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Items: 1 to 50 of 217

1.

Automated Meningioma Segmentation in Multiparametric MRI : Comparable Effectiveness of a Deep Learning Model and Manual Segmentation.

Laukamp KR, Pennig L, Thiele F, Reimer R, Görtz L, Shakirin G, Zopfs D, Timmer M, Perkuhn M, Borggrefe J.

Clin Neuroradiol. 2020 Feb 14. doi: 10.1007/s00062-020-00884-4. [Epub ahead of print]

PMID:
32060575
2.

β-Lactamase of Mycobacterium tuberculosis shows dynamics in the active site that increase upon inhibitor binding.

Elings W, Gaur A, Blok AJ, Timmer M, van Ingen H, Ubbink M.

Antimicrob Agents Chemother. 2019 Dec 23. pii: AAC.02025-19. doi: 10.1128/AAC.02025-19. [Epub ahead of print]

PMID:
31871087
3.

ortho-Substituted lipidated Brartemicin derivative shows promising Mincle-mediated adjuvant activity.

Foster AJ, Kodar K, Timmer MSM, Stocker BL.

Org Biomol Chem. 2020 Feb 14;18(6):1095-1103. doi: 10.1039/c9ob02397f. Epub 2019 Dec 23.

PMID:
31868870
4.

Reliability and Feasibility of the Self-Administered ISTH-Bleeding Assessment Tool.

Punt MC, Blaauwgeers MW, Timmer MA, Welsing PMJ, Schutgens REG, van Galen KPM.

TH Open. 2019 Nov 29;3(4):e350-e355. doi: 10.1055/s-0039-3400483. eCollection 2019 Oct.

5.

Characterization of bidirectional impulse turbines for thermoacoustic engines.

Timmer MAG, van der Meer TH.

J Acoust Soc Am. 2019 Nov;146(5):3524. doi: 10.1121/1.5134450.

PMID:
31795679
6.

Stereochemistry, lipid length and branching influences Mincle agonist activity of monoacylglycerides.

Khan A, Braganza CD, Kodar K, Timmer MSM, Stocker BL.

Org Biomol Chem. 2020 Jan 22;18(3):425-430. doi: 10.1039/c9ob02302j.

PMID:
31774425
7.

An efficient synthesis of a 6″-BODIPY-α-Galactosylceramide probe for monitoring α-Galactosylceramide uptake by cells.

Cheng JMH, Chee SH, Dölen Y, Verdoes M, Timmer MSM, Stocker BL.

Carbohydr Res. 2019 Dec 1;486:107840. doi: 10.1016/j.carres.2019.107840. Epub 2019 Oct 18.

PMID:
31689579
8.

Correlations between genomic subgroup and clinical features in a cohort of more than 3000 meningiomas.

Youngblood MW, Duran D, Montejo JD, Li C, Omay SB, Özduman K, Sheth AH, Zhao AY, Tyrtova E, Miyagishima DF, Fomchenko EI, Hong CS, Clark VE, Riche M, Peyre M, Boetto J, Sohrabi S, Koljaka S, Baranoski JF, Knight J, Zhu H, Pamir MN, Avşar T, Kilic T, Schramm J, Timmer M, Goldbrunner R, Gong Y, Bayri Y, Amankulor N, Hamilton RL, Bilguvar K, Tikhonova I, Tomak PR, Huttner A, Simon M, Krischek B, Kalamarides M, Erson-Omay EZ, Moliterno J, Günel M.

J Neurosurg. 2019 Oct 25:1-10. doi: 10.3171/2019.8.JNS191266. [Epub ahead of print]

PMID:
31653806
9.

Does Meningioma Volume Correlate With Clinical Disease Manifestation Irrespective of Histopathologic Tumor Grade?

Kauke M, Safi AF, Stavrinou P, Krischek B, Goldbrunner R, Timmer M.

J Craniofac Surg. 2019 Nov-Dec;30(8):e799-e802. doi: 10.1097/SCS.0000000000005845.

PMID:
31633669
10.

Tumor Vessel Normalization, Immunostimulatory Reprogramming, and Improved Survival in Glioblastoma with Combined Inhibition of PD-1, Angiopoietin-2, and VEGF.

Di Tacchio M, Macas J, Weissenberger J, Sommer K, Bähr O, Steinbach JP, Senft C, Seifert V, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Scheel AH, Büttner R, Grauer OM, Schittenhelm J, Tabatabai G, Harter PN, Günther S, Devraj K, Plate KH, Reiss Y.

Cancer Immunol Res. 2019 Dec;7(12):1910-1927. doi: 10.1158/2326-6066.CIR-18-0865. Epub 2019 Oct 9.

PMID:
31597643
11.

The effect of MR1 ligand glyco-analogues on mucosal-associated invariant T (MAIT) cell activation.

Braganza CD, Shibata K, Fujiwara A, Motozono C, Sonoda KH, Yamasaki S, Stocker BL, Timmer MSM.

Org Biomol Chem. 2019 Oct 28;17(40):8992-9000. doi: 10.1039/c9ob01436e. Epub 2019 Sep 9.

PMID:
31497838
12.

Accuracy of Radiomics-Based Feature Analysis on Multiparametric Magnetic Resonance Images for Noninvasive Meningioma Grading.

Laukamp KR, Shakirin G, Baeßler B, Thiele F, Zopfs D, Hokamp NG, Timmer M, Kabbasch C, Perkuhn M, Borggrefe J.

World Neurosurg. 2019 Dec;132:e366-e390. doi: 10.1016/j.wneu.2019.08.148. Epub 2019 Aug 30.

PMID:
31476455
13.

Independent Risk Factors for Postoperative Seizures in Chronic Subdural Hematoma Identified by Multiple Logistic Regression Analysis.

Goertz L, Speier J, Schulte AP, Stavrinou P, Krischek B, Goldbrunner R, Timmer M.

World Neurosurg. 2019 Dec;132:e716-e721. doi: 10.1016/j.wneu.2019.08.032. Epub 2019 Aug 14.

PMID:
31421304
14.

Beneficial effect of personalized lifestyle advice compared to generic advice on wellbeing among Dutch seniors - An explorative study.

Doets EL, de Hoogh IM, Holthuysen N, Wopereis S, Verain MCD, van den Puttelaar J, Hogenelst K, Boorsma A, Bouwman EP, Timmer M, Pasman WJ, van Erk M, Reinders MJ.

Physiol Behav. 2019 Oct 15;210:112642. doi: 10.1016/j.physbeh.2019.112642. Epub 2019 Aug 5.

15.

Angiographic Characteristics of Lobulated Intracranial Aneurysms.

Goertz L, Hamisch C, Pflaeging M, Kabbasch C, Borggrefe J, Timmer M, Stravrinou P, Goldbrunner R, Brinker G, Mpotsaris A, Krischek B.

World Neurosurg. 2019 Nov;131:e353-e361. doi: 10.1016/j.wneu.2019.07.163. Epub 2019 Jul 27.

PMID:
31362105
16.

Application of Intraoperative FLOW 800 Indocyanine Green Videoangiography Color-Coded Maps for Microsurgical Clipping of Intracranial Aneurysms.

Goertz L, Hof M, Timmer M, Schulte AP, Kabbasch C, Krischek B, Stavrinou P, Reiner M, Goldbrunner R, Brinker G.

World Neurosurg. 2019 Nov;131:e192-e200. doi: 10.1016/j.wneu.2019.07.113. Epub 2019 Jul 19.

PMID:
31330337
17.

A Double-Armed, Hydrophilic Transition Metal Complex as a Paramagnetic NMR Probe.

Miao Q, Liu WM, Kock T, Blok A, Timmer M, Overhand M, Ubbink M.

Angew Chem Int Ed Engl. 2019 Sep 9;58(37):13093-13100. doi: 10.1002/anie.201906049. Epub 2019 Aug 13. Review.

18.

The synthesis and evaluation of quinolinequinones as anti-mycobacterial agents.

Santoso KT, Menorca A, Cheung CY, Cook GM, Stocker BL, Timmer MSM.

Bioorg Med Chem. 2019 Aug 15;27(16):3532-3545. doi: 10.1016/j.bmc.2019.06.002. Epub 2019 Jun 1.

PMID:
31262663
19.

Expression of CD40 Correlates Negatively with Overall and Progression-Free Survival of Low- and High-Grade Gliomas.

Werner JM, Kuhl S, Ulrich K, Krischek B, Stavrinou P, Goldbrunner R, Timmer M.

World Neurosurg. 2019 Oct;130:e17-e25. doi: 10.1016/j.wneu.2019.05.112. Epub 2019 May 21.

PMID:
31125770
20.

Death Receptor 6 (DR6) Is Overexpressed in Astrocytomas.

Stegmann S, Werner JM, Kuhl S, Röhn G, Krischek B, Stavrinou P, Goldbrunner R, Timmer M.

Anticancer Res. 2019 May;39(5):2299-2306. doi: 10.21873/anticanres.13346.

PMID:
31092421
21.

Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma.

Katsigiannis S, Krischek B, Barleanu S, Grau S, Galldiks N, Timmer M, Kabbasch C, Goldbrunner R, Stavrinou P.

Radiat Oncol. 2019 Apr 29;14(1):73. doi: 10.1186/s13014-019-1272-6.

22.

Impact of aneurysm shape and neck configuration on cerebral infarction during microsurgical clipping of intracranial aneurysms.

Goertz L, Hamisch C, Kabbasch C, Borggrefe J, Hof M, Dempfle AK, Lenschow M, Stavrinou P, Timmer M, Brinker G, Goldbrunner R, Krischek B.

J Neurosurg. 2019 Apr 12:1-9. doi: 10.3171/2019.1.JNS183193. [Epub ahead of print]

PMID:
30978687
23.

Heterogeneity of Human Gliomas: Glutathione-S-Transferase Expression Profile During Disease Progression and Under Systemic Therapy.

Tjiong R, Stavrinou P, Röhn G, Krischek B, Koch A, Goldbrunner R, Timmer M.

Anticancer Res. 2019 Apr;39(4):1795-1805. doi: 10.21873/anticanres.13286.

PMID:
30952719
24.

Qualitative and Quantitative Analysis of IDH1 Mutation in Progressive Gliomas by Allele-Specific qPCR and Western Blot Analysis.

Perrech M, Dreher L, Röhn G, Stavrinou P, Krischek B, Toliat M, Goldbrunner R, Timmer M.

Technol Cancer Res Treat. 2019 Jan 1;18:1533033819828396. doi: 10.1177/1533033819828396.

25.

Vein Graft Interposition: A Training Model Using Gradually Thawed Cryopreserved Vessels.

Safi AF, Safi S, Tayeh M, Gojowy D, Timmer M, Goldbrunner R, Kauke M.

J Craniofac Surg. 2019 May/Jun;30(3):e213-e216. doi: 10.1097/SCS.0000000000005197.

PMID:
30845093
26.

MSU Crystals Enhance TDB-Mediated Inflammatory Macrophage IL-1β Secretion.

Wahi K, Kodar K, McConnell MJ, Harper JL, Timmer MSM, Stocker BL.

Inflammation. 2019 Jun;42(3):1129-1136. doi: 10.1007/s10753-019-00976-5.

PMID:
30806957
27.

Elective Treatment of Additional and Recurrent Aneurysms in Patients with a Previous Subarachnoid Hemorrhage: A Single-Center Analysis of Complications and Clinical Outcome.

Goertz L, Brinker G, Hamisch C, Kabbasch C, Borggrefe J, Hof M, Timmer M, Stavrinou P, Goldbrunner R, Krischek B.

World Neurosurg. 2019 May;125:e1196-e1202. doi: 10.1016/j.wneu.2019.01.279. Epub 2019 Feb 19.

PMID:
30794974
28.

Long-Term Outcome and Health-Related Quality of Life of Elderly Patients After Meningioma Surgery.

Timmer M, Seibl-Leven M, Wittenstein K, Grau S, Stavrinou P, Röhn G, Krischek B, Goldbrunner R.

World Neurosurg. 2019 May;125:e697-e710. doi: 10.1016/j.wneu.2019.01.158. Epub 2019 Feb 5.

PMID:
30735873
29.

Synthesis and Investigation of Phthalazinones as Antitubercular Agents.

Santoso KT, Cheung CY, Hards K, Cook GM, Stocker BL, Timmer MSM.

Chem Asian J. 2019 Apr 15;14(8):1278-1285. doi: 10.1002/asia.201801805. Epub 2019 Feb 13.

PMID:
30680937
30.

A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications.

Gobin M, Nazarov PV, Warta R, Timmer M, Reifenberger G, Felsberg J, Vallar L, Chalmers AJ, Herold-Mende CC, Goldbrunner R, Niclou SP, Van Dyck E.

Cancer Res. 2019 Mar 15;79(6):1226-1238. doi: 10.1158/0008-5472.CAN-18-2076. Epub 2019 Jan 23.

31.

The effects of trehalose glycolipid presentation on cytokine production by GM-CSF macrophages.

Stocker BL, Kodar K, Wahi K, Foster AJ, Harper JL, Mori D, Yamasaki S, Timmer MSM.

Glycoconj J. 2019 Feb;36(1):69-78. doi: 10.1007/s10719-018-09857-9. Epub 2019 Jan 8.

PMID:
30617946
32.

Survival effects of a strategy favoring second-line multimodal treatment compared to supportive care in glioblastoma patients at first progression.

Stavrinou P, Kalyvas A, Grau S, Hamisch C, Galldiks N, Katsigiannis S, Kabbasch C, Timmer M, Goldbrunner R, Stranjalis G.

J Neurosurg. 2018 Nov 1:1-6. doi: 10.3171/2018.7.JNS18228. [Epub ahead of print]

PMID:
30544353
33.

Measurement of joint health in persons with haemophilia: A systematic review of the measurement properties of haemophilia-specific instruments.

Gouw SC, Timmer MA, Srivastava A, de Kleijn P, Hilliard P, Peters M, Blanchette V, Fischer K.

Haemophilia. 2019 Jan;25(1):e1-e10. doi: 10.1111/hae.13631. Epub 2018 Nov 14.

PMID:
30427100
34.

Long-Term Outcome after Joint Bleeds in Von Willebrand Disease Compared to Haemophilia A: A Post Hoc Analysis.

van Galen KPM, Timmer M, de Kleijn P, Leebeek FWG, Foppen W, Schutgens REG, Eikenboom J, Meijer K, Fijnvandraat K, Laros-van Gorkom BAP, Twisk JW, Mauser-Bunschoten EP, Fischer K; WiN Studygroup.

Thromb Haemost. 2018 Oct;118(10):1690-1700. doi: 10.1055/s-0038-1670704. Epub 2018 Oct 1.

PMID:
30273954
35.

ACTB and SDHA Are Suitable Endogenous Reference Genes for Gene Expression Studies in Human Astrocytomas Using Quantitative RT-PCR.

Röhn G, Koch A, Krischek B, Stavrinou P, Goldbrunner R, Timmer M.

Technol Cancer Res Treat. 2018 Jan 1;17:1533033818802318. doi: 10.1177/1533033818802318.

36.

Thioredoxin Confers Intrinsic Resistance to Cytostatic Drugs in Human Glioma Cells.

Haas B, Schütte L, Wos-Maganga M, Weickhardt S, Timmer M, Eckstein N.

Int J Mol Sci. 2018 Sep 21;19(10). pii: E2874. doi: 10.3390/ijms19102874.

37.

Impact of aneurysm shape on morbidity after clipping of unruptured intracranial aneurysms.

Goertz L, Kasuya H, Hamisch C, Kabbasch C, von Spreckelsen N, Ludyga D, Timmer M, Stavrinou P, Goldbrunner R, Brinker G, Krischek B.

Acta Neurochir (Wien). 2018 Nov;160(11):2169-2176. doi: 10.1007/s00701-018-3675-9. Epub 2018 Sep 17.

PMID:
30225810
38.

Preoperative Three-Dimensional Angiography May Reduce Ischemic Complications During Clipping of Ruptured Intracranial Aneurysms.

Goertz L, Kabbasch C, Borggrefe J, Hamisch C, Telentschak S, von Spreckelsen N, Stavrinou P, Timmer M, Brinker G, Goldbrunner R, Krischek B.

World Neurosurg. 2018 Dec;120:e1163-e1170. doi: 10.1016/j.wneu.2018.09.026. Epub 2018 Sep 12.

PMID:
30218797
39.

Epineurial Nerve Coaptation: A Biological Nonliving Training Model Using Gradually Thawed Cryopreserved Sciatic Nerves.

Safi AF, Safi S, Timmer M, Goldbrunner R, Kauke M.

J Craniofac Surg. 2018 Oct;29(7):e708-e712. doi: 10.1097/SCS.0000000000004998.

PMID:
30192297
40.

Enhanced motivation of cognitive control in Parkinson's disease.

Timmer MHM, Aarts E, Esselink RAJ, Cools R.

Eur J Neurosci. 2018 Sep;48(6):2374-2384. doi: 10.1111/ejn.14137. Epub 2018 Sep 16.

41.

Mechanisms Underlying Dopamine-Induced Risky Choice in Parkinson's Disease With and Without Depression (History).

Timmer MHM, Sescousse G, Esselink RAJ, Piray P, Cools R.

Comput Psychiatr. 2018 Feb 1;2:11-27. doi: 10.1162/CPSY_a_00011. eCollection 2018 Feb.

42.

Impact of Aneurysm Shape on Intraoperative Rupture During Clipping of Ruptured Intracranial Aneurysms.

Goertz L, Hamisch C, Telentschak S, Kabbasch C, von Spreckelsen N, Stavrinou P, Timmer M, Goldbrunner R, Brinker G, Krischek B.

World Neurosurg. 2018 Oct;118:e806-e812. doi: 10.1016/j.wneu.2018.07.058. Epub 2018 Jul 18.

PMID:
30031199
43.

Fully automated detection and segmentation of meningiomas using deep learning on routine multiparametric MRI.

Laukamp KR, Thiele F, Shakirin G, Zopfs D, Faymonville A, Timmer M, Maintz D, Perkuhn M, Borggrefe J.

Eur Radiol. 2019 Jan;29(1):124-132. doi: 10.1007/s00330-018-5595-8. Epub 2018 Jun 25.

44.

Methyl group reorientation under ligand binding probed by pseudocontact shifts.

Lescanne M, Ahuja P, Blok A, Timmer M, Akerud T, Ubbink M.

J Biomol NMR. 2018 Aug;71(4):275-285. doi: 10.1007/s10858-018-0190-5. Epub 2018 Jun 2.

45.

A novel microsurgical anastomosis training model using gradually thawed cryopreserved microvessels of rat cadavers.

Safi AF, Safi S, Tayeh M, Timmer M, Goldbrunner R, Kauke M.

J Craniomaxillofac Surg. 2018 Jul;46(7):1126-1131. doi: 10.1016/j.jcms.2018.05.018. Epub 2018 May 22.

PMID:
29802058
46.

Synthesis of Branched Trehalose Glycolipids and Their Mincle Agonist Activity.

Bird JH, Khan AA, Nishimura N, Yamasaki S, Timmer MSM, Stocker BL.

J Org Chem. 2018 Aug 3;83(15):7593-7605. doi: 10.1021/acs.joc.7b03269. Epub 2018 Jun 12.

PMID:
29781274
47.

Early or late cranioplasty following decompressive craniotomy for traumatic brain injury: A systematic review and meta-analysis.

Zheng F, Xu H, von Spreckelsen N, Stavrinou P, Timmer M, Goldbrunner R, Cao F, Ran Q, Li G, Fan R, Zhang Q, Chen W, Yao S, Krischek B.

J Int Med Res. 2018 Jul;46(7):2503-2512. doi: 10.1177/0300060518755148. Epub 2018 May 21.

48.

Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs.

Haas B, Klinger V, Keksel C, Bonigut V, Kiefer D, Caspers J, Walther J, Wos-Maganga M, Weickhardt S, Röhn G, Timmer M, Frötschl R, Eckstein N.

Cancer Cell Int. 2018 May 4;18:69. doi: 10.1186/s12935-018-0565-4. eCollection 2018.

49.

Does volumetric measurement of cervical lymph nodes serve as an imaging biomarker for locoregional recurrence of oral squamous cell carcinoma?

Safi AF, Kauke M, Jung H, Timmer M, Borggrefe J, Persigehl T, Nickenig HJ, Zinser M, Maintz D, Kreppel M, Zöller J.

J Craniomaxillofac Surg. 2018 Jun;46(6):1013-1018. doi: 10.1016/j.jcms.2018.04.001. Epub 2018 Apr 10.

PMID:
29709330
50.

Integrated genomic analyses of de novo pathways underlying atypical meningiomas.

Harmancı AS, Youngblood MW, Clark VE, Coşkun S, Henegariu O, Duran D, Erson-Omay EZ, Kaulen LD, Lee TI, Abraham BJ, Simon M, Krischek B, Timmer M, Goldbrunner R, Omay SB, Baranoski J, Baran B, Carrión-Grant G, Bai H, Mishra-Gorur K, Schramm J, Moliterno J, Vortmeyer AO, Bilgüvar K, Yasuno K, Young RA, Günel M.

Nat Commun. 2018 Apr 20;9:16215. doi: 10.1038/ncomms16215.

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