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Items: 1 to 50 of 272

1.

Malaria parasites fine-tune mutations to resist drugs.

Tilley L, Rosenthal PJ.

Nature. 2019 Dec;576(7786):217-219. doi: 10.1038/d41586-019-03587-0. No abstract available.

PMID:
31822828
2.

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum.

Dumont L, Richardson MB, van der Peet P, Marapana DS, Triglia T, Dixon MWA, Cowman AF, Williams SJ, Tilley L, McConville MJ, Cobbold SA.

MBio. 2019 Dec 10;10(6). pii: e02060-19. doi: 10.1128/mBio.02060-19.

3.

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance.

Yang T, Yeoh LM, Tutor MV, Dixon MW, McMillan PJ, Xie SC, Bridgford JL, Gillett DL, Duffy MF, Ralph SA, McConville MJ, Tilley L, Cobbold SA.

Cell Rep. 2019 Nov 26;29(9):2917-2928.e5. doi: 10.1016/j.celrep.2019.10.095.

4.

The proteasome as a target for protozoan parasites.

Xie SC, Dick LR, Gould A, Brand S, Tilley L.

Expert Opin Ther Targets. 2019 Nov;23(11):903-914. doi: 10.1080/14728222.2019.1685981. Epub 2019 Nov 4.

PMID:
31679410
5.

Feasibility of increasing the dosage of inpatient occupational therapy and physiotherapy rehabilitation via independent tasks and exercises: 'My Therapy'.

Brusco NK, Tilley L, Walpole B, Kugler H, Li R, Kennedy E, Morris ME.

Aust Occup Ther J. 2019 Oct 11. doi: 10.1111/1440-1630.12614. [Epub ahead of print]

PMID:
31602693
6.

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.

Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L.

Nat Microbiol. 2019 Nov;4(11):1990-2000. doi: 10.1038/s41564-019-0524-4. Epub 2019 Aug 5.

PMID:
31384003
7.

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking.

Kennedy K, Cobbold SA, Hanssen E, Birnbaum J, Spillman NJ, McHugh E, Brown H, Tilley L, Spielmann T, McConville MJ, Ralph SA.

PLoS Biol. 2019 Jul 18;17(7):e3000376. doi: 10.1371/journal.pbio.3000376. eCollection 2019 Jul.

8.

The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly.

Looker O, Blanch AJ, Liu B, Nunez-Iglesias J, McMillan PJ, Tilley L, Dixon MWA.

PLoS Pathog. 2019 May 9;15(5):e1007761. doi: 10.1371/journal.ppat.1007761. eCollection 2019 May.

9.

Multimodal analysis of Plasmodium knowlesi-infected erythrocytes reveals large invaginations, swelling of the host cell, and rheological defects.

Liu B, Blanch AJ, Namvar A, Carmo O, Tiash S, Andrew D, Hanssen E, Rajagopal V, Dixon MWA, Tilley L.

Cell Microbiol. 2019 May;21(5):e13005. doi: 10.1111/cmi.13005. Epub 2019 Feb 11.

10.

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome.

Xie SC, Gillett DL, Spillman NJ, Tsu C, Luth MR, Ottilie S, Duffy S, Gould AE, Hales P, Seager BA, Charron CL, Bruzzese F, Yang X, Zhao X, Huang SC, Hutton CA, Burrows JN, Winzeler EA, Avery VM, Dick LR, Tilley L.

J Med Chem. 2018 Nov 21;61(22):10053-10066. doi: 10.1021/acs.jmedchem.8b01161. Epub 2018 Nov 7.

11.

Neighborhoods matter. A systematic review of neighborhood characteristics and adolescent reproductive health outcomes.

Decker MJ, Isquick S, Tilley L, Zhi Q, Gutman A, Luong W, Brindis CD.

Health Place. 2018 Nov;54:178-190. doi: 10.1016/j.healthplace.2018.09.001. Epub 2018 Oct 10.

PMID:
30312942
12.

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome.

Bridgford JL, Xie SC, Cobbold SA, Pasaje CFA, Herrmann S, Yang T, Gillett DL, Dick LR, Ralph SA, Dogovski C, Spillman NJ, Tilley L.

Nat Commun. 2018 Sep 18;9(1):3801. doi: 10.1038/s41467-018-06221-1.

13.

Correction: Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage.

Deligianni E, Silmon de Monerri NC, McMillan PJ, Bertuccini L, Superti F, Manola M, Spanos L, Louis C, Blackman MJ, Tilley L, Siden-Kiamos I.

PLoS One. 2018 Sep 12;13(9):e0204083. doi: 10.1371/journal.pone.0204083. eCollection 2018.

14.

A 'cold case' of care: Looking at old data from a new perspective in mummy research.

Tilley L, Nystrom K.

Int J Paleopathol. 2019 Jun;25:72-81. doi: 10.1016/j.ijpp.2018.08.001. Epub 2018 Aug 16. Review.

PMID:
30120031
15.

Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage.

Deligianni E, Silmon de Monerri NC, McMillan PJ, Bertuccini L, Superti F, Manola M, Spanos L, Louis C, Blackman MJ, Tilley L, Siden-Kiamos I.

PLoS One. 2018 Aug 13;13(8):e0201651. doi: 10.1371/journal.pone.0201651. eCollection 2018. Erratum in: PLoS One. 2018 Sep 12;13(9):e0204083.

16.

Mummy studies and the bioarchaeology of care.

Nystrom KC, Tilley L.

Int J Paleopathol. 2019 Jun;25:64-71. doi: 10.1016/j.ijpp.2018.06.004. Epub 2018 Jul 13.

PMID:
30017496
17.

Spatial organization of protein export in malaria parasite blood stages.

Charnaud SC, Jonsdottir TK, Sanders PR, Bullen HE, Dickerman BK, Kouskousis B, Palmer CS, Pietrzak HM, Laumaea AE, Erazo AB, McHugh E, Tilley L, Crabb BS, Gilson PR.

Traffic. 2018 Aug;19(8):605-623. doi: 10.1111/tra.12577. Epub 2018 May 23.

18.

A new Python library to analyse skeleton images confirms malaria parasite remodelling of the red blood cell membrane skeleton.

Nunez-Iglesias J, Blanch AJ, Looker O, Dixon MW, Tilley L.

PeerJ. 2018 Feb 15;6:e4312. doi: 10.7717/peerj.4312. eCollection 2018.

19.

Young Adults Changing Insurance Status: Gaps in Health Insurance Literacy.

Tilley L, Yarger J, Brindis CD.

J Community Health. 2018 Aug;43(4):680-687. doi: 10.1007/s10900-018-0469-1. No abstract available.

20.

Erythrocyte β spectrin can be genetically targeted to protect mice from malaria.

Lelliott PM, Huang HM, Dixon MW, Namvar A, Blanch AJ, Rajagopal V, Tilley L, Coban C, McMorran BJ, Foote SJ, Burgio G.

Blood Adv. 2017 Dec 12;1(26):2624-2636. doi: 10.1182/bloodadvances.2017009274. eCollection 2017 Dec 12.

21.

Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity.

Giannangelo C, Stingelin L, Yang T, Tilley L, Charman SA, Creek DJ.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01566-17. doi: 10.1128/AAC.01566-17. Print 2018 Mar.

22.

Nanocrystallography measurements of early stage synthetic malaria pigment.

Dilanian RA, Streltsov V, Coughlan HD, Quiney HM, Martin AV, Klonis N, Dogovski C, Boutet S, Messerschmidt M, Williams GJ, Williams S, Phillips NW, Nugent KA, Tilley L, Abbey B.

J Appl Crystallogr. 2017 Sep 28;50(Pt 5):1533-1540. doi: 10.1107/S1600576717012663. eCollection 2017 Oct 1.

23.

A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum.

Cao P, Klonis N, Zaloumis S, Dogovski C, Xie SC, Saralamba S, White LJ, Fowkes FJI, Tilley L, Simpson JA, McCaw JM.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e00618-17. doi: 10.1128/AAC.00618-17. Print 2017 Dec.

24.

Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development.

Parkyn Schneider M, Liu B, Glock P, Suttie A, McHugh E, Andrew D, Batinovic S, Williamson N, Hanssen E, McMillan P, Hliscs M, Tilley L, Dixon MWA.

PLoS Pathog. 2017 Oct 6;13(10):e1006659. doi: 10.1371/journal.ppat.1006659. eCollection 2017 Oct.

25.

A thiol probe for measuring unfolded protein load and proteostasis in cells.

Chen MZ, Moily NS, Bridgford JL, Wood RJ, Radwan M, Smith TA, Song Z, Tang BZ, Tilley L, Xu X, Reid GE, Pouladi MA, Hong Y, Hatters DM.

Nat Commun. 2017 Sep 7;8(1):474. doi: 10.1038/s41467-017-00203-5.

26.

Structured illumination microscopy reveals actin I localization in discreet foci in Plasmodium berghei gametocytes.

Curra C, McMillan PJ, Spanos L, Mollard V, Deligianni E, McFadden G, Tilley L, Siden-Kiamos I.

Exp Parasitol. 2017 Oct;181:82-87. doi: 10.1016/j.exppara.2017.08.001. Epub 2017 Aug 10.

PMID:
28803903
27.

Ankyrin-1 Gene Exhibits Allelic Heterogeneity in Conferring Protection Against Malaria.

Huang HM, Bauer DC, Lelliott PM, Dixon MWA, Tilley L, McMorran BJ, Foote SJ, Burgio G.

G3 (Bethesda). 2017 Sep 7;7(9):3133-3144. doi: 10.1534/g3.117.300079.

28.

The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites.

Charnaud SC, Dixon MWA, Nie CQ, Chappell L, Sanders PR, Nebl T, Hanssen E, Berriman M, Chan JA, Blanch AJ, Beeson JG, Rayner JC, Przyborski JM, Tilley L, Crabb BS, Gilson PR.

PLoS One. 2017 Jul 21;12(7):e0181656. doi: 10.1371/journal.pone.0181656. eCollection 2017.

29.

A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection.

Cao P, Klonis N, Zaloumis S, Khoury DS, Cromer D, Davenport MP, Tilley L, Simpson JA, McCaw JM.

J Theor Biol. 2017 Oct 7;430:117-127. doi: 10.1016/j.jtbi.2017.07.017. Epub 2017 Jul 18.

PMID:
28728995
30.

An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes.

Batinovic S, McHugh E, Chisholm SA, Matthews K, Liu B, Dumont L, Charnaud SC, Schneider MP, Gilson PR, de Koning-Ward TF, Dixon MWA, Tilley L.

Nat Commun. 2017 Jul 10;8:16044. doi: 10.1038/ncomms16044.

31.

Resistance to malaria through structural variation of red blood cell invasion receptors.

Leffler EM, Band G, Busby GBJ, Kivinen K, Le QS, Clarke GM, Bojang KA, Conway DJ, Jallow M, Sisay-Joof F, Bougouma EC, Mangano VD, Modiano D, Sirima SB, Achidi E, Apinjoh TO, Marsh K, Ndila CM, Peshu N, Williams TN, Drakeley C, Manjurano A, Reyburn H, Riley E, Kachala D, Molyneux M, Nyirongo V, Taylor T, Thornton N, Tilley L, Grimsley S, Drury E, Stalker J, Cornelius V, Hubbart C, Jeffreys AE, Rowlands K, Rockett KA, Spencer CCA, Kwiatkowski DP; Malaria Genomic Epidemiology Network.

Science. 2017 Jun 16;356(6343). pii: eaam6393. doi: 10.1126/science.aam6393. Epub 2017 May 18.

32.

Initiation of gametocytogenesis at very low parasite density in Plasmodium falciparum infection.

Farid R, Dixon MW, Tilley L, McCarthy JS.

J Infect Dis. 2017 Apr 1;215(7):1167-1174. doi: 10.1093/infdis/jix035.

33.

Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150.

Elsworth B, Sanders PR, Nebl T, Batinovic S, Kalanon M, Nie CQ, Charnaud SC, Bullen HE, de Koning Ward TF, Tilley L, Crabb BS, Gilson PR.

Cell Microbiol. 2016 Nov;18(11):1551-1569. doi: 10.1111/cmi.12596. Epub 2016 May 3.

PMID:
27019089
34.

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose.

Chahal JS, Khan OF, Cooper CL, McPartlan JS, Tsosie JK, Tilley LD, Sidik SM, Lourido S, Langer R, Bavari S, Ploegh HL, Anderson DG.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4133-42. doi: 10.1073/pnas.1600299113. Epub 2016 Jul 5. Erratum in: Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5250.

35.

Plasmodium species: master renovators of their host cells.

de Koning-Ward TF, Dixon MW, Tilley L, Gilson PR.

Nat Rev Microbiol. 2016 Aug;14(8):494-507. doi: 10.1038/nrmicro.2016.79. Epub 2016 Jul 4. Review.

PMID:
27374802
36.

A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability.

da Silva FL, Dixon MW, Stack CM, Teuscher F, Taran E, Jones MK, Lovas E, Tilley L, Brown CL, Trenholme KR, Dalton JP, Gardiner DL, Skinner-Adams TS.

Exp Parasitol. 2016 Oct;169:13-21. doi: 10.1016/j.exppara.2016.06.013. Epub 2016 Jun 30.

PMID:
27373432
37.

Clinical variability of neuroacanthocytosis syndromes-a series of six patients with long follow-up.

Dulski J, Sołtan W, Schinwelski M, Rudzińska M, Wójcik-Pędziwiatr M, Wictor L, Schön F, Puschmann A, Klempíř J, Tilley L, Roth J, Tacik P, Fujioka S, Drozdowski W, Sitek EJ, Wszolek Z, Sławek J.

Clin Neurol Neurosurg. 2016 Aug;147:78-83. doi: 10.1016/j.clineuro.2016.05.028. Epub 2016 Jun 1.

PMID:
27310290
38.

Artemisinin Action and Resistance in Plasmodium falciparum.

Tilley L, Straimer J, Gnädig NF, Ralph SA, Fidock DA.

Trends Parasitol. 2016 Sep;32(9):682-696. doi: 10.1016/j.pt.2016.05.010. Epub 2016 Jun 9. Review.

39.

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains.

Yang T, Xie SC, Cao P, Giannangelo C, McCaw J, Creek DJ, Charman SA, Klonis N, Tilley L.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4501-10. doi: 10.1128/AAC.00574-16. Print 2016 Aug.

40.

Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages.

Dearnley M, Chu T, Zhang Y, Looker O, Huang C, Klonis N, Yeoman J, Kenny S, Arora M, Osborne JM, Chandramohanadas R, Zhang S, Dixon MW, Tilley L.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4800-5. doi: 10.1073/pnas.1520194113. Epub 2016 Apr 11.

41.

Contrasting Inducible Knockdown of the Auxiliary PTEX Component PTEX88 in P. falciparum and P. berghei Unmasks a Role in Parasite Virulence.

Chisholm SA, McHugh E, Lundie R, Dixon MW, Ghosh S, O'Keefe M, Tilley L, Kalanon M, de Koning-Ward TF.

PLoS One. 2016 Feb 17;11(2):e0149296. doi: 10.1371/journal.pone.0149296. eCollection 2016.

42.

Structure- and function-based design of Plasmodium-selective proteasome inhibitors.

Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M.

Nature. 2016 Feb 11;530(7589):233-6. doi: 10.1038/nature16936.

43.

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins.

Xie SC, Dogovski C, Hanssen E, Chiu F, Yang T, Crespo MP, Stafford C, Batinovic S, Teguh S, Charman S, Klonis N, Tilley L.

J Cell Sci. 2016 Jan 15;129(2):406-16. doi: 10.1242/jcs.178830. Epub 2015 Dec 16.

44.

The Conundrum of Training and Capacity Building for People with Learning Disabilities Doing Research.

Nind M, Chapman R, Seale J, Tilley L.

J Appl Res Intellect Disabil. 2016 Nov;29(6):542-551. doi: 10.1111/jar.12213. Epub 2015 Sep 2.

45.

Specific expression and export of the Plasmodium falciparum Gametocyte EXported Protein-5 marks the gametocyte ring stage.

Tibúrcio M, Dixon MW, Looker O, Younis SY, Tilley L, Alano P.

Malar J. 2015 Aug 28;14:334. doi: 10.1186/s12936-015-0853-6.

46.

A repeat sequence domain of the ring-exported protein-1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking.

McHugh E, Batinovic S, Hanssen E, McMillan PJ, Kenny S, Griffin MD, Crawford S, Trenholme KR, Gardiner DL, Dixon MW, Tilley L.

Mol Microbiol. 2015 Dec;98(6):1101-14. doi: 10.1111/mmi.13201. Epub 2015 Sep 25.

47.

Toward a Unified Mechanism for Oxoammonium Salt-Mediated Oxidation Reactions: A Theoretical and Experimental Study Using a Hydride Transfer Model.

Hamlin TA, Kelly CB, Ovian JM, Wiles RJ, Tilley LJ, Leadbeater NE.

J Org Chem. 2015 Aug 21;80(16):8150-67. doi: 10.1021/acs.joc.5b01240. Epub 2015 Jul 30.

PMID:
26167866
48.

Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite.

Zhang Y, Huang C, Kim S, Golkaram M, Dixon MW, Tilley L, Li J, Zhang S, Suresh S.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6068-73. doi: 10.1073/pnas.1505584112. Epub 2015 Apr 27.

49.

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.

Dogovski C, Xie SC, Burgio G, Bridgford J, Mok S, McCaw JM, Chotivanich K, Kenny S, Gnädig N, Straimer J, Bozdech Z, Fidock DA, Simpson JA, Dondorp AM, Foote S, Klonis N, Tilley L.

PLoS Biol. 2015 Apr 22;13(4):e1002132. doi: 10.1371/journal.pbio.1002132. eCollection 2015 Apr.

50.

Accommodating difference in the prehistoric past: Revisiting the case of Romito 2 from a bioarchaeology of care perspective.

Tilley L.

Int J Paleopathol. 2015 Mar;8:64-74. doi: 10.1016/j.ijpp.2014.10.003. Epub 2014 Nov 29.

PMID:
29539484

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