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Correction of aging phenotype in the liver.

Rodriguez K, Cast A, Timchenko NA.

Aging (Albany NY). 2018 Aug 10;10(8):1795-1796. doi: 10.18632/aging.101523. No abstract available.


Elimination of Age-Associated Hepatic Steatosis and Correction of Aging Phenotype by Inhibition of cdk4-C/EBPα-p300 Axis.

Nguyen P, Valanejad L, Cast A, Wright M, Garcia JM, El-Serag HB, Karns R, Timchenko NA.

Cell Rep. 2018 Aug 7;24(6):1597-1609. doi: 10.1016/j.celrep.2018.07.014.


Reduction of Cellular Nucleic Acid Binding Protein Encoded by a Myotonic Dystrophy Type 2 Gene Causes Muscle Atrophy.

Wei C, Stock L, Schneider-Gold C, Sommer C, Timchenko NA, Timchenko L.

Mol Cell Biol. 2018 Jun 28;38(14). pii: e00649-17. doi: 10.1128/MCB.00649-17. Print 2018 Jul 15.


Correction of GSK3β at young age prevents muscle pathology in mice with myotonic dystrophy type 1.

Wei C, Stock L, Valanejad L, Zalewski ZA, Karns R, Puymirat J, Nelson D, Witte D, Woodgett J, Timchenko NA, Timchenko L.

FASEB J. 2018 Apr;32(4):2073-2085. doi: 10.1096/fj.201700700R. Epub 2018 Jan 5.


Intravenous miR-144 inhibits tumor growth in diethylnitrosamine-induced hepatocellular carcinoma in mice.

He Q, Wang F, Honda T, Lindquist DM, Dillman JR, Timchenko NA, Redington AN.

Tumour Biol. 2017 Oct;39(10):1010428317737729. doi: 10.1177/1010428317737729.


Ghrelin deletion protects against age-associated hepatic steatosis by downregulating the C/EBPα-p300/DGAT1 pathway.

Guillory B, Jawanmardi N, Iakova P, Anderson B, Zang P, Timchenko NA, Garcia JM.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12688. Epub 2017 Oct 12.


Mitochondrial and anabolic pathways in hepatocellular carcinoma.

Timchenko NA.

Hepatology. 2018 Mar;67(3):823-825. doi: 10.1002/hep.29559. Epub 2018 Jan 30. No abstract available.


Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease.

Jin J, Valanejad L, Nguyen TP, Lewis K, Wright M, Cast A, Stock L, Timchenko L, Timchenko NA.

Cell Rep. 2016 Jul 19;16(3):744-56. doi: 10.1016/j.celrep.2016.06.019. Epub 2016 Jun 30.


Generation of pediatric liver cancer patient-derived xenograft platforms for pediatric liver cancer: A critical stage in the development of anticancer treatments.

Tiao G, Geller J, Timchenko NA.

Hepatology. 2016 Oct;64(4):1017-9. doi: 10.1002/hep.28711. Epub 2016 Aug 2. No abstract available.


Cell-type specific functions of epidermal growth factor receptor are involved in development of hepatocellular carcinoma.

Timchenko NA.

Hepatology. 2015 Jul;62(1):314-6. doi: 10.1002/hep.27863. Epub 2015 May 20. No abstract available.


Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration.

Jin J, Hong IH, Lewis K, Iakova P, Breaux M, Jiang Y, Sullivan E, Jawanmardi N, Timchenko L, Timchenko NA.

Hepatology. 2015 Jan;61(1):315-25. doi: 10.1002/hep.27295. Epub 2014 Nov 20.


Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice.

Jiang Y, Jin J, Iakova P, Hernandez JC, Jawanmardi N, Sullivan E, Guo GL, Timchenko NA, Darlington GJ.

Mech Ageing Dev. 2013 Sep;134(9):407-15. doi: 10.1016/j.mad.2013.08.003. Epub 2013 Sep 2.


Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late stages of liver cancer.

Jin J, Iakova P, Jiang Y, Lewis K, Sullivan E, Jawanmardi N, Donehower L, Timchenko L, Timchenko NA.

J Biol Chem. 2013 May 17;288(20):14451-62. doi: 10.1074/jbc.M113.460840. Epub 2013 Apr 5.


Increased expression of enzymes of triglyceride synthesis is essential for the development of hepatic steatosis.

Jin J, Iakova P, Breaux M, Sullivan E, Jawanmardi N, Chen D, Jiang Y, Medrano EM, Timchenko NA.

Cell Rep. 2013 Mar 28;3(3):831-43. doi: 10.1016/j.celrep.2013.02.009. Epub 2013 Mar 14.


GSK3β is a new therapeutic target for myotonic dystrophy type 1.

Wei C, Jones K, Timchenko NA, Timchenko L.

Rare Dis. 2013 Sep 26;1:e26555. doi: 10.4161/rdis.26555. eCollection 2013.


Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer.

Jiang Y, Iakova P, Jin J, Sullivan E, Sharin V, Hong IH, Anakk S, Mayor A, Darlington G, Finegold M, Moore D, Timchenko NA.

Hepatology. 2013 Mar;57(3):1098-106. doi: 10.1002/hep.26146. Epub 2013 Feb 15.


GSK3β mediates muscle pathology in myotonic dystrophy.

Jones K, Wei C, Iakova P, Bugiardini E, Schneider-Gold C, Meola G, Woodgett J, Killian J, Timchenko NA, Timchenko LT.

J Clin Invest. 2012 Dec;122(12):4461-72. doi: 10.1172/JCI64081. Epub 2012 Nov 19.


The role of CUGBP1 in age-dependent changes of liver functions.

Jones K, Timchenko L, Timchenko NA.

Ageing Res Rev. 2012 Sep;11(4):442-9. doi: 10.1016/j.arr.2012.02.007. Epub 2012 Mar 14. Review.


The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation.

Jin J, Iakova P, Jiang Y, Medrano EE, Timchenko NA.

Hepatology. 2011 Sep 2;54(3):989-98. doi: 10.1002/hep.24471. Epub 2011 Jul 27.


Intracellular signaling and hepatocellular carcinoma.

Iakova P, Timchenko L, Timchenko NA.

Semin Cancer Biol. 2011 Feb;21(1):28-34. doi: 10.1016/j.semcancer.2010.09.001. Epub 2010 Sep 17. Review.


Epigenetic changes play critical role in age-associated dysfunctions of the liver.

Jin J, Wang GL, Iakova P, Shi X, Haefliger S, Finegold M, Timchenko NA.

Aging Cell. 2010 Oct;9(5):895-910. doi: 10.1111/j.1474-9726.2010.00617.x.


Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice.

Wang GL, Shi X, Haefliger S, Jin J, Major A, Iakova P, Finegold M, Timchenko NA.

J Clin Invest. 2010 Jul;120(7):2549-62. doi: 10.1172/JCI41933.


Calmodulin controls liver proliferation via interactions with C/EBPbeta-LAP and C/EBPbeta-LIP.

Orellana D, Liu X, Wang GL, Jin J, Iakova P, Timchenko NA.

J Biol Chem. 2010 Jul 23;285(30):23444-56. doi: 10.1074/jbc.M110.129825. Epub 2010 May 24.


SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta.

Lin Q, Chen D, Timchenko NA, Medrano EE.

Cell Cycle. 2010 May;9(9):1684-9. Epub 2010 May 21.


GSK3beta and aging liver.

Jin J, Wang GL, Timchenko L, Timchenko NA.

Aging (Albany NY). 2009 Jun 22;1(6):582-5. Review.


SKI knockdown inhibits human melanoma tumor growth in vivo.

Chen D, Lin Q, Box N, Roop D, Ishii S, Matsuzaki K, Fan T, Hornyak TJ, Reed JA, Stavnezer E, Timchenko NA, Medrano EE.

Pigment Cell Melanoma Res. 2009 Dec;22(6):761-72. doi: 10.1111/j.1755-148X.2009.00603.x.


Role of HDAC1 in senescence, aging, and cancer.

Willis-Martinez D, Richards HW, Timchenko NA, Medrano EE.

Exp Gerontol. 2010 Apr;45(4):279-85. doi: 10.1016/j.exger.2009.10.001. Epub 2009 Oct 8. Review.


Unfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid leukaemia.

Schardt JA, Eyholzer M, Timchenko NA, Mueller BU, Pabst T.

J Cell Mol Med. 2010 Jun;14(6B):1509-19. doi: 10.1111/j.1582-4934.2009.00870.x. Epub 2009 Jul 31.


Expression of RNA CCUG repeats dysregulates translation and degradation of proteins in myotonic dystrophy 2 patients.

Salisbury E, Schoser B, Schneider-Gold C, Wang GL, Huichalaf C, Jin B, Sirito M, Sarkar P, Krahe R, Timchenko NA, Timchenko LT.

Am J Pathol. 2009 Aug;175(2):748-62. doi: 10.2353/ajpath.2009.090047. Epub 2009 Jul 9.


GSK3beta-cyclin D3-CUGBP1-eIF2 pathway in aging and in myotonic dystrophy.

Jin J, Wang GL, Salisbury E, Timchenko L, Timchenko NA.

Cell Cycle. 2009 Aug;8(15):2356-9. Epub 2009 Aug 11. Review.


The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration.

Jin J, Wang GL, Shi X, Darlington GJ, Timchenko NA.

Mol Cell Biol. 2009 Jul;29(14):3867-80. doi: 10.1128/MCB.00456-09. Epub 2009 Apr 27.


Aging and liver regeneration.

Timchenko NA.

Trends Endocrinol Metab. 2009 May;20(4):171-6. doi: 10.1016/j.tem.2009.01.005. Epub 2009 Apr 7. Review.


HDAC1 cooperates with C/EBPalpha in the inhibition of liver proliferation in old mice.

Wang GL, Salisbury E, Shi X, Timchenko L, Medrano EE, Timchenko NA.

J Biol Chem. 2008 Sep 19;283(38):26169-78. doi: 10.1074/jbc.M803544200. Epub 2008 Jul 11.


HDAC1 promotes liver proliferation in young mice via interactions with C/EBPbeta.

Wang GL, Salisbury E, Shi X, Timchenko L, Medrano EE, Timchenko NA.

J Biol Chem. 2008 Sep 19;283(38):26179-87. doi: 10.1074/jbc.M803545200. Epub 2008 Jul 11.


Regulation of apoptotic and growth inhibitory activities of C/EBPalpha in different cell lines.

Wang GL, Shi X, Salisbury E, Timchenko NA.

Exp Cell Res. 2008 Apr 15;314(7):1626-39. doi: 10.1016/j.yexcr.2008.01.028. Epub 2008 Feb 13.


C/EBPbeta suppression by interruption of CUGBP1 resulting from a complex rearrangement of MLL.

Choi WT, Folsom MR, Azim MF, Meyer C, Kowarz E, Marschalek R, Timchenko NA, Naeem RC, Lee DA.

Cancer Genet Cytogenet. 2007 Sep;177(2):108-14.


Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi.

Bandyopadhyay D, Curry JL, Lin Q, Richards HW, Chen D, Hornsby PJ, Timchenko NA, Medrano EE.

Aging Cell. 2007 Aug;6(4):577-91. Epub 2007 Jun 18.


Regulation of the promoter of CUG triplet repeat binding protein, Cugbp1, during myogenesis.

Huichalaf CH, Sakai K, Wang GL, Timchenko NA, Timchenko L.

Gene. 2007 Jul 15;396(2):391-402. Epub 2007 Apr 29.


Growth hormone corrects proliferation and transcription of phosphoenolpyruvate carboxykinase in livers of old mice via elimination of CCAAT/enhancer-binding protein alpha-Brm complex.

Wang GL, Shi X, Salisbury E, Sun Y, Albrecht JH, Smith RG, Timchenko NA.

J Biol Chem. 2007 Jan 12;282(2):1468-78. Epub 2006 Nov 15.


Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver.

Timchenko LT, Salisbury E, Wang GL, Nguyen H, Albrecht JH, Hershey JW, Timchenko NA.

J Biol Chem. 2006 Oct 27;281(43):32806-19. Epub 2006 Aug 24.


CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities.

Lee YJ, Jones LC, Timchenko NA, Perrotti D, Tenen DG, Kogan SC.

Blood. 2006 Oct 1;108(7):2416-9. Epub 2006 Jun 20.


Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging.

Karagiannides I, Thomou T, Tchkonia T, Pirtskhalava T, Kypreos KE, Cartwright A, Dalagiorgou G, Lash TL, Farmer SR, Timchenko NA, Kirkland JL.

J Biol Chem. 2006 Aug 11;281(32):23025-33. Epub 2006 Jun 5.


Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression.

Harrison-Findik DD, Schafer D, Klein E, Timchenko NA, Kulaksiz H, Clemens D, Fein E, Andriopoulos B, Pantopoulos K, Gollan J.

J Biol Chem. 2006 Aug 11;281(32):22974-82. Epub 2006 May 31.


Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha.

McFie PJ, Wang GL, Timchenko NA, Wilson HL, Hu X, Roesler WJ.

J Biol Chem. 2006 Jun 30;281(26):18069-80. Epub 2006 Apr 27.


Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes.

Wang GL, Shi X, Salisbury E, Sun Y, Albrecht JH, Smith RG, Timchenko NA.

Mol Cell Biol. 2006 Apr;26(7):2570-82.


CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16).

Helbling D, Mueller BU, Timchenko NA, Schardt J, Eyer M, Betts DR, Jotterand M, Meyer-Monard S, Fey MF, Pabst T.

Blood. 2005 Aug 15;106(4):1369-75. Epub 2005 Apr 26.


The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin.

Helbling D, Mueller BU, Timchenko NA, Hagemeijer A, Jotterand M, Meyer-Monard S, Lister A, Rowley JD, Huegli B, Fey MF, Pabst T.

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13312-7. Epub 2004 Aug 23.

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