Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 124

1.

De Novo Heterozygous POLR2A Variants Cause a Neurodevelopmental Syndrome with Profound Infantile-Onset Hypotonia.

Haijes HA, Koster MJE, Rehmann H, Li D, Hakonarson H, Cappuccio G, Hancarova M, Lehalle D, Reardon W, Schaefer GB, Lehman A, van de Laar IMBH, Tesselaar CD, Turner C, Goldenberg A, Patrier S, Thevenon J, Pinelli M, Brunetti-Pierri N, Prchalová D, Havlovicová M, Vlckova M, Sedláček Z, Lopez E, Ragoussis V, Pagnamenta AT, Kini U, Vos HR, van Es RM, van Schaik RFMA, van Essen TAJ, Kibaek M, Taylor JC, Sullivan J, Shashi V, Petrovski S, Fagerberg C, Martin DM, van Gassen KLI, Pfundt R, Falk MJ, McCormick EM, Timmers HTM, van Hasselt PM.

Am J Hum Genet. 2019 Aug 1;105(2):283-301. doi: 10.1016/j.ajhg.2019.06.016. Epub 2019 Jul 25.

PMID:
31353023
2.

Promoter Recognition: Putting TFIID on the Spot.

Bhuiyan T, Timmers HTM.

Trends Cell Biol. 2019 Sep;29(9):752-763. doi: 10.1016/j.tcb.2019.06.004. Epub 2019 Jul 9. Review.

PMID:
31300188
3.

Epigenetics and transcription regulation during eukaryotic diversification: the saga of TFIID.

Antonova SV, Boeren J, Timmers HTM, Snel B.

Genes Dev. 2019 Aug 1;33(15-16):888-902. doi: 10.1101/gad.300475.117. Epub 2019 May 23.

PMID:
31123066
4.

Co-translational assembly of mammalian nuclear multisubunit complexes.

Kamenova I, Mukherjee P, Conic S, Mueller F, El-Saafin F, Bardot P, Garnier JM, Dembele D, Capponi S, Timmers HTM, Vincent SD, Tora L.

Nat Commun. 2019 Apr 15;10(1):1740. doi: 10.1038/s41467-019-09749-y.

5.

Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly.

Antonova SV, Haffke M, Corradini E, Mikuciunas M, Low TY, Signor L, van Es RM, Gupta K, Scheer E, Vos HR, Tora L, Heck AJR, Timmers HTM, Berger I.

Nat Struct Mol Biol. 2018 Dec;25(12):1119-1127. doi: 10.1038/s41594-018-0156-z. Epub 2018 Dec 3.

6.

Transcript Buffering: A Balancing Act between mRNA Synthesis and mRNA Degradation.

Timmers HTM, Tora L.

Mol Cell. 2018 Oct 4;72(1):10-17. doi: 10.1016/j.molcel.2018.08.023. Review.

PMID:
30290147
7.

Genomic integrity of ground-state pluripotency.

Jafari N, Giehr P, Hesaraki M, Baas R, de Graaf P, Timmers HTM, Walter J, Baharvand H, Totonchi M.

J Cell Biochem. 2018 Dec;119(12):9781-9789. doi: 10.1002/jcb.27296. Epub 2018 Sep 1.

PMID:
30171711
8.

SAGA Is a General Cofactor for RNA Polymerase II Transcription.

Baptista T, Grünberg S, Minoungou N, Koster MJE, Timmers HTM, Hahn S, Devys D, Tora L.

Mol Cell. 2018 Jun 21;70(6):1163-1164. doi: 10.1016/j.molcel.2018.06.007. No abstract available.

9.

DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment.

Conemans EB, Lodewijk L, Moelans CB, Offerhaus GJA, Pieterman CRC, Morsink FH, Dekkers OM, de Herder WW, Hermus AR, van der Horst-Schrivers AN, Drent ML, Bisschop PH, Havekes B, Brosens LAA, Dreijerink KMA, Borel Rinkes IHM, Timmers HTM, Valk GD, Vriens MR.

Eur J Endocrinol. 2018 Sep;179(3):153-160. doi: 10.1530/EJE-18-0195. Epub 2018 Jun 14.

PMID:
29903750
10.

Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly.

Aneichyk T, Hendriks WT, Yadav R, Shin D, Gao D, Vaine CA, Collins RL, Domingo A, Currall B, Stortchevoi A, Multhaupt-Buell T, Penney EB, Cruz L, Dhakal J, Brand H, Hanscom C, Antolik C, Dy M, Ragavendran A, Underwood J, Cantsilieris S, Munson KM, Eichler EE, Acuña P, Go C, Jamora RDG, Rosales RL, Church DM, Williams SR, Garcia S, Klein C, Müller U, Wilhelmsen KC, Timmers HTM, Sapir Y, Wainger BJ, Henderson D, Ito N, Weisenfeld N, Jaffe D, Sharma N, Breakefield XO, Ozelius LJ, Bragg DC, Talkowski ME.

Cell. 2018 Feb 22;172(5):897-909.e21. doi: 10.1016/j.cell.2018.02.011.

11.

Expression of p27Kip1 and p18Ink4c in human multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors.

Conemans EB, Raicu-Ionita GM, Pieterman CRC, Dreijerink KMA, Dekkers OM, Hermus AR, de Herder WW, Drent ML, van der Horst-Schrivers ANA, Havekes B, Bisschop PH, Offerhaus GJ, Borel Rinkes IHM, Valk GD, Timmers HTM, Vriens MR.

J Endocrinol Invest. 2018 Jun;41(6):655-661. doi: 10.1007/s40618-017-0783-y. Epub 2017 Nov 13.

PMID:
29134609
12.

Mitotic Chromosomes: Not So Silent After All.

Timmers HTM, Verrijzer CP.

Dev Cell. 2017 Oct 23;43(2):119-121. doi: 10.1016/j.devcel.2017.10.002.

13.

The mixed lineage leukemia 4 (MLL4) methyltransferase complex is involved in transforming growth factor beta (TGF-β)-activated gene transcription.

Baas R, van Teeffelen HAAM, Tjalsma SJD, Timmers HTM.

Transcription. 2018;9(2):67-74. doi: 10.1080/21541264.2017.1373890. Epub 2017 Nov 3.

14.

SAGA Is a General Cofactor for RNA Polymerase II Transcription.

Baptista T, Grünberg S, Minoungou N, Koster MJE, Timmers HTM, Hahn S, Devys D, Tora L.

Mol Cell. 2017 Oct 5;68(1):130-143.e5. doi: 10.1016/j.molcel.2017.08.016. Epub 2017 Sep 14. Erratum in: Mol Cell. 2018 Jun 21;70(6):1163-1164.

15.

Twenty years of menin: emerging opportunities for restoration of transcriptional regulation in MEN1.

Dreijerink KMA, Timmers HTM, Brown M.

Endocr Relat Cancer. 2017 Oct;24(10):T135-T145. doi: 10.1530/ERC-17-0281. Epub 2017 Aug 15. Review.

16.

Prognostic value of WHO grade in pancreatic neuro-endocrine tumors in Multiple Endocrine Neoplasia type 1: Results from the DutchMEN1 Study Group.

Conemans EB, Brosens LAA, Raicu-Ionita GM, Pieterman CRC, de Herder WW, Dekkers OM, Hermus AR, van der Horst-Schrivers AN, Bisschop PH, Havekes B, Drent ML, Timmers HTM, Offerhaus GJ, Valk GD, Vriens MR.

Pancreatology. 2017 Sep - Oct;17(5):766-772. doi: 10.1016/j.pan.2017.07.196. Epub 2017 Jul 31.

PMID:
28811081
17.

Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals.

Xue Y, Pradhan SK, Sun F, Chronis C, Tran N, Su T, Van C, Vashisht A, Wohlschlegel J, Peterson CL, Timmers HTM, Kurdistani SK, Carey MF.

Mol Cell. 2017 Aug 17;67(4):594-607.e4. doi: 10.1016/j.molcel.2017.06.029. Epub 2017 Jul 20.

18.

Genesis of chromatin and transcription dynamics in the origin of species.

Koster MJ, Snel B, Timmers HT.

Cell. 2015 May 7;161(4):724-36. doi: 10.1016/j.cell.2015.04.033. Review.

19.

Regulation of anti-sense transcription by Mot1p and NC2 via removal of TATA-binding protein (TBP) from the 3'-end of genes.

Koster MJ, Timmers HT.

Nucleic Acids Res. 2015 Jan;43(1):143-52. doi: 10.1093/nar/gku1263. Epub 2014 Nov 28.

20.

Breast-cancer predisposition in multiple endocrine neoplasia type 1.

Dreijerink KM, Goudet P, Burgess JR, Valk GD; International Breast Cancer in MEN1 Study Group.

N Engl J Med. 2014 Aug 7;371(6):583-4. doi: 10.1056/NEJMc1406028. No abstract available.

21.

Suppression of intragenic transcription requires the MOT1 and NC2 regulators of TATA-binding protein.

Koster MJ, Yildirim AD, Weil PA, Holstege FC, Timmers HT.

Nucleic Acids Res. 2014 Apr;42(7):4220-9. doi: 10.1093/nar/gkt1398. Epub 2014 Jan 22.

22.

Thoracic and duodenopancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1: natural history and function of menin in tumorigenesis.

Pieterman CR, Conemans EB, Dreijerink KM, de Laat JM, Timmers HT, Vriens MR, Valk GD.

Endocr Relat Cancer. 2014 May 6;21(3):R121-42. doi: 10.1530/ERC-13-0482. Print 2014 Jun. Review.

PMID:
24389729
23.

A novel microscopy-based high-throughput screening method to identify proteins that regulate global histone modification levels.

Baas R, Lelieveld D, van Teeffelen H, Lijnzaad P, Castelijns B, van Schaik FM, Vermeulen M, Egan DA, Timmers HT, de Graaf P.

J Biomol Screen. 2014 Feb;19(2):287-96. doi: 10.1177/1087057113515024. Epub 2013 Dec 11.

PMID:
24334265
24.

A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation.

Schram AW, Baas R, Jansen PW, Riss A, Tora L, Vermeulen M, Timmers HT.

PLoS One. 2013 Jul 23;8(7):e70035. doi: 10.1371/journal.pone.0070035. Print 2013.

25.

Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain.

van Nuland R, van Schaik FM, Simonis M, van Heesch S, Cuppen E, Boelens R, Timmers HM, van Ingen H.

Epigenetics Chromatin. 2013 May 8;6(1):12. doi: 10.1186/1756-8935-6-12.

26.

Epigenetic dynamics in psychiatric disorders: environmental programming of neurodevelopmental processes.

Kofink D, Boks MP, Timmers HT, Kas MJ.

Neurosci Biobehav Rev. 2013 Jun;37(5):831-45. doi: 10.1016/j.neubiorev.2013.03.020. Epub 2013 Apr 6. Review.

PMID:
23567520
27.

Balancing of histone H3K4 methylation states by the Kdm5c/SMCX histone demethylase modulates promoter and enhancer function.

Outchkourov NS, Muiño JM, Kaufmann K, van Ijcken WF, Groot Koerkamp MJ, van Leenen D, de Graaf P, Holstege FC, Grosveld FG, Timmers HT.

Cell Rep. 2013 Apr 25;3(4):1071-9. doi: 10.1016/j.celrep.2013.02.030. Epub 2013 Mar 28.

28.

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

van Nuland R, Smits AH, Pallaki P, Jansen PW, Vermeulen M, Timmers HT.

Mol Cell Biol. 2013 May;33(10):2067-77. doi: 10.1128/MCB.01742-12. Epub 2013 Mar 18.

29.

A central role for TFIID in the pluripotent transcription circuitry.

Pijnappel WW, Esch D, Baltissen MP, Wu G, Mischerikow N, Bergsma AJ, van der Wal E, Han DW, Bruch Hv, Moritz S, Lijnzaad P, Altelaar AF, Sameith K, Zaehres H, Heck AJ, Holstege FC, Schöler HR, Timmers HT.

Nature. 2013 Mar 28;495(7442):516-9. doi: 10.1038/nature11970. Epub 2013 Mar 17.

PMID:
23503660
30.

Dynamic control of selectivity in the ubiquitination pathway revealed by an ASP to GLU substitution in an intra-molecular salt-bridge network.

van Wijk SJ, Melquiond AS, de Vries SJ, Timmers HT, Bonvin AM.

PLoS Comput Biol. 2012;8(11):e1002754. doi: 10.1371/journal.pcbi.1002754. Epub 2012 Nov 1.

31.

Benchmarking stable isotope labeling based quantitative proteomics.

Altelaar AF, Frese CK, Preisinger C, Hennrich ML, Schram AW, Timmers HT, Heck AJ, Mohammed S.

J Proteomics. 2013 Aug 2;88:14-26. doi: 10.1016/j.jprot.2012.10.009. Epub 2012 Oct 22.

PMID:
23085607
32.

Cell cycle regulation by the PRMT6 arginine methyltransferase through repression of cyclin-dependent kinase inhibitors.

Kleinschmidt MA, de Graaf P, van Teeffelen HA, Timmers HT.

PLoS One. 2012;7(8):e41446. doi: 10.1371/journal.pone.0041446. Epub 2012 Aug 20.

33.

ATAC-king the complexity of SAGA during evolution.

Spedale G, Timmers HT, Pijnappel WW.

Genes Dev. 2012 Mar 15;26(6):527-41. doi: 10.1101/gad.184705.111. Review.

34.

Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome.

Choukrallah MA, Kobi D, Martianov I, Pijnappel WW, Mischerikow N, Ye T, Heck AJ, Timmers HT, Davidson I.

Nucleic Acids Res. 2012 Feb;40(4):1446-59. doi: 10.1093/nar/gkr802. Epub 2011 Oct 19.

35.

Tight cooperation between Mot1p and NC2β in regulating genome-wide transcription, repression of transcription following heat shock induction and genetic interaction with SAGA.

Spedale G, Meddens CA, Koster MJ, Ko CW, van Hooff SR, Holstege FC, Timmers HT, Pijnappel WW.

Nucleic Acids Res. 2012 Feb;40(3):996-1008. doi: 10.1093/nar/gkr784. Epub 2011 Oct 5.

36.

Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin.

Sandler H, Kreth J, Timmers HT, Stoecklin G.

Nucleic Acids Res. 2011 May;39(10):4373-86. doi: 10.1093/nar/gkr011. Epub 2011 Jan 29.

37.

A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.

Varier RA, Outchkourov NS, de Graaf P, van Schaik FM, Ensing HJ, Wang F, Higgins JM, Kops GJ, Timmers HT.

EMBO J. 2010 Dec 1;29(23):3967-78. doi: 10.1038/emboj.2010.261. Epub 2010 Oct 15.

38.

Histone lysine methylation and demethylation pathways in cancer.

Varier RA, Timmers HT.

Biochim Biophys Acta. 2011 Jan;1815(1):75-89. doi: 10.1016/j.bbcan.2010.10.002. Epub 2010 Oct 15. Review.

PMID:
20951770
39.

The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties.

Bonnet J, Wang YH, Spedale G, Atkinson RA, Romier C, Hamiche A, Pijnappel WW, Timmers HT, Tora L, Devys D, Kieffer B.

EMBO Rep. 2010 Aug;11(8):612-8. doi: 10.1038/embor.2010.98. Epub 2010 Jul 16.

40.

Chromatin interaction of TATA-binding protein is dynamically regulated in human cells.

de Graaf P, Mousson F, Geverts B, Scheer E, Tora L, Houtsmuller AB, Timmers HT.

J Cell Sci. 2010 Aug 1;123(Pt 15):2663-71. doi: 10.1242/jcs.064097. Epub 2010 Jul 13.

41.

Grasping trimethylation of histone H3 at lysine 4.

Vermeulen M, Timmers HT.

Epigenomics. 2010 Jun;2(3):395-406. doi: 10.2217/epi.10.11. Review.

PMID:
22121900
42.

Identification of Pep4p as the protease responsible for formation of the SAGA-related SLIK protein complex.

Spedale G, Mischerikow N, Heck AJ, Timmers HT, Pijnappel WW.

J Biol Chem. 2010 Jul 23;285(30):22793-9. doi: 10.1074/jbc.M110.108787. Epub 2010 May 24.

43.

A role for BAF57 in cell cycle-dependent transcriptional regulation by the SWI/SNF chromatin remodeling complex.

Hah N, Kolkman A, Ruhl DD, Pijnappel WW, Heck AJ, Timmers HT, Kraus WL.

Cancer Res. 2010 Jun 1;70(11):4402-11. doi: 10.1158/0008-5472.CAN-09-2767. Epub 2010 May 11.

44.

PHF8 targets histone methylation and RNA polymerase II to activate transcription.

Fortschegger K, de Graaf P, Outchkourov NS, van Schaik FM, Timmers HT, Shiekhattar R.

Mol Cell Biol. 2010 Jul;30(13):3286-98. doi: 10.1128/MCB.01520-09. Epub 2010 Apr 26.

45.

Phosphorylation of Not4p functions parallel to BUR2 to regulate resistance to cellular stresses in Saccharomyces cerevisiae.

Lau NC, Mulder KW, Brenkman AB, Mohammed S, van den Broek NJ, Heck AJ, Timmers HT.

PLoS One. 2010 Apr 8;5(4):e9864. doi: 10.1371/journal.pone.0009864.

46.

Comparing genome-wide chromatin profiles using ChIP-chip or ChIP-seq.

Johannes F, Wardenaar R, Colomé-Tatché M, Mousson F, de Graaf P, Mokry M, Guryev V, Timmers HT, Cuppen E, Jansen RC.

Bioinformatics. 2010 Apr 15;26(8):1000-6. doi: 10.1093/bioinformatics/btq087. Epub 2010 Mar 5.

PMID:
20208068
47.

The TATA box regulates TATA-binding protein (TBP) dynamics in vivo.

Tora L, Timmers HT.

Trends Biochem Sci. 2010 Jun;35(6):309-14. doi: 10.1016/j.tibs.2010.01.007. Epub 2010 Feb 21.

PMID:
20176488
48.

The spectacular landscape of chromatin and ncRNAs under the Tico sunlight.

Timmers HT, Tora L.

EMBO Rep. 2010 Mar;11(3):147-9. doi: 10.1038/embor.2010.26. Epub 2010 Feb 12.

49.

Quantitative mass spectrometry of TATA binding protein-containing complexes and subunit phosphorylations during the cell cycle.

Pijnappel WP, Kolkman A, Baltissen MP, Heck AJ, Timmers HM.

Proteome Sci. 2009 Dec 24;7:46. doi: 10.1186/1477-5956-7-46.

50.

The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins.

van Wijk SJ, Timmers HT.

FASEB J. 2010 Apr;24(4):981-93. doi: 10.1096/fj.09-136259. Epub 2009 Nov 25. Review.

PMID:
19940261

Supplemental Content

Loading ...
Support Center