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Items: 10


IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.

Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA.

Immunity. 2002 Jun;16(6):779-90.


Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.

Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA.

J Immunol. 2001 Aug 1;167(3):1440-6.


Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D, de Waal-Malefyt R, Hannum C, Bazan JF, Kastelein RA.

Immunity. 2000 Nov;13(5):715-25.


IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18.

Debets R, Timans JC, Churakowa T, Zurawski S, de Waal Malefyt R, Moore KW, Abrams JS, O'Garra A, Bazan JF, Kastelein RA.

J Immunol. 2000 Nov 1;165(9):4950-6.


OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily.

Patel N, Brinkman-Van der Linden EC, Altmann SW, Gish K, Balasubramanian S, Timans JC, Peterson D, Bell MP, Bazan JF, Varki A, Kastelein RA.

J Biol Chem. 1999 Aug 6;274(32):22729-38. Erratum in: J Biol Chem 1999 Sep 24;274(39):28058.


A family of human receptors structurally related to Drosophila Toll.

Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF.

Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):588-93.


Functional replacement of cytokine receptor extracellular domains by leucine zippers.

Patel N, Herrman JM, Timans JC, Kastelein RA.

J Biol Chem. 1996 Nov 29;271(48):30386-91.


A newly defined interleukin-1?

Bazan JF, Timans JC, Kastelein RA.

Nature. 1996 Feb 15;379(6566):591. No abstract available.


Expression and purification of a synthetic human obese gene product.

Altmann SW, Timans JC, Rock FL, Bazan JF, Kastelein RA.

Protein Expr Purif. 1995 Dec;6(6):722-6.


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