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Items: 1 to 50 of 295

1.

Discovery of INT131: a selective PPARĪ³ modulator that enhances insulin sensitivity.

Taygerly JP, McGee LR, Rubenstein SM, Houze JB, Cushing TD, Li Y, Motani A, Chen JL, Frankmoelle W, Ye G, Learned MR, Jaen J, Miao S, Timmermans PB, Thoolen M, Kearney P, Flygare J, Beckmann H, Weiszmann J, Lindstrom M, Walker N, Liu J, Biermann D, Wang Z, Hagiwara A, Iida T, Aramaki H, Kitao Y, Shinkai H, Furukawa N, Nishiu J, Nakamura M.

Bioorg Med Chem. 2013 Feb 15;21(4):979-92. doi: 10.1016/j.bmc.2012.11.058. Epub 2012 Dec 10.

PMID:
23294830
2.

Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.

Menzella HG, Tran TT, Carney JR, Lau-Wee J, Galazzo J, Reeves CD, Carreras C, Mukadam S, Eng S, Zhong Z, Timmermans PB, Murli S, Ashley GW.

J Med Chem. 2009 Mar 26;52(6):1518-21. doi: 10.1021/jm900012a.

PMID:
19231864
3.

Identification of nuclear export inhibitors with potent anticancer activity in vivo.

Mutka SC, Yang WQ, Dong SD, Ward SL, Craig DA, Timmermans PB, Murli S.

Cancer Res. 2009 Jan 15;69(2):510-7. doi: 10.1158/0008-5472.CAN-08-0858.

4.

Pharmacological properties of angiotensin II receptor antagonists.

Timmermans PB.

Can J Cardiol. 1999 Nov;15 Suppl F:26F-8F. Review.

PMID:
10579749
5.
6.

Selective, covalent modification of beta-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors.

Shan B, Medina JC, Santha E, Frankmoelle WP, Chou TC, Learned RM, Narbut MR, Stott D, Wu P, Jaen JC, Rosen T, Timmermans PB, Beckmann H.

Proc Natl Acad Sci U S A. 1999 May 11;96(10):5686-91.

7.

Rationale, background, and design of the randomized angiotensin receptor antagonist--angiotensin-converting enzyme inhibitor study (RAAS).

Pitt B, Chang P, Grossman W, Dunlay M, Timmermans PB.

Am J Cardiol. 1996 Nov 15;78(10):1129-31.

PMID:
8914876
8.

Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.

Wexler RR, Greenlee WJ, Irvin JD, Goldberg MR, Prendergast K, Smith RD, Timmermans PB.

J Med Chem. 1996 Feb 2;39(3):625-56. Review. No abstract available.

PMID:
8576904
9.

Historical development of losartan (DuP 753) and angiotensin II receptor subtypes.

Wong PC, Timmermans PB.

Blood Press Suppl. 1996;3:11-4. Review.

PMID:
8973760
10.

The diversified pharmacology of angiotensin II-receptor blockade.

Timmermans PB, Smith RD.

Blood Press Suppl. 1996;2:53-61. Review.

PMID:
8913541
11.

Discovery of losartan, the first angiotensin II receptor antagonist.

Timmermans PB, Duncia JV, Carini DJ, Chiu AT, Wong PC, Wexler RR, Smith RD.

J Hum Hypertens. 1995 Nov;9 Suppl 5:S3-18. Review.

PMID:
8583479
12.

Pharmacology and pharmacokinetics of a novel nonpeptide angiotensin II receptor antagonist--DMP 811.

Wong PC, Huang SM, Ardecky RJ, Carini DJ, Chiu AT, Price WA Jr, Agra AM, Wexler RR, Timmermans PB.

Clin Exp Hypertens. 1995 Nov;17(8):1233-56.

PMID:
8563699
13.
14.

Balanced AT1/AT2 receptor antagonists. 4. XR510 and related 5-(3-amidopropanoyl)imidazoles possessing equal affinity for the AT1 and AT2 receptors.

Quan ML, Chiu AT, Ellis CD, Wong PC, Wexler RR, Timmermans PB.

J Med Chem. 1995 Jul 21;38(15):2938-45.

PMID:
7636854
15.

The preclinical basis of the therapeutic evaluation of losartan.

Timmermans PB, Wong PC, Chiu AT, Smith RD.

J Hypertens Suppl. 1995 Jul;13(1):S1-13. Review.

PMID:
18800450
16.

Proposed update of angiotensin receptor nomenclature.

de Gasparo M, Husain A, Alexander W, Catt KJ, Chiu AT, Drew M, Goodfriend T, Harding JW, Inagami T, Timmermans PB.

Hypertension. 1995 May;25(5):924-7. No abstract available.

PMID:
7737728
17.

Angiotensin II receptor subtypes: selective antagonists and functional correlates.

Timmermans PB, Smith RD.

Eur Heart J. 1994 Dec;15 Suppl D:79-87. Review.

PMID:
7713119
18.

A new class of therapeutic agents: the angiotensin II receptor antagonists.

Timmermans PB, Smith RD.

Cardiologia. 1994 Dec;39(12 Suppl 1):397-400.

PMID:
7634303
19.
20.

EXP597, a nonpeptide angiotensin II receptor antagonist with high affinities for the angiotensin AT1 and AT2 receptor subtypes.

Wong PC, Duncia JV, Santella JB 3rd, Smith RD, Wexler RR, Timmermans PB, Chiu AT.

Eur J Pharmacol. 1994 Aug 1;260(2-3):261-4.

PMID:
7988654
21.

Human angiotensin receptor subtypes.

Smith RD, Timmermans PB.

Curr Opin Nephrol Hypertens. 1994 Jan;3(1):112-22. Review.

PMID:
7850406
22.

A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site.

VanAtten MK, Ensinger CL, Chiu AT, McCall DE, Nguyen TT, Wexler RR, Timmermans PB.

J Med Chem. 1993 Dec 10;36(25):3985-92.

PMID:
8258820
23.

EXP063, a nonpeptide angiotensin II and beta adrenergic receptor antagonist.

Wong PC, Duncia JV, Chiu AT, Olson RE, Rominger DH, Tam SW, Timmermans PB.

J Pharmacol Exp Ther. 1993 Nov;267(2):641-7.

PMID:
7902431
24.

Immunological reactivity of angiotensin II receptor antagonists: possible implications for receptor binding sites.

Bensoussan M, Mitchell T, Reilly T, Timmermans PB, Verroust PJ, Ronco PM.

Eur J Pharmacol. 1993 Oct 15;247(2):169-75.

PMID:
8282006
25.

New perspectives in angiotensin system control.

Timmermans PB, Wong PC, Chiu AT, Herblin WF, Smith RD.

J Hum Hypertens. 1993 Aug;7 Suppl 2:S19-31. Review.

PMID:
8230085
26.

Angiotensin II receptors and angiotensin II receptor antagonists.

Timmermans PB, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JA, Smith RD.

Pharmacol Rev. 1993 Jun;45(2):205-51. Review. No abstract available.

PMID:
8372104
27.

Preservation of regional and global left ventricular function by intracoronary infusion with oxygenated fluorocarbon emulsion Therox in dogs.

Thoolen MJ, Rasbach DE, Shaw JH, Raynolds S, Timmermans PB.

Biomater Artif Cells Immobilization Biotechnol. 1993;21(1):53-62.

PMID:
8461436
28.

Control of blood pressure and end-organ damage in maturing salt-loaded stroke-prone spontaneously hypertensive rats by oral angiotensin II receptor blockade.

Camargo MJ, von Lutterotti N, Campbell WG Jr, Pecker MS, James GD, Timmermans PB, Laragh JH.

J Hypertens. 1993 Jan;11(1):31-40.

PMID:
8382237
29.

Angiotensin II receptors and functional correlates.

Timmermans PB, Benfield P, Chiu AT, Herblin WF, Wong PC, Smith RD.

Am J Hypertens. 1992 Dec;5(12 Pt 2):221S-235S. Review.

PMID:
1290617
30.

Rationale for the chemical development of angiotensin II receptor antagonists.

Wexler RR, Carini DJ, Duncia JV, Johnson AL, Wells GJ, Chiu AT, Wong PC, Timmermans PB.

Am J Hypertens. 1992 Dec;5(12 Pt 2):209S-220S. Review.

PMID:
1290616
31.

Enhancement of losartan (DuP 753)-induced angiotensin II receptor antagonism by PD123177 in rats.

Wong PC, Christ DD, Timmermans PB.

Eur J Pharmacol. 1992 Sep 22;220(2-3):267-70.

PMID:
1425998
32.

Angiotensin II receptor antagonist delays renal damage and stroke in salt-loaded Dahl salt-sensitive rats.

von Lutterotti N, Camargo MJ, Campbell WG Jr, Mueller FB, Timmermans PB, Sealey JE, Laragh JH.

J Hypertens. 1992 Sep;10(9):949-57.

PMID:
1328376
33.

AT1 receptors mediate the release of prostaglandins in porcine smooth muscle cells and rat astrocytes.

Leung KH, Chang RS, Lotti VJ, Roscoe WA, Smith RD, Timmermans PB, Chiu AT.

Am J Hypertens. 1992 Sep;5(9):648-56.

PMID:
1418854
34.

Characterization of biochemical responses of angiotensin II (AT2) binding sites in the rat pheochromocytoma PC12W cells.

Leung KH, Roscoe WA, Smith RD, Timmermans PB, Chiu AT.

Eur J Pharmacol. 1992 Sep 1;227(1):63-70.

PMID:
1330640
35.

Angiotensin II receptor antagonists and receptor subtypes.

Wong PC, Chiu AT, Duncia JV, Herblin WF, Smith RD, Timmermans PB.

Trends Endocrinol Metab. 1992 Aug;3(6):211-7.

PMID:
18407102
36.

Monoclonal antibodies to the nonpeptide angiotensin II receptor antagonist, losartan.

Reilly TM, Christ DD, Duncia JV, Pierce SK, Timmermans PB.

Eur J Pharmacol. 1992 Jun 5;226(2):179-82.

PMID:
1639114
37.

Effect of blocking angiotensin II receptor subtype on rat sympathetic nerve function.

Wong PC, Bernard R, Timmermans PB.

Hypertension. 1992 Jun;19(6 Pt 2):663-7.

PMID:
1592464
38.

Angiotensin II receptor subtypes.

Timmermans PB, Chiu AT, Herblin WF, Wong PC, Smith RD.

Am J Hypertens. 1992 Jun;5(6 Pt 1):406-10. Review.

PMID:
1524767
39.

The discovery of DuP 753, a potent, orally active nonpeptide angiotensin II receptor antagonist.

Duncia JV, Carini DJ, Chiu AT, Johnson AL, Price WA, Wong PC, Wexler RR, Timmermans PB.

Med Res Rev. 1992 Mar;12(2):149-91. Review. No abstract available.

PMID:
1619965
40.

In vivo characterization of a new synthetic thrombin inhibitor.

Knabb RM, Kettner CA, Timmermans PB, Reilly TM.

Thromb Haemost. 1992 Jan 23;67(1):56-9.

PMID:
1615483
41.

Pharmacology of nonpeptide angiotensin II receptor antagonists.

Smith RD, Chiu AT, Wong PC, Herblin WF, Timmermans PB.

Annu Rev Pharmacol Toxicol. 1992;32:135-65. Review. No abstract available.

PMID:
1605566
42.

Multiple angiotensin receptors: selective ligands and functional correlates.

Timmermans PB, Chiu AT, Herblin WF, Smith RD, Wong PC.

Jpn J Pharmacol. 1992;58 Suppl 2:135P-141P. Review. No abstract available.

43.

Novel non-peptide angiotensin II receptor antagonists.

Timmermans PB, Chiu AT, Smith RD, Wong PC.

Proc West Pharmacol Soc. 1992;35:65-71. Review. No abstract available.

PMID:
1502242
44.

Angiotensin II receptor antagonists. From discovery to antihypertensive drugs.

Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Wexler RR, Johnson AL.

Hypertension. 1991 Nov;18(5 Suppl):III136-42. Review.

PMID:
1937677
45.

Pharmacology of DuP 532, a selective and noncompetitive AT1 receptor antagonist.

Wong PC, Hart SD, Chiu AT, Herblin WF, Carini DJ, Smith RD, Wexler RR, Timmermans PB.

J Pharmacol Exp Ther. 1991 Nov;259(2):861-70.

PMID:
1941632
46.
47.
48.

Inhibition of the thrombin-platelet reactions by DuP 714.

Chiu AT, Mousa SA, Pease LJ, Roscoe WA, Bozarth JM, Reilly TM, Smith RD, Timmermans PB.

Biochem Biophys Res Commun. 1991 Sep 30;179(3):1500-8.

PMID:
1930190
49.

Nonpeptide angiotensin II receptor antagonists. Studies with DuP 753 and EXP3174 in dogs.

Wong PC, Hart SD, Duncia JV, Timmermans PB.

Eur J Pharmacol. 1991 Sep 24;202(3):323-30.

PMID:
1748155

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