, Jelocnik M, Huston WM, Timms P, Polkinghorne A.

Infect Immun. 2018 Mar 22;86(4). pii: e00714-17. doi: 10.1128/IAI.00714-17. Print 2018 Apr.


Epidemiology of chlamydial infection and disease in a free-ranging koala (Phascolarctos cinereus) population.

Nyari S, Waugh CA, Dong J, Quigley BL, Hanger J, Loader J, Polkinghorne A, Timms P.

PLoS One. 2017 Dec 27;12(12):e0190114. doi: 10.1371/journal.pone.0190114. eCollection 2017.


A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women.

Wee BA, Thomas M, Sweeney EL, Frentiu FD, Samios M, Ravel J, Gajer P, Myers G, Timms P, Allan JA, Huston WM.

Aust N Z J Obstet Gynaecol. 2018 Jun;58(3):341-348. doi: 10.1111/ajo.12754. Epub 2017 Dec 26.


Development of a Chlamydia trachomatis vaccine for urogenital infections: novel tools and new strategies point to bright future prospects.

Hafner LM, Timms P.

Expert Rev Vaccines. 2018 Jan;17(1):57-69. doi: 10.1080/14760584.2018.1417044. Epub 2017 Dec 21. Review.


Molecular Dynamics and Mode of Transmission of Koala Retrovirus as It Invades and Spreads through a Wild Queensland Koala Population

Quigley BL, Ong VA, Hanger J, Timms P.

J Virol. 2018 Mar 1;92(5). pii: e01871-17. doi: 10.1128/JVI.01871-17. Epub 2017 Dec 13.


Humoral immune response against two surface antigens of Chlamydia pecorum in vaccinated and naturally infected sheep.

Bommana S, Walker E, Desclozeaux M, Timms P, Polkinghorne A.

PLoS One. 2017 Nov 30;12(11):e0188370. doi: 10.1371/journal.pone.0188370. eCollection 2017.


Long-read genome sequence assembly provides insight into ongoing retroviral invasion of the koala germline.

Hobbs M, King A, Salinas R, Chen Z, Tsangaras K, Greenwood AD, Johnson RN, Belov K, Wilkins MR, Timms P.

Sci Rep. 2017 Nov 20;7(1):15838. doi: 10.1038/s41598-017-16171-1.


Systemic antibody response to Chlamydia Trachomatis infection in patients either infected or reinfected with different Chlamydia serovars.

Gupta VK, Waugh CA, Ziklo N, Huston WM, Hocking JS, Timms P.

Indian J Med Microbiol. 2017 Jul-Sep;35(3):394-401. doi: 10.4103/ijmm.IJMM_17_1.


A Devil's dictionary for mental health.

Timms P.

BJPsych Bull. 2017 Oct;41(5):244-246. doi: 10.1192/pb.bp.116.055442.


Molecular evidence of Chlamydia pecorum and arthropod-associated Chlamydiae in an expanded range of marsupials.

Burnard D, Huston WM, Webb JK, Jelocnik M, Reiss A, Gillett A, Fitzgibbon S, Carver S, Carrucan J, Flanagan C, Timms P, Polkinghorne A.

Sci Rep. 2017 Oct 9;7(1):12844. doi: 10.1038/s41598-017-13164-y.


Editorial: Novel strategies for developing vaccines bring encouraging progress.

Timms P.

Pathog Dis. 2017 Sep 29;75(7). doi: 10.1093/femspd/ftx095. No abstract available.


Characterisation of MHC class I genes in the koala.

Cheng Y, Polkinghorne A, Gillett A, Jones EA, O'Meally D, Timms P, Belov K.

Immunogenetics. 2018 Feb;70(2):125-133. doi: 10.1007/s00251-017-1018-2. Epub 2017 Jul 1.


CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic target.

Marsh JW, Ong VA, Lott WB, Timms P, Tyndall JD, Huston WM.

Future Microbiol. 2017 Jul;12:817-829. doi: 10.2217/fmb-2017-0017. Epub 2017 Jun 8. Review.


Immunization of a wild koala population with a recombinant Chlamydia pecorum Major Outer Membrane Protein (MOMP) or Polymorphic Membrane Protein (PMP) based vaccine: New insights into immune response, protection and clearance.

Desclozeaux M, Robbins A, Jelocnik M, Khan SA, Hanger J, Gerdts V, Potter A, Polkinghorne A, Timms P.

PLoS One. 2017 Jun 2;12(6):e0178786. doi: 10.1371/journal.pone.0178786. eCollection 2017.


Safety and immunogenicity of a prototype anti-Chlamydia pecorum recombinant protein vaccine in lambs and pregnant ewes.

Desclozeaux M, Jelocnik M, Whitting K, Saifzadeh S, Bommana S, Potter A, Gerdts V, Timms P, Polkinghorne A.

Vaccine. 2017 Jun 14;35(27):3461-3465. doi: 10.1016/j.vaccine.2017.03.091. Epub 2017 May 18.


Measurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS).

Vodstrcil LA, Rupasinghe TWT, Kong FYS, Tull D, Worthington K, Chen MY, Huston WM, Timms P, McConville MJ, Fairley CK, Bradshaw CS, Tabrizi SN, Hocking JS.

PLoS One. 2017 May 12;12(5):e0177615. doi: 10.1371/journal.pone.0177615. eCollection 2017.


Sectioning on the street - futility or utility?

Timms P, Perry J.

BJPsych Bull. 2016 Dec;40(6):302-305. doi: 10.1192/pb.bp.115.052449.


Infection with koala retrovirus subgroup B (KoRV-B), but not KoRV-A, is associated with chlamydial disease in free-ranging koalas (Phascolarctos cinereus).

Waugh CA, Hanger J, Loader J, King A, Hobbs M, Johnson R, Timms P.

Sci Rep. 2017 Mar 9;7(1):134. doi: 10.1038/s41598-017-00137-4.


Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK.

Jolliffe DA, James WY, Hooper RL, Barnes NC, Greiller CL, Islam K, Bhowmik A, Timms PM, Rajakulasingam RK, Choudhury AB, Simcock DE, Hyppönen E, Walton RT, Corrigan CJ, Griffiths CJ, Martineau AR.

J Steroid Biochem Mol Biol. 2018 Jan;175:138-145. doi: 10.1016/j.jsbmb.2017.01.019. Epub 2017 Feb 1.

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