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Items: 30


Dried-Blood-Spot Technique to Monitor Direct Oral Anticoagulants: Clinical Validation of a UPLC-MS/MS-Based Assay.

Foerster KI, Huppertz A, Meid AD, Müller OJ, Rizos T, Tilemann L, Haefeli WE, Burhenne J.

Anal Chem. 2018 Aug 7;90(15):9395-9402. doi: 10.1021/acs.analchem.8b02046. Epub 2018 Jul 17.


Cardio-oncology: conflicting priorities of anticancer treatment and cardiovascular outcome.

Tilemann LM, Heckmann MB, Katus HA, Lehmann LH, Müller OJ.

Clin Res Cardiol. 2018 Apr;107(4):271-280. doi: 10.1007/s00392-018-1202-x. Epub 2018 Feb 16. Review.


AAV-9 mediated phosphatase-1 inhibitor-1 overexpression improves cardiac contractility in unchallenged mice but is deleterious in pressure-overload.

Schwab DM, Tilemann L, Bauer R, Heckmann M, Jungmann A, Wagner M, Burgis J, Vettel C, Katus HA, El-Armouche A, Müller OJ.

Gene Ther. 2018 Jan;25(1):13-19. doi: 10.1038/gt.2017.97. Epub 2018 Jan 19.


Platelet function monitoring for stent thrombosis in critically III patients with an acute Coronary syndrome.

Tilemann L, Mohr SK, Preusch M, Chorianopoulos E, Giannitsis E, Katus HA, Müller OJ.

J Interv Cardiol. 2018 Jun;31(3):277-283. doi: 10.1111/joic.12474. Epub 2017 Dec 6.


Simultaneous quantification of direct oral anticoagulants currently used in anticoagulation therapy.

Foerster KI, Huppertz A, Müller OJ, Rizos T, Tilemann L, Haefeli WE, Burhenne J.

J Pharm Biomed Anal. 2018 Jan 30;148:238-244. doi: 10.1016/j.jpba.2017.10.011. Epub 2017 Oct 16.


Efficacy of enteral ticagrelor in hypothermic patients after out-of-hospital cardiac arrest.

Tilemann LM, Stiepak J, Zelniker T, Chorianopoulos E, Giannitsis E, Katus HA, Müller OJ, Preusch M.

Clin Res Cardiol. 2016 Apr;105(4):332-40. doi: 10.1007/s00392-015-0925-1. Epub 2015 Oct 27.


Reply to "Letter to the editor: Characterizing preclinical model of ischemic heart failure: difference between LAD and LCx infarctions".

Ishikawa K, Aguero J, Tilemann L, Ladage D, Hammoudi N, Kawase Y, Santos-Gallego CG, Fish K, Levine RA, Hajjar RJ.

Am J Physiol Heart Circ Physiol. 2015 Feb 15;308(4):H365-6. doi: 10.1152/ajpheart.00855.2014. No abstract available.


Stem cell factor gene transfer improves cardiac function after myocardial infarction in swine.

Ishikawa K, Fish K, Aguero J, Yaniz-Galende E, Jeong D, Kho C, Tilemann L, Fish L, Liang L, Eltoukhy AA, Anderson DG, Zsebo K, Costa KD, Hajjar RJ.

Circ Heart Fail. 2015 Jan;8(1):167-74. doi: 10.1161/CIRCHEARTFAILURE.114.001711. Epub 2014 Oct 23.


Characterizing preclinical models of ischemic heart failure: differences between LAD and LCx infarctions.

Ishikawa K, Aguero J, Tilemann L, Ladage D, Hammoudi N, Kawase Y, Santos-Gallego CG, Fish K, Levine RA, Hajjar RJ.

Am J Physiol Heart Circ Physiol. 2014 Nov 15;307(10):H1478-86. doi: 10.1152/ajpheart.00797.2013. Epub 2014 Sep 12.


Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure.

Ishikawa K, Fish KM, Tilemann L, Rapti K, Aguero J, Santos-Gallego CG, Lee A, Karakikes I, Xie C, Akar FG, Shimada YJ, Gwathmey JK, Asokan A, McPhee S, Samulski J, Samulski RJ, Sigg DC, Weber T, Kranias EG, Hajjar RJ.

Mol Ther. 2014 Dec;22(12):2038-45. doi: 10.1038/mt.2014.127. Epub 2014 Jul 15.


SUMO-1 gene transfer improves cardiac function in a large-animal model of heart failure.

Tilemann L, Lee A, Ishikawa K, Aguero J, Rapti K, Santos-Gallego C, Kohlbrenner E, Fish KM, Kho C, Hajjar RJ.

Sci Transl Med. 2013 Nov 13;5(211):211ra159. doi: 10.1126/scitranslmed.3006487.


Stimulating myocardial regeneration with periostin Peptide in large mammals improves function post-myocardial infarction but increases myocardial fibrosis.

Ladage D, Yaniz-Galende E, Rapti K, Ishikawa K, Tilemann L, Shapiro S, Takewa Y, Muller-Ehmsen J, Schwarz M, Garcia MJ, Sanz J, Hajjar RJ, Kawase Y.

PLoS One. 2013 May 20;8(5):e59656. doi: 10.1371/journal.pone.0059656. Print 2013.


AAV9.I-1c delivered via direct coronary infusion in a porcine model of heart failure improves contractility and mitigates adverse remodeling.

Fish KM, Ladage D, Kawase Y, Karakikes I, Jeong D, Ly H, Ishikawa K, Hadri L, Tilemann L, Muller-Ehmsen J, Samulski RJ, Kranias EG, Hajjar RJ.

Circ Heart Fail. 2013 Mar;6(2):310-7. doi: 10.1161/CIRCHEARTFAILURE.112.971325. Epub 2012 Dec 27.


Comparison of left ventricular stroke volume assessment by two- and three-dimensional echocardiography in a swine model of acute myocardial infarction validated by thermodilution method.

Shimada YJ, Ishikawa K, Kawase Y, Ladage D, Tilemann L, Shiota T, Hajjar RJ.

Echocardiography. 2012 Oct;29(9):1091-5. doi: 10.1111/j.1540-8175.2012.01753.x. Epub 2012 Jun 5.


Percutaneous methods of vector delivery in preclinical models.

Ladage D, Ishikawa K, Tilemann L, Müller-Ehmsen J, Kawase Y.

Gene Ther. 2012 Jun;19(6):637-41. doi: 10.1038/gt.2012.14. Epub 2012 Mar 15. Review.


Gene therapy for heart failure.

Tilemann L, Ishikawa K, Weber T, Hajjar RJ.

Circ Res. 2012 Mar 2;110(5):777-93. doi: 10.1161/CIRCRESAHA.111.252981. Review.


Sterile abscess in the myocardium after direct intramyocardial injection related to gene therapy in a Swine model.

Ishikawa K, Ladage D, Tilemann L, Kawase Y, Hajjar RJ.

ISRN Cardiol. 2011;2011:319453. doi: 10.5402/2011/319453. Epub 2011 Apr 6.


Assessing left ventricular systolic dysfunction after myocardial infarction: are ejection fraction and dP/dt(max) complementary or redundant?

Ishikawa K, Chemaly ER, Tilemann L, Fish K, Ladage D, Aguero J, Vahl T, Santos-Gallego C, Kawase Y, Hajjar RJ.

Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1423-8. doi: 10.1152/ajpheart.01211.2011. Epub 2012 Feb 3.


Cardiac gene therapy in large animals: bridge from bench to bedside.

Ishikawa K, Tilemann L, Ladage D, Aguero J, Leonardson L, Fish K, Kawase Y.

Gene Ther. 2012 Jun;19(6):670-7. doi: 10.1038/gt.2012.3. Epub 2012 Feb 2. Review.


Temporal changes of strain parameters in the progress of chronic ischemia: with comparison to transmural infarction.

Ishikawa K, Kawase Y, Ladage D, Chemaly ER, Tilemann L, Fish K, Sanz J, Garcia MJ, Hajjar RJ.

Int J Cardiovasc Imaging. 2012 Oct;28(7):1671-81. doi: 10.1007/s10554-012-0010-z. Epub 2012 Jan 10.


Concomitant intravenous nitroglycerin with intracoronary delivery of AAV1.SERCA2a enhances gene transfer in porcine hearts.

Karakikes I, Hadri L, Rapti K, Ladage D, Ishikawa K, Tilemann L, Yi GH, Morel C, Gwathmey JK, Zsebo K, Weber T, Kawase Y, Hajjar RJ.

Mol Ther. 2012 Mar;20(3):565-71. doi: 10.1038/mt.2011.268. Epub 2012 Jan 3.


Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.

Ladage D, Tilemann L, Ishikawa K, Correll RN, Kawase Y, Houser SR, Molkentin JD, Hajjar RJ.

Circ Res. 2011 Dec 9;109(12):1396-400. doi: 10.1161/CIRCRESAHA.111.255687. Epub 2011 Oct 13.


Gene delivery methods in cardiac gene therapy.

Ishikawa K, Tilemann L, Fish K, Hajjar RJ.

J Gene Med. 2011 Oct;13(10):566-72. doi: 10.1002/jgm.1609. Review.


Differences in local and systemic inflammatory markers in patients with obstructive airways disease.

Tilemann L, Gindner L, Meyer F, Szecsenyi J, Schneider A.

Prim Care Respir J. 2011 Dec;20(4):407-14. doi: 10.4104/pcrj.2011.00069.


Gene transfer for ischemic heart failure in a preclinical model.

Ishikawa K, Ladage D, Tilemann L, Fish K, Kawase Y, Hajjar RJ.

J Vis Exp. 2011 May 15;(51). pii: 2778. doi: 10.3791/2778.


Development of a preclinical model of ischemic cardiomyopathy in swine.

Ishikawa K, Ladage D, Takewa Y, Yaniz E, Chen J, Tilemann L, Sakata S, Badimon JJ, Hajjar RJ, Kawase Y.

Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H530-7. doi: 10.1152/ajpheart.01103.2010. Epub 2011 May 6.


[Screening for COPD in primary care].

Karsch M, Tilemann L, Schneider A.

MMW Fortschr Med. 2010 Oct 7;152(40):35-7. German. No abstract available.


[Diagnostic value of peak flow variability in patients with suspected diagnosis of bronchial asthma in general practice].

Tilemann L, Gindner L, Meyer FJ, Laux G, Szecsenyi J, Schneider A.

Dtsch Med Wochenschr. 2009 Oct;134(41):2053-8. doi: 10.1055/s-0029-1237554. Epub 2009 Oct 2. German.


Diagnostic accuracy of spirometry in primary care.

Schneider A, Gindner L, Tilemann L, Schermer T, Dinant GJ, Meyer FJ, Szecsenyi J.

BMC Pulm Med. 2009 Jul 10;9:31. doi: 10.1186/1471-2466-9-31.


Diagnosing asthma in general practice with portable exhaled nitric oxide measurement--results of a prospective diagnostic study: FENO < or = 16 ppb better than FENO < or =12 ppb to rule out mild and moderate to severe asthma [added].

Schneider A, Tilemann L, Schermer T, Gindner L, Laux G, Szecsenyi J, Meyer FJ.

Respir Res. 2009 Mar 3;10:15. doi: 10.1186/1465-9921-10-15. Erratum in: Respir Res. 2009;10: 64 doi:10.1186/1465-9921-10-64.

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