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Items: 1 to 50 of 155

1.

EBF recommendation on practical management of critical reagents for antidrug antibody ligand-binding assays.

Pihl S, van der Strate BW, Golob M, Ryding J, Vermet L, Jaitner B, Goodman J, Timmerman P.

Bioanalysis. 2019 Oct;11(19):1787-1798. doi: 10.4155/bio-2019-0248. Epub 2019 Oct 28.

2.

Feedback from the Fifth European Bioanalysis Forum Young Scientist Symposium.

Protti M, Babylon T, Delahaye L, Faber J, Fox C, Mahammed F, Mercolini L, McDonald T, Salger M, Vantcheva A, Timmerman P.

Bioanalysis. 2019 Aug;11(16):1453-1458. doi: 10.4155/bio-2019-0206. Epub 2019 Sep 12.

3.

Data integrity in regulated bioanalysis: a summary from the European Bioanalysis Forum Workshop in collaboration with the MHRA.

Arfvidsson C, Bedaf DV, Doig M, Globig S, Knutsson M, Lewis M, McDougall S, Michi M, Mokrzycki N, Timmerman P.

Bioanalysis. 2019 Jun;11(13):1227-1231. doi: 10.4155/bio-2019-0139.

4.

High-Affinity α5β1-Integrin-Selective Bicyclic RGD Peptides Identified via Screening of Designed Random Libraries.

Bernhagen D, Jungbluth V, Gisbert Quilis N, Dostalek J, White PB, Jalink K, Timmerman P.

ACS Comb Sci. 2019 Aug 12;21(8):598-607. doi: 10.1021/acscombsci.9b00081. Epub 2019 Aug 1.

PMID:
31269394
5.

Feedback from the European Bioanalysis Forum liquid microsampling consortium: microsampling: assessing accuracy and precision of handheld pipettes and capillaries.

Hawthorne G, Dillen L, Barfield M, Cobb Z, Kandira A, Schroeter K, White S, Karp NA, Love I, Boutet V, Rohde M, Kranenborgh M, Timmerman P.

Bioanalysis. 2019 Mar;11(6):533-542. doi: 10.4155/bio-2019-0018. Epub 2019 Apr 11. Erratum in: Bioanalysis. 2019 Aug;11(15):1451.

6.

Feedback from the European Bioanalysis Forum liquid microsampling consortium: capillary liquid microsampling and assessment of homogeneity of the resultant samples.

Cobb Z, Rohde M, Love I, Boutet V, Schroeter K, Hawthorne G, Dillen L, Barfield M, Kandira A, Kranenborgh M, White S, Timmerman P.

Bioanalysis. 2019 Mar;11(6):525-532. doi: 10.4155/bio-2019-0017. Epub 2019 Apr 11.

7.

Microsampling for quantitative bioanalysis, an industry update: output from an AAPS/EBF survey.

Patel SR, Bryan P, Spooner N, Timmerman P, Wickremsinhe E.

Bioanalysis. 2019 Apr;11(7):619-628. doi: 10.4155/bio-2019-0019. Epub 2019 Apr 11.

8.

A note from the European Bioanalysis Forum (EBF).

Timmerman P.

Bioanalysis. 2019 Apr;11(7):561-562. doi: 10.4155/bio-2019-0046. Epub 2019 Apr 4. No abstract available.

9.

Synthesis of Constrained Tetracyclic Peptides by Consecutive CEPS, CLIPS, and Oxime Ligation.

Streefkerk DE, Schmidt M, Ippel JH, Hackeng TM, Nuijens T, Timmerman P, van Maarseveen JH.

Org Lett. 2019 Apr 5;21(7):2095-2100. doi: 10.1021/acs.orglett.9b00378. Epub 2019 Mar 26.

10.

Incurred sample reproducibility.

Vazvaei F, Timmerman P.

Bioanalysis. 2018 Nov 1;10(21):1705-1706. doi: 10.4155/bio-2018-0267. Epub 2018 Nov 13. No abstract available.

11.

Bicyclic RGD peptides with high integrin α v β 3 and α 5 β 1 affinity promote cell adhesion on elastin-like recombinamers.

Cipriani F, Bernhagen D, García-Arévalo C, de Torre IG, Timmerman P, Rodríguez-Cabello JC.

Biomed Mater. 2019 Mar 27;14(3):035009. doi: 10.1088/1748-605X/aafd83.

PMID:
30630151
12.

Bicyclic RGD Peptides with Exquisite Selectivity for the Integrin αvβ3 Receptor Using a "Random Design" Approach.

Bernhagen D, Jungbluth V, Quilis NG, Dostalek J, White PB, Jalink K, Timmerman P.

ACS Comb Sci. 2019 Mar 11;21(3):198-206. doi: 10.1021/acscombsci.8b00144. Epub 2019 Jan 26.

PMID:
30624885
13.

European Bioanalysis Forum recommendation on the best practices to demonstrate processed sample stability.

Wilson A, Barker S, Freisleben A, Laakso S, Staelens L, White S, Timmerman P.

Bioanalysis. 2019 Jan;11(1):7-11. doi: 10.4155/bio-2018-0271. Epub 2018 Nov 26.

PMID:
30475068
14.

Incurred sample reproducibility: what have we learned and how can we build on our learnings?

Timmerman P.

Bioanalysis. 2018 Nov 1;10(21):1707-1709. doi: 10.4155/bio-2018-0275. Epub 2018 Nov 13. No abstract available.

PMID:
30421622
15.

Incurred sample reproducibility: 10 years of experiences: views and recommendations from the European Bioanalysis Forum.

Kall MA, Michi M, van der Strate B, Freisleben A, Stoellner D, Timmerman P.

Bioanalysis. 2018 Nov 1;10(21):1723-1732. doi: 10.4155/bio-2018-0194. Epub 2018 Nov 6.

16.

Feedback from the fourth European Bioanalysis Forum Young Scientist Symposium.

Velghe S, Mercolini L, McDonagh R, Maguire C, Mahammed F, Lucey R, Kahnt A, Hlatshwayo G, Faber J, Timmerman P.

Bioanalysis. 2018 Oct 1;10(20):1631-1634. doi: 10.4155/bio-2018-0222. Epub 2018 Oct 24.

17.

EBF recommendation on practical management of critical reagents for PK ligand-binding assays.

Pihl S, van der Strate BW, Golob M, Vermet L, Jaitner B, Goodman J, Fjording MS, Timmerman P.

Bioanalysis. 2018 Oct 1;10(19):1557-1565. doi: 10.4155/bio-2018-0230. Epub 2018 Sep 18.

18.

Toward decision-based acceptance criteria for Bioanalytical Method Validation: a proposal for discussion from the European Bioanalysis Forum.

Timmerman P, Golob M, Goodman J, Knutsson M, Nelson R, Fjording MS, White S.

Bioanalysis. 2018 Aug 1;10(16):1255-1259. doi: 10.4155/bio-2018-0131. Epub 2018 Aug 21. No abstract available.

19.

A One-Pot "Triple-C" Multicyclization Methodology for the Synthesis of Highly Constrained Isomerically Pure Tetracyclic Peptides.

Richelle GJJ, Schmidt M, Ippel H, Hackeng TM, van Maarseveen JH, Nuijens T, Timmerman P.

Chembiochem. 2018 Sep 17;19(18):1934-1938. doi: 10.1002/cbic.201800346. Epub 2018 Aug 2.

PMID:
29944773
20.

Feedback from the European Bioanalysis Forum: focus workshop on current analysis of immunogenicity: best practices and regulatory hurdles.

Goodman J, Cowen S, Devanarayan V, Egging D, Emrich T, Golob M, Kramer D, McNally J, Munday J, Nelson R, Pedras-Vasconcelos JA, Piironen T, Sickert D, Skibeli V, Fjording MS, Timmerman P.

Bioanalysis. 2018 Feb;10(4):197-204. doi: 10.4155/bio-2017-4971. Epub 2018 Jan 18.

21.

Editorial for the special issue on "constrained peptides".

van Maarseveen JH, Timmerman P.

Drug Discov Today Technol. 2017 Dec;26:1-2. doi: 10.1016/j.ddtec.2017.12.001. No abstract available.

PMID:
29249236
22.

General and Facile Route to Isomerically Pure Tricyclic Peptides Based on Templated Tandem CLIPS/CuAAC Cyclizations.

Richelle GJJ, Ori S, Hiemstra H, van Maarseveen JH, Timmerman P.

Angew Chem Int Ed Engl. 2018 Jan 8;57(2):501-505. doi: 10.1002/anie.201709127. Epub 2017 Dec 14.

PMID:
29193727
23.

Addressing the challenges of biomarker calibration standards in ligand-binding assays: a European Bioanalysis Forum perspective.

Kunz U, Goodman J, Loevgren U, Piironen T, Elsby K, Robinson P, Pihl S, Versteilen A, Companjen A, Fjording MS, Timmerman P.

Bioanalysis. 2017 Oct;9(19):1493-1508. doi: 10.4155/bio-2017-0141. Epub 2017 Oct 21.

24.

Feedback from the EBF - Focus Workshop: bringing assay validation and analysis of biomarkers into practice.

Timmerman P, Scheel Fjording M, Allinson J, Arfvidsson C, Barroso B, Diczfalusy U, Freeman A, Hickford E, Kandousi H, Katugampola S, Kunz U, Nelson R, Smeraglia J.

Bioanalysis. 2017 May;9(9):675-681. doi: 10.4155/bio-2017-0045. Epub 2017 May 18.

25.

High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors.

Bernhagen D, De Laporte L, Timmerman P.

Anal Chem. 2017 Jun 6;89(11):5991-5997. doi: 10.1021/acs.analchem.7b00554. Epub 2017 May 24.

PMID:
28492301
26.

Reply to Marchiò et al.: Antitumor immune regulation by angiostatic therapy.

Wentink MQ, Huijbers EJM, Timmerman P, Griffioen AW.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3166-E3167. doi: 10.1073/pnas.1703074114. Epub 2017 Apr 11. No abstract available.

27.

The application of capillary microsampling in GLP toxicology studies.

Verhaeghe T, Dillen L, Stieltjes H, Zwart L, Feyen B, Diels L, Vroman A, Timmerman P.

Bioanalysis. 2017 Apr;9(7):531-540. doi: 10.4155/bio-2016-0297. Epub 2017 Mar 16.

PMID:
28300424
28.

PET/CT surveillance detects asymptomatic recurrences in stage IIIB and IIIC melanoma patients: a prospective cohort study.

Madu MF, Timmerman P, Wouters MWJM, van der Hiel B, van der Hage JA, van Akkooi ACJ.

Melanoma Res. 2017 Jun;27(3):251-257. doi: 10.1097/CMR.0000000000000347.

PMID:
28225434
29.

Proactive Versus Standard Percutaneous Catheter Drainage for Infected Necrotizing Pancreatitis.

van Grinsven J, Timmerman P, van Lienden KP, Haveman JW, Boerma D, van Eijck CH, Fockens P, van Santvoort HC, Boermeester MA, Besselink MG; Dutch Pancreatitis Study Group.

Pancreas. 2017 Apr;46(4):518-523. doi: 10.1097/MPA.0000000000000785.

PMID:
28196022
30.

Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity.

Wentink MQ, Hackeng TM, Tabruyn SP, Puijk WC, Schwamborn K, Altschuh D, Meloen RH, Schuurman T, Griffioen AW, Timmerman P.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12532-12537. Epub 2016 Oct 17.

31.

Assessment of light stability of drugs in blood and plasma.

de Vries R, Diels L, Dillen L, Sips L, Van Roosbroek D, Verhaeghe T, Timmerman P.

Bioanalysis. 2016 Oct;8(19):2007-21. doi: 10.4155/bio-2016-0109. Epub 2016 Sep 9.

PMID:
27611836
32.

The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6.

Boschert V, Frisch C, Back JW, van Pee K, Weidauer SE, Muth EM, Schmieder P, Beerbaum M, Knappik A, Timmerman P, Mueller TD.

Open Biol. 2016 Aug;6(8). pii: 160120. doi: 10.1098/rsob.160120.

33.

Biomarker assay validation: are we having the right discussions?

Timmerman P.

Bioanalysis. 2016 Nov;8(22):2299-2303. Epub 2016 Jul 15. No abstract available.

PMID:
27418538
34.

Co-medication and interference testing in bioanalysis: a European Bioanalysis Forum recommendation.

de Zwart M, Lausecker B, Globig S, Neddermann D, Le Bras B, Guenzi A, White S, Scheel-Fjording M, Timmerman P.

Bioanalysis. 2016 Oct;8(19):2065-70. doi: 10.4155/bio-2016-0179. Epub 2016 Jul 15.

35.

Best practices for metabolite quantification in drug development: updated recommendation from the European Bioanalysis Forum.

Timmerman P, Blech S, White S, Green M, Delatour C, McDougall S, Mannens G, Smeraglia J, Williams S, Young G.

Bioanalysis. 2016 Jun;8(12):1297-305. doi: 10.4155/bio-2016-0103. Epub 2016 May 24.

36.

Microscale bioanalysis.

Knutsson M, Timmerman P, Gomez FA.

Bioanalysis. 2016 May;8(9):859-62. doi: 10.4155/bio-2016-0081. No abstract available.

37.

Bioanalysis of ibrutinib and its active metabolite in human plasma: selectivity issue, impact assessment and resolution.

de Vries R, Huang M, Bode N, Jejurkar P, Jong Jd, Sukbuntherng J, Sips L, Weng N, Timmerman P, Verhaeghe T.

Bioanalysis. 2015;7(20):2713-24. doi: 10.4155/bio.15.159. Epub 2015 Oct 28.

PMID:
26507928
38.

Tiered approach into practice: scientific validation for chromatography-based assays in early development - a recommendation from the European Bioanalysis Forum.

Timmerman P, White S, McDougall S, Kall MA, Smeraglia J, Fjording MS, Knutsson M.

Bioanalysis. 2015 Sep;7(18):2387-2398. doi: 10.4155/bio.15.168. Epub 2015 Sep 10.

39.

Scientific or regulated validation: a tiered approach? Meeting report from a joint EBF/DVDMDG workshop.

Timmerman P, Lowes S, McDougall S, Colligon I, Miksic J, Chowdhury S, White S, Aubry AF, Jenkins R, Kemper C.

Bioanalysis. 2015;7(14):1703-10. doi: 10.4155/bio.15.115.

40.

Simultaneous occurrence of Meckel's diverticulum and patent urachus.

Penninga L, Timmerman P, Reurings JC, Nellensteijn DR.

BMJ Case Rep. 2015 Jul 8;2015. pii: bcr2015210147. doi: 10.1136/bcr-2015-210147.

41.

Determination of tapentadol and tapentadol-O-glucuronide in human serum samples by UPLC-MS/MS.

Hillewaert V, Pusecker K, Sips L, Verhaeghe T, de Vries R, Langhans M, Terlinden R, Timmerman P.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Feb 15;981-982:40-7. doi: 10.1016/j.jchromb.2014.12.013. Epub 2015 Jan 8.

PMID:
25600054
42.

Implementing dried blood spot sampling for clinical pharmacokinetic determinations: considerations from the IQ Consortium Microsampling Working Group.

Evans C, Arnold M, Bryan P, Duggan J, James CA, Li W, Lowes S, Matassa L, Olah T, Timmerman P, Wang X, Wickremsinhe E, Williams J, Woolf E, Zane P.

AAPS J. 2015 Mar;17(2):292-300. doi: 10.1208/s12248-014-9695-3. Epub 2014 Dec 9. No abstract available.

43.

Reconstructing the discontinuous and conformational β1/β3-loop binding site on hFSH/hCG by using highly constrained multicyclic peptides.

Smeenk LE, Timmers-Parohi D, Benschop JJ, Puijk WC, Hiemstra H, van Maarseveen JH, Timmerman P.

Chembiochem. 2015 Jan 2;16(1):91-9. doi: 10.1002/cbic.201402540. Epub 2014 Dec 2.

PMID:
25469830
44.

Feedback from the European Bioanalysis Forum Workshop: taking tiered approach to the next level.

Timmerman P, White S, Knutsson M, Kall MA, Fjording MS, Smeraglia J, McDougall S.

Bioanalysis. 2014;6(19):2593-8. doi: 10.4155/bio.14.224. No abstract available.

PMID:
25411702
45.

EBF: reflection on bioanalytical assay requirements used to support liquid microsampling.

White S, Hawthorne G, Dillen L, Spooner N, Woods K, Sangster T, Cobb Z, Timmerman P.

Bioanalysis. 2014;6(19):2581-6. doi: 10.4155/bio.14.211. No abstract available.

46.

Tiered approaches to chromatographic bioanalytical method performance evaluation: recommendation for best practices and harmonization from the Global Bioanalysis Consortium harmonization team.

Lowes S, Hucker R, Jemal M, Marini JC, Rezende VM, Shoup R, Singhal P, Timmerman P, Yoneyama T, Weng N, Zimmer D.

AAPS J. 2015 Jan;17(1):17-23. doi: 10.1208/s12248-014-9656-x. Epub 2014 Oct 23.

47.

Introduction to the proposals from the global bioanalysis consortium harmonization team.

Timmerman P, Arnold M, DeSilva B, Garofolo F, Golob M, van Amsterdam P, Kudoh S, Singhal P, Tang D, Riccio MF, Barrientos R, Savale S, Kurokawa T.

AAPS J. 2014 Nov;16(6):1159-61. doi: 10.1208/s12248-014-9609-4. Epub 2014 Oct 2. No abstract available.

48.

European Bioanalysis Forum continued plans to support liquid microsampling.

Timmerman P, White S, Cobb Z, Woods K, de Vries R, Spooner N, Sangster T, Dillen L, Hawthorne G.

Bioanalysis. 2014;6(14):1897-900. doi: 10.4155/bio.14.99. No abstract available.

PMID:
25158961
49.

Recommendations from the European Bioanalysis Forum on method establishment for tissue homogenates.

Timmerman P, Mokrzycki N, Delrat P, De Meulder M, Erbach E, Lentheric I, McIntosh M, Dzygiel P.

Bioanalysis. 2014;6(12):1647-56. doi: 10.4155/bio.14.34.

50.

Feedback from a European Bioanalysis Forum survey on bioanalysis of drugs in tissues.

Mokrzycki N, Delrat P, De Meulder M, Erbach E, Lenthéric I, McIntosh M, Dzygiel P, Timmerman P.

Bioanalysis. 2014;6(12):1617-26. doi: 10.4155/bio.14.35.

PMID:
25077623

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