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Items: 18


Concomitant Disruption of CD4 and CD8 Genes Facilitates the Development of Double Negative αβ TCR+ Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen.

Chowdhary VR, Krogman A, Tilahun AY, Alexander MP, David CS, Rajagopalan G.

J Immunol. 2017 Jun 1;198(11):4413-4424. doi: 10.4049/jimmunol.1601991. Epub 2017 May 3.


Superantigen-Producing Staphylococcus aureus Elicits Systemic Immune Activation in a Murine Wound Colonization Model.

Kim CK, Karau MJ, Greenwood-Quaintance KE, Tilahun AY, Krogman A, David CS, Pritt BS, Patel R, Rajagopalan G.

Toxins (Basel). 2015 Dec 8;7(12):5308-19. doi: 10.3390/toxins7124886.


A Central Role for HLA-DR3 in Anti-Smith Antibody Responses and Glomerulonephritis in a Transgenic Mouse Model of Spontaneous Lupus.

Chowdhary VR, Dai C, Tilahun AY, Hanson JA, Smart MK, Grande JP, Rajagopalan G, Fu SM, David CS.

J Immunol. 2015 Nov 15;195(10):4660-7. doi: 10.4049/jimmunol.1501073. Epub 2015 Oct 16.


Superantigens in Staphylococcus aureus isolated from prosthetic joint infection.

Kim CK, Karau MJ, Greenwood-Quaintance KE, Tilahun AY, David CS, Mandrekar JN, Patel R, Rajagopalan G.

Diagn Microbiol Infect Dis. 2015 Mar;81(3):201-7. doi: 10.1016/j.diagmicrobio.2014.11.007. Epub 2014 Nov 24.


Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndrome.

Tilahun AY, Chowdhary VR, David CS, Rajagopalan G.

J Immunol. 2014 Sep 15;193(6):2919-30. doi: 10.4049/jimmunol.1400980. Epub 2014 Aug 4.


The impact of Staphylococcus aureus-associated molecular patterns on staphylococcal superantigen-induced toxic shock syndrome and pneumonia.

Tilahun AY, Karau M, Ballard A, Gunaratna MP, Thapa A, David CS, Patel R, Rajagopalan G.

Mediators Inflamm. 2014;2014:468285. doi: 10.1155/2014/468285. Epub 2014 Jun 12.


Low incidence of spontaneous type 1 diabetes in non-obese diabetic mice raised on gluten-free diets is associated with changes in the intestinal microbiome.

Marietta EV, Gomez AM, Yeoman C, Tilahun AY, Clark CR, Luckey DH, Murray JA, White BA, Kudva YC, Rajagopalan G.

PLoS One. 2013 Nov 13;8(11):e78687. doi: 10.1371/journal.pone.0078687. eCollection 2013.


Linezolid is superior to vancomycin in experimental pneumonia caused by Superantigen-Producing staphylococcus aureus in HLA class II transgenic mice.

Karau MJ, Tilahun AY, Schmidt SM, Clark CR, Patel R, Rajagopalan G.

Antimicrob Agents Chemother. 2012 Oct;56(10):5401-5. doi: 10.1128/AAC.01080-12. Epub 2012 Jul 30.


Chronic exposure to staphylococcal superantigen elicits a systemic inflammatory disease mimicking lupus.

Chowdhary VR, Tilahun AY, Clark CR, Grande JP, Rajagopalan G.

J Immunol. 2012 Aug 15;189(4):2054-62. doi: 10.4049/jimmunol.1201097. Epub 2012 Jul 13.


The impact of tacrolimus on the immunopathogenesis of staphylococcal enterotoxin-induced systemic inflammatory response syndrome and pneumonia.

Tilahun AY, Karau MJ, Clark CR, Patel R, Rajagopalan G.

Microbes Infect. 2012 Jun;14(6):528-36. doi: 10.1016/j.micinf.2012.01.001. Epub 2012 Jan 10.


Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB.

Tilahun ME, Kwan A, Natarajan K, Quinn M, Tilahun AY, Xie C, Margulies DH, Osborne BA, Goldsby RA, Rajagopalan G.

PLoS One. 2011;6(11):e27203. doi: 10.1371/journal.pone.0027203. Epub 2011 Nov 15.


Human leukocyte antigen class II transgenic mouse model unmasks the significant extrahepatic pathology in toxic shock syndrome.

Tilahun AY, Marietta EV, Wu TT, Patel R, David CS, Rajagopalan G.

Am J Pathol. 2011 Jun;178(6):2760-73. doi: 10.1016/j.ajpath.2011.02.033.


HLA-DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation.

Rajagopalan G, Tilahun AY, Iijima K, David CS, Kita H, Juhn YJ.

Tissue Antigens. 2011 Jun;77(6):589-92. doi: 10.1111/j.1399-0039.2010.01617.x. Epub 2011 Mar 30.


Interferon gamma-dependent intestinal pathology contributes to the lethality in bacterial superantigen-induced toxic shock syndrome.

Tilahun AY, Holz M, Wu TT, David CS, Rajagopalan G.

PLoS One. 2011 Feb 3;6(2):e16764. doi: 10.1371/journal.pone.0016764.


Detrimental effect of the proteasome inhibitor, bortezomib in bacterial superantigen- and lipopolysaccharide-induced systemic inflammation.

Tilahun AY, Theuer JE, Patel R, David CS, Rajagopalan G.

Mol Ther. 2010 Jun;18(6):1143-54. doi: 10.1038/mt.2010.53. Epub 2010 Apr 6.


Potent neutralization of staphylococcal enterotoxin B by synergistic action of chimeric antibodies.

Tilahun ME, Rajagopalan G, Shah-Mahoney N, Lawlor RG, Tilahun AY, Xie C, Natarajan K, Margulies DH, Ratner DI, Osborne BA, Goldsby RA.

Infect Immun. 2010 Jun;78(6):2801-11. doi: 10.1128/IAI.01121-09. Epub 2010 Mar 22.


Early gene expression changes induced by the bacterial superantigen staphylococcal enterotoxin B and its modulation by a proteasome inhibitor.

Rajagopalan G, Tilahun AY, Asmann YW, David CS.

Physiol Genomics. 2009 May 13;37(3):279-93. doi: 10.1152/physiolgenomics.90385.2008. Epub 2009 Mar 31.


Cyclooxygenase 2 pathway and its therapeutic inhibition in superantigen-induced toxic shock.

Rajagopalan G, Asmann YW, Lytle AK, Tilahun AY, Theuer JE, Smart MK, Patel R, David CS.

Shock. 2008 Dec;30(6):721-8. doi: 10.1097/SHK.0b013e31817048f7.


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