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The Lyme disease spirochete's BpuR DNA/RNA-binding protein is differentially expressed during the mammal-tick infectious cycle, which affects translation of the SodA superoxide dismutase.

Jutras BL, Savage CR, Arnold WK, Lethbridge KG, Carroll DW, Tilly K, Bestor A, Zhu H, Seshu J, Z├╝ckert WR, Stewart PE, Rosa PA, Brissette CA, Stevenson B.

Mol Microbiol. 2019 Sep;112(3):973-991. doi: 10.1111/mmi.14336. Epub 2019 Jul 7.


Borrelia burgdorferi SpoVG DNA- and RNA-Binding Protein Modulates the Physiology of the Lyme Disease Spirochete.

Savage CR, Jutras BL, Bestor A, Tilly K, Rosa PA, Tourand Y, Stewart PE, Brissette CA, Stevenson B.

J Bacteriol. 2018 May 24;200(12). pii: e00033-18. doi: 10.1128/JB.00033-18. Print 2018 Jun 15.


Infection history of the blood-meal host dictates pathogenic potential of the Lyme disease spirochete within the feeding tick vector.

Bhatia B, Hillman C, Carracoi V, Cheff BN, Tilly K, Rosa PA.

PLoS Pathog. 2018 Apr 5;14(4):e1006959. doi: 10.1371/journal.ppat.1006959. eCollection 2018 Apr.


Functional Equivalence of OspA and OspB, but Not OspC, in Tick Colonization by Borrelia burgdorferi.

Tilly K, Bestor A, Rosa PA.

Infect Immun. 2016 Apr 22;84(5):1565-1573. doi: 10.1128/IAI.00063-16. Print 2016 May.


Virulence of the Lyme disease spirochete before and after the tick bloodmeal: a quantitative assessment.

Kasumba IN, Bestor A, Tilly K, Rosa PA.

Parasit Vectors. 2016 Mar 7;9:129. doi: 10.1186/s13071-016-1380-1.


Long-term survival of Borrelia burgdorferi lacking the hibernation promotion factor homolog in the unfed tick vector.

Fazzino L, Tilly K, Dulebohn DP, Rosa PA.

Infect Immun. 2015 Dec;83(12):4800-10. doi: 10.1128/IAI.00925-15. Epub 2015 Oct 5.


Use of an endogenous plasmid locus for stable in trans complementation in Borrelia burgdorferi.

Kasumba IN, Bestor A, Tilly K, Rosa PA.

Appl Environ Microbiol. 2015 Feb;81(3):1038-46. doi: 10.1128/AEM.03657-14. Epub 2014 Dec 1.


Regulatory protein BBD18 of the lyme disease spirochete: essential role during tick acquisition?

Hayes BM, Dulebohn DP, Sarkar A, Tilly K, Bestor A, Ambroggio X, Rosa PA.

MBio. 2014 Apr 1;5(2):e01017-14. doi: 10.1128/mBio.01017-14. Erratum in: MBio. 2014;5(4):doi: 10.1128/mBio.01608-14.


Lipoprotein succession in Borrelia burgdorferi: similar but distinct roles for OspC and VlsE at different stages of mammalian infection.

Tilly K, Bestor A, Rosa PA.

Mol Microbiol. 2013 Jul;89(2):216-27. doi: 10.1111/mmi.12271. Epub 2013 Jun 7.


Competitive advantage of Borrelia burgdorferi with outer surface protein BBA03 during tick-mediated infection of the mammalian host.

Bestor A, Rego RO, Tilly K, Rosa PA.

Infect Immun. 2012 Oct;80(10):3501-11. doi: 10.1128/IAI.00521-12. Epub 2012 Jul 30.


Requirements for Borrelia burgdorferi plasmid maintenance.

Tilly K, Checroun C, Rosa PA.

Plasmid. 2012 Jul;68(1):1-12. doi: 10.1016/j.plasmid.2012.01.009. Epub 2012 Jan 24.


Use of the Cre-lox recombination system to investigate the lp54 gene requirement in the infectious cycle of Borrelia burgdorferi.

Bestor A, Stewart PE, Jewett MW, Sarkar A, Tilly K, Rosa PA.

Infect Immun. 2010 Jun;78(6):2397-407. doi: 10.1128/IAI.01059-09. Epub 2010 Mar 15.


Borrelia burgdorferi resistance to a major skin antimicrobial peptide is independent of outer surface lipoprotein content.

Sarkar A, Tilly K, Stewart P, Bestor A, Battisti JM, Rosa PA.

Antimicrob Agents Chemother. 2009 Oct;53(10):4490-4. doi: 10.1128/AAC.00558-09. Epub 2009 Aug 3.


OspC-independent infection and dissemination by host-adapted Borrelia burgdorferi.

Tilly K, Bestor A, Dulebohn DP, Rosa PA.

Infect Immun. 2009 Jul;77(7):2672-82. doi: 10.1128/IAI.01193-08. Epub 2009 Apr 27.


Biology of infection with Borrelia burgdorferi.

Tilly K, Rosa PA, Stewart PE.

Infect Dis Clin North Am. 2008 Jun;22(2):217-34, v. doi: 10.1016/j.idc.2007.12.013. Review.


Genetic basis for retention of a critical virulence plasmid of Borrelia burgdorferi.

Jewett MW, Byram R, Bestor A, Tilly K, Lawrence K, Burtnick MN, Gherardini F, Rosa PA.

Mol Microbiol. 2007 Nov;66(4):975-90. Epub 2007 Oct 4.


The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi.

Jewett MW, Lawrence K, Bestor AC, Tilly K, Grimm D, Shaw P, VanRaden M, Gherardini F, Rosa PA.

Mol Microbiol. 2007 Jun;64(5):1358-74.


Rapid clearance of Lyme disease spirochetes lacking OspC from skin.

Tilly K, Bestor A, Jewett MW, Rosa P.

Infect Immun. 2007 Mar;75(3):1517-9. Epub 2006 Dec 11.


Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection.

Tilly K, Krum JG, Bestor A, Jewett MW, Grimm D, Bueschel D, Byram R, Dorward D, Vanraden MJ, Stewart P, Rosa P.

Infect Immun. 2006 Jun;74(6):3554-64.


Delineating the requirement for the Borrelia burgdorferi virulence factor OspC in the mammalian host.

Stewart PE, Wang X, Bueschel DM, Clifton DR, Grimm D, Tilly K, Carroll JA, Weis JJ, Rosa PA.

Infect Immun. 2006 Jun;74(6):3547-53.


Cleavage of cytoskeletal proteins by caspases during ovarian cell death: evidence that cell-free systems do not always mimic apoptotic events in intact cells.

Maravei DV, Trbovich AM, Perez GI, Tilly KI, Banach D, Talanian RV, Wong WW, Tilly JL.

Cell Death Differ. 1997 Dec;4(8):707-12.


Defining plasmids required by Borrelia burgdorferi for colonization of tick vector Ixodes scapularis (Acari: Ixodidae).

Grimm D, Tilly K, Bueschel DM, Fisher MA, Policastro PF, Gherardini FC, Schwan TG, Rosa PA.

J Med Entomol. 2005 Jul;42(4):676-84.


The burgeoning molecular genetics of the Lyme disease spirochaete.

Rosa PA, Tilly K, Stewart PE.

Nat Rev Microbiol. 2005 Feb;3(2):129-43. Review.


The plasmids of Borrelia burgdorferi: essential genetic elements of a pathogen.

Stewart PE, Byram R, Grimm D, Tilly K, Rosa PA.

Plasmid. 2005 Jan;53(1):1-13. Epub 2004 Dec 16. Review.


Role of apoptosis in functional luteolysis in the pregnant rabbit corpus luteum: evidence of a role for placental-derived factors in promoting luteal cell survival.

Dharmarajan AM, Goodman SB, Atiya N, Parkinson SP, Lareu RR, Tilly KI, Tilly JL.

Apoptosis. 2004 Nov;9(6):807-14.


Experimental assessment of the roles of linear plasmids lp25 and lp28-1 of Borrelia burgdorferi throughout the infectious cycle.

Grimm D, Eggers CH, Caimano MJ, Tilly K, Stewart PE, Elias AF, Radolf JD, Rosa PA.

Infect Immun. 2004 Oct;72(10):5938-46.


Infectious cycle analysis of a Borrelia burgdorferi mutant defective in transport of chitobiose, a tick cuticle component.

Tilly K, Grimm D, Bueschel DM, Krum JG, Rosa P.

Vector Borne Zoonotic Dis. 2004 Summer;4(2):159-68.


Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals.

Grimm D, Tilly K, Byram R, Stewart PE, Krum JG, Bueschel DM, Schwan TG, Policastro PF, Elias AF, Rosa PA.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3142-7. Epub 2004 Feb 17.


Plasmid stability during in vitro propagation of Borrelia burgdorferi assessed at a clonal level.

Grimm D, Elias AF, Tilly K, Rosa PA.

Infect Immun. 2003 Jun;71(6):3138-45.


Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background.

Elias AF, Stewart PE, Grimm D, Caimano MJ, Eggers CH, Tilly K, Bono JL, Akins DR, Radolf JD, Schwan TG, Rosa P.

Infect Immun. 2002 Apr;70(4):2139-50.


Genetics and regulation of chitobiose utilization in Borrelia burgdorferi.

Tilly K, Elias AF, Errett J, Fischer E, Iyer R, Schwartz I, Bono JL, Rosa P.

J Bacteriol. 2001 Oct;183(19):5544-53.


Telomere resolution in the Lyme disease spirochete.

Chaconas G, Stewart PE, Tilly K, Bono JL, Rosa P.

EMBO J. 2001 Jun 15;20(12):3229-37.


DNA exchange and insertional inactivation in spirochetes.

Tilly K, Elias AF, Bono JL, Stewart P, Rosa P.

J Mol Microbiol Biotechnol. 2000 Oct;2(4):433-42. Review.


Altered stationary-phase response in a Borrelia burgdorferi rpoS mutant.

Elias AF, Bono JL, Carroll JA, Stewart P, Tilly K, Rosa P.

J Bacteriol. 2000 May;182(10):2909-18.


Efficient targeted mutagenesis in Borrelia burgdorferi.

Bono JL, Elias AF, Kupko JJ 3rd, Stevenson B, Tilly K, Rosa P.

J Bacteriol. 2000 May;182(9):2445-52.


Temperature-regulated expression of bacterial virulence genes.

Konkel ME, Tilly K.

Microbes Infect. 2000 Feb;2(2):157-66. Review.


Localization, regulation and possible consequences of apoptotic protease-activating factor-1 (Apaf-1) expression in granulosa cells of the mouse ovary.

Robles R, Tao XJ, Trbovich AM, Maravel DV, Nahum R, Perez GI, Tilly KI, Tilly JL.

Endocrinology. 1999 Jun;140(6):2641-4.


Analysis of apoptosis and expression of bcl-2 gene family members in the human and baboon ovary.

Kugu K, Ratts VS, Piquette GN, Tilly KI, Tao XJ, Martimbeau S, Aberdeen GW, Krajewski S, Reed JC, Pepe GJ, Albrecht ED, Tilly JL.

Cell Death Differ. 1998 Jan;5(1):67-76.


Growth of infectious and non-infectious B. burgdorferi at different salt concentrations.

Elias A, Bono JL, Tilly K, Rosa P.

Wien Klin Wochenschr. 1998 Dec 23;110(24):863-5.


Genetic studies in Borrelia burgdorferi.

Rosa P, Bono J, Elias A, Errett J, Kupko J, Stevenson B, Taylor G, Tilly K.

Wien Klin Wochenschr. 1998 Dec 23;110(24):859-62. Review.


Models to elucidate the regulation of adrenal cell death.

Carsia RV, Nagele RG, Morita Y, Tilly KI, Tilly JL.

Endocr Res. 1998 Aug-Nov;24(3-4):899-908.


Characterization of circular plasmid dimers in Borrelia burgdorferi.

Tilly K, Lubke L, Rosa P.

J Bacteriol. 1998 Nov;180(21):5676-81.


Estradiol-mediated suppression of apoptosis in the rabbit corpus luteum is associated with a shift in expression of bcl-2 family members favoring cellular survival.

Goodman SB, Kugu K, Chen SH, Preutthipan S, Tilly KI, Tilly JL, Dharmarajan AM.

Biol Reprod. 1998 Oct;59(4):820-7.


Transformation of the Lyme disease spirochete Borrelia burgdorferi with heterologous DNA.

Stevenson B, Bono JL, Elias A, Tilly K, Rosa P.

J Bacteriol. 1998 Sep;180(18):4850-5.


Oligopeptide permease in Borrelia burgdorferi: putative peptide-binding components encoded by both chromosomal and plasmid loci.

Bono JL, Tilly K, Stevenson B, Hogan D, Rosa P.

Microbiology. 1998 Apr;144 ( Pt 4):1033-44.


Differential expression of members of the bcl-2 gene family in proliferative and secretory human endometrium: glandular epithelial cell apoptosis is associated with increased expression of bax.

Tao XJ, Tilly KI, Maravei DV, Shifren JL, Krajewski S, Reed JC, Tilly JL, Isaacson KB.

J Clin Endocrinol Metab. 1997 Aug;82(8):2738-46.


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