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Items: 1 to 50 of 359

1.

A case report of an unusual non-mucinous papillary variant of CPAM type 1 with KRAS mutations.

Koopman T, Rottier BL, Ter Elst A, Timens W.

BMC Pulm Med. 2020 Feb 24;20(1):52. doi: 10.1186/s12890-020-1088-z.

2.

Human lung extracellular matrix hydrogels resemble the stiffness and viscoelasticity of native lung tissue.

de Hilster RHJ, Sharma PK, Jonker MR, White ES, Gercama EA, Roobeek M, Timens W, Harmsen MC, Hylkema MN, Burgess JK.

Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L698-L704. doi: 10.1152/ajplung.00451.2019. Epub 2020 Feb 12.

3.

Circulating tumor cells in lung cancer are prognostic and predictive for worse tumor response in both targeted- and chemotherapy.

Tamminga M, de Wit S, Schuuring E, Timens W, Terstappen LWMM, Hiltermann TJN, Groen HJM.

Transl Lung Cancer Res. 2019 Dec;8(6):854-861. doi: 10.21037/tlcr.2019.11.06.

4.

Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1.

Brandsma CA, Guryev V, Timens W, Ciconelle A, Postma DS, Bischoff R, Johansson M, Ovchinnikova ES, Malm J, Marko-Varga G, Fehniger TE, van den Berge M, Horvatovich P.

Thorax. 2020 Feb;75(2):180-183. doi: 10.1136/thoraxjnl-2019-213200. Epub 2020 Jan 14.

5.

Atypical goblet cell hyperplasia occurs in CPAM 1, 2, and 3, and is a probable precursor lesion for childhood adenocarcinoma.

Fakler F, Aykutlu U, Brcic L, Eidenhammer S, Thueringer A, Kashofer K, Kulka J, Timens W, Popper H.

Virchows Arch. 2019 Dec 19. doi: 10.1007/s00428-019-02732-4. [Epub ahead of print]

PMID:
31858221
6.

Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution.

Duclos GE, Teixeira VH, Autissier P, Gesthalter YB, Reinders-Luinge MA, Terrano R, Dumas YM, Liu G, Mazzilli SA, Brandsma CA, van den Berge M, Janes SM, Timens W, Lenburg ME, Spira A, Campbell JD, Beane J.

Sci Adv. 2019 Dec 11;5(12):eaaw3413. doi: 10.1126/sciadv.aaw3413. eCollection 2019 Dec.

7.

Multicentre study on the consistency of PD-L1 immunohistochemistry as predictive test for immunotherapy in non-small cell lung cancer.

Butter R, 't Hart NA, Hooijer GKJ, Monkhorst K, Speel EJ, Theunissen P, Thunnissen E, Von der Thüsen JH, Timens W, van de Vijver MJ.

J Clin Pathol. 2019 Dec 10. pii: jclinpath-2019-205993. doi: 10.1136/jclinpath-2019-205993. [Epub ahead of print]

PMID:
31822512
8.

Marked TGF-β-regulated miRNA expression changes in both COPD and control lung fibroblasts.

Ong J, Faiz A, Timens W, van den Berge M, Terpstra MM, Kok K, van den Berg A, Kluiver J, Brandsma CA.

Sci Rep. 2019 Dec 3;9(1):18214. doi: 10.1038/s41598-019-54728-4.

9.

Analysis of Released Circulating Tumor Cells During Surgery for Non-Small Cell Lung Cancer.

Tamminga M, de Wit S, van de Wauwer C, van den Bos H, Swennenhuis JF, Klinkenberg TJ, Hiltermann TJN, Andree KC, Spierings DCJ, Lansdorp PM, van den Berg A, Timens W, Terstappen LWMM, Groen HJM.

Clin Cancer Res. 2020 Apr 1;26(7):1656-1666. doi: 10.1158/1078-0432.CCR-19-2541. Epub 2019 Nov 26.

PMID:
31772122
10.

Current perspectives on the role of interleukin-1 signalling in the pathogenesis of asthma and COPD.

Osei ET, Brandsma CA, Timens W, Heijink IH, Hackett TL.

Eur Respir J. 2020 Feb 20;55(2). pii: 1900563. doi: 10.1183/13993003.00563-2019. Print 2020 Feb.

PMID:
31727692
11.

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.

Allen RJ, Guillen-Guio B, Oldham JM, Ma SF, Dressen A, Paynton ML, Kraven LM, Obeidat M, Li X, Ng M, Braybrooke R, Molina-Molina M, Hobbs BD, Putman RK, Sakornsakolpat P, Booth HL, Fahy WA, Hart SP, Hill MR, Hirani N, Hubbard RB, McAnulty RJ, Millar AB, Navaratnam V, Oballa E, Parfrey H, Saini G, Whyte MKB, Zhang Y, Kaminski N, Adegunsoye A, Strek ME, Neighbors M, Sheng XR, Gudmundsson G, Gudnason V, Hatabu H, Lederer DJ, Manichaikul A, Newell JD Jr, O'Connor GT, Ortega VE, Xu H, Fingerlin TE, Bossé Y, Hao K, Joubert P, Nickle DC, Sin DD, Timens W, Furniss D, Morris AP, Zondervan KT, Hall IP, Sayers I, Tobin MD, Maher TM, Cho MH, Hunninghake GM, Schwartz DA, Yaspan BL, Molyneaux PL, Flores C, Noth I, Jenkins RG, Wain LV.

Am J Respir Crit Care Med. 2020 Mar 1;201(5):564-574. doi: 10.1164/rccm.201905-1017OC.

12.

Differential DNA methylation in bronchial biopsies between persistent asthma and asthma in remission.

Vermeulen CJ, Xu CJ, Vonk JM, Ten Hacken NHT, Timens W, Heijink IH, Nawijn MC, Boekhoudt J, van Oosterhout AJ, Affleck K, Weckmann M, Koppelman GH, van den Berge M.

Eur Respir J. 2020 Feb 6;55(2). pii: 1901280. doi: 10.1183/13993003.01280-2019. Print 2020 Feb.

PMID:
31699840
13.

Transcriptome-wide association study reveals candidate causal genes for lung cancer.

Bossé Y, Li Z, Xia J, Manem V, Carreras-Torres R, Gabriel A, Gaudreault N, Albanes D, Aldrich MC, Andrew A, Arnold S, Bickeböller H, Bojesen SE, Brennan P, Brunnstrom H, Caporaso N, Chen C, Christiani DC, Field JK, Goodman G, Grankvist K, Houlston R, Johansson M, Johansson M, Kiemeney LA, Lam S, Landi MT, Lazarus P, Le Marchand L, Liu G, Melander O, Rennert G, Risch A, Rosenberg SM, Schabath MB, Shete S, Song Z, Stevens VL, Tardon A, Wichmann HE, Woll P, Zienolddiny S, Obeidat M, Timens W, Hung RJ, Joubert P, Amos CI, McKay JD.

Int J Cancer. 2020 Apr 1;146(7):1862-1878. doi: 10.1002/ijc.32771. Epub 2019 Dec 9.

PMID:
31696517
14.

Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine.

Brandsma CA, Van den Berge M, Hackett TL, Brusselle G, Timens W.

J Pathol. 2019 Nov 5. doi: 10.1002/path.5364. [Epub ahead of print] Review.

PMID:
31691283
15.

Cigarette smoke exposure alters phosphodiesterases in human structural lung cells.

Zuo H, Faiz A, van den Berge M, Mudiyanselage SNHR, Borghuis T, Timens W, Nikolaev VO, Burgess JK, Schmidt M.

Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L59-L64. doi: 10.1152/ajplung.00319.2019. Epub 2019 Oct 30.

PMID:
31664853
16.

Current Smoking is Associated with Decreased Expression of miR-335-5p in Parenchymal Lung Fibroblasts.

Ong J, van den Berg A, Faiz A, Boudewijn IM, Timens W, Vermeulen CJ, Oliver BG, Kok K, Terpstra MM, van den Berge M, Brandsma CA, Kluiver J.

Int J Mol Sci. 2019 Oct 18;20(20). pii: E5176. doi: 10.3390/ijms20205176.

17.

ALK immunohistochemistry positive, FISH negative NSCLC is infrequent, but associated with impaired survival following treatment with crizotinib.

Thunnissen E, Lissenberg-Witte BI, van den Heuvel MM, Monkhorst K, Skov BG, Sørensen JB, Mellemgaard A, Dingemans AMC, Speel EJM, de Langen AJ, Hashemi SMS, Bahce I, van der Drift MA, Looijen-Salamon MG, Gosney J, Postmus PE, Samii SMS, Duplaquet F, Weynand B, Durando X, Penault-Llorca F, Finn S, Grady AO, Oz B, Akyurek N, Buettner R, Wolf J, Bubendorf L, Duin S, Marondel I, Heukamp LC, Timens W, Schuuring EMD, Pauwels P, Smit EF.

Lung Cancer. 2019 Dec;138:13-18. doi: 10.1016/j.lungcan.2019.09.023. Epub 2019 Oct 3.

PMID:
31630043
18.

Laminin α4 contributes to airway remodeling and inflammation in asthma.

Prabhala P, Wright DB, Robbe P, Bitter C, Pera T, Ten Hacken NHT, van den Berge M, Timens W, Meurs H, Dekkers BGJ.

Am J Physiol Lung Cell Mol Physiol. 2019 Dec 1;317(6):L768-L777. doi: 10.1152/ajplung.00222.2019. Epub 2019 Sep 25.

PMID:
31553662
19.

MiR-31-5p: A shared regulator of chronic mucus hypersecretion in asthma and chronic obstructive pulmonary disease.

Tasena H, Boudewijn IM, Faiz A, Timens W, Hylkema MN, Berg M, Ten Hacken NHT, Brandsma CA, Heijink IH, van den Berge M.

Allergy. 2020 Mar;75(3):703-706. doi: 10.1111/all.14060. Epub 2019 Oct 23. No abstract available.

PMID:
31545509
20.

Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma.

George L, Taylor AR, Esteve-Codina A, Soler Artigas M, Thun GA, Bates S, Pavlidis S, Wagers S, Boland A, Prasse A, Boschetto P, Parr DG, Nowinski A, Barta I, Hohlfeld J, Greulich T, van den Berge M, Hiemstra PS, Timens W, Hinks T, Wenzel S, Siddiqui S, Richardson M, Venge P, Heath S, Gut I, Tobin MD, Edwards L, Riley JH, Djukanovic R, Auffray C, De-Meulder B, Erik-Dahlen S, Adcock IM, Chung KF, Ziegler-Heitbrock L, Sterk PJ, Singh D, Brightling CE; U-BIOPRED and the EvA study teams.

Allergy. 2020 Feb;75(2):370-380. doi: 10.1111/all.14016. Epub 2019 Sep 10.

21.

Circulating tumor cells in advanced non-small cell lung cancer patients are associated with worse tumor response to checkpoint inhibitors.

Tamminga M, de Wit S, Hiltermann TJN, Timens W, Schuuring E, Terstappen LWMM, Groen HJM.

J Immunother Cancer. 2019 Jul 10;7(1):173. doi: 10.1186/s40425-019-0649-2.

22.

A cellular census of human lungs identifies novel cell states in health and in asthma.

Vieira Braga FA, Kar G, Berg M, Carpaij OA, Polanski K, Simon LM, Brouwer S, Gomes T, Hesse L, Jiang J, Fasouli ES, Efremova M, Vento-Tormo R, Talavera-López C, Jonker MR, Affleck K, Palit S, Strzelecka PM, Firth HV, Mahbubani KT, Cvejic A, Meyer KB, Saeb-Parsy K, Luinge M, Brandsma CA, Timens W, Angelidis I, Strunz M, Koppelman GH, van Oosterhout AJ, Schiller HB, Theis FJ, van den Berge M, Nawijn MC, Teichmann SA.

Nat Med. 2019 Jul;25(7):1153-1163. doi: 10.1038/s41591-019-0468-5. Epub 2019 Jun 17.

PMID:
31209336
23.

Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD.

van den Berge M, Brandsma CA, Faiz A, de Vries M, Rathnayake SNH, Paré PD, Sin DD, Bossé Y, Laviolette M, Nickle DC, Hao K, Obeidat M, Dragani TA, Colombo F, Timens W, Postma DS.

Eur Respir J. 2019 Jul 18;54(1). pii: 1702567. doi: 10.1183/13993003.02567-2017. Print 2019 Jul. No abstract available.

PMID:
31164434
24.

99mTc-HYNIC-IL-2 scintigraphy to detect acute rejection in lung transplantation patients: a proof-of-concept study.

Telenga ED, van der Bij W, de Vries EFJ, Verschuuren EAM, Timens W, Luurtsema G, Slart RHJA, Signore A, Glaudemans AWJM.

EJNMMI Res. 2019 May 10;9(1):41. doi: 10.1186/s13550-019-0511-z.

25.

The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease.

Schiller HB, Montoro DT, Simon LM, Rawlins EL, Meyer KB, Strunz M, Vieira Braga FA, Timens W, Koppelman GH, Budinger GRS, Burgess JK, Waghray A, van den Berge M, Theis FJ, Regev A, Kaminski N, Rajagopal J, Teichmann SA, Misharin AV, Nawijn MC.

Am J Respir Cell Mol Biol. 2019 Jul;61(1):31-41. doi: 10.1165/rcmb.2018-0416TR. Review.

PMID:
30995076
26.

CX Chemokine Receptor 7 Contributes to Survival of KRAS-Mutant Non-Small Cell Lung Cancer upon Loss of Epidermal Growth Factor Receptor.

Liu B, Song S, Setroikromo R, Chen S, Hu W, Chen D, van der Wekken AJ, Melgert BN, Timens W, van den Berg A, Saber A, Haisma HJ.

Cancers (Basel). 2019 Mar 30;11(4). pii: E455. doi: 10.3390/cancers11040455.

27.

Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD.

Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, Eijgenraam TR, Jonker MR, Koppelman GH, Pouwels SD, Liu G, Alekseyev YO, Lam S, Hiemstra PS, Sterk PJ, Timens W, Brandsma CA, Heijink IH, van den Berge M.

Eur Respir J. 2019 Apr 25;53(4). pii: 1801202. doi: 10.1183/13993003.01202-2018. Print 2019 Apr.

PMID:
30846474
28.

Age-related gene and miRNA expression changes in airways of healthy individuals.

Ong J, Woldhuis RR, Boudewijn IM, van den Berg A, Kluiver J, Kok K, Terpstra MM, Guryev V, de Vries M, Vermeulen CJ, Timens W, van den Berge M, Brandsma CA.

Sci Rep. 2019 Mar 6;9(1):3765. doi: 10.1038/s41598-019-39873-0.

29.

Alveolar Septal Widening as an "Alert" Signal to Look Into Lung Antibody-mediated Rejection: A Multicenter Pilot Study.

Calabrese F, Hirschi S, Neil D, Montero-Fernandez A, Timens W, Verbeken E, Chenard MP, Ivanovic M, Le Pavec J, Pena T, Dorfmüller P, Roux A, Rice A, Perissinotto E, Lunardi F, Levine DJ, Cozzi E, Goddard M.

Transplantation. 2019 Nov;103(11):2440-2447. doi: 10.1097/TP.0000000000002688.

PMID:
30830043
30.

Small airway hyperresponsiveness in COPD: relationship between structure and function in lung slices.

Maarsingh H, Bidan CM, Brook BS, Zuidhof AB, Elzinga CRS, Smit M, Oldenburger A, Gosens R, Timens W, Meurs H.

Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L537-L546. doi: 10.1152/ajplung.00325.2018. Epub 2019 Jan 10.

31.

Lung cancer susceptibility genetic variants modulate HOXB2 expression in the lung.

Clemenceau A, Boucherat O, Landry-Truchon K, Lamontagne M, Biardel S, Joubert P, Gobeil S, Secco B, Laplante M, Morissette M, Obeidat M, Timens W, Jeannotte L, Bossé Y.

Int J Dev Biol. 2018;62(11-12):857-864. doi: 10.1387/ijdb.180210yb.

32.

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.

Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R 3rd, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG.

J Clin Invest. 2019 Jan 2;129(1):169-181. doi: 10.1172/JCI121087. Epub 2018 Nov 26.

33.

The DNA repair transcriptome in severe COPD.

Sauler M, Lamontagne M, Finnemore E, Herazo-Maya JD, Tedrow J, Zhang X, Morneau JE, Sciurba F, Timens W, Paré PD, Lee PJ, Kaminski N, Bossé Y, Gomez JL.

Eur Respir J. 2018 Oct 4;52(4). pii: 1701994. doi: 10.1183/13993003.01994-2017. Print 2018 Oct.

34.

Meta-analysis of exome array data identifies six novel genetic loci for lung function.

Jackson VE, Latourelle JC, Wain LV, Smith AV, Grove ML, Bartz TM, Obeidat M, Province MA, Gao W, Qaiser B, Porteous DJ, Cassano PA, Ahluwalia TS, Grarup N, Li J, Altmaier E, Marten J, Harris SE, Manichaikul A, Pottinger TD, Li-Gao R, Lind-Thomsen A, Mahajan A, Lahousse L, Imboden M, Teumer A, Prins B, Lyytikäinen LP, Eiriksdottir G, Franceschini N, Sitlani CM, Brody JA, Bossé Y, Timens W, Kraja A, Loukola A, Tang W, Liu Y, Bork-Jensen J, Justesen JM, Linneberg A, Lange LA, Rawal R, Karrasch S, Huffman JE, Smith BH, Davies G, Burkart KM, Mychaleckyj JC, Bonten TN, Enroth S, Lind L, Brusselle GG, Kumar A, Stubbe B; Understanding Society Scientific Group, Kähönen M, Wyss AB, Psaty BM, Heckbert SR, Hao K, Rantanen T, Kritchevsky SB, Lohman K, Skaaby T, Pisinger C, Hansen T, Schulz H, Polasek O, Campbell A, Starr JM, Rich SS, Mook-Kanamori DO, Johansson Å, Ingelsson E, Uitterlinden AG, Weiss S, Raitakari OT, Gudnason V, North KE, Gharib SA, Sin DD, Taylor KD, O'Connor GT, Kaprio J, Harris TB, Pederson O, Vestergaard H, Wilson JG, Strauch K, Hayward C, Kerr S, Deary IJ, Barr RG, de Mutsert R, Gyllensten U, Morris AP, Ikram MA, Probst-Hensch N, Gläser S, Zeggini E, Lehtimäki T, Strachan DP, Dupuis J, Morrison AC, Hall IP, Tobin MD, London SJ.

Wellcome Open Res. 2018 Jan 12;3:4. doi: 10.12688/wellcomeopenres.12583.3. eCollection 2018.

35.

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Ji X, Bossé Y, Landi MT, Gui J, Xiao X, Qian D, Joubert P, Lamontagne M, Li Y, Gorlov I, de Biasi M, Han Y, Gorlova O, Hung RJ, Wu X, McKay J, Zong X, Carreras-Torres R, Christiani DC, Caporaso N, Johansson M, Liu G, Bojesen SE, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Chen C, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman C, Wilkens L, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden EHFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty J, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Manz J, Muley T, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd F, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston R, McLaughlin J, Stevens V, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Artigas MS, Tobin MD, Wain LV, Gu F, Byun J, Kamal A, Zhu D, Tyndale RF, Wei WQ, Chanock S, Brennan P, Amos CI.

Nat Commun. 2018 Aug 13;9(1):3221. doi: 10.1038/s41467-018-05074-y.

36.

microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.

Tasena H, Faiz A, Timens W, Noordhoek J, Hylkema MN, Gosens R, Hiemstra PS, Spira A, Postma DS, Tew GW, Grimbaldeston MA, van den Berge M, Heijink IH, Brandsma CA.

Eur Respir J. 2018 Sep 6;52(3). pii: 1701556. doi: 10.1183/13993003.01556-2017. Print 2018 Sep.

37.

Essential preanalytics in PD-L1 immunocytochemistry.

T Hart NA, van der Starre-Gaal J, Vonk JM, Timens W.

Histopathology. 2019 Jan;74(2):362-364. doi: 10.1111/his.13717. Epub 2018 Oct 23. No abstract available.

PMID:
30019344
38.

Impact of acute exposure to cigarette smoke on airway gene expression.

Billatos E, Faiz A, Gesthalter Y, LeClerc A, Alekseyev YO, Xiao X, Liu G, Ten Hacken NHT, Heijink IH, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME.

Physiol Genomics. 2018 Sep 1;50(9):705-713. doi: 10.1152/physiolgenomics.00092.2017. Epub 2018 Jun 22.

39.

Serum periostin does not reflect type 2-driven inflammation in COPD.

Carpaij OA, Muntinghe FOW, Wagenaar MB, Habing JW, Timens W, Kerstjens HAM, Nawijn MC, Kunz LIZ, Hiemstra PS, Tew GW, Holweg CTJ, Brandsma CA, van den Berge M.

Respir Res. 2018 Jun 7;19(1):112. doi: 10.1186/s12931-018-0818-8.

40.

Mesenchymal Stromal Cells to Regenerate Emphysema: On the Horizon?

Kruk DMLW, Heijink IH, Slebos DJ, Timens W, Ten Hacken NH.

Respiration. 2018;96(2):148-158. doi: 10.1159/000488149. Epub 2018 May 2. Review.

41.

Leveraging lung tissue transcriptome to uncover candidate causal genes in COPD genetic associations.

Lamontagne M, Bérubé JC, Obeidat M, Cho MH, Hobbs BD, Sakornsakolpat P, de Jong K, Boezen HM; International COPD Genetics Consortium, Nickle D, Hao K, Timens W, van den Berge M, Joubert P, Laviolette M, Sin DD, Paré PD, Bossé Y.

Hum Mol Genet. 2018 May 15;27(10):1819-1829. doi: 10.1093/hmg/ddy091.

42.

Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling.

Wang J, Faiz A, Ge Q, Vermeulen CJ, Van der Velden J, Snibson KJ, van de Velde R, Sawant S, Xenaki D, Oliver B, Timens W, Ten Hacken N, van den Berge M, James A, Elliot JG, Dong L, Burgess JK, Ashton AW.

J Cell Mol Med. 2018 May;22(5):2826-2837. doi: 10.1111/jcmm.13576. Epub 2018 Mar 7.

43.

Mutations in EMT-Related Genes in ALK Positive Crizotinib Resistant Non-Small Cell Lung Cancers.

Wei J, van der Wekken AJ, Saber A, Terpstra MM, Schuuring E, Timens W, Hiltermann TJN, Groen HJM, van den Berg A, Kok K.

Cancers (Basel). 2018 Jan 4;10(1). pii: E10. doi: 10.3390/cancers10010010.

44.

Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression.

Boudewijn IM, Faiz A, Steiling K, van der Wiel E, Telenga ED, Hoonhorst SJM, Ten Hacken NHT, Brandsma CA, Kerstjens HAM, Timens W, Heijink IH, Jonker MR, de Bruin HG, Sebastiaan Vroegop J, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Spira A, Lenburg ME, Guryev V, Postma DS, van den Berge M.

Respir Res. 2017 Dec 21;18(1):213. doi: 10.1186/s12931-017-0696-5.

45.

Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

Brandsma CA, de Vries M, Costa R, Woldhuis RR, Königshoff M, Timens W.

Eur Respir Rev. 2017 Dec 6;26(146). pii: 170073. doi: 10.1183/16000617.0073-2017. Print 2017 Dec 31. Review.

46.

Lung tissue gene-expression signature for the ageing lung in COPD.

de Vries M, Faiz A, Woldhuis RR, Postma DS, de Jong TV, Sin DD, Bossé Y, Nickle DC, Guryev V, Timens W, van den Berge M, Brandsma CA.

Thorax. 2017 Dec 6. pii: thoraxjnl-2017-210074. doi: 10.1136/thoraxjnl-2017-210074. [Epub ahead of print]

PMID:
29212667
47.

Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation.

Obeidat M, Li X, Burgess S, Zhou G, Fishbane N, Hansel NN, Bossé Y, Joubert P, Hao K, Nickle DC, van den Berge M, Timens W, Cho MH, Hobbs BD, de Jong K, Boezen M, Hung RJ, Rafaels N, Mathias R, Ruczinski I, Beaty TH, Barnes KC, Paré PD, Sin DD; International COPD Genetics Consortium, Lung eQTL Consortium, Lung Health Study.

Eur Respir J. 2017 Nov 30;50(5). pii: 1700657. doi: 10.1183/13993003.00657-2017. Print 2017 Nov.

48.

The fetal programming effect of prenatal smoking on Igf1r and Igf1 methylation is organ- and sex-specific.

Meyer KF, Verkaik-Schakel RN, Timens W, Kobzik L, Plösch T, Hylkema MN.

Epigenetics. 2017;12(12):1076-1091. doi: 10.1080/15592294.2017.1403691.

49.

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

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