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Items: 1 to 50 of 116


Mimetic sHDL nanoparticles: A novel drug-delivery strategy to target triple-negative breast cancer.

Wang T, Subramanian C, Yu M, White PT, Kuai R, Sanchez J, Moon JJ, Timmermann BN, Schwendeman A, Cohen MS.

Surgery. 2019 Dec;166(6):1168-1175. doi: 10.1016/j.surg.2019.06.010. Epub 2019 Jul 29.


Mimicry in viceroy butterflies is dependent on abundance of the model queen butterfly.

Prudic KL, Timmermann BN, Papaj DR, Ritland DB, Oliver JC.

Commun Biol. 2019 Feb 18;2:68. doi: 10.1038/s42003-019-0303-z. eCollection 2019.


Relative Selectivity of Plant Cardenolides for Na+/K+-ATPases From the Monarch Butterfly and Non-resistant Insects.

Petschenka G, Fei CS, Araya JJ, Schröder S, Timmermann BN, Agrawal AA.

Front Plant Sci. 2018 Sep 28;9:1424. doi: 10.3389/fpls.2018.01424. eCollection 2018.


Synthetic high-density lipoprotein nanoconjugate targets neuroblastoma stem cells, blocking migration and self-renewal.

Subramanian C, White PT, Kuai R, Kalidindi A, Castle VP, Moon JJ, Timmermann BN, Schwendeman A, Cohen MS.

Surgery. 2018 May 9. pii: S0039-6060(18)30080-1. doi: 10.1016/j.surg.2018.01.023. [Epub ahead of print]


Novel natural withanolides induce apoptosis and inhibit migration of neuroblastoma cells through down regulation of N-myc and suppression of Akt/mTOR/NF-κB activation.

Subramanian C, Grogan PT, Opipari VP, Timmermann BN, Cohen MS.

Oncotarget. 2018 Feb 7;9(18):14509-14523. doi: 10.18632/oncotarget.24429. eCollection 2018 Mar 6.


Synthetic high-density lipoprotein nanodisks for targeted withalongolide delivery to adrenocortical carcinoma.

Kuai R, Subramanian C, White PT, Timmermann BN, Moon JJ, Cohen MS, Schwendeman A.

Int J Nanomedicine. 2017 Sep 6;12:6581-6594. doi: 10.2147/IJN.S140591. eCollection 2017.


Anti-Inflammatory Effects of the Essential Oils of Ginger (Zingiber officinale Roscoe) in Experimental Rheumatoid Arthritis.

Funk JL, Frye JB, Oyarzo JN, Chen J, Zhang H, Timmermann BN.

PharmaNutrition. 2016 Jul;4(3):123-131. Epub 2016 Jun 4.


Withanolide Structural Revisions by (13)C NMR Spectroscopic Analysis Inclusive of the γ-Gauche Effect.

Zhang H, Timmermann BN.

J Nat Prod. 2016 Apr 22;79(4):732-42. doi: 10.1021/acs.jnatprod.5b00648. Epub 2016 Feb 19.


Novel HSP90 inhibitors effectively target functions of thyroid cancer stem cell preventing migration and invasion.

White PT, Subramanian C, Zhu Q, Zhang H, Zhao H, Gallagher R, Timmermann BN, Blagg BS, Cohen MS.

Surgery. 2016 Jan;159(1):142-51. doi: 10.1016/j.surg.2015.07.050. Epub 2015 Nov 2.


Withanolides and Sucrose Esters from Physalis neomexicana.

Cao CM, Wu X, Kindscher K, Xu L, Timmermann BN.

J Nat Prod. 2015 Oct 23;78(10):2488-93. doi: 10.1021/acs.jnatprod.5b00698. Epub 2015 Oct 8.


In Memoriam - Lester A. Mitscher (1931-2015).

Timmermann BN.

Pharm Biol. 2015;53(12):1875-6. doi: 10.3109/13880209.2015.1058399. Epub 2015 Jul 2. No abstract available.


Analysis of Major Withanolides in Physalis longifolia Nutt. by HPLC-PDA.

Cao CM, Kindscher K, Gallagher RJ, Zhang H, Timmermann BN.

J Chromatogr Sci. 2015 Aug;53(7):1044-7. doi: 10.1093/chromsci/bmu162. Epub 2014 Dec 2.


Withanolides from Physalis coztomatl.

Zhang H, Cao CM, Gallagher RJ, Day VW, Kindscher K, Timmermann BN.

Phytochemistry. 2015 Jan;109:147-53. doi: 10.1016/j.phytochem.2014.10.012. Epub 2014 Nov 8.


Antiproliferative withanolides from several solanaceous species.

Zhang H, Cao CM, Gallagher RJ, Timmermann BN.

Nat Prod Res. 2014;28(22):1941-51. doi: 10.1080/14786419.2014.919286. Epub 2014 May 28. Review.


Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation.

Grogan PT, Sarkaria JN, Timmermann BN, Cohen MS.

Invest New Drugs. 2014 Aug;32(4):604-17. doi: 10.1007/s10637-014-0084-7. Epub 2014 Apr 10.


Withanolides from Physalis hispida.

Cao CM, Zhang H, Gallagher RJ, Day VW, Kindscher K, Grogan P, Cohen MS, Timmermann BN.

J Nat Prod. 2014 Mar 28;77(3):631-9. doi: 10.1021/np400953n. Epub 2014 Jan 23.


Withanolides from Jaborosa caulescens var. bipinnatifida.

Zhang H, Cao CM, Gallagher RJ, Day VW, Montenegro G, Timmermann BN.

Phytochemistry. 2014 Feb;98:232-5. doi: 10.1016/j.phytochem.2013.11.005. Epub 2013 Dec 5.


Synthesis and Cytotoxicity of Semisynthetic Withalongolide A Analogues.

Motiwala HF, Bazzill J, Samadi A, Zhang H, Timmermann BN, Cohen MS, Aubé J.

ACS Med Chem Lett. 2013 Nov 14;4(11). doi: 10.1021/ml400267q.


Withanolide artifacts formed in methanol.

Cao CM, Zhang H, Gallagher RJ, Timmermann BN.

J Nat Prod. 2013 Nov 22;76(11):2040-6. doi: 10.1021/np400296s. Epub 2013 Oct 23.


Curcuminoids limit neutrophil-mediated reperfusion injury in experimental stroke by targeting the endothelium.

Funk JL, Frye JB, Davis-Gorman G, Spera AL, Bernas MJ, Witte MH, Weinand ME, Timmermann BN, McDonagh PF, Ritter L.

Microcirculation. 2013 Aug;20(6):544-54. doi: 10.1111/micc.12054.


Plant polyphenols and health benefitts.

Isemura M, Timmermann BN.

Curr Pharm Des. 2013;19(34):6051-2. No abstract available.


Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer.

Wright LE, Frye JB, Gorti B, Timmermann BN, Funk JL.

Curr Pharm Des. 2013;19(34):6218-25.


Special issue in honor of Lester A. Mitscher.

Timmermann BN, Prisinzano TE.

J Nat Prod. 2013 Mar 22;76(3):303-4. doi: 10.1021/np400090f. Epub 2013 Feb 7. No abstract available.


Antiproliferative withanolides from Datura wrightii.

Zhang H, Bazzill J, Gallagher RJ, Subramanian C, Grogan PT, Day VW, Kindscher K, Cohen MS, Timmermann BN.

J Nat Prod. 2013 Mar 22;76(3):445-9. doi: 10.1021/np300766p. Epub 2012 Dec 19.


A novel combination of withaferin A and sorafenib shows synergistic efficacy against both papillary and anaplastic thyroid cancers.

Cohen SM, Mukerji R, Timmermann BN, Samadi AK, Cohen MS.

Am J Surg. 2012 Dec;204(6):895-900; discussion 900-1. doi: 10.1016/j.amjsurg.2012.07.027.


Curcuminoids block TGF-β signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis.

Wright LE, Frye JB, Lukefahr AL, Timmermann BN, Mohammad KS, Guise TA, Funk JL.

J Nat Prod. 2013 Mar 22;76(3):316-21. doi: 10.1021/np300663v. Epub 2012 Nov 12.


Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways.

Grogan PT, Sleder KD, Samadi AK, Zhang H, Timmermann BN, Cohen MS.

Invest New Drugs. 2013 Jun;31(3):545-57. doi: 10.1007/s10637-012-9888-5. Epub 2012 Nov 6.


Natural withanolide withaferin A induces apoptosis in uveal melanoma cells by suppression of Akt and c-MET activation.

Samadi AK, Cohen SM, Mukerji R, Chaguturu V, Zhang X, Timmermann BN, Cohen MS, Person EA.

Tumour Biol. 2012 Aug;33(4):1179-89. doi: 10.1007/s13277-012-0363-x. Epub 2012 Apr 5.


Verticillosides A-M: Polyoxygenated pregnane glycosides from Asclepias verticillata L.

Araya JJ, Binns F, Kindscher K, Timmermann BN.

Phytochemistry. 2012 Jun;78:179-89. doi: 10.1016/j.phytochem.2012.02.019. Epub 2012 Mar 23.


Cytotoxic cardiac glycosides and other compounds from Asclepias syriaca.

Araya JJ, Kindscher K, Timmermann BN.

J Nat Prod. 2012 Mar 23;75(3):400-7. doi: 10.1021/np2008076. Epub 2012 Feb 8.


Anti-proliferative withanolides from the Solanaceae: a structure-activity study.

Zhang H, Samadi AK, Cohen MS, Timmermann BN.

Pure Appl Chem. 2012;84(6):1353-1367.


A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor.

Li G, Lin W, Araya JJ, Chen T, Timmermann BN, Guo GL.

Toxicol Appl Pharmacol. 2012 Jan 15;258(2):268-74. doi: 10.1016/j.taap.2011.11.006. Epub 2011 Dec 4.


Chlorinated Withanolides from Withania somnifera.

Tong X, Zhang H, Timmermann BN.

Phytochem Lett. 2011 Dec;4(4):411-414.


Cytotoxic withanolide constituents of Physalis longifolia.

Zhang H, Samadi AK, Gallagher RJ, Araya JJ, Tong X, Day VW, Cohen MS, Kindscher K, Gollapudi R, Timmermann BN.

J Nat Prod. 2011 Dec 27;74(12):2532-44. doi: 10.1021/np200635r. Epub 2011 Nov 18. Erratum in: J Nat Prod. 2012 Feb 24;75(2):306.


Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae).

Roth M, Araya JJ, Timmermann BN, Hagenbuch B.

J Pharmacol Exp Ther. 2011 Nov;339(2):624-32. doi: 10.1124/jpet.111.184564. Epub 2011 Aug 16.


Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach.

Araya JJ, Zhang H, Prisinzano TE, Mitscher LA, Timmermann BN.

Phytochemistry. 2011 Jun;72(9):935-41. doi: 10.1016/j.phytochem.2011.03.007. Epub 2011 Apr 15.


Cytotoxic oleanane-type saponins from Albizia inundata.

Zhang H, Samadi AK, Rao KV, Cohen MS, Timmermann BN.

J Nat Prod. 2011 Mar 25;74(3):477-82. doi: 10.1021/np100702p. Epub 2011 Feb 11.


Interactions of green tea catechins with organic anion-transporting polypeptides.

Roth M, Timmermann BN, Hagenbuch B.

Drug Metab Dispos. 2011 May;39(5):920-6. doi: 10.1124/dmd.110.036640. Epub 2011 Jan 28.


A novel RET inhibitor with potent efficacy against medullary thyroid cancer in vivo.

Samadi AK, Mukerji R, Shah A, Timmermann BN, Cohen MS.

Surgery. 2010 Dec;148(6):1228-36; discussion 1236. doi: 10.1016/j.surg.2010.09.026.


Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma.

Samadi AK, Tong X, Mukerji R, Zhang H, Timmermann BN, Cohen MS.

J Nat Prod. 2010 Sep 24;73(9):1476-81. doi: 10.1021/np100112p.


Application of phase-trafficking methods to natural products research.

Araya JJ, Montenegro G, Mitscher LA, Timmermann BN.

J Nat Prod. 2010 Sep 24;73(9):1568-72. doi: 10.1021/np100465h. Erratum in: J Nat Prod. 2011 Apr 25;74(4):916.


Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) is dependent on extract composition.

Wright LE, Frye JB, Timmermann BN, Funk JL.

J Agric Food Chem. 2010 Sep 8;58(17):9498-504. doi: 10.1021/jf101873f.


Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.).

Funk JL, Frye JB, Oyarzo JN, Zhang H, Timmermann BN.

J Agric Food Chem. 2010 Jan 27;58(2):842-9. doi: 10.1021/jf9027206.


A novel HSP90 modulator with selective activity against thyroid cancers in vitro.

Samadi A, Loo P, Mukerji R, O'Donnell G, Tong X, Timmermann BN, Cohen MS.

Surgery. 2009 Dec;146(6):1196-207. doi: 10.1016/j.surg.2009.09.028.


Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis.

Funk JL, Frye JB, Oyarzo JN, Timmermann BN.

J Nat Prod. 2009 Mar 27;72(3):403-7. doi: 10.1021/np8006183.


Isolation, identification, and quantification of potential defensive compounds in the viceroy butterfly and its larval host-plant, Carolina willow.

Prudic KL, Khera S, Sólyom A, Timmermann BN.

J Chem Ecol. 2007 Jun;33(6):1149-59. Epub 2007 Apr 13.


Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis.

Funk JL, Frye JB, Oyarzo JN, Kuscuoglu N, Wilson J, McCaffrey G, Stafford G, Chen G, Lantz RC, Jolad SD, Sólyom AM, Kiela PR, Timmermann BN.

Arthritis Rheum. 2006 Nov;54(11):3452-64.


Instrument dependence of electrospray ionization and tandem mass spectrometric fragmentation of the gingerols.

Jiang H, Somogyi A, Timmermann BN, Gang DR.

Rapid Commun Mass Spectrom. 2006;20(20):3089-100.


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