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Evolving Radiotherapy Techniques in Paediatric Oncology.

Steinmeier T, Schulze Schleithoff S, Timmermann B.

Clin Oncol (R Coll Radiol). 2019 Jan 10. pii: S0936-6555(18)30562-4. doi: 10.1016/j.clon.2018.12.005. [Epub ahead of print]


DPM as a radiation transport engine for PRIMO.

Rodriguez M, Sempau J, Bäumer C, Timmermann B, Brualla L.

Radiat Oncol. 2018 Dec 27;13(1):256. doi: 10.1186/s13014-018-1188-6.


Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency.

Adachi K, Kopp W, Wu G, Heising S, Greber B, Stehling M, Araúzo-Bravo MJ, Boerno ST, Timmermann B, Vingron M, Schöler HR.

Cell Stem Cell. 2018 Dec 6;23(6):900-904. doi: 10.1016/j.stem.2018.11.009. No abstract available.


Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak Protons.

Oeck S, Szymonowicz K, Wiel G, Krysztofiak A, Lambert J, Koska B, Iliakis G, Timmermann B, Jendrossek V.

Int J Mol Sci. 2018 Nov 28;19(12). pii: E3779. doi: 10.3390/ijms19123779.


Motion effects in proton treatments of hepatocellular carcinoma-4D robustly optimised pencil beam scanning plans versus double scattering plans.

Pfeiler T, Ahmad Khalil D, Ayadi M, Bäumer C, Blanck O, Chan M, Engwall E, Geismar D, Peters S, Plaude S, Spaan B, Timmermann B, Wulff J.

Phys Med Biol. 2018 Nov 23;63(23):235006. doi: 10.1088/1361-6560/aaecfc.


Patterns of proton therapy use in pediatric cancer management in 2016: An international survey.

Journy N, Indelicato DJ, Withrow DR, Akimoto T, Alapetite C, Araya M, Chang A, Chang JH, Chon B, Confer ME, Demizu Y, Dendale R, Doyen J, Ermoian R, Gurtner K, Hill-Kayser C, Iwata H, Kim JY, Kwok Y, Laack NN, Lee C, Lim DH, Loredo L, Mangona VS, Mansur DB, Murakami M, Murayama S, Ogino T, Ondrová B, Parikh RR, Paulino AC, Perkins S, Ramakrishna NR, Richter R, Rombi B, Shibata S, Shimizu S, Timmermann B, Vern-Gross T, Wang CJ, Weber DC, Wilkinson JB, Witt Nyström P, Yock TI, Kleinerman RA, Berrington de Gonzalez A.

Radiother Oncol. 2018 Nov 7. pii: S0167-8140(18)33546-1. doi: 10.1016/j.radonc.2018.10.022. [Epub ahead of print]


Author Correction: LSD1 modulates the non-canonical integrin β3 signaling pathway in non-small cell lung carcinoma cells.

Lim SY, Macheleidt I, Dalvi P, Schäfer SC, Kerick M, Ozretić L, Ortiz-Cuaran S, George J, Merkelbach-Bruse S, Wolf J, Timmermann B, Thomas RK, Schweiger MR, Buettner R, Odenthal M.

Sci Rep. 2018 Nov 1;8(1):16452. doi: 10.1038/s41598-018-31451-0.


Relative Selectivity of Plant Cardenolides for Na+/K+-ATPases From the Monarch Butterfly and Non-resistant Insects.

Petschenka G, Fei CS, Araya JJ, Schröder S, Timmermann BN, Agrawal AA.

Front Plant Sci. 2018 Sep 28;9:1424. doi: 10.3389/fpls.2018.01424. eCollection 2018.


Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis.

Kragesteen BK, Spielmann M, Paliou C, Heinrich V, Schöpflin R, Esposito A, Annunziatella C, Bianco S, Chiariello AM, Jerković I, Harabula I, Guckelberger P, Pechstein M, Wittler L, Chan WL, Franke M, Lupiáñez DG, Kraft K, Timmermann B, Vingron M, Visel A, Nicodemi M, Mundlos S, Andrey G.

Nat Genet. 2018 Oct;50(10):1463-1473. doi: 10.1038/s41588-018-0221-x. Epub 2018 Sep 27.


Impact of Whole Lung Irradiation on Survival Outcome in Patients With Lung Relapsed Ewing Sarcoma.

Scobioala S, Ranft A, Wolters H, Jabar S, Paulussen M, Timmermann B, Juergens H, Hassenpflug W, Klingebiel T, Elsayad K, Eich HT, Dirksen U.

Int J Radiat Oncol Biol Phys. 2018 Nov 1;102(3):584-592. doi: 10.1016/j.ijrobp.2018.06.032. Epub 2018 Jul 3.


Impact of the Interdisciplinary Tumor Board of the Cooperative Ewing Sarcoma Study Group on local therapy and overall survival of Ewing sarcoma patients after induction therapy.

Kreyer J, Ranft A, Timmermann B, Juergens H, Jung S, Wiebe K, Boelling T, Schuck A, Vieth V, Streitbuerger A, Hardes J, Heinemann M, Dirksen U.

Pediatr Blood Cancer. 2018 Dec;65(12):e27384. doi: 10.1002/pbc.27384. Epub 2018 Aug 7.


Development and validation of NTCP models for acute side-effects resulting from proton beam therapy of brain tumours.

Dutz A, Lühr A, Agolli L, Troost EGC, Krause M, Baumann M, Vermeren X, Geismar D, Schapira EF, Bussière M, Daly JE, Bussière MR, Timmermann B, Shih HA, Löck S.

Radiother Oncol. 2018 Jul 19. pii: S0167-8140(18)33351-6. doi: 10.1016/j.radonc.2018.06.036. [Epub ahead of print]


Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance.

Grasse S, Lienhard M, Frese S, Kerick M, Steinbach A, Grimm C, Hussong M, Rolff J, Becker M, Dreher F, Schirmer U, Boerno S, Ramisch A, Leschber G, Timmermann B, Grohé C, Lüders H, Vingron M, Fichtner I, Klein S, Odenthal M, Büttner R, Lehrach H, Sültmann H, Herwig R, Schweiger MR.

Genome Med. 2018 Jul 20;10(1):55. doi: 10.1186/s13073-018-0562-1.


Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency.

Adachi K, Kopp W, Wu G, Heising S, Greber B, Stehling M, Araúzo-Bravo MJ, Boerno ST, Timmermann B, Vingron M, Schöler HR.

Cell Stem Cell. 2018 Aug 2;23(2):266-275.e6. doi: 10.1016/j.stem.2018.05.020. Epub 2018 Jun 14. Erratum in: Cell Stem Cell. 2018 Dec 6;23(6):900-904.


Radiation dose constraints for organs at risk in neuro-oncology; the European Particle Therapy Network consensus.

Lambrecht M, Eekers DBP, Alapetite C, Burnet NG, Calugaru V, Coremans IEM, Fossati P, Høyer M, Langendijk JA, Romero AM, Paulsen F, Perpar A, Renard L, de Ruysscher D, Timmermann B, Vitek P, Weber DC, van der Weide HL, Whitfield GA, Wiggenraad R, Roelofs E, Nyström PW, Troost EGC; work package 1 of the taskforce “European Particle Therapy Network” of ESTRO.

Radiother Oncol. 2018 Jul;128(1):26-36. doi: 10.1016/j.radonc.2018.05.001. Epub 2018 May 17. Review.


Synthetic high-density lipoprotein nanoconjugate targets neuroblastoma stem cells, blocking migration and self-renewal.

Subramanian C, White PT, Kuai R, Kalidindi A, Castle VP, Moon JJ, Timmermann BN, Schwendeman A, Cohen MS.

Surgery. 2018 May 9. pii: S0039-6060(18)30080-1. doi: 10.1016/j.surg.2018.01.023. [Epub ahead of print]


TOPAS/Geant4 configuration for ionization chamber calculations in proton beams.

Wulff J, Baumann KS, Verbeek N, Bäumer C, Timmermann B, Zink K.

Phys Med Biol. 2018 Jun 7;63(11):115013. doi: 10.1088/1361-6560/aac30e.


SIOPE - Brain tumor group consensus guideline on craniospinal target volume delineation for high-precision radiotherapy.

Ajithkumar T, Horan G, Padovani L, Thorp N, Timmermann B, Alapetite C, Gandola L, Ramos M, Van Beek K, Christiaens M, Lassen-Ramshad Y, Magelssen H, Nilsson K, Saran F, Rombi B, Kortmann R, Janssens GO; SIOPE BTG Radiotherapy Group.

Radiother Oncol. 2018 Aug;128(2):192-197. doi: 10.1016/j.radonc.2018.04.016. Epub 2018 May 2.


Dosimetric comparison of five different techniques for craniospinal irradiation across 15 European centers: analysis on behalf of the SIOP-E-BTG (radiotherapy working group).

Seravalli E, Bosman M, Lassen-Ramshad Y, Vestergaard A, Oldenburger F, Visser J, Koutsouveli E, Paraskevopoulou C, Horan G, Ajithkumar T, Timmermann B, Fuentes CS, Whitfield G, Marchant T, Padovani L, Garnier E, Gandola L, Meroni S, Hoeben BAW, Kusters M, Alapetite C, Losa S, Goudjil F, Magelssen H, Evensen ME, Saran F, Smyth G, Rombi B, Righetto R, Kortmann RD, Janssens GO.

Acta Oncol. 2018 Sep;57(9):1240-1249. doi: 10.1080/0284186X.2018.1465588. Epub 2018 Apr 26.


Novel natural withanolides induce apoptosis and inhibit migration of neuroblastoma cells through down regulation of N-myc and suppression of Akt/mTOR/NF-κB activation.

Subramanian C, Grogan PT, Opipari VP, Timmermann BN, Cohen MS.

Oncotarget. 2018 Feb 7;9(18):14509-14523. doi: 10.18632/oncotarget.24429. eCollection 2018 Mar 6.


Author Correction: Global delay in nascent strand DNA methylation.

Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A.

Nat Struct Mol Biol. 2018 Apr;25(4):355. doi: 10.1038/s41594-018-0055-3.


Collimated proton pencil-beam scanning for superficial targets: impact of the order of range shifter and aperture.

Bäumer C, Janson M, Timmermann B, Wulff J.

Phys Med Biol. 2018 Apr 20;63(8):085020. doi: 10.1088/1361-6560/aab79c.


The EPTN consensus-based atlas for CT- and MR-based contouring in neuro-oncology.

Eekers DB, In 't Ven L, Roelofs E, Postma A, Alapetite C, Burnet NG, Calugaru V, Compter I, Coremans IEM, Høyer M, Lambrecht M, Nyström PW, Romero AM, Paulsen F, Perpar A, de Ruysscher D, Renard L, Timmermann B, Vitek P, Weber DC, van der Weide HL, Whitfield GA, Wiggenraad R, Troost EGC; “European Particle Therapy Network” of ESTRO.

Radiother Oncol. 2018 Jul;128(1):37-43. doi: 10.1016/j.radonc.2017.12.013. Epub 2018 Mar 13. Review.


Global delay in nascent strand DNA methylation.

Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A.

Nat Struct Mol Biol. 2018 Apr;25(4):327-332. doi: 10.1038/s41594-018-0046-4. Epub 2018 Mar 12. Erratum in: Nat Struct Mol Biol. 2018 Mar 26;:.


Genome-wide strategies identify downstream target genes of chick connective tissue-associated transcription factors.

Orgeur M, Martens M, Leonte G, Nassari S, Bonnin MA, Börno ST, Timmermann B, Hecht J, Duprez D, Stricker S.

Development. 2018 Mar 29;145(7). pii: dev161208. doi: 10.1242/dev.161208.


Proton Therapy for Craniopharyngioma - An Early Report from a Single European Centre.

Ajithkumar T, Mazhari AL, Stickan-Verfürth M, Kramer PH, Fuentes CS, Lambert J, Thomas H, Müller H, Fleischhack G, Timmermann B.

Clin Oncol (R Coll Radiol). 2018 May;30(5):307-316. doi: 10.1016/j.clon.2018.01.012. Epub 2018 Feb 17.


Genome-wide tracking of dCas9-methyltransferase footprints.

Galonska C, Charlton J, Mattei AL, Donaghey J, Clement K, Gu H, Mohammad AW, Stamenova EK, Cacchiarelli D, Klages S, Timmermann B, Cantz T, Schöler HR, Gnirke A, Ziller MJ, Meissner A.

Nat Commun. 2018 Feb 9;9(1):597. doi: 10.1038/s41467-017-02708-5.


The extraordinary challenge of treating patients with congenital rhabdoid tumors-a collaborative European effort.

Nemes K, Clément N, Kachanov D, Bens S, Hasselblatt M, Timmermann B, Schneppenheim R, Gerss J, Siebert R, Furtwängler R, Bourdeaut F, Frühwald MC; EU-RHAB consortium.

Pediatr Blood Cancer. 2018 Jun;65(6):e26999. doi: 10.1002/pbc.26999. Epub 2018 Feb 8.


Genetics of intellectual disability in consanguineous families.

Hu H, Kahrizi K, Musante L, Fattahi Z, Herwig R, Hosseini M, Oppitz C, Abedini SS, Suckow V, Larti F, Beheshtian M, Lipkowitz B, Akhtarkhavari T, Mehvari S, Otto S, Mohseni M, Arzhangi S, Jamali P, Mojahedi F, Taghdiri M, Papari E, Soltani Banavandi MJ, Akbari S, Tonekaboni SH, Dehghani H, Ebrahimpour MR, Bader I, Davarnia B, Cohen M, Khodaei H, Albrecht B, Azimi S, Zirn B, Bastami M, Wieczorek D, Bahrami G, Keleman K, Vahid LN, Tzschach A, Gärtner J, Gillessen-Kaesbach G, Varaghchi JR, Timmermann B, Pourfatemi F, Jankhah A, Chen W, Nikuei P, Kalscheuer VM, Oladnabi M, Wienker TF, Ropers HH, Najmabadi H.

Mol Psychiatry. 2018 Jan 4. doi: 10.1038/s41380-017-0012-2. [Epub ahead of print]


Comprehensive clinical commissioning and validation of the RayStation treatment planning system for proton therapy with active scanning and passive treatment techniques.

Bäumer C, Geismar D, Koska B, Kramer PH, Lambert J, Lemke M, Plaude S, Pschichholz L, Qamhiyeh S, Schiemann A, Timmermann B, Vermeren X.

Phys Med. 2017 Nov;43:15-24. doi: 10.1016/j.ejmp.2017.09.136. Epub 2017 Oct 20.


A dual transcript-discovery approach to improve the delimitation of gene features from RNA-seq data in the chicken model.

Orgeur M, Martens M, Börno ST, Timmermann B, Duprez D, Stricker S.

Biol Open. 2018 Jan 17;7(1). pii: bio028498. doi: 10.1242/bio.028498.


Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development.

Vallecillo-García P, Orgeur M, Vom Hofe-Schneider S, Stumm J, Kappert V, Ibrahim DM, Börno ST, Hayashi S, Relaix F, Hildebrandt K, Sengle G, Koch M, Timmermann B, Marazzi G, Sassoon DA, Duprez D, Stricker S.

Nat Commun. 2017 Oct 31;8(1):1218. doi: 10.1038/s41467-017-01120-3.


Protein interaction perturbation profiling at amino-acid resolution.

Woodsmith J, Apelt L, Casado-Medrano V, Özkan Z, Timmermann B, Stelzl U.

Nat Methods. 2017 Dec;14(12):1213-1221. doi: 10.1038/nmeth.4464. Epub 2017 Oct 16.


Synthetic high-density lipoprotein nanodisks for targeted withalongolide delivery to adrenocortical carcinoma.

Kuai R, Subramanian C, White PT, Timmermann BN, Moon JJ, Cohen MS, Schwendeman A.

Int J Nanomedicine. 2017 Sep 6;12:6581-6594. doi: 10.2147/IJN.S140591. eCollection 2017.


The cancer-associated U2AF35 470A>G (Q157R) mutation creates an in-frame alternative 5' splice site that impacts splicing regulation in Q157R patients.

Herdt O, Neumann A, Timmermann B, Heyd F.

RNA. 2017 Dec;23(12):1796-1806. doi: 10.1261/rna.061432.117. Epub 2017 Sep 11.


LSD1 modulates the non-canonical integrin β3 signaling pathway in non-small cell lung carcinoma cells.

Lim SY, Macheleidt I, Dalvi P, Schäfer SC, Kerick M, Ozretić L, Ortiz-Cuaran S, George J, Merkelbach-Bruse S, Wolf J, Timmermann B, Thomas RK, Schweiger MR, Buettner R, Odenthal M.

Sci Rep. 2017 Aug 31;7(1):10292. doi: 10.1038/s41598-017-09554-x. Erratum in: Sci Rep. 2018 Nov 1;8(1):16452.


Experimental validation of a 4D dose calculation routine for pencil beam scanning proton therapy.

Pfeiler T, Bäumer C, Engwall E, Geismar D, Spaan B, Timmermann B.

Z Med Phys. 2018 Apr;28(2):121-133. doi: 10.1016/j.zemedi.2017.07.005. Epub 2017 Aug 23.


Haplotype-resolved sweet potato genome traces back its hexaploidization history.

Yang J, Moeinzadeh MH, Kuhl H, Helmuth J, Xiao P, Haas S, Liu G, Zheng J, Sun Z, Fan W, Deng G, Wang H, Hu F, Zhao S, Fernie AR, Boerno S, Timmermann B, Zhang P, Vingron M.

Nat Plants. 2017 Sep;3(9):696-703. doi: 10.1038/s41477-017-0002-z. Epub 2017 Aug 21.


Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors.

Koch F, Scholze M, Wittler L, Schifferl D, Sudheer S, Grote P, Timmermann B, Macura K, Herrmann BG.

Dev Cell. 2017 Sep 11;42(5):514-526.e7. doi: 10.1016/j.devcel.2017.07.021. Epub 2017 Aug 17.


Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome.

Binder H, Hopp L, Schweiger MR, Hoffmann S, Jühling F, Kerick M, Timmermann B, Siebert S, Grimm C, Nersisyan L, Arakelyan A, Herberg M, Buske P, Loeffler-Wirth H, Rosolowski M, Engel C, Przybilla J, Peifer M, Friedrichs N, Moeslein G, Odenthal M, Hussong M, Peters S, Holzapfel S, Nattermann J, Hueneburg R, Schmiegel W, Royer-Pokora B, Aretz S, Kloth M, Kloor M, Buettner R, Galle J, Loeffler M.

J Pathol. 2017 Oct;243(2):242-254. doi: 10.1002/path.4948. Epub 2017 Sep 5.


Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a.

Lange L, Marks M, Liu J, Wittler L, Bauer H, Piehl S, Bläß G, Timmermann B, Herrmann BG.

Biol Open. 2017 Jun 15;6(6):752-764. doi: 10.1242/bio.023200.


2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic Tumors.

Simon T, Hero B, Schulte JH, Deubzer H, Hundsdoerfer P, von Schweinitz D, Fuchs J, Schmidt M, Prasad V, Krug B, Timmermann B, Leuschner I, Fischer M, Langer T, Astrahantseff K, Berthold F, Lode H, Eggert A.

Klin Padiatr. 2017 May;229(3):147-167. doi: 10.1055/s-0043-103086. Epub 2017 May 30.


Wild tobacco genomes reveal the evolution of nicotine biosynthesis.

Xu S, Brockmöller T, Navarro-Quezada A, Kuhl H, Gase K, Ling Z, Zhou W, Kreitzer C, Stanke M, Tang H, Lyons E, Pandey P, Pandey SP, Timmermann B, Gaquerel E, Baldwin IT.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6133-6138. doi: 10.1073/pnas.1700073114. Epub 2017 May 23.


The Evolving Role of Proton Beam Therapy for Sarcomas.

Frisch S, Timmermann B.

Clin Oncol (R Coll Radiol). 2017 Aug;29(8):500-506. doi: 10.1016/j.clon.2017.04.034. Epub 2017 May 12. Review.


Transcriptomic and proteomic insight into the effects of a defined European mistletoe extract in Ewing sarcoma cells reveals cellular stress responses.

Twardziok M, Meierhofer D, Börno S, Timmermann B, Jäger S, Boral S, Eggert A, Delebinski CI, Seifert G.

BMC Complement Altern Med. 2017 Apr 28;17(1):237. doi: 10.1186/s12906-017-1715-2.


Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group.

Stacchiotti S, Gronchi A, Fossati P, Akiyama T, Alapetite C, Baumann M, Blay JY, Bolle S, Boriani S, Bruzzi P, Capanna R, Caraceni A, Casadei R, Colia V, Debus J, Delaney T, Desai A, Dileo P, Dijkstra S, Doglietto F, Flanagan A, Froelich S, Gardner PA, Gelderblom H, Gokaslan ZL, Haas R, Heery C, Hindi N, Hohenberger P, Hornicek F, Imai R, Jeys L, Jones RL, Kasper B, Kawai A, Krengli M, Leithner A, Logowska I, Martin Broto J, Mazzatenta D, Morosi C, Nicolai P, Norum OJ, Patel S, Penel N, Picci P, Pilotti S, Radaelli S, Ricchini F, Rutkowski P, Scheipl S, Sen C, Tamborini E, Thornton KA, Timmermann B, Torri V, Tunn PU, Uhl M, Yamada Y, Weber DC, Vanel D, Varga PP, Vleggeert-Lankamp CLA, Casali PG, Sommer J.

Ann Oncol. 2017 Jun 1;28(6):1230-1242. doi: 10.1093/annonc/mdx054. Review.


Ewing sarcoma during follow-up.

Heinemann M, Ranft A, Jürgens H, Langer T, Vieth V, Timmermann B, Weckesser M, Dirksen U, Stegger L.

Nuklearmedizin. 2017;56(6):233-238. doi: 10.3413/Nukmed-0909-17-07. Epub 2018 Jan 11.


Fake penicillin, The Third Man, and Operation Claptrap.

Newton PN, Timmermann B.

BMJ. 2016 Dec 13;355:i6494. doi: 10.1136/bmj.i6494. No abstract available.


Characterization of hundreds of regulatory landscapes in developing limbs reveals two regimes of chromatin folding.

Andrey G, Schöpflin R, Jerković I, Heinrich V, Ibrahim DM, Paliou C, Hochradel M, Timmermann B, Haas S, Vingron M, Mundlos S.

Genome Res. 2017 Feb;27(2):223-233. doi: 10.1101/gr.213066.116. Epub 2016 Dec 6.


QSEA-modelling of genome-wide DNA methylation from sequencing enrichment experiments.

Lienhard M, Grasse S, Rolff J, Frese S, Schirmer U, Becker M, Börno S, Timmermann B, Chavez L, Sültmann H, Leschber G, Fichtner I, Schweiger MR, Herwig R.

Nucleic Acids Res. 2017 Apr 7;45(6):e44. doi: 10.1093/nar/gkw1193.

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