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Liver Proliferation Is an Essential Driver of Fibrosis in Mouse Models of Nonalcoholic Fatty Liver Disease.

Cast A, Kumbaji M, D'Souza A, Rodriguez K, Gupta A, Karns R, Timchenko L, Timchenko N.

Hepatol Commun. 2019 Jul 17;3(8):1036-1049. doi: 10.1002/hep4.1381. eCollection 2019 Aug.


[Efficacy, tolerability and safety of the treatment with teberif: the results of a 2-year randomized clinical trial of treatment naïve patients with remitting multiple sclerosis, who have not received DMT, after switching from other interferon β-1a].

Boyko AN, Bosenko LP, Vasilovskiy VV, Volkova LI, Zakharova MN, Kotov SV, Lekomtseva EV, Negrich TI, Parshina EV, Patrusheva OP, Prokopenko SV, Sazonov DV, Timchenko LV, Trinitatskiy YV, Khabirov FA, Khavunka MY, Chichanovskaya LV, Sherman MA, Ivanov RA, Lin'kova YN, Stukalina EY, Zinkina-Orikhan AV, Obukhova IG.

Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(2. Vyp. 2):73-85. doi: 10.17116/jnevro20191192273. Russian.


[The influence of the drying method for food properties and hypolidemic potential of oyster mushrooms (Pleurotus ostreatus)].

Piskov SI, Timchenko LD, Rzhepakovsky IV, Avanesyan SS, Sizonenko MN, Areshidze DA, Kovalev DA.

Vopr Pitan. 2018;87(2):65-76. doi: 10.24411/0042-8833-2018-10020. Epub 2018 Feb 26. Russian.


Reduction of Cellular Nucleic Acid Binding Protein Encoded by a Myotonic Dystrophy Type 2 Gene Causes Muscle Atrophy.

Wei C, Stock L, Schneider-Gold C, Sommer C, Timchenko NA, Timchenko L.

Mol Cell Biol. 2018 Jun 28;38(14). pii: e00649-17. doi: 10.1128/MCB.00649-17. Print 2018 Jul 15.


Correction of GSK3β at young age prevents muscle pathology in mice with myotonic dystrophy type 1.

Wei C, Stock L, Valanejad L, Zalewski ZA, Karns R, Puymirat J, Nelson D, Witte D, Woodgett J, Timchenko NA, Timchenko L.

FASEB J. 2018 Apr;32(4):2073-2085. doi: 10.1096/fj.201700700R. Epub 2018 Jan 5.


RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner.

Lewis K, Valanejad L, Cast A, Wright M, Wei C, Iakova P, Stock L, Karns R, Timchenko L, Timchenko N.

Mol Cell Biol. 2017 Jul 28;37(16). pii: e00128-17. doi: 10.1128/MCB.00128-17. Print 2017 Aug 15.


Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases.

Palomo V, Perez DI, Roca C, Anderson C, Rodríguez-Muela N, Perez C, Morales-Garcia JA, Reyes JA, Campillo NE, Perez-Castillo AM, Rubin LL, Timchenko L, Gil C, Martinez A.

J Med Chem. 2017 Jun 22;60(12):4983-5001. doi: 10.1021/acs.jmedchem.7b00395. Epub 2017 Jun 6.


FXR-Gankyrin axis is involved in development of pediatric liver cancer.

Valanejad L, Lewis K, Wright M, Jiang Y, D'Souza A, Karns R, Sheridan R, Gupta A, Bove K, Witte D, Geller J, Tiao G, Nelson DL, Timchenko L, Timchenko N.

Carcinogenesis. 2017 Jul 1;38(7):738-747. doi: 10.1093/carcin/bgx050.


Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts.

Tajhya RB, Hu X, Tanner MR, Huq R, Kongchan N, Neilson JR, Rodney GG, Horrigan FT, Timchenko LT, Beeton C.

Cell Death Dis. 2016 Oct 20;7(10):e2426. doi: 10.1038/cddis.2016.324.


Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease.

Jin J, Valanejad L, Nguyen TP, Lewis K, Wright M, Cast A, Stock L, Timchenko L, Timchenko NA.

Cell Rep. 2016 Jul 19;16(3):744-56. doi: 10.1016/j.celrep.2016.06.019. Epub 2016 Jun 30.


p300 Regulates Liver Functions by Controlling p53 and C/EBP Family Proteins through Multiple Signaling Pathways.

Breaux M, Lewis K, Valanejad L, Iakova P, Chen F, Mo Q, Medrano E, Timchenko L, Timchenko N.

Mol Cell Biol. 2015 Sep 1;35(17):3005-16. doi: 10.1128/MCB.00421-15. Epub 2015 Jun 22.


Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5.

Jones K, Wei C, Schoser B, Meola G, Timchenko N, Timchenko L.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8041-5. doi: 10.1073/pnas.1422273112. Epub 2015 Jun 15.


Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration.

Jin J, Hong IH, Lewis K, Iakova P, Breaux M, Jiang Y, Sullivan E, Jawanmardi N, Timchenko L, Timchenko NA.

Hepatology. 2015 Jan;61(1):315-25. doi: 10.1002/hep.27295. Epub 2014 Nov 20.


Most expression and splicing changes in myotonic dystrophy type 1 and type 2 skeletal muscle are shared with other muscular dystrophies.

Bachinski LL, Baggerly KA, Neubauer VL, Nixon TJ, Raheem O, Sirito M, Unruh AK, Zhang J, Nagarajan L, Timchenko LT, Bassez G, Eymard B, Gamez J, Ashizawa T, Mendell JR, Udd B, Krahe R.

Neuromuscul Disord. 2014 Mar;24(3):227-40. doi: 10.1016/j.nmd.2013.11.001. Epub 2013 Nov 15.


Age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4 treatments.

Hong IH, Lewis K, Iakova P, Jin J, Sullivan E, Jawanmardi N, Timchenko L, Timchenko N.

J Biol Chem. 2014 Jan 10;289(2):1106-18. doi: 10.1074/jbc.M113.526780. Epub 2013 Nov 22.


[Organization of specialized medical care to patients with stroke in the Krasnodar kray].

Tsukurova LA, Timchenko LV, Golovko EN.

Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(9 Pt 2):77-80. Russian. No abstract available.


[The discrepancy of clinical signs and paraclinical data in the diagnosis of brain death].

Tsurkova LA, Timchenko LV, Golovko EN.

Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(6):84-5. Russian. No abstract available.


Molecular mechanisms of muscle atrophy in myotonic dystrophies.

Timchenko L.

Int J Biochem Cell Biol. 2013 Oct;45(10):2280-7. doi: 10.1016/j.biocel.2013.06.010. Epub 2013 Jun 21. Review.


Smaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy.

de Haro M, Al-Ramahi I, Jones KR, Holth JK, Timchenko LT, Botas J.

PLoS Genet. 2013 Apr;9(4):e1003445. doi: 10.1371/journal.pgen.1003445. Epub 2013 Apr 18.


Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late stages of liver cancer.

Jin J, Iakova P, Jiang Y, Lewis K, Sullivan E, Jawanmardi N, Donehower L, Timchenko L, Timchenko NA.

J Biol Chem. 2013 May 17;288(20):14451-62. doi: 10.1074/jbc.M113.460840. Epub 2013 Apr 5.


Dysfunction of protein homeostasis in myotonic dystrophies.

Meola G, Jones K, Wei C, Timchenko LT.

Histol Histopathol. 2013 Sep;28(9):1089-98. doi: 10.14670/HH-28.1089. Epub 2013 Mar 28. Review.


GSK3β is a new therapeutic target for myotonic dystrophy type 1.

Wei C, Jones K, Timchenko NA, Timchenko L.

Rare Dis. 2013 Sep 26;1:e26555. doi: 10.4161/rdis.26555. eCollection 2013.


GSK3β mediates muscle pathology in myotonic dystrophy.

Jones K, Wei C, Iakova P, Bugiardini E, Schneider-Gold C, Meola G, Woodgett J, Killian J, Timchenko NA, Timchenko LT.

J Clin Invest. 2012 Dec;122(12):4461-72. doi: 10.1172/JCI64081. Epub 2012 Nov 19.


The role of CUGBP1 in age-dependent changes of liver functions.

Jones K, Timchenko L, Timchenko NA.

Ageing Res Rev. 2012 Sep;11(4):442-9. doi: 10.1016/j.arr.2012.02.007. Epub 2012 Mar 14. Review.


RNA Foci, CUGBP1, and ZNF9 are the primary targets of the mutant CUG and CCUG repeats expanded in myotonic dystrophies type 1 and type 2.

Jones K, Jin B, Iakova P, Huichalaf C, Sarkar P, Schneider-Gold C, Schoser B, Meola G, Shyu AB, Timchenko N, Timchenko L.

Am J Pathol. 2011 Nov;179(5):2475-89. doi: 10.1016/j.ajpath.2011.07.013. Epub 2011 Sep 1.


Quantitative measurement of GLUT4 translocation to the plasma membrane by flow cytometry.

Koshy S, Alizadeh P, Timchenko LT, Beeton C.

J Vis Exp. 2010 Nov 7;(45). pii: 2429. doi: 10.3791/2429.


Myotonic dystrophies 1 and 2: complex diseases with complex mechanisms.

Schoser B, Timchenko L.

Curr Genomics. 2010 Apr;11(2):77-90. doi: 10.2174/138920210790886844.


Intracellular signaling and hepatocellular carcinoma.

Iakova P, Timchenko L, Timchenko NA.

Semin Cancer Biol. 2011 Feb;21(1):28-34. doi: 10.1016/j.semcancer.2010.09.001. Epub 2010 Sep 17. Review.


Expansion of CUG RNA repeats causes stress and inhibition of translation in myotonic dystrophy 1 (DM1) cells.

Huichalaf C, Sakai K, Jin B, Jones K, Wang GL, Schoser B, Schneider-Gold C, Sarkar P, Pereira-Smith OM, Timchenko N, Timchenko L.

FASEB J. 2010 Oct;24(10):3706-19. doi: 10.1096/fj.09-151159. Epub 2010 May 17.


CCUG repeats reduce the rate of global protein synthesis in myotonic dystrophy type 2.

Schneider-Gold C, Timchenko LT.

Rev Neurosci. 2010;21(1):19-28. Review.


GSK3beta and aging liver.

Jin J, Wang GL, Timchenko L, Timchenko NA.

Aging (Albany NY). 2009 Jun 22;1(6):582-5. Review.


Reduction of the rate of protein translation in patients with myotonic dystrophy 2.

Huichalaf C, Schoser B, Schneider-Gold C, Jin B, Sarkar P, Timchenko L.

J Neurosci. 2009 Jul 15;29(28):9042-9. doi: 10.1523/JNEUROSCI.1983-09.2009.


Expression of RNA CCUG repeats dysregulates translation and degradation of proteins in myotonic dystrophy 2 patients.

Salisbury E, Schoser B, Schneider-Gold C, Wang GL, Huichalaf C, Jin B, Sirito M, Sarkar P, Krahe R, Timchenko NA, Timchenko LT.

Am J Pathol. 2009 Aug;175(2):748-62. doi: 10.2353/ajpath.2009.090047. Epub 2009 Jul 9.


GSK3beta-cyclin D3-CUGBP1-eIF2 pathway in aging and in myotonic dystrophy.

Jin J, Wang GL, Salisbury E, Timchenko L, Timchenko NA.

Cell Cycle. 2009 Aug;8(15):2356-9. Epub 2009 Aug 11. Review.


HDAC1 cooperates with C/EBPalpha in the inhibition of liver proliferation in old mice.

Wang GL, Salisbury E, Shi X, Timchenko L, Medrano EE, Timchenko NA.

J Biol Chem. 2008 Sep 19;283(38):26169-78. doi: 10.1074/jbc.M803544200. Epub 2008 Jul 11.


HDAC1 promotes liver proliferation in young mice via interactions with C/EBPbeta.

Wang GL, Salisbury E, Shi X, Timchenko L, Medrano EE, Timchenko NA.

J Biol Chem. 2008 Sep 19;283(38):26179-87. doi: 10.1074/jbc.M803545200. Epub 2008 Jul 11.


Ectopic expression of cyclin D3 corrects differentiation of DM1 myoblasts through activation of RNA CUG-binding protein, CUGBP1.

Salisbury E, Sakai K, Schoser B, Huichalaf C, Schneider-Gold C, Nguyen H, Wang GL, Albrecht JH, Timchenko LT.

Exp Cell Res. 2008 Jul 1;314(11-12):2266-78. doi: 10.1016/j.yexcr.2008.04.018. Epub 2008 May 10.


Regulation of the promoter of CUG triplet repeat binding protein, Cugbp1, during myogenesis.

Huichalaf CH, Sakai K, Wang GL, Timchenko NA, Timchenko L.

Gene. 2007 Jul 15;396(2):391-402. Epub 2007 Apr 29.


Reversal of fortune.

Timchenko L.

Nat Genet. 2006 Sep;38(9):976-7. No abstract available.


Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver.

Timchenko LT, Salisbury E, Wang GL, Nguyen H, Albrecht JH, Hershey JW, Timchenko NA.

J Biol Chem. 2006 Oct 27;281(43):32806-19. Epub 2006 Aug 24.


(1)H, (15)N and (13)C chemical shift assignments of RNA repeats binding protein -- CUGBP1ab.

Jun KY, Xia Y, Han X, Zhang H, Timchenko L, Swanson MS, Gao X.

J Biomol NMR. 2004 Nov;30(3):371-2. No abstract available.


Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate.

Iakova P, Wang GL, Timchenko L, Michalak M, Pereira-Smith OM, Smith JR, Timchenko NA.

EMBO J. 2004 Jan 28;23(2):406-17. Epub 2004 Jan 15.


Overexpression of CUG triplet repeat-binding protein, CUGBP1, in mice inhibits myogenesis.

Timchenko NA, Patel R, Iakova P, Cai ZJ, Quan L, Timchenko LT.

J Biol Chem. 2004 Mar 26;279(13):13129-39. Epub 2004 Jan 13.


Viral vector producing antisense RNA restores myotonic dystrophy myoblast functions.

Furling D, Doucet G, Langlois MA, Timchenko L, Belanger E, Cossette L, Puymirat J.

Gene Ther. 2003 May;10(9):795-802.


Myotonic dystrophy: discussion of molecular basis.

Timchenko LT, Tapscott SJ, Cooper TA, Monckton DG.

Adv Exp Med Biol. 2002;516:27-45. Review. No abstract available.


[Betaserc treatment of acute disorders of cerebral circulation with vestibulo-ataxic and cochleo-vestibular syndromes].

Berdichevskiĭ MIa, Karmirian SA, Geĭko II, Miroshnichenko VE, Parkhaeva TN, Popova VG, Timchenko LV, Filina TV, Aristova LA.

Vestn Otorinolaringol. 2002;(4):32-3. Russian. No abstract available.


Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins.

Timchenko LT, Iakova P, Welm AL, Cai ZJ, Timchenko NA.

Mol Cell Biol. 2002 Oct;22(20):7242-57.


Molecular basis for impaired muscle differentiation in myotonic dystrophy.

Timchenko NA, Iakova P, Cai ZJ, Smith JR, Timchenko LT.

Mol Cell Biol. 2001 Oct;21(20):6927-38.


RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1.

Timchenko NA, Cai ZJ, Welm AL, Reddy S, Ashizawa T, Timchenko LT.

J Biol Chem. 2001 Mar 16;276(11):7820-6. Epub 2000 Dec 21.

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