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Items: 1 to 50 of 69

1.

Evidence-based obviousness for use in patent prosecution and review.

Timmins GS.

Nat Biotechnol. 2019 Sep;37(9):997-1000. doi: 10.1038/s41587-019-0232-x. No abstract available.

PMID:
31485044
2.

Potential for breath test diagnosis of urease positive pathogens in lung infections.

Bishai WR, Timmins GS.

J Breath Res. 2019 Jun 4;13(3):032002. doi: 10.1088/1752-7163/ab2225.

PMID:
31096193
3.

Enhancement of lung levels of antibiotics by ambroxol and bromhexine.

Deretic V, Timmins GS.

Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218. doi: 10.1080/17425255.2019.1578748. Epub 2019 Feb 7. Review.

PMID:
30721101
4.

Pharmacist perceptions of the New Mexico pharmacist-performed tuberculosis testing program.

Logothetis SJ, Borrego ME, Roberts MH, Bachyrycz A, Timmins GS, Jakeman B.

J Am Pharm Assoc (2003). 2018 Nov - Dec;58(6):647-651. doi: 10.1016/j.japh.2018.08.010. Epub 2018 Sep 28.

PMID:
30274884
5.

Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity.

Choi SW, Gu Y, Peters RS, Salgame P, Ellner JJ, Timmins GS, Deretic V.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e01019-18. doi: 10.1128/AAC.01019-18. Print 2018 Sep.

6.

Normobaric Hyperoxia Reduces Blood Occludin Fragments in Rats and Patients With Acute Ischemic Stroke.

Shi S, Qi Z, Ma Q, Pan R, Timmins GS, Zhao Y, Shi W, Zhang Y, Ji X, Liu KJ.

Stroke. 2017 Oct;48(10):2848-2854. doi: 10.1161/STROKEAHA.117.017713. Epub 2017 Sep 20.

7.

Deuterated drugs; updates and obviousness analysis.

Timmins GS.

Expert Opin Ther Pat. 2017 Dec;27(12):1353-1361. doi: 10.1080/13543776.2017.1378350. Epub 2017 Sep 14. Review. Erratum in: Expert Opin Ther Pat. 2018 Aug;28(8):653.

PMID:
28885861
8.

Stool microbiome reveals diverse bacterial ureases as confounders of oral urea breath testing for Helicobacter pylori and Mycobacterium tuberculosis in Bamako, Mali.

Maiga M, Cohen K, Baya B, Srikrishna G, Siddiqui S, Sanogo M, Somboro AM, Diarra B, Diallo MH, Mazumdar V, Yoder C, Orsega S, Belson M, Kassambara H, Goita D, Murphy RL, Dao S, Polis M, Diallo S, Timmins GS, Dodd L, Earl AM, Bishai WR.

J Breath Res. 2016 Aug 17;10(3):036012. doi: 10.1088/1752-7155/10/3/036012.

9.
10.

Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential.

Chauhan S, Ahmed Z, Bradfute SB, Arko-Mensah J, Mandell MA, Won Choi S, Kimura T, Blanchet F, Waller A, Mudd MH, Jiang S, Sklar L, Timmins GS, Maphis N, Bhaskar K, Piguet V, Deretic V.

Nat Commun. 2015 Oct 27;6:8620. doi: 10.1038/ncomms9620.

11.

Spray-Dried Multiscale Nano-biocomposites Containing Living Cells.

Johnson PE, Muttil P, MacKenzie D, Carnes EC, Pelowitz J, Mara NA, Mook WM, Jett SD, Dunphy DR, Timmins GS, Brinker CJ.

ACS Nano. 2015 Jul 28;9(7):6961-77. doi: 10.1021/acsnano.5b01139. Epub 2015 Jun 17.

PMID:
26083188
12.

Detecting virulence and drug-resistance mycobacterial phenotypes in vivo.

Timmins GS.

Trends Microbiol. 2015 Jun;23(6):321-3. doi: 10.1016/j.tim.2015.02.013. Epub 2015 Mar 21.

13.

Autophagy Mediates Astrocyte Death During Zinc-Potentiated Ischemia--Reperfusion Injury.

Pan R, Timmins GS, Liu W, Liu KJ.

Biol Trace Elem Res. 2015 Jul;166(1):89-95. doi: 10.1007/s12011-015-0287-6. Epub 2015 Mar 12.

14.

Rapid in vivo detection of isoniazid-sensitive Mycobacterium tuberculosis by breath test.

Choi SW, Maiga M, Maiga MC, Atudorei V, Sharp ZD, Bishai WR, Timmins GS.

Nat Commun. 2014 Sep 23;5:4989. doi: 10.1038/ncomms5989.

15.

Deuterated drugs: where are we now?

Timmins GS.

Expert Opin Ther Pat. 2014 Oct;24(10):1067-75. doi: 10.1517/13543776.2014.943184. Epub 2014 Jul 29. Review.

16.

In vitro and in vivo studies of a rapid and selective breath test for tuberculosis based upon mycobacterial CO dehydrogenase.

Maiga M, Choi SW, Atudorei V, Maiga MC, Sharp ZD, Bishai WR, Timmins GS.

MBio. 2014 Apr 15;5(2):e00990. doi: 10.1128/mBio.00990-14.

17.

Nox2 modification of LDL is essential for optimal apolipoprotein B-mediated control of agr type III Staphylococcus aureus quorum-sensing.

Hall PR, Elmore BO, Spang CH, Alexander SM, Manifold-Wheeler BC, Castleman MJ, Daly SM, Peterson MM, Sully EK, Femling JK, Otto M, Horswill AR, Timmins GS, Gresham HD.

PLoS Pathog. 2013 Feb;9(2):e1003166. doi: 10.1371/journal.ppat.1003166. Epub 2013 Feb 14.

18.

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation.

Castillo EF, Dekonenko A, Arko-Mensah J, Mandell MA, Dupont N, Jiang S, Delgado-Vargas M, Timmins GS, Bhattacharya D, Yang H, Hutt J, Lyons CR, Dobos KM, Deretic V.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3168-76. doi: 10.1073/pnas.1210500109. Epub 2012 Oct 23.

19.

Reporter phage and breath tests: emerging phenotypic assays for diagnosing active tuberculosis, antibiotic resistance, and treatment efficacy.

Jain P, Thaler DS, Maiga M, Timmins GS, Bishai WR, Hatfull GF, Larsen MH, Jacobs WR.

J Infect Dis. 2011 Nov 15;204 Suppl 4:S1142-50. doi: 10.1093/infdis/jir454. Review.

20.

13[C]-urea breath test as a novel point-of-care biomarker for tuberculosis treatment and diagnosis.

Jassal MS, Nedeltchev GG, Lee JH, Choi SW, Atudorei V, Sharp ZD, Deretic V, Timmins GS, Bishai WR.

PLoS One. 2010 Aug 27;5(8):e12451. doi: 10.1371/journal.pone.0012451.

21.

Stable isotope-labeled excipients for drug product identification and counterfeit detection.

Felton LA, Shah PP, Sharp Z, Atudorei V, Timmins GS.

Drug Dev Ind Pharm. 2011 Jan;37(1):88-92. doi: 10.3109/03639045.2010.492397. Epub 2010 Jun 19.

PMID:
20560792
22.

Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria.

Carnes EC, Lopez DM, Donegan NP, Cheung A, Gresham H, Timmins GS, Brinker CJ.

Nat Chem Biol. 2010 Jan;6(1):41-5. doi: 10.1038/nchembio.264. Epub 2009 Nov 22.

23.

Direct visualization of mouse brain oxygen distribution by electron paramagnetic resonance imaging: application to focal cerebral ischemia.

Shen J, Sood R, Weaver J, Timmins GS, Schnell A, Miyake M, Kao JP, Rosen GM, Liu KJ.

J Cereb Blood Flow Metab. 2009 Oct;29(10):1695-703. doi: 10.1038/jcbfm.2009.89. Epub 2009 Jul 15.

24.

Drugs: From Discovery to Approval:Drugs: From Discovery to Approval.

Timmins GS.

Drug Dev Ind Pharm. 2009 May 26. [Epub ahead of print] No abstract available.

PMID:
19466899
25.

Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity.

Qin XJ, Hudson LG, Liu W, Timmins GS, Liu KJ.

Toxicol Appl Pharmacol. 2008 Oct 1;232(1):41-50. doi: 10.1016/j.taap.2008.05.019. Epub 2008 Jul 10.

26.

Mycobacterium tuberculosis prevents inflammasome activation.

Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V.

Cell Host Microbe. 2008 Apr 17;3(4):224-32. doi: 10.1016/j.chom.2008.03.003.

27.
28.

Pharmacological modulation of cGMP levels by phosphodiesterase 5 inhibitors as a therapeutic strategy for treatment of respiratory pathology in cystic fibrosis.

Poschet JF, Timmins GS, Taylor-Cousar JL, Ornatowski W, Fazio J, Perkett E, Wilson KR, Yu HD, de Jonge HR, Deretic V.

Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L712-9. Epub 2007 Jun 22.

29.

Melanoma, long wavelength ultraviolet and sunscreens: controversies and potential resolutions.

Lund LP, Timmins GS.

Pharmacol Ther. 2007 May;114(2):198-207. Epub 2007 Feb 15. Review.

PMID:
17376535
30.

Nitrosative stress inhibits production of the virulence factor alginate in mucoid Pseudomonas aeruginosa.

Wood SR, Firoved AM, Ornatowski W, Mai T, Deretic V, Timmins GS.

Free Radic Res. 2007 Feb;41(2):208-15.

PMID:
17364947
31.

Mechanisms of action of isoniazid.

Timmins GS, Deretic V.

Mol Microbiol. 2006 Dec;62(5):1220-7. Epub 2006 Oct 27. Review.

32.

UV radiation induces delayed hyperrecombination associated with hypermutation in human cells.

Durant ST, Paffett KS, Shrivastav M, Timmins GS, Morgan WF, Nickoloff JA.

Mol Cell Biol. 2006 Aug;26(16):6047-55.

33.

Endosomal hyperacidification in cystic fibrosis is due to defective nitric oxide-cylic GMP signalling cascade.

Poschet JF, Fazio JA, Timmins GS, Ornatowski W, Perkett E, Delgado M, Deretic V.

EMBO Rep. 2006 May;7(5):553-9. Epub 2006 Apr 13.

34.

Molecular and physiological effects of mycobacterial oxyR inactivation.

Pagán-Ramos E, Master SS, Pritchett CL, Reimschuessel R, Trucksis M, Timmins GS, Deretic V.

J Bacteriol. 2006 Apr;188(7):2674-80.

35.

A nondestructive technique to determine the rate of oxygen permeation into solid dosage forms.

Felton LA, Timmins GS.

Pharm Dev Technol. 2006 Feb;11(1):141-7.

PMID:
16544917
36.

UV causation of melanoma in Xiphophorus is dominated by melanin photosensitized oxidant production.

Wood SR, Berwick M, Ley RD, Walter RB, Setlow RB, Timmins GS.

Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4111-5. Epub 2006 Mar 6.

37.

Measurement of S-nitrosothiols in extracellular fluids from healthy human volunteers and rheumatoid arthritis patients, using electron paramagnetic resonance spectrometry.

Rocks SA, Davies CA, Hicks SL, Webb AJ, Klocke R, Timmins GS, Johnston A, Jawad AS, Blake DR, Benjamin N, Winyard PG.

Free Radic Biol Med. 2005 Oct 1;39(7):937-48.

PMID:
16140213
38.

Endothelin-1-mediated increase in reactive oxygen species and NADPH Oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null mice.

Lund AK, Peterson SL, Timmins GS, Walker MK.

Toxicol Sci. 2005 Nov;88(1):265-73. Epub 2005 Aug 17.

PMID:
16107552
39.

Application of in vivo EPR in brain research: monitoring tissue oxygenation, blood flow, and oxidative stress.

Liu S, Timmins GS, Shi H, Gasparovic CM, Liu KJ.

NMR Biomed. 2004 Aug;17(5):327-34.

PMID:
15366032
40.

Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense.

Rothfork JM, Timmins GS, Harris MN, Chen X, Lusis AJ, Otto M, Cheung AL, Gresham HD.

Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13867-72. Epub 2004 Sep 7.

41.
42.

Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis.

Timmins GS, Master S, Rusnak F, Deretic V.

Antimicrob Agents Chemother. 2004 Aug;48(8):3006-9.

43.

Microarray analysis and functional characterization of the nitrosative stress response in nonmucoid and mucoid Pseudomonas aeruginosa.

Firoved AM, Wood SR, Ornatowski W, Deretic V, Timmins GS.

J Bacteriol. 2004 Jun;186(12):4046-50.

44.

Xanthine oxidase activates pro-matrix metalloproteinase-2 in cultured rat vascular smooth muscle cells through non-free radical mechanisms.

Liu W, Rosenberg GA, Shi H, Furuichi T, Timmins GS, Cunningham LA, Liu KJ.

Arch Biochem Biophys. 2004 Jun 1;426(1):11-7.

PMID:
15130778
45.

Mycobacteria inhibit nitric oxide synthase recruitment to phagosomes during macrophage infection.

Miller BH, Fratti RA, Poschet JF, Timmins GS, Master SS, Burgos M, Marletta MA, Deretic V.

Infect Immun. 2004 May;72(5):2872-8.

46.

Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats.

Liu S, Shi H, Liu W, Furuichi T, Timmins GS, Liu KJ.

J Cereb Blood Flow Metab. 2004 Mar;24(3):343-9.

PMID:
15091115
47.

Comparison of cross-linked polyethylene materials for orthopaedic applications.

Collier JP, Currier BH, Kennedy FE, Currier JH, Timmins GS, Jackson SK, Brewer RL.

Clin Orthop Relat Res. 2003 Sep;(414):289-304.

PMID:
12966304
48.

Determining the site of spin trapping of the equine myoglobin radical by combined use of EPR, electrophoretic purification, and mass spectrometry.

Harris MN, Burchiel SW, Winyard PG, Engen JR, Mobarak CD, Timmins GS.

Chem Res Toxicol. 2002 Dec;15(12):1589-94.

PMID:
12482241
49.

Oxidative stress response genes in Mycobacterium tuberculosis: role of ahpC in resistance to peroxynitrite and stage-specific survival in macrophages.

Master SS, Springer B, Sander P, Boettger EC, Deretic V, Timmins GS.

Microbiology. 2002 Oct;148(Pt 10):3139-44.

PMID:
12368447

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