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Items: 1 to 50 of 222

1.

MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance.

Yang S, Wang L, Pan W, Bayer W, Thoens C, Heim K, Dittmer U, Timm J, Wang Q, Yu Q, Luo J, Liu Y, Hofmann M, Thimme R, Zhang X, Chen H, Wang H, Feng X, Yang X, Lu Y, Lu M, Yang D, Liu J.

J Hepatol. 2019 Jun 4. pii: S0168-8278(19)30299-5. doi: 10.1016/j.jhep.2019.05.013. [Epub ahead of print]

PMID:
31173811
2.

Disparate effects of first and second generation antipsychotics on cognition in schizophrenia - Findings from the randomized NeSSy trial.

Veselinović T, Scharpenberg M, Heinze M, Cordes J, Mühlbauer B, Juckel G, Habel U, Rüther E, Timm J, Gründer G; NeSSy Study Group.

Eur Neuropsychopharmacol. 2019 Jun;29(6):720-739. doi: 10.1016/j.euroneuro.2019.03.014. Epub 2019 Apr 10.

PMID:
30981585
3.

Diagnostic accuracy of glycated hemoglobin for gestational diabetes mellitus: a systematic review and meta-analysis.

Renz PB, Chume FC, Timm JRT, Pimentel AL, Camargo JL.

Clin Chem Lab Med. 2019 Mar 20. pii: /j/cclm.ahead-of-print/cclm-2018-1191/cclm-2018-1191.xml. doi: 10.1515/cclm-2018-1191. [Epub ahead of print] Review.

PMID:
30893053
4.

The carbon monoxide dehydrogenase accessory protein CooJ is a histidine-rich multidomain dimer containing an unexpected Ni(II)-binding site.

Alfano M, Pérard J, Carpentier P, Basset C, Zambelli B, Timm J, Crouzy S, Ciurli S, Cavazza C.

J Biol Chem. 2019 May 10;294(19):7601-7614. doi: 10.1074/jbc.RA119.008011. Epub 2019 Mar 11.

PMID:
30858174
5.

A pan-genotypic Hepatitis C Virus NS5A amplification method for reliable genotyping and resistance testing.

Walker A, Ennker KS, Kaiser R, Lübke N, Timm J.

J Clin Virol. 2019 Apr;113:8-13. doi: 10.1016/j.jcv.2019.01.012. Epub 2019 Jan 30.

PMID:
30771598
6.

ERAP1 allotypes shape the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection.

Kemming J, Reeves E, Nitschke K, Widmeier V, Emmerich F, Hermle T, Gostick E, Walker A, Timm J, Price DA, Hofmann M, Thimme R, James E, Neumann-Haefelin C.

J Hepatol. 2019 Jun;70(6):1072-1081. doi: 10.1016/j.jhep.2019.01.034. Epub 2019 Feb 13.

7.

Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8+ T Cells and Evolve at the Population Level.

Karimzadeh H, Kiraithe MM, Oberhardt V, Salimi Alizei E, Bockmann J, Schulze Zur Wiesch J, Budeus B, Hoffmann D, Wedemeyer H, Cornberg M, Krawczyk A, Rashidi-Alavijeh J, Rodríguez-Frías F, Casillas R, Buti M, Smedile A, Alavian SM, Heinold A, Emmerich F, Panning M, Gostick E, Price DA, Timm J, Hofmann M, Raziorrouh B, Thimme R, Protzer U, Roggendorf M, Neumann-Haefelin C.

Gastroenterology. 2019 May;156(6):1820-1833. doi: 10.1053/j.gastro.2019.02.003. Epub 2019 Feb 12.

8.

Evaluation of Flexible and Integrative Psychiatric Treatment Models in Germany-A Mixed-Method Patient and Staff-Oriented Exploratory Study.

von Peter S, Ignatyev Y, Johne J, Indefrey S, Kankaya OA, Rehr B, Zeipert M, Bechdolf A, Birkner T, Deister A, Duve A, Rout S, Scherk H, Schulz-Dubois A, Wilms B, Zedlick D, Grollich P, Braun B, Timm J, Heinze M.

Front Psychiatry. 2019 Jan 22;9:785. doi: 10.3389/fpsyt.2018.00785. eCollection 2018.

9.

Phenotype and function of HBV-specific T cells is determined by the targeted epitope in addition to the stage of infection.

Hoogeveen RC, Robidoux MP, Schwarz T, Heydmann L, Cheney JA, Kvistad D, Aneja J, Melgaço JG, Fernandes CA, Chung RT, Boonstra A, Kim AY, Baumert TF, Timm J, Lewis-Ximenez LL, Tonnerre P, Lauer GM.

Gut. 2019 May;68(5):893-904. doi: 10.1136/gutjnl-2018-316644. Epub 2018 Dec 22.

PMID:
30580250
10.

SEC14L2, a lipid-binding protein, regulates HCV replication in culture with inter- and intra-genotype variations.

Costa R, Todt D, Zapatero-Belinchón F, Schenk C, Anastasiou OE, Walker A, Hertel B, Timmer L, Bojkova D, Ruckert M, Sarrazin C, Timm J, Lohmann V, Manns MP, Steinmann E, von Hahn T, Ciesek S.

J Hepatol. 2019 Apr;70(4):603-614. doi: 10.1016/j.jhep.2018.11.012. Epub 2018 Nov 23.

PMID:
30472319
11.

Immunotopological Analysis of the Treponema denticola Major Surface Protein (Msp).

Godovikova V, Goetting-Minesky MP, Timm JC, Fenno JC.

J Bacteriol. 2018 Dec 20;201(2). pii: e00528-18. doi: 10.1128/JB.00528-18. Print 2019 Jan 15.

PMID:
30373754
12.

Differential escape of HCV from CD8+ T cell selection pressure between China and Germany depends on the presenting HLA class I molecule.

Xia Y, Pan W, Ke X, Skibbe K, Walker A, Hoffmann D, Lu Y, Yang X, Feng X, Tong Q, Timm J, Yang D.

J Viral Hepat. 2019 Jan;26(1):73-82. doi: 10.1111/jvh.13011. Epub 2018 Nov 28.

PMID:
30260541
13.

Clinical Outcome and Viral Genome Variability of Hepatitis B Virus-Induced Acute Liver Failure.

Anastasiou OE, Widera M, Westhaus S, Timmer L, Korth J, Gerken G, Canbay A, Todt D, Steinmann E, Schwarz T, Timm J, Verheyen J, Ciesek S.

Hepatology. 2019 Mar;69(3):993-1003. doi: 10.1002/hep.30279. Epub 2019 Feb 11.

PMID:
30229977
14.

Evaluation of new flexible and integrative psychiatric treatment models in Germany- assessment and preliminary validation of specific program components.

Johne J, von Peter S, Schwarz J, Timm J, Heinze M, Ignatyev Y.

BMC Psychiatry. 2018 Sep 3;18(1):278. doi: 10.1186/s12888-018-1861-1.

15.

Role of BK polyomavirus (BKV) and Torque teno virus (TTV) in liver transplant recipients with renal impairment.

Herrmann A, Sandmann L, Adams O, Herrmann D, Dirks M, Widera M, Westhaus S, Kaiser R, di Cristanziano V, Manns MP, Korth J, Richter N, Anastasiou O, Timm J, von Hahn T, Ciesek S.

J Med Microbiol. 2018 Oct;67(10):1496-1508. doi: 10.1099/jmm.0.000823. Epub 2018 Aug 23.

PMID:
30136921
16.

A Single-Nucleotide Polymorphism Upstream of the HLA-C Locus Is Associated With an Anti-Hepatitis C Virus-Seronegative State in a High-Risk Exposed Cohort.

Thoens C, Heinold A, Lindemann M, Horn PA, Chang DI, Scherbaum N, Timm J, Heinemann FM.

J Infect Dis. 2018 Nov 5;218(12):2016-2019. doi: 10.1093/infdis/jiy492.

PMID:
30102364
17.

Outcome of a hepatitis B vaccination program for clients of a drug consumption facility.

Scherbaum N, Timm J, Richter F, Bonnet U, Bombeck J, Lajos S, Specka M.

J Clin Virol. 2018 Sep;106:28-32. doi: 10.1016/j.jcv.2018.04.014. Epub 2018 Apr 23.

PMID:
30015286
18.

CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection.

Khairnar V, Duhan V, Patil AM, Zhou F, Bhat H, Thoens C, Sharma P, Adomati T, Friendrich SK, Bezgovsek J, Dreesen JD, Wennemuth G, Westendorf AM, Zelinskyy G, Dittmer U, Hardt C, Timm J, Göthert JR, Lang PA, Singer BB, Lang KS.

Nat Commun. 2018 Jul 2;9(1):2561. doi: 10.1038/s41467-018-04832-2.

19.

[Prophylaxis, diagnosis and therapy of hepatitis-C-virus (HCV) infection: the German guidelines on the management of HCV infection - AWMF-Register-No.: 021/012].

Sarrazin C, Zimmermann T, Berg T, Neumann UP, Schirmacher P, Schmidt H, Spengler U, Timm J, Wedemeyer H, Wirth S, Zeuzem S; Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS); Deutsche Gesellschaft für Pathologie e.V. (DGP); Deutsche Leberstiftung; Gesellschaft für Virologie e.V. (GfV); Gesellschaft für Pädiatrische Gastroenterologie und Ernährung (GPGE); Österreichische Gesellschaft für Gastroenterologie und Hepatologie (ÖGGH); Schweizerische Gesellschaft für Gastroenterologie (SGG); Deutsche Transplantationsgesellschaft e.V. (DTG); Deutsche Leberhilfe e.V; Deutsche Gesellschaft für Infektiologie e.V. (DGI); Deutsche Gesellschaft für Suchtmedizin e.V. (DGS); Deutsche AIDS-Gesellschaft e.V. (DAIG); Deutsche Arbeitsgemeinschaft niedergelassener Ärzte für die Versorgung HIV-Infizierter (DAGNÄ); Robert Koch-Institut.

Z Gastroenterol. 2018 Jul;56(7):756-838. doi: 10.1055/a-0599-1320. Epub 2018 Jun 26. German. No abstract available.

20.

Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8+ T Cells.

Karimzadeh H, Kiraithe MM, Kosinska AD, Glaser M, Fiedler M, Oberhardt V, Salimi Alizei E, Hofmann M, Mok JY, Nguyen M, van Esch WJE, Budeus B, Grabowski J, Homs M, Olivero A, Keyvani H, Rodríguez-Frías F, Tabernero D, Buti M, Heinold A, Alavian SM, Bauer T, Schulze Zur Wiesch J, Raziorrouh B, Hoffmann D, Smedile A, Rizzetto M, Wedemeyer H, Timm J, Antes I, Neumann-Haefelin C, Protzer U, Roggendorf M.

J Virol. 2018 Jun 13;92(13). pii: e01891-17. doi: 10.1128/JVI.01891-17. Print 2018 Jul 1.

21.

High efficacy of sofosbuvir/velpatasvir and impact of baseline resistance-associated substitutions in hepatitis C genotype 3 infection.

von Felden J, Vermehren J, Ingiliz P, Mauss S, Lutz T, Simon KG, Busch HW, Baumgarten A, Schewe K, Hueppe D, Boesecke C, Rockstroh JK, Daeumer M, Luebke N, Timm J, Schulze Zur Wiesch J, Sarrazin C, Christensen S.

Aliment Pharmacol Ther. 2018 May;47(9):1288-1295. doi: 10.1111/apt.14592. Epub 2018 Mar 14.

PMID:
29536554
22.

A crystalline and 3D periodically ordered mesoporous quaternary semiconductor for photocatalytic hydrogen generation.

Weller T, Deilmann L, Timm J, Dörr TS, Beaucage PA, Cherevan AS, Wiesner UB, Eder D, Marschall R.

Nanoscale. 2018 Feb 15;10(7):3225-3234. doi: 10.1039/c7nr09251b.

PMID:
29383360
23.

Assessing the risk of CMV reactivation and reconstitution of antiviral immune response post bone marrow transplantation by the QuantiFERON-CMV-assay and real time PCR.

Krawczyk A, Ackermann J, Goitowski B, Trenschel R, Ditschkowski M, Timm J, Ottinger H, Beelen DW, Grüner N, Fiedler M.

J Clin Virol. 2018 Feb - Mar;99-100:61-66. doi: 10.1016/j.jcv.2018.01.002. Epub 2018 Jan 9.

24.

TLR2 Expression in Peripheral CD4+ T Cells Promotes Th17 Response and Is Associated with Disease Aggravation of Hepatitis B Virus-Related Acute-On-Chronic Liver Failure.

Xu C, Lu Y, Zheng X, Feng X, Yang X, Timm J, Wu J, Wang B, Lu M, Yang D, Liu J.

Front Immunol. 2017 Nov 23;8:1609. doi: 10.3389/fimmu.2017.01609. eCollection 2017.

25.

[Specific components for integrative and flexible care models according to § 64b SGB V].

von Peter S, Ignatyev Y, Indefrey S, Johne J, Schwarz J, Timm J, Heinze M.

Nervenarzt. 2018 May;89(5):559-564. doi: 10.1007/s00115-017-0459-z. German.

PMID:
29209751
26.

Lymphocytes Negatively Regulate NK Cell Activity via Qa-1b following Viral Infection.

Xu HC, Huang J, Pandyra AA, Lang E, Zhuang Y, Thöns C, Timm J, Häussinger D, Colonna M, Cantor H, Lang KS, Lang PA.

Cell Rep. 2017 Nov 28;21(9):2528-2540. doi: 10.1016/j.celrep.2017.11.001.

27.

Transplantation of Renal Allografts From Organ Donors Reactive for HCV Antibodies to HCV-Negative Recipients: Safety and Clinical Outcome.

Nowak KM, Witzke O, Sotiropoulos GC, Benkö T, Fiedler M, Timm J, Kribben A, Wilde B, Saner F, Paul A, Treckmann J.

Kidney Int Rep. 2016 Oct 6;2(1):53-59. doi: 10.1016/j.ekir.2016.09.058. eCollection 2017 Jan.

28.

The influence of immunosuppressants on direct-acting antiviral therapy is dependent on the hepatitis C virus genotype.

Frey A, Piras-Straub K, Walker A, Timm J, Gerken G, Herzer K.

Transpl Infect Dis. 2018 Feb;20(1). doi: 10.1111/tid.12803. Epub 2017 Dec 21.

PMID:
29111569
29.

Challenges and Perspectives in Bridging In- and Outpatient Sectors: The Implementation of Two Alternative Models of Care and Their Effect on the Average Length of Stay.

Wullschleger A, Wosniok W, Timm J, Heinze M.

Front Psychiatry. 2017 Oct 5;8:196. doi: 10.3389/fpsyt.2017.00196. eCollection 2017.

30.

Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection.

Wolski D, Foote PK, Chen DY, Lewis-Ximenez LL, Fauvelle C, Aneja J, Walker A, Tonnerre P, Torres-Cornejo A, Kvistad D, Imam S, Waring MT, Tully DC, Allen TM, Chung RT, Timm J, Haining WN, Kim AY, Baumert TF, Lauer GM.

Immunity. 2017 Oct 17;47(4):648-663.e8. doi: 10.1016/j.immuni.2017.09.006.

31.

Effects of the Mammalian Target of Rapamycin Inhibitor Everolimus on Hepatitis C Virus Replication In Vitro and In Vivo.

Frey A, Ecker EM, Piras-Straub K, Walker A, Hofmann TG, Timm J, Singer BB, Gerken G, Herzer K.

Transplant Proc. 2017 Oct;49(8):1947-1955. doi: 10.1016/j.transproceed.2017.04.012.

PMID:
28923653
32.

Development and Preliminary Validation of the Scale for Evaluation of Psychiatric Integrative and Continuous Care-Patient's Version.

Ignatyev Y, Timm J, Heinze M, Indefrey S, von Peter S.

Front Psychiatry. 2017 Aug 31;8:162. doi: 10.3389/fpsyt.2017.00162. eCollection 2017.

33.

Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation in Trypanosoma brucei.

Timm J, Valente M, García-Caballero D, Wilson KS, González-Pacanowska D.

mSphere. 2017 Aug 16;2(4). pii: e00226-17. doi: 10.1128/mSphere.00226-17. eCollection 2017 Jul-Aug.

34.

Effectiveness and cost-effectiveness of an integrated care program for schizophrenia: an analysis of routine data.

Kerkemeyer L, Wasem J, Neumann A, Brannath W, Mester B, Timm J, Wobrock T, Bartels C, Falkai P, Biermann J.

Eur Arch Psychiatry Clin Neurosci. 2018 Sep;268(6):611-619. doi: 10.1007/s00406-017-0830-x. Epub 2017 Aug 8.

PMID:
28791485
35.

Detection of a genetic footprint of the sofosbuvir resistance-associated substitution S282T after HCV treatment failure.

Walker A, Filke S, Lübke N, Obermeier M, Kaiser R, Häussinger D, Timm J, Bock HH.

Virol J. 2017 Jun 8;14(1):106. doi: 10.1186/s12985-017-0779-4.

36.

A genotype independent, full-genome reverse-transcription protocol for HCV genotyping and resistance testing.

Walker A, Bergmann M, Camdereli J, Kaiser R, Lübke N, Timm J.

J Clin Virol. 2017 Jun;91:42-48. doi: 10.1016/j.jcv.2017.04.008. Epub 2017 Apr 10.

PMID:
28463753
37.

The CO dehydrogenase accessory protein CooT is a novel nickel-binding protein.

Timm J, Brochier-Armanet C, Perard J, Zambelli B, Ollagnier-de-Choudens S, Ciurli S, Cavazza C.

Metallomics. 2017 May 24;9(5):575-583. doi: 10.1039/c7mt00063d.

PMID:
28447092
38.

HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugs.

Thöns C, Senff T, Hydes TJ, Manser AR, Heinemann FM, Heinold A, Heilmann M, Kim AY, Uhrberg M, Scherbaum N, Lauer GM, Khakoo SI, Timm J.

J Hepatol. 2017 Sep;67(3):462-470. doi: 10.1016/j.jhep.2017.03.040. Epub 2017 Apr 13.

PMID:
28412292
39.

Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1.

Sauer PV, Timm J, Liu D, Sitbon D, Boeri-Erba E, Velours C, Mücke N, Langowski J, Ochsenbein F, Almouzni G, Panne D.

Elife. 2017 Mar 18;6. pii: e23474. doi: 10.7554/eLife.23474.

40.

New Daily Persistent Headache Caused by a Multinodular Goiter and Headaches Associated With Thyroid Disease.

Evans RW, Timm JS.

Headache. 2017 Feb;57(2):285-289. doi: 10.1111/head.13011. Epub 2016 Dec 27.

PMID:
28025831
41.

Treatment of fulminant acute Hepatitis B with nucles(t)id analogues is safe and does not lead to secondary chronification of Hepatitis B.

Jochum C, Maischack F, Anastasiou OE, Verheyen J, Timm J, Bechmann L, Gerken G, Canbay A.

Z Gastroenterol. 2016 Dec;54(12):1306-1311. Epub 2016 Dec 9.

PMID:
27936480
42.

Pre-exposure prophylaxis failure with tenofovir disoproxil.

Streeck H, Verheyen J, Storim J, Dittmer U, Jochum C, Timm J, Esser S.

AIDS. 2017 Jan 2;31(1):176-177. No abstract available.

PMID:
27898596
43.

Liver transplantation from HCV RNA-positive donors in the era of interferon-free HCV therapeutics: a re-examination of the situation.

Willuweit K, Canbay A, Gerken G, Timm J, Paul A, Treckmann J, Herzer K.

Minerva Gastroenterol Dietol. 2017 Mar;63(1):55-61. doi: 10.23736/S1121-421X.16.02347-3. Epub 2016 Nov 8. Review.

PMID:
27824245
44.

Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection.

Levy G, Habib N, Guzzardi MA, Kitsberg D, Bomze D, Ezra E, Uygun BE, Uygun K, Trippler M, Schlaak JF, Shibolet O, Sklan EH, Cohen M, Timm J, Friedman N, Nahmias Y.

Nat Chem Biol. 2016 Dec;12(12):1037-1045. doi: 10.1038/nchembio.2193. Epub 2016 Oct 10.

PMID:
27723751
45.

Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma brucei.

Valente M, Timm J, Castillo-Acosta VM, Ruiz-Pérez LM, Balzarini T, Nettleship JE, Bird LE, Rada H, Wilson KS, González-Pacanowska D.

Mol Microbiol. 2016 Nov;102(3):365-385. doi: 10.1111/mmi.13467. Epub 2016 Aug 31.

46.

Genotypic resistance testing of HCV - is there a clinical need?

Walker A, Kaiser R, Bartenschlager R, Timm J.

GMS Infect Dis. 2016 Aug 4;4:Doc05. doi: 10.3205/id000023. eCollection 2016. Review.

47.

Effect of cholecalciferol supplementation on urine podocyte-associated messenger RNAs in patients with chronic kidney disease.

Timm JR, Karohl C, Santos MD, Souza ML, Zancan R, Almeida Rd, Veronese FV.

J Bras Nefrol. 2016 Jun;38(2):173-82. doi: 10.5935/0101-2800.20160026. English, Portuguese.

48.

Effects of first-generation antipsychotics versus second-generation antipsychotics on quality of life in schizophrenia: a double-blind, randomised study.

Gründer G, Heinze M, Cordes J, Mühlbauer B, Juckel G, Schulz C, Rüther E, Timm J; NeSSy Study Group.

Lancet Psychiatry. 2016 Aug;3(8):717-729. doi: 10.1016/S2215-0366(16)00085-7. Epub 2016 Jun 2.

PMID:
27265548
49.

Geno2pheno[HCV] - A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents.

Kalaghatgi P, Sikorski AM, Knops E, Rupp D, Sierra S, Heger E, Neumann-Fraune M, Beggel B, Walker A, Timm J, Walter H, Obermeier M, Kaiser R, Bartenschlager R, Lengauer T.

PLoS One. 2016 May 19;11(5):e0155869. doi: 10.1371/journal.pone.0155869. eCollection 2016.

50.

Sensory suppression of brain responses to self-generated sounds is observed with and without the perception of agency.

Timm J, Schönwiesner M, Schröger E, SanMiguel I.

Cortex. 2016 Jul;80:5-20. doi: 10.1016/j.cortex.2016.03.018. Epub 2016 Apr 2.

PMID:
27137101

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