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Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response.

Dvornikov D, Schneider MA, Ohse S, Szczygieł M, Titkova I, Rosenblatt M, Muley T, Warth A, Herth FJ, Dienemann H, Thomas M, Timmer J, Schilling M, Busch H, Boerries M, Meister M, Klingmüller U.

Sci Rep. 2018 Jun 22;8(1):9517. doi: 10.1038/s41598-018-27912-1.


Characterization of the synthetic biology-inspired implementation of a materials-based positive feedback loop.

Wagner HJ, Engesser R, Ermes K, Geraths C, Timmer J, Weber W.

Data Brief. 2018 May 18;19:665-677. doi: 10.1016/j.dib.2018.05.074. eCollection 2018 Aug.


Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.

Oppelt A, Kaschek D, Huppelschoten S, Sison-Young R, Zhang F, Buck-Wiese M, Herrmann F, Malkusch S, Krüger CL, Meub M, Merkt B, Zimmermann L, Schofield A, Jones RP, Malik H, Schilling M, Heilemann M, van de Water B, Goldring CE, Park BK, Timmer J, Klingmüller U.

NPJ Syst Biol Appl. 2018 Jun 11;4:23. doi: 10.1038/s41540-018-0058-z. eCollection 2018.


BRAF V600E Mutations in Nevi and Melanocytic Tumors of Uncertain Malignant Potential (MELTUMPs).

Seitz-Alghrouz R, Hidalgo JV, Kayser C, Kreutz C, Technau-Hafsi K, Diaz C, von Deimling A, Timmer J, Werner M, Malkovsky M, Fisch P.

J Invest Dermatol. 2018 May 15. pii: S0022-202X(18)31973-0. doi: 10.1016/j.jid.2018.04.035. [Epub ahead of print] No abstract available.


A Green-Light-Responsive System for the Control of Transgene Expression in Mammalian and Plant Cells.

Chatelle C, Ochoa-Fernandez R, Engesser R, Schneider N, Beyer HM, Jones AR, Timmer J, Zurbriggen MD, Weber W.

ACS Synth Biol. 2018 May 18;7(5):1349-1358. doi: 10.1021/acssynbio.7b00450. Epub 2018 Apr 19.


Synthetic Biology Makes Polymer Materials Count.

Beyer HM, Engesser R, Hörner M, Koschmieder J, Beyer P, Timmer J, Zurbriggen MD, Weber W.

Adv Mater. 2018 May;30(21):e1800472. doi: 10.1002/adma.201800472. Epub 2018 Mar 30.


Minimal starting time of data reconstruction for qualitative myocardial perfusion rubidium-82 positron emission tomography imaging.

van Dijk JD, Huizing ED, van Dalen JA, Timmer JR, Jager PL.

Nucl Med Commun. 2018 Jun;39(6):533-538. doi: 10.1097/MNM.0000000000000830.


Predictors of severe stenosis at invasive coronary angiography in patients with normal myocardial perfusion imaging.

Yokota S, Ottervanger JP, Mouden M, de Boer MJ, Jager PL, Timmer JR.

Neth Heart J. 2018 Apr;26(4):192-202. doi: 10.1007/s12471-018-1091-7.


Impaired verbal episodic memory in healthy older adults is marked by increased F2-Isoprostanes.

Downey LA, Simpson T, Timmer J, Nolidin K, Croft K, Wesnes KA, Scholey A, Deleuil S, Stough C.

Prostaglandins Leukot Essent Fatty Acids. 2018 Feb;129:32-37. doi: 10.1016/j.plefa.2018.02.001. Epub 2018 Feb 3.


Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression.

Lucarelli P, Schilling M, Kreutz C, Vlasov A, Boehm ME, Iwamoto N, Steiert B, Lattermann S, Wäsch M, Stepath M, Matter MS, Heikenwälder M, Hoffmann K, Deharde D, Damm G, Seehofer D, Muciek M, Gretz N, Lehmann WD, Timmer J, Klingmüller U.

Cell Syst. 2018 Jan 24;6(1):75-89.e11. doi: 10.1016/j.cels.2017.11.010. Epub 2017 Dec 13.


Plant-type phytoene desaturase: Functional evaluation of structural implications.

Koschmieder J, Fehling-Kaschek M, Schaub P, Ghisla S, Brausemann A, Timmer J, Beyer P.

PLoS One. 2017 Nov 27;12(11):e0187628. doi: 10.1371/journal.pone.0187628. eCollection 2017.


Hepatocyte Ploidy Is a Diversity Factor for Liver Homeostasis.

Kreutz C, MacNelly S, Follo M, Wäldin A, Binninger-Lacour P, Timmer J, Bartolomé-Rodríguez MM.

Front Physiol. 2017 Oct 31;8:862. doi: 10.3389/fphys.2017.00862. eCollection 2017.


Corrigendum: Enzymatic study on AtCCD4 and AtCCD7 and their potential to form acyclic regulatory metabolites.

Bruno M, Koschmieder J, Wuest F, Schaub P, Fehling-Kaschek M, Timmer J, Beyer P, Al-Babili S.

J Exp Bot. 2017 Nov 2;68(18):5249. doi: 10.1093/jxb/erx347. No abstract available.


Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.

Sobotta S, Raue A, Huang X, Vanlier J, Jünger A, Bohl S, Albrecht U, Hahnel MJ, Wolf S, Mueller NS, D'Alessandro LA, Mueller-Bohl S, Boehm ME, Lucarelli P, Bonefas S, Damm G, Seehofer D, Lehmann WD, Rose-John S, van der Hoeven F, Gretz N, Theis FJ, Ehlting C, Bode JG, Timmer J, Schilling M, Klingmüller U.

Front Physiol. 2017 Oct 9;8:775. doi: 10.3389/fphys.2017.00775. eCollection 2017.


Mathematical model of early Reelin-induced Src family kinase-mediated signaling.

Hass H, Kipkeew F, Gauhar A, Bouché E, May P, Timmer J, Bock HH.

PLoS One. 2017 Oct 19;12(10):e0186927. doi: 10.1371/journal.pone.0186927. eCollection 2017.


A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.

Kaschek D, Sharanek A, Guillouzo A, Timmer J, Weaver RJ.

Toxicol Sci. 2018 Jan 1;161(1):48-57. doi: 10.1093/toxsci/kfx199.


Predicting ligand-dependent tumors from multi-dimensional signaling features.

Hass H, Masson K, Wohlgemuth S, Paragas V, Allen JE, Sevecka M, Pace E, Timmer J, Stelling J, MacBeath G, Schoeberl B, Raue A.

NPJ Syst Biol Appl. 2017 Sep 20;3:27. doi: 10.1038/s41540-017-0030-3. eCollection 2017.


Coronary calcium score influences referral for invasive coronary angiography after normal myocardial perfusion SPECT.

Yokota S, Mouden M, Ottervanger JP, Engbers E, Jager PL, Timmer JR, Knollema S.

J Nucl Cardiol. 2017 Sep 15. doi: 10.1007/s12350-017-1067-9. [Epub ahead of print]


Minimizing rubidium-82 tracer activity for relative PET myocardial perfusion imaging.

Huizing ED, van Dijk JD, van Dalen JA, Timmer JR, Arkies H, Slump CH, Jager PL.

Nucl Med Commun. 2017 Aug;38(8):708-714. doi: 10.1097/MNM.0000000000000701.


Partial break in tolerance of NKG2A-/LIR-1- single KIR+ NK cells early in the course of HLA-matched, KIR-mismatched hematopoietic cell transplantation.

Rathmann S, Keck C, Kreutz C, Weit N, Müller M, Timmer J, Glatzel S, Follo M, Malkovsky M, Werner M, Handgretinger R, Finke J, Fisch P.

Bone Marrow Transplant. 2017 Aug;52(8):1144-1155. doi: 10.1038/bmt.2017.81. Epub 2017 May 8.


Changes in cardiovascular medication after coronary artery calcium scanning and normal single photon emission computed tomography myocardial perfusion imaging in symptomatic patients.

Engbers EM, Timmer JR, Mouden M, Knollema S, Jager PL, Ottervanger JP.

Am Heart J. 2017 Apr;186:56-62. doi: 10.1016/j.ahj.2017.01.009. Epub 2017 Jan 19.


Prognostic Value of Myocardial Perfusion Imaging with a Cadmium-Zinc-Telluride SPECT Camera in Patients Suspected of Having Coronary Artery Disease.

Engbers EM, Timmer JR, Mouden M, Knollema S, Jager PL, Ottervanger JP.

J Nucl Med. 2017 Sep;58(9):1459-1463. doi: 10.2967/jnumed.116.188516. Epub 2017 Apr 27.


Two-year outcome after early or late Intervention in non-ST elevation acute coronary syndrome.

Badings EA, Remkes WS, The SH, Dambrink JE, Tjeerdsma G, Rasoul S, Timmer JR, van der Wielen ML, Lok DJ, Hermanides RS, Van Wijngaarden J, Suryapranata H, van 't Hof AW.

Open Heart. 2017 Mar 2;4(1):e000538. doi: 10.1136/openhrt-2016-000538. eCollection 2017.


The Immunomodulatory Effects of Plant Extracts and Plant Secondary Metabolites on Chronic Neuroinflammation and Cognitive Aging: A Mechanistic and Empirical Review.

Kure C, Timmer J, Stough C.

Front Pharmacol. 2017 Mar 10;8:117. doi: 10.3389/fphar.2017.00117. eCollection 2017. Review.


IL-1β-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification.

Kulawik A, Engesser R, Ehlting C, Raue A, Albrecht U, Hahn B, Lehmann WD, Gaestel M, Klingmüller U, Häussinger D, Timmer J, Bode JG.

J Biol Chem. 2017 Apr 14;292(15):6291-6302. doi: 10.1074/jbc.M117.775023. Epub 2017 Feb 21.


Coronary artery calcium score as a gatekeeper in the non-invasive evaluation of suspected coronary artery disease in symptomatic patients.

Engbers EM, Timmer JR, Ottervanger JP.

J Nucl Cardiol. 2017 Jun;24(3):826-831. doi: 10.1007/s12350-017-0792-4. Epub 2017 Feb 1. No abstract available.


Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation.

Adlung L, Kar S, Wagner MC, She B, Chakraborty S, Bao J, Lattermann S, Boerries M, Busch H, Wuchter P, Ho AD, Timmer J, Schilling M, Höfer T, Klingmüller U.

Mol Syst Biol. 2017 Jan 24;13(1):904. doi: 10.15252/msb.20167258.


Profile likelihood-based analyses of infectious disease models.

Tönsing C, Timmer J, Kreutz C.

Stat Methods Med Res. 2018 Jul;27(7):1979-1998. doi: 10.1177/0962280217746444. Epub 2018 Mar 7.


Enzymatic study on AtCCD4 and AtCCD7 and their potential to form acyclic regulatory metabolites.

Bruno M, Koschmieder J, Wuest F, Schaub P, Fehling-Kaschek M, Timmer J, Beyer P, Al-Babili S.

J Exp Bot. 2016 Nov;67(21):5993-6005. Epub 2016 Oct 6.


Quantification of oxygen metabolic rates in Human brain with dynamic 17 O MRI: Profile likelihood analysis.

Kurzhunov D, Borowiak R, Hass H, Wagner P, Krafft AJ, Timmer J, Bock M.

Magn Reson Med. 2017 Sep;78(3):1157-1167. doi: 10.1002/mrm.26476. Epub 2016 Nov 1.


Impact of Gender on the Prognostic Value of Coronary Artery Calcium in Symptomatic Patients With Normal Single-Photon Emission Computed Tomography Myocardial Perfusion.

Engbers EM, Timmer JR, Ottervanger JP, Mouden M, Knollema S, Jager PL.

Am J Cardiol. 2016 Dec 1;118(11):1611-1615. doi: 10.1016/j.amjcard.2016.08.037. Epub 2016 Aug 30.


A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β.

Ucar O, Li K, Dvornikov D, Kreutz C, Timmer J, Matt S, Brenner L, Smedley C, Travis MA, Hofmann TG, Klingmüller U, Kyewski B.

Cell Rep. 2016 Oct 4;17(2):448-457. doi: 10.1016/j.celrep.2016.09.027.


Driving the Model to Its Limit: Profile Likelihood Based Model Reduction.

Maiwald T, Hass H, Steiert B, Vanlier J, Engesser R, Raue A, Kipkeew F, Bock HH, Kaschek D, Kreutz C, Timmer J.

PLoS One. 2016 Sep 2;11(9):e0162366. doi: 10.1371/journal.pone.0162366. eCollection 2016.


L1 regularization facilitates detection of cell type-specific parameters in dynamical systems.

Steiert B, Timmer J, Kreutz C.

Bioinformatics. 2016 Sep 1;32(17):i718-i726. doi: 10.1093/bioinformatics/btw461.


Early or late intervention in patients with transient ST-segment elevation acute coronary syndrome: Subgroup analysis of the ELISA-3 trial.

Badings EA, Remkes WS, The SH, Dambrink JE, Tjeerdsma G, Rasoul S, Timmer JR, van der Wielen ML, Lok DJ, Hermanides R, van Wijngaarden J, Suryapranata H, van 't Hof AW.

Catheter Cardiovasc Interv. 2016 Nov;88(5):755-764. doi: 10.1002/ccd.26719. Epub 2016 Aug 27.


Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells.

Merkle R, Steiert B, Salopiata F, Depner S, Raue A, Iwamoto N, Schelker M, Hass H, Wäsch M, Böhm ME, Mücke O, Lipka DB, Plass C, Lehmann WD, Kreutz C, Timmer J, Schilling M, Klingmüller U.

PLoS Comput Biol. 2016 Aug 5;12(8):e1005049. doi: 10.1371/journal.pcbi.1005049. eCollection 2016 Aug.


Dealing with prognostic signature instability: a strategy illustrated for cardiovascular events in patients with end-stage renal disease.

Binder H, Kurz T, Teschner S, Kreutz C, Geyer M, Donauer J, Kraemer-Guth A, Timmer J, Schumacher M, Walz G.

BMC Med Genomics. 2016 Jul 20;9(1):43. doi: 10.1186/s12920-016-0210-9.


Proximal Soil Sensing - A Contribution for Species Habitat Distribution Modelling of Earthworms in Agricultural Soils?

Schirrmann M, Joschko M, Gebbers R, Kramer E, Zörner M, Barkusky D, Timmer J.

PLoS One. 2016 Jun 29;11(6):e0158271. doi: 10.1371/journal.pone.0158271. eCollection 2016.


Customized Steady-State Constraints for Parameter Estimation in Non-Linear Ordinary Differential Equation Models.

Rosenblatt M, Timmer J, Kaschek D.

Front Cell Dev Biol. 2016 May 11;4:41. doi: 10.3389/fcell.2016.00041. eCollection 2016.


Prognostic Value of Coronary Artery Calcium Scoring in Addition to Single-Photon Emission Computed Tomographic Myocardial Perfusion Imaging in Symptomatic Patients.

Engbers EM, Timmer JR, Ottervanger JP, Mouden M, Knollema S, Jager PL.

Circ Cardiovasc Imaging. 2016 May;9(5). pii: e003966. doi: 10.1161/CIRCIMAGING.115.003966.


Sequential SPECT/CT imaging starting with stress SPECT in patients with left bundle branch block suspected for coronary artery disease.

Engbers EM, Timmer JR, Mouden M, Knollema S, Jager PL, Ottervanger JP.

Eur Radiol. 2017 Jan;27(1):178-187. Epub 2016 May 11.


MRSA Infections in HIV-Infected People Are Associated with Decreased MRSA-Specific Th1 Immunity.

Utay NS, Roque A, Timmer JK, Morcock DR, DeLeage C, Somasunderam A, Weintrob AC, Agan BK, Estes JD, Crum-Cianflone NF, Douek DC.

PLoS Pathog. 2016 Apr 19;12(4):e1005580. doi: 10.1371/journal.ppat.1005580. eCollection 2016 Apr.


Visual estimation of coronary calcium on computed tomography for attenuation correction.

Engbers EM, Timmer JR, Mouden M, Jager PL, Knollema S, Oostdijk AH, Ottervanger JP.

J Cardiovasc Comput Tomogr. 2016 Jul-Aug;10(4):327-9. doi: 10.1016/j.jcct.2016.04.002. Epub 2016 Apr 11.


Timing of intervention in high-risk non-ST-elevation acute coronary syndromes in PCI versus non-PCI centres : Sub-group analysis of the ELISA-3 trial.

Badings EA, Remkes WS, Dambrink JH, The SH, Van Wijngaarden J, Tjeerdsma G, Rasoul S, Timmer JR, van der Wielen ML, Lok DJ, van 't Hof AW.

Neth Heart J. 2016 Mar;24(3):181-7. doi: 10.1007/s12471-015-0801-7.


Fast integration-based prediction bands for ordinary differential equation models.

Hass H, Kreutz C, Timmer J, Kaschek D.

Bioinformatics. 2016 Apr 15;32(8):1204-10. doi: 10.1093/bioinformatics/btv743. Epub 2015 Dec 17.


Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus.

Uchiyama S, Döhrmann S, Timmer AM, Dixit N, Ghochani M, Bhandari T, Timmer JC, Sprague K, Bubeck-Wardenburg J, Simon SI, Nizet V.

Front Immunol. 2015 Nov 16;6:581. doi: 10.3389/fimmu.2015.00581. eCollection 2015.


Sequential SPECT/CT imaging for detection of coronary artery disease in a large cohort: evaluation of the need for additional imaging and radiation exposure.

Engbers EM, Timmer JR, Ottervanger JP, Mouden M, Oostdijk AHJ, Knollema S, Jager PL.

J Nucl Cardiol. 2017 Feb;24(1):212-223. doi: 10.1007/s12350-015-0243-z. Epub 2015 Sep 22.


Prognostic value of normal stress-only myocardial perfusion imaging: a comparison between conventional and CZT-based SPECT.

Yokota S, Mouden M, Ottervanger JP, Engbers E, Knollema S, Timmer JR, Jager PL.

Eur J Nucl Med Mol Imaging. 2016 Feb;43(2):296-301. doi: 10.1007/s00259-015-3192-5. Epub 2015 Sep 21.


Higher-order Lie symmetries in identifiability and predictability analysis of dynamic models.

Merkt B, Timmer J, Kaschek D.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Jul;92(1):012920. Epub 2015 Jul 28.


Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations.

Schwen LO, Schenk A, Kreutz C, Timmer J, Bartolomé Rodríguez MM, Kuepfer L, Preusser T.

PLoS One. 2015 Jul 29;10(7):e0133653. doi: 10.1371/journal.pone.0133653. eCollection 2015.

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