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1-Year Outcomes of Delayed Versus Immediate Intervention in Patients With Transient ST-Segment Elevation Myocardial Infarction.

Janssens GN, van der Hoeven NW, Lemkes JS, Everaars H, van de Ven PM, Marques KMJ, Nap A, van Leeuwen MAH, Appelman Y, Knaapen P, Verouden NJW, Allaart CP, Brinckman SL, Saraber CE, Plomp KJ, Timmer JR, Kedhi E, Hermanides RS, Meuwissen M, Schaap J, van der Weerdt AP, van Rossum AC, Nijveldt R, van Royen N.

JACC Cardiovasc Interv. 2019 Aug 27. pii: S1936-8798(19)31533-X. doi: 10.1016/j.jcin.2019.07.018. [Epub ahead of print]


Mathematical modeling of drug-induced receptor internalization in the HER2-positive SKBR3 breast cancer cell-line.

Fehling-Kaschek M, Peckys DB, Kaschek D, Timmer J, Jonge N.

Sci Rep. 2019 Sep 3;9(1):12709. doi: 10.1038/s41598-019-49019-x.


Deconstructing and Reconstructing Resilience: A Dynamic Network Approach.

Kalisch R, Cramer AOJ, Binder H, Fritz J, Leertouwer I, Lunansky G, Meyer B, Timmer J, Veer IM, van Harmelen AL.

Perspect Psychol Sci. 2019 Sep;14(5):765-777. doi: 10.1177/1745691619855637. Epub 2019 Jul 31.


Extensions of ℓ1 regularization increase detection specificity for cell-type specific parameters in dynamic models.

Dolejsch P, Hass H, Timmer J.

BMC Bioinformatics. 2019 Jul 16;20(1):395. doi: 10.1186/s12859-019-2976-1.


Local Riemannian geometry of model manifolds and its implications for practical parameter identifiability.

Lill D, Timmer J, Kaschek D.

PLoS One. 2019 Jun 3;14(6):e0217837. doi: 10.1371/journal.pone.0217837. eCollection 2019.


Mapping connections in signaling networks with ambiguous modularity.

Lill D, Rukhlenko OS, Mc Elwee AJ, Kashdan E, Timmer J, Kholodenko BN.

NPJ Syst Biol Appl. 2019 May 23;5:19. doi: 10.1038/s41540-019-0096-1. eCollection 2019.


Impact of elevated HbA1c on long-term mortality in patients presenting with acute myocardial infarction in daily clinical practice: insights from a 'real world' prospective registry of the Zwolle Myocardial Infarction Study Group.

Hermanides RS, Kennedy MW, Kedhi E, van Dijk PR, Timmer JR, Ottervanger JP, Dambrink JH, Gosselink AM, Roolvink V, Miedema K, Slingerland RJ, Koopmans P, Bilo HJ, van 't Hof AW.

Eur Heart J Acute Cardiovasc Care. 2019 May 24:2048872619849921. doi: 10.1177/2048872619849921. [Epub ahead of print]


Higher plasma levels of F2-isoprostanes are associated with slower psychomotor speed in healthy older adults.

Camfield DA, Nolidin K, Savage K, Timmer J, Croft K, Tangestani Fard M, Simpson T, Downey L, Scholey A, Pipingas A, Deleuil S, Stough C.

Free Radic Res. 2019 Apr;53(4):377-386. doi: 10.1080/10715762.2018.1513133. Epub 2019 May 22.


Does fractional flow reserve overestimate severity of LAD lesions?

Yokota S, Borren NM, Ottervanger JP, Mouden M, Timmer JR, Knollema S, Jager PL.

J Nucl Cardiol. 2019 May 1. doi: 10.1007/s12350-019-01712-0. [Epub ahead of print]


Recipes for Analysis of Molecular Networks Using the Data2Dynamics Modeling Environment.

Steiert B, Kreutz C, Raue A, Timmer J.

Methods Mol Biol. 2019;1945:341-362. doi: 10.1007/978-1-4939-9102-0_16.


Influence of coronary calcification on hyperemic response during fractional flow reserve measurements.

Borren NM, Ottervanger JP, Mouden M, Dambrink JHE, Timmer JR, Jager PL.

Int J Cardiol. 2019 Jun 15;285:93-96. doi: 10.1016/j.ijcard.2019.02.037. Epub 2019 Feb 19.


Biofunctionalized Materials Featuring Feedforward and Feedback Circuits Exemplified by the Detection of Botulinum Toxin A.

Wagner HJ, Kemmer S, Engesser R, Timmer J, Weber W.

Adv Sci (Weinh). 2018 Nov 28;6(4):1801320. doi: 10.1002/advs.201801320. eCollection 2019 Feb 20.


Phytochrome-Based Extracellular Matrix with Reversibly Tunable Mechanical Properties.

Hörner M, Raute K, Hummel B, Madl J, Creusen G, Thomas OS, Christen EH, Hotz N, Gübeli RJ, Engesser R, Rebmann B, Lauer J, Rolauffs B, Timmer J, Schamel WWA, Pruszak J, Römer W, Zurbriggen MD, Friedrich C, Walther A, Minguet S, Sawarkar R, Weber W.

Adv Mater. 2019 Mar;31(12):e1806727. doi: 10.1002/adma.201806727. Epub 2019 Jan 27.


Benchmark problems for dynamic modeling of intracellular processes.

Hass H, Loos C, Raimúndez-Álvarez E, Timmer J, Hasenauer J, Kreutz C.

Bioinformatics. 2019 Sep 1;35(17):3073-3082. doi: 10.1093/bioinformatics/btz020.


Functional Proteomics of Breast Cancer Metabolism Identifies GLUL as Responder during Hypoxic Adaptation.

Bernhardt S, Tönsing C, Mitra D, Erdem N, Müller-Decker K, Korf U, Kreutz C, Timmer J, Wiemann S.

J Proteome Res. 2019 Mar 1;18(3):1352-1362. doi: 10.1021/acs.jproteome.8b00944. Epub 2019 Jan 18.


Bias From Potentially Mischievous Responders on Large-Scale Estimates of Lesbian, Gay, Bisexual, or Questioning (LGBQ)-Heterosexual Youth Health Disparities.

Cimpian JR, Timmer JD, Birkett MA, Marro RL, Turner BC, Phillips GL 2nd.

Am J Public Health. 2018 Nov;108(S4):S258-S265. doi: 10.2105/AJPH.2018.304407.


Timing of revascularization in patients with transient ST-segment elevation myocardial infarction: a randomized clinical trial.

Lemkes JS, Janssens GN, van der Hoeven NW, van de Ven PM, Marques KMJ, Nap A, van Leeuwen MAH, Appelman YEA, Knaapen P, Verouden NJW, Allaart CP, Brinckman SL, Saraber CE, Plomp KJ, Timmer JR, Kedhi E, Hermanides RS, Meuwissen M, Schaap J, van der Weerdt AP, van Rossum AC, Nijveldt R, van Royen N.

Eur Heart J. 2019 Jan 14;40(3):283-291. doi: 10.1093/eurheartj/ehy651.


Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells.

Baaske J, Gonschorek P, Engesser R, Dominguez-Monedero A, Raute K, Fischbach P, Müller K, Cachat E, Schamel WWA, Minguet S, Davies JA, Timmer J, Weber W, Zurbriggen MD.

Sci Rep. 2018 Oct 9;8(1):15024. doi: 10.1038/s41598-018-32929-7.


Anatomically and functionally relevant coronary stenoses in patients with normal single-photon emission computed tomography but persistent stable angina.

Yokota S, Borren N, Mouden M, Timmer JR, Knollema S, Jager PL, Ottervanger JP.

Eur Heart J Cardiovasc Imaging. 2018 Dec 1;19(12):1327-1333. doi: 10.1093/ehjci/jey126.


Risk-based breast cancer follow-up stratified by age.

Witteveen A, Otten JWM, Vliegen IMH, Siesling S, Timmer JB, IJzerman MJ.

Cancer Med. 2018 Oct;7(10):5291-5298. doi: 10.1002/cam4.1760. Epub 2018 Sep 11.


Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response.

Dvornikov D, Schneider MA, Ohse S, Szczygieł M, Titkova I, Rosenblatt M, Muley T, Warth A, Herth FJ, Dienemann H, Thomas M, Timmer J, Schilling M, Busch H, Boerries M, Meister M, Klingmüller U.

Sci Rep. 2018 Jun 22;8(1):9517. doi: 10.1038/s41598-018-27912-1.


Characterization of the synthetic biology-inspired implementation of a materials-based positive feedback loop.

Wagner HJ, Engesser R, Ermes K, Geraths C, Timmer J, Weber W.

Data Brief. 2018 May 18;19:665-677. doi: 10.1016/j.dib.2018.05.074. eCollection 2018 Aug.


Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.

Oppelt A, Kaschek D, Huppelschoten S, Sison-Young R, Zhang F, Buck-Wiese M, Herrmann F, Malkusch S, Krüger CL, Meub M, Merkt B, Zimmermann L, Schofield A, Jones RP, Malik H, Schilling M, Heilemann M, van de Water B, Goldring CE, Park BK, Timmer J, Klingmüller U.

NPJ Syst Biol Appl. 2018 Jun 11;4:23. doi: 10.1038/s41540-018-0058-z. eCollection 2018.


BRAF V600E Mutations in Nevi and Melanocytic Tumors of Uncertain Malignant Potential.

Seitz-Alghrouz R, Hidalgo JV, Kayser C, Kreutz C, Technau-Hafsi K, Diaz C, von Deimling A, Timmer J, Werner M, Malkovsky M, Fisch P.

J Invest Dermatol. 2018 Nov;138(11):2489-2491. doi: 10.1016/j.jid.2018.04.035. Epub 2018 Jul 12. No abstract available.


A Green-Light-Responsive System for the Control of Transgene Expression in Mammalian and Plant Cells.

Chatelle C, Ochoa-Fernandez R, Engesser R, Schneider N, Beyer HM, Jones AR, Timmer J, Zurbriggen MD, Weber W.

ACS Synth Biol. 2018 May 18;7(5):1349-1358. doi: 10.1021/acssynbio.7b00450. Epub 2018 Apr 19.


Synthetic Biology Makes Polymer Materials Count.

Beyer HM, Engesser R, Hörner M, Koschmieder J, Beyer P, Timmer J, Zurbriggen MD, Weber W.

Adv Mater. 2018 May;30(21):e1800472. doi: 10.1002/adma.201800472. Epub 2018 Mar 30.


Minimal starting time of data reconstruction for qualitative myocardial perfusion rubidium-82 positron emission tomography imaging.

van Dijk JD, Huizing ED, van Dalen JA, Timmer JR, Jager PL.

Nucl Med Commun. 2018 Jun;39(6):533-538. doi: 10.1097/MNM.0000000000000830.


Predictors of severe stenosis at invasive coronary angiography in patients with normal myocardial perfusion imaging.

Yokota S, Ottervanger JP, Mouden M, de Boer MJ, Jager PL, Timmer JR.

Neth Heart J. 2018 Apr;26(4):192-202. doi: 10.1007/s12471-018-1091-7.


Impaired verbal episodic memory in healthy older adults is marked by increased F2-Isoprostanes.

Downey LA, Simpson T, Timmer J, Nolidin K, Croft K, Wesnes KA, Scholey A, Deleuil S, Stough C.

Prostaglandins Leukot Essent Fatty Acids. 2018 Feb;129:32-37. doi: 10.1016/j.plefa.2018.02.001. Epub 2018 Feb 3.


Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression.

Lucarelli P, Schilling M, Kreutz C, Vlasov A, Boehm ME, Iwamoto N, Steiert B, Lattermann S, Wäsch M, Stepath M, Matter MS, Heikenwälder M, Hoffmann K, Deharde D, Damm G, Seehofer D, Muciek M, Gretz N, Lehmann WD, Timmer J, Klingmüller U.

Cell Syst. 2018 Jan 24;6(1):75-89.e11. doi: 10.1016/j.cels.2017.11.010. Epub 2017 Dec 13.


Plant-type phytoene desaturase: Functional evaluation of structural implications.

Koschmieder J, Fehling-Kaschek M, Schaub P, Ghisla S, Brausemann A, Timmer J, Beyer P.

PLoS One. 2017 Nov 27;12(11):e0187628. doi: 10.1371/journal.pone.0187628. eCollection 2017.


Hepatocyte Ploidy Is a Diversity Factor for Liver Homeostasis.

Kreutz C, MacNelly S, Follo M, Wäldin A, Binninger-Lacour P, Timmer J, Bartolomé-Rodríguez MM.

Front Physiol. 2017 Oct 31;8:862. doi: 10.3389/fphys.2017.00862. eCollection 2017.


Corrigendum: Enzymatic study on AtCCD4 and AtCCD7 and their potential to form acyclic regulatory metabolites.

Bruno M, Koschmieder J, Wuest F, Schaub P, Fehling-Kaschek M, Timmer J, Beyer P, Al-Babili S.

J Exp Bot. 2017 Nov 2;68(18):5249. doi: 10.1093/jxb/erx347. No abstract available.


Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.

Sobotta S, Raue A, Huang X, Vanlier J, Jünger A, Bohl S, Albrecht U, Hahnel MJ, Wolf S, Mueller NS, D'Alessandro LA, Mueller-Bohl S, Boehm ME, Lucarelli P, Bonefas S, Damm G, Seehofer D, Lehmann WD, Rose-John S, van der Hoeven F, Gretz N, Theis FJ, Ehlting C, Bode JG, Timmer J, Schilling M, Klingmüller U.

Front Physiol. 2017 Oct 9;8:775. doi: 10.3389/fphys.2017.00775. eCollection 2017.


Mathematical model of early Reelin-induced Src family kinase-mediated signaling.

Hass H, Kipkeew F, Gauhar A, Bouché E, May P, Timmer J, Bock HH.

PLoS One. 2017 Oct 19;12(10):e0186927. doi: 10.1371/journal.pone.0186927. eCollection 2017.


A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.

Kaschek D, Sharanek A, Guillouzo A, Timmer J, Weaver RJ.

Toxicol Sci. 2018 Jan 1;161(1):48-57. doi: 10.1093/toxsci/kfx199.


Predicting ligand-dependent tumors from multi-dimensional signaling features.

Hass H, Masson K, Wohlgemuth S, Paragas V, Allen JE, Sevecka M, Pace E, Timmer J, Stelling J, MacBeath G, Schoeberl B, Raue A.

NPJ Syst Biol Appl. 2017 Sep 20;3:27. doi: 10.1038/s41540-017-0030-3. eCollection 2017.


Coronary calcium score influences referral for invasive coronary angiography after normal myocardial perfusion SPECT.

Yokota S, Mouden M, Ottervanger JP, Engbers E, Jager PL, Timmer JR, Knollema S.

J Nucl Cardiol. 2019 Apr;26(2):602-612. doi: 10.1007/s12350-017-1067-9. Epub 2017 Sep 15.


Minimizing rubidium-82 tracer activity for relative PET myocardial perfusion imaging.

Huizing ED, van Dijk JD, van Dalen JA, Timmer JR, Arkies H, Slump CH, Jager PL.

Nucl Med Commun. 2017 Aug;38(8):708-714. doi: 10.1097/MNM.0000000000000701.


Partial break in tolerance of NKG2A-/LIR-1- single KIR+ NK cells early in the course of HLA-matched, KIR-mismatched hematopoietic cell transplantation.

Rathmann S, Keck C, Kreutz C, Weit N, Müller M, Timmer J, Glatzel S, Follo M, Malkovsky M, Werner M, Handgretinger R, Finke J, Fisch P.

Bone Marrow Transplant. 2017 Aug;52(8):1144-1155. doi: 10.1038/bmt.2017.81. Epub 2017 May 8.


Changes in cardiovascular medication after coronary artery calcium scanning and normal single photon emission computed tomography myocardial perfusion imaging in symptomatic patients.

Engbers EM, Timmer JR, Mouden M, Knollema S, Jager PL, Ottervanger JP.

Am Heart J. 2017 Apr;186:56-62. doi: 10.1016/j.ahj.2017.01.009. Epub 2017 Jan 19.


Prognostic Value of Myocardial Perfusion Imaging with a Cadmium-Zinc-Telluride SPECT Camera in Patients Suspected of Having Coronary Artery Disease.

Engbers EM, Timmer JR, Mouden M, Knollema S, Jager PL, Ottervanger JP.

J Nucl Med. 2017 Sep;58(9):1459-1463. doi: 10.2967/jnumed.116.188516. Epub 2017 Apr 27.


Two-year outcome after early or late Intervention in non-ST elevation acute coronary syndrome.

Badings EA, Remkes WS, The SH, Dambrink JE, Tjeerdsma G, Rasoul S, Timmer JR, van der Wielen ML, Lok DJ, Hermanides RS, Van Wijngaarden J, Suryapranata H, van 't Hof AW.

Open Heart. 2017 Mar 2;4(1):e000538. doi: 10.1136/openhrt-2016-000538. eCollection 2017.


The Immunomodulatory Effects of Plant Extracts and Plant Secondary Metabolites on Chronic Neuroinflammation and Cognitive Aging: A Mechanistic and Empirical Review.

Kure C, Timmer J, Stough C.

Front Pharmacol. 2017 Mar 10;8:117. doi: 10.3389/fphar.2017.00117. eCollection 2017. Review.


IL-1β-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification.

Kulawik A, Engesser R, Ehlting C, Raue A, Albrecht U, Hahn B, Lehmann WD, Gaestel M, Klingmüller U, Häussinger D, Timmer J, Bode JG.

J Biol Chem. 2017 Apr 14;292(15):6291-6302. doi: 10.1074/jbc.M117.775023. Epub 2017 Feb 21.


Coronary artery calcium score as a gatekeeper in the non-invasive evaluation of suspected coronary artery disease in symptomatic patients.

Engbers EM, Timmer JR, Ottervanger JP.

J Nucl Cardiol. 2017 Jun;24(3):826-831. doi: 10.1007/s12350-017-0792-4. Epub 2017 Feb 1. No abstract available.


Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation.

Adlung L, Kar S, Wagner MC, She B, Chakraborty S, Bao J, Lattermann S, Boerries M, Busch H, Wuchter P, Ho AD, Timmer J, Schilling M, Höfer T, Klingmüller U.

Mol Syst Biol. 2017 Jan 24;13(1):904. doi: 10.15252/msb.20167258.


Profile likelihood-based analyses of infectious disease models.

Tönsing C, Timmer J, Kreutz C.

Stat Methods Med Res. 2018 Jul;27(7):1979-1998. doi: 10.1177/0962280217746444. Epub 2018 Mar 7.


Enzymatic study on AtCCD4 and AtCCD7 and their potential to form acyclic regulatory metabolites.

Bruno M, Koschmieder J, Wuest F, Schaub P, Fehling-Kaschek M, Timmer J, Beyer P, Al-Babili S.

J Exp Bot. 2016 Nov;67(21):5993-6005. Epub 2016 Oct 6. Erratum in: J Exp Bot. 2017 Nov 2;68(18):5249.


Quantification of oxygen metabolic rates in Human brain with dynamic 17 O MRI: Profile likelihood analysis.

Kurzhunov D, Borowiak R, Hass H, Wagner P, Krafft AJ, Timmer J, Bock M.

Magn Reson Med. 2017 Sep;78(3):1157-1167. doi: 10.1002/mrm.26476. Epub 2016 Nov 1.


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