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Items: 1 to 50 of 72

1.

Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overload.

Ahmad F, Singh AP, Tomar D, Rahmani M, Zhang Q, Woodgett JR, Tilley DG, Lal H, Force T.

J Mol Cell Cardiol. 2019 May;130:65-75. doi: 10.1016/j.yjmcc.2019.03.020. Epub 2019 Mar 27.

PMID:
30928428
2.

Prior β-blocker treatment decreases leukocyte responsiveness to injury.

Grisanti LA, de Lucia C, Thomas TP, Stark A, Strony JT, Myers VD, Beretta R, Yu D, Sardu C, Marfella R, Gao E, Houser SR, Koch WJ, Hamad EA, Tilley DG.

JCI Insight. 2019 Mar 28;5. pii: 99485. doi: 10.1172/jci.insight.99485.

3.

Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation.

Sato PY, Chuprun JK, Grisanti LA, Woodall MC, Brown BR, Roy R, Traynham CJ, Ibetti J, Lucchese AM, Yuan A, Drosatos K, Tilley DG, Gao E, Koch WJ.

Sci Signal. 2018 Dec 11;11(560). pii: eaau0144. doi: 10.1126/scisignal.aau0144.

4.

The Role of Leukocytes in Diabetic Cardiomyopathy.

Bajpai A, Tilley DG.

Front Physiol. 2018 Nov 1;9:1547. doi: 10.3389/fphys.2018.01547. eCollection 2018. Review.

5.

Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling.

Grisanti LA, Thomas TP, Carter RL, de Lucia C, Gao E, Koch WJ, Benovic JL, Tilley DG.

Theranostics. 2018 Sep 9;8(17):4664-4678. doi: 10.7150/thno.26619. eCollection 2018.

6.

Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease.

Grisanti LA, Schumacher SM, Tilley DG, Koch WJ.

JACC Basic Transl Sci. 2018 Aug 28;3(4):550-562. doi: 10.1016/j.jacbts.2017.12.002. eCollection 2018 Aug. Review.

7.

G protein-coupled receptor kinase 2 contributes to impaired fatty acid metabolism in the failing heart.

Pfleger J, Gross P, Johnson J, Carter RL, Gao E, Tilley DG, Houser SR, Koch WJ.

J Mol Cell Cardiol. 2018 Oct;123:108-117. doi: 10.1016/j.yjmcc.2018.08.025. Epub 2018 Aug 29.

PMID:
30171848
8.

Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals.

Myers VD, Gerhard GS, McNamara DM, Tomar D, Madesh M, Kaniper S, Ramsey FV, Fisher SG, Ingersoll RG, Kasch-Semenza L, Wang J, Hanley-Yanez K, Lemster B, Schwisow JA, Ambardekar AV, Degann SH, Bristow MR, Sheppard R, Alexis JD, Tilley DG, Kontos CD, McClung JM, Taylor AL, Yancy CW, Khalili K, Seidman JG, Seidman CE, McTiernan CF, Cheung JY, Feldman AM.

JAMA Cardiol. 2018 Oct 1;3(10):929-938. doi: 10.1001/jamacardio.2018.2541.

PMID:
30140897
9.

Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury.

Hooshdaran B, Kolpakov MA, Guo X, Miller SA, Wang T, Tilley DG, Rafiq K, Sabri A.

Basic Res Cardiol. 2017 Sep 14;112(6):62. doi: 10.1007/s00395-017-0652-z.

10.

Impact of paroxetine on proximal β-adrenergic receptor signaling.

Guo S, Carter RL, Grisanti LA, Koch WJ, Tilley DG.

Cell Signal. 2017 Oct;38:127-133. doi: 10.1016/j.cellsig.2017.07.006. Epub 2017 Jul 12.

11.

Gαq Signaling in the Regulation of Autophagy and Heart Failure.

Kolpakov MA, Tilley DG, Sabri A.

J Cardiovasc Pharmacol. 2017 Apr;69(4):212-214. doi: 10.1097/FJC.0000000000000471. No abstract available.

12.

Adeno-associated Virus Serotype 9 - Driven Expression of BAG3 Improves Left Ventricular Function in Murine Hearts with Left Ventricular Dysfunction Secondary to a Myocardial Infarction.

Knezevic T, Myers VD, Su F, Wang J, Song J, Zhang XQ, Gao E, Gao G, Muniswamy M, Gupta MK, Gordon J, Weiner KN, Rabinowitz J, Ramsey FV, Tilley DG, Khalili K, Cheung JY, Feldman AM.

JACC Basic Transl Sci. 2016 Dec;1(7):647-656. doi: 10.1016/j.jacbts.2016.08.008.

13.

Cardiac GPCR-Mediated EGFR Transactivation: Impact and Therapeutic Implications.

Grisanti LA, Guo S, Tilley DG.

J Cardiovasc Pharmacol. 2017 Jul;70(1):3-9. doi: 10.1097/FJC.0000000000000462. Review.

14.

DUSPs as critical regulators of cardiac hypertrophy.

Tilley DG, Sabri A.

Clin Sci (Lond). 2017 Jan 1;131(2):155-158. doi: 10.1042/CS20160766.

PMID:
28011900
15.

β2-Adrenergic receptor-dependent chemokine receptor 2 expression regulates leukocyte recruitment to the heart following acute injury.

Grisanti LA, Traynham CJ, Repas AA, Gao E, Koch WJ, Tilley DG.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15126-15131. doi: 10.1073/pnas.1611023114. Epub 2016 Dec 12.

16.

Bcl-2-associated athanogene 3 protects the heart from ischemia/reperfusion injury.

Su F, Myers VD, Knezevic T, Wang J, Gao E, Madesh M, Tahrir FG, Gupta MK, Gordon J, Rabinowitz J, Ramsey FV, Tilley DG, Khalili K, Cheung JY, Feldman AM.

JCI Insight. 2016 Nov 17;1(19):e90931. doi: 10.1172/jci.insight.90931.

17.

Vasopressin type 1A receptor deletion enhances cardiac contractility, β-adrenergic receptor sensitivity and acute cardiac injury-induced dysfunction.

Wasilewski MA, Grisanti LA, Song J, Carter RL, Repas AA, Myers VD, Gao E, Koch WJ, Cheung JY, Feldman AM, Tilley DG.

Clin Sci (Lond). 2016 Nov 1;130(22):2017-2027. doi: 10.1042/CS20160363. Epub 2016 Sep 2.

18.

Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy.

Woodall BP, Woodall MC, Luongo TS, Grisanti LA, Tilley DG, Elrod JW, Koch WJ.

J Biol Chem. 2016 Oct 14;291(42):21913-21924. Epub 2016 Aug 26.

19.

Leukocyte-Expressed β2-Adrenergic Receptors Are Essential for Survival After Acute Myocardial Injury.

Grisanti LA, Gumpert AM, Traynham CJ, Gorsky JE, Repas AA, Gao E, Carter RL, Yu D, Calvert JW, García AP, Ibáñez B, Rabinowitz JE, Koch WJ, Tilley DG.

Circulation. 2016 Jul 12;134(2):153-67. doi: 10.1161/CIRCULATIONAHA.116.022304. Epub 2016 Jun 30.

20.

β-arrestin-biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction.

Carr R 3rd, Schilling J, Song J, Carter RL, Du Y, Yoo SM, Traynham CJ, Koch WJ, Cheung JY, Tilley DG, Benovic JL.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4107-16. doi: 10.1073/pnas.1606267113. Epub 2016 Jun 27.

21.

BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.

Feldman AM, Gordon J, Wang J, Song J, Zhang XQ, Myers VD, Tilley DG, Gao E, Hoffman NE, Tomar D, Madesh M, Rabinowitz J, Koch WJ, Su F, Khalili K, Cheung JY.

J Mol Cell Cardiol. 2016 Mar;92:10-20. doi: 10.1016/j.yjmcc.2016.01.015. Epub 2016 Jan 19.

22.

Caspase-1 mediates hyperlipidemia-weakened progenitor cell vessel repair.

Li YF, Huang X, Li X, Gong R, Yin Y, Nelson J, Gao E, Zhang H, Hoffman NE, Houser SR, Madesh M, Tilley DG, Choi ET, Jiang X, Huang CX, Wang H, Yang XF.

Front Biosci (Landmark Ed). 2016 Jan 1;21:178-91.

23.

Cardiac Dysfunction in HIV-1 Transgenic Mouse: Role of Stress and BAG3.

Cheung JY, Gordon J, Wang J, Song J, Zhang XQ, Tilley DG, Gao E, Koch WJ, Rabinowitz J, Klotman PE, Khalili K, Feldman AM.

Clin Transl Sci. 2015 Aug;8(4):305-10. doi: 10.1111/cts.12331. Epub 2015 Aug 24.

24.

Arginine vasopressin receptor signaling and functional outcomes in heart failure.

Wasilewski MA, Myers VD, Recchia FA, Feldman AM, Tilley DG.

Cell Signal. 2016 Mar;28(3):224-233. doi: 10.1016/j.cellsig.2015.07.021. Epub 2015 Jul 30. Review. No abstract available.

25.

Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation.

Yan G, Zhu N, Huang S, Yi B, Shang X, Chen M, Wang N, Zhang GX, Talarico JA, Tilley DG, Gao E, Sun J.

Mol Cell Biol. 2015 Oct;35(19):3312-23. doi: 10.1128/MCB.00229-15. Epub 2015 Jul 20.

26.

The Lysophosphatidylinositol Receptor GPR55 Modulates Pain Perception in the Periaqueductal Gray.

Deliu E, Sperow M, Console-Bram L, Carter RL, Tilley DG, Kalamarides DJ, Kirby LG, Brailoiu GC, Brailoiu E, Benamar K, Abood ME.

Mol Pharmacol. 2015 Aug;88(2):265-72. doi: 10.1124/mol.115.099333. Epub 2015 May 13.

27.

BAG3: a new player in the heart failure paradigm.

Knezevic T, Myers VD, Gordon J, Tilley DG, Sharp TE 3rd, Wang J, Khalili K, Cheung JY, Feldman AM.

Heart Fail Rev. 2015 Jul;20(4):423-34. doi: 10.1007/s10741-015-9487-6. Review.

28.

Role of epidermal growth factor receptor and endoplasmic reticulum stress in vascular remodeling induced by angiotensin II.

Takayanagi T, Kawai T, Forrester SJ, Obama T, Tsuji T, Fukuda Y, Elliott KJ, Tilley DG, Davisson RL, Park JY, Eguchi S.

Hypertension. 2015 Jun;65(6):1349-55. doi: 10.1161/HYPERTENSIONAHA.115.05344. Epub 2015 Apr 27.

29.

Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway.

Yin Y, Li X, Sha X, Xi H, Li YF, Shao Y, Mai J, Virtue A, Lopez-Pastrana J, Meng S, Tilley DG, Monroy MA, Choi ET, Thomas CJ, Jiang X, Wang H, Yang XF.

Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):804-16. doi: 10.1161/ATVBAHA.115.305282. Epub 2015 Feb 19.

30.

Temporal and gefitinib-sensitive regulation of cardiac cytokine expression via chronic β-adrenergic receptor stimulation.

Grisanti LA, Repas AA, Talarico JA, Gold JI, Carter RL, Koch WJ, Tilley DG.

Am J Physiol Heart Circ Physiol. 2015 Feb 15;308(4):H316-30. doi: 10.1152/ajpheart.00635.2014. Epub 2014 Dec 5.

31.

GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity.

Hullmann JE, Grisanti LA, Makarewich CA, Gao E, Gold JI, Chuprun JK, Tilley DG, Houser SR, Koch WJ.

Circ Res. 2014 Dec 5;115(12):976-85. doi: 10.1161/CIRCRESAHA.116.304475. Epub 2014 Oct 20.

32.

Response to "clarification of enrolled subjects in tolvaptan HF trials".

Feldman AM, Hamad E, Tsai E, Zhu W, Tilley DG, Alvarez R, Cheung JY.

Clin Pharmacol Ther. 2014 Dec;96(6):661. doi: 10.1038/clpt.2014.191. Epub 2014 Sep 18. No abstract available.

PMID:
25232760
33.

β-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling.

Tilley DG, Zhu W, Myers VD, Barr LA, Gao E, Li X, Song J, Carter RL, Makarewich CA, Yu D, Troupes CD, Grisanti LA, Coleman RC, Koch WJ, Houser SR, Cheung JY, Feldman AM.

Circulation. 2014 Nov 11;130(20):1800-11. doi: 10.1161/CIRCULATIONAHA.114.010434. Epub 2014 Sep 9.

34.

β-adrenergic receptor-dependent alterations in murine cardiac transcript expression are differentially regulated by gefitinib in vivo.

Talarico JA, Carter RL, Grisanti LA, Yu JE, Repas AA, Tilley DG.

PLoS One. 2014 Jun 5;9(6):e99195. doi: 10.1371/journal.pone.0099195. eCollection 2014.

35.

Dynamic mass redistribution analysis of endogenous β-adrenergic receptor signaling in neonatal rat cardiac fibroblasts.

Carter RL, Grisanti LA, Yu JE, Repas AA, Woodall M, Ibetti J, Koch WJ, Jacobson MA, Tilley DG.

Pharmacol Res Perspect. 2014 Feb;2(1). doi: 10.1002/prp2.24.

36.

Decreased levels of BAG3 in a family with a rare variant and in idiopathic dilated cardiomyopathy.

Feldman AM, Begay RL, Knezevic T, Myers VD, Slavov DB, Zhu W, Gowan K, Graw SL, Jones KL, Tilley DG, Coleman RC, Walinsky P, Cheung JY, Mestroni L, Khalili K, Taylor MR.

J Cell Physiol. 2014 Nov;229(11):1697-702. doi: 10.1002/jcp.24615.

37.

β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt.

Grisanti LA, Talarico JA, Carter RL, Yu JE, Repas AA, Radcliffe SW, Tang HA, Makarewich CA, Houser SR, Tilley DG.

J Mol Cell Cardiol. 2014 Jul;72:39-51. doi: 10.1016/j.yjmcc.2014.02.009. Epub 2014 Feb 22.

38.

Urotensin II promotes vagal-mediated bradycardia by activating cardiac-projecting parasympathetic neurons of nucleus ambiguus.

Brailoiu GC, Deliu E, Rabinowitz JE, Tilley DG, Koch WJ, Brailoiu E.

J Neurochem. 2014 May;129(4):628-36. doi: 10.1111/jnc.12679. Epub 2014 Mar 6.

39.

Direct evidence of intracrine angiotensin II signaling in neurons.

Deliu E, Brailoiu GC, Eguchi S, Hoffman NE, Rabinowitz JE, Tilley DG, Madesh M, Koch WJ, Brailoiu E.

Am J Physiol Cell Physiol. 2014 Apr 15;306(8):C736-44. doi: 10.1152/ajpcell.00131.2013. Epub 2014 Jan 8.

40.

Vasopressin antagonists for patients with acute heart failure: interpreting new clinical and translational data.

Feldman AM, Hamad E, Tsai EJ, Zhu W, Tilley DG, Alvarez R, Cheung JY.

Clin Pharmacol Ther. 2014 Apr;95(4):373-5. doi: 10.1038/clpt.2013.240. Epub 2013 Dec 17. No abstract available.

PMID:
24346421
41.

Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury.

Huang ZM, Gao E, Fonseca FV, Hayashi H, Shang X, Hoffman NE, Chuprun JK, Tian X, Tilley DG, Madesh M, Lefer DJ, Stamler JS, Koch WJ.

Sci Signal. 2013 Oct 29;6(299):ra95. doi: 10.1126/scisignal.2004225.

42.

Increased vasopressin 1A receptor expression in failing human hearts.

Zhu W, Tilley DG, Myers VD, Tsai EJ, Feldman AM.

J Am Coll Cardiol. 2014 Feb 4;63(4):375-6. doi: 10.1016/j.jacc.2013.09.032. Epub 2013 Oct 16. No abstract available.

43.

Cardiac progenitor cells engineered with βARKct have enhanced β-adrenergic tolerance.

Khan M, Mohsin S, Toko H, Alkatib M, Nguyen J, Truffa S, Gude N, Chuprun K, Tilley DG, Koch WJ, Sussman MA.

Mol Ther. 2014 Jan;22(1):178-85. doi: 10.1038/mt.2013.200. Epub 2013 Sep 3.

44.

Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55.

Yu J, Deliu E, Zhang XQ, Hoffman NE, Carter RL, Grisanti LA, Brailoiu GC, Madesh M, Cheung JY, Force T, Abood ME, Koch WJ, Tilley DG, Brailoiu E.

J Biol Chem. 2013 Aug 2;288(31):22481-92. doi: 10.1074/jbc.M113.456178. Epub 2013 Jun 27.

45.

Nesfatin-1 activates cardiac vagal neurons of nucleus ambiguus and elicits bradycardia in conscious rats.

Brailoiu GC, Deliu E, Tica AA, Rabinowitz JE, Tilley DG, Benamar K, Koch WJ, Brailoiu E.

J Neurochem. 2013 Sep;126(6):739-48. doi: 10.1111/jnc.12355. Epub 2013 Jul 19.

46.

Arginine vasopressin enhances cell survival via a G protein-coupled receptor kinase 2/β-arrestin1/extracellular-regulated kinase 1/2-dependent pathway in H9c2 cells.

Zhu W, Tilley DG, Myers VD, Coleman RC, Feldman AM.

Mol Pharmacol. 2013 Aug;84(2):227-35. doi: 10.1124/mol.113.086322. Epub 2013 May 20.

47.

Unexpected cardiac hypertrophy by epidermal growth factor receptor silencing.

Eguchi A, Eguchi S, Tilley DG.

Hypertension. 2013 May;61(5):e46. doi: 10.1161/HYPERTENSIONAHA.113.01184. Epub 2013 Apr 1. No abstract available.

PMID:
23547237
48.

Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process.

Gold JI, Martini JS, Hullmann J, Gao E, Chuprun JK, Lee L, Tilley DG, Rabinowitz JE, Bossuyt J, Bers DM, Koch WJ.

PLoS One. 2013;8(3):e57324. doi: 10.1371/journal.pone.0057324. Epub 2013 Mar 5.

49.

β-Adrenergic regulation of cardiac progenitor cell death versus survival and proliferation.

Khan M, Mohsin S, Avitabile D, Siddiqi S, Nguyen J, Wallach K, Quijada P, McGregor M, Gude N, Alvarez R, Tilley DG, Koch WJ, Sussman MA.

Circ Res. 2013 Feb 1;112(3):476-86. doi: 10.1161/CIRCRESAHA.112.280735. Epub 2012 Dec 14.

50.

Development of a cardiopulmonary mathematical model incorporating a baro-chemoreceptor reflex control system.

Lin J, Ngwompo RF, Tilley DG.

Proc Inst Mech Eng H. 2012 Oct;226(10):787-803.

PMID:
23157080

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