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Items: 1 to 50 of 199

1.

Unfavorable Reduction in the Ratio of Endothelin B to A Receptors in Experimental 5/6 Nephrectomy and Adenine Models of Chronic Renal Insufficiency.

Törmänen S, Lakkisto P, Eräranta A, Kööbi P, Tikkanen I, Niemelä O, Mustonen J, Pörsti I.

Int J Mol Sci. 2020 Jan 31;21(3). pii: E936. doi: 10.3390/ijms21030936.

2.

Vezf1 regulates cardiac structure and contractile function.

Paavola J, Alakoski T, Ulvila J, Kilpiö T, Sirén J, Perttunen S, Narumanchi S, Wang H, Lin R, Porvari K, Junttila J, Huikuri H, Immonen K, Lakkisto P, Magga J, Tikkanen I, Kerkelä R.

EBioMedicine. 2020 Jan;51:102608. doi: 10.1016/j.ebiom.2019.102608. Epub 2020 Jan 3.

3.

The association of endothelial injury and systemic inflammation with perioperative myocardial infarction.

Ollila A, Vikatmaa L, Virolainen J, Nisula S, Lakkisto P, Vikatmaa P, Tikkanen I, Venermo M, Pettilä V.

Ann Clin Biochem. 2019 Nov;56(6):674-683. doi: 10.1177/0004563219873357. Epub 2019 Sep 4. No abstract available.

PMID:
31409092
4.

Inhibition of let-7c Regulates Cardiac Regeneration after Cryoinjury in Adult Zebrafish.

Narumanchi S, Kalervo K, Perttunen S, Wang H, Immonen K, Kosonen R, Laine M, Ruskoaho H, Tikkanen I, Lakkisto P, Paavola J.

J Cardiovasc Dev Dis. 2019 Apr 4;6(2). pii: E16. doi: 10.3390/jcdd6020016.

5.

Circulating levels of microRNA 423-5p are associated with 90 day mortality in cardiogenic shock.

Jäntti T, Segersvärd H, Tolppanen H, Tarvasmäki T, Lassus J, Devaux Y, Vausort M, Pulkki K, Sionis A, Bayes-Genis A, Tikkanen I, Lakkisto P, Harjola VP.

ESC Heart Fail. 2019 Feb;6(1):98-102. doi: 10.1002/ehf2.12377. Epub 2018 Nov 24.

6.

Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia.

Kaartokallio T, Utge S, Klemetti MM, Paananen J, Pulkki K, Romppanen J, Tikkanen I, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Lakkisto P, Laivuori H.

Hypertension. 2018 Jan;71(1):95-102. doi: 10.1161/HYPERTENSIONAHA.117.10425. Epub 2017 Dec 4.

PMID:
29203625
7.

Endothelin A receptor blocker and calcimimetic in the adenine rat model of chronic renal insufficiency.

Törmänen S, Pörsti I, Lakkisto P, Tikkanen I, Niemelä O, Paavonen T, Mustonen J, Eräranta A.

BMC Nephrol. 2017 Oct 27;18(1):323. doi: 10.1186/s12882-017-0742-z.

8.

Carbon monoxide releasing molecule improves structural and functional cardiac recovery after myocardial injury.

Segersvärd H, Lakkisto P, Hänninen M, Forsten H, Siren J, Immonen K, Kosonen R, Sarparanta M, Laine M, Tikkanen I.

Eur J Pharmacol. 2018 Jan 5;818:57-66. doi: 10.1016/j.ejphar.2017.10.031. Epub 2017 Oct 18.

PMID:
29055786
9.

Blood pressure response to renal denervation is correlated with baseline blood pressure variability: a patient-level meta-analysis.

Persu A, Gordin D, Jacobs L, Thijs L, Bots ML, Spiering W, Miroslawska A, Spaak J, Rosa J, de Jong MR, Berra E, Fadl Elmula FEM, Wuerzner G, Taylor AHM, Olszanecka A, Czarnecka D, Mark PB, Burnier M, Renkin J, Kjeldsen SE, Widimský J, Elvan A, Kahan T, Steigen TK, Blankestijn PJ, Tikkanen I, Staessen JA; European Network COordinating research on Renal Denervation (ENCOReD).

J Hypertens. 2018 Feb;36(2):221-229. doi: 10.1097/HJH.0000000000001582.

PMID:
29045339
10.

Pooled analysis of Phase III trials indicate contrasting influences of renal function on blood pressure, body weight, and HbA1c reductions with empagliflozin.

Cherney DZI, Cooper ME, Tikkanen I, Pfarr E, Johansen OE, Woerle HJ, Broedl UC, Lund SS.

Kidney Int. 2018 Jan;93(1):231-244. doi: 10.1016/j.kint.2017.06.017. Epub 2017 Aug 30.

PMID:
28860019
11.

The effects of baroreflex activation therapy on blood pressure and sympathetic function in patients with refractory hypertension: the rationale and design of the Nordic BAT study.

Gordin D, Fadl Elmula FEM, Andersson B, Gottsäter A, Elf J, Kahan T, Christensen KL, Vikatmaa P, Vikatmaa L, Bastholm Olesen T, Groop PH, Olsen MH, Tikkanen I; Nordic BAT Study Group.

Blood Press. 2017 Oct;26(5):294-302. doi: 10.1080/08037051.2017.1332477. Epub 2017 Jun 8.

PMID:
28595464
12.

Impact of empagliflozin on blood pressure in dipper and non-dipper patients with type 2 diabetes mellitus and hypertension.

Chilton R, Tikkanen I, Hehnke U, Woerle HJ, Johansen OE.

Diabetes Obes Metab. 2017 Nov;19(11):1620-1624. doi: 10.1111/dom.12962. Epub 2017 Jul 7.

PMID:
28387058
13.

Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish.

Dash SN, Narumanchi S, Paavola J, Perttunen S, Wang H, Lakkisto P, Tikkanen I, Lehtonen S.

Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H1085-H1095. doi: 10.1152/ajpheart.00394.2016. Epub 2017 Mar 24.

14.

Impact of Empagliflozin on Blood Pressure in Patients With Type 2 Diabetes Mellitus and Hypertension by Background Antihypertensive Medication.

Mancia G, Cannon CP, Tikkanen I, Zeller C, Ley L, Woerle HJ, Broedl UC, Johansen OE.

Hypertension. 2016 Dec;68(6):1355-1364. Epub 2016 Oct 10.

PMID:
27977392
15.

Postoperative Cardiac Ischemia Detection by Continuous 12-Lead Electrocardiographic Monitoring in Vascular Surgery Patients: A Prospective, Observational Study.

Ollila A, Virolainen J, Vanhatalo J, Vikatmaa P, Tikkanen I, Venermo M, Salmenperä M, Pettilä V, Vikatmaa L.

J Cardiothorac Vasc Anesth. 2017 Jun;31(3):950-956. doi: 10.1053/j.jvca.2016.09.027. Epub 2016 Sep 28.

PMID:
27919716
16.

Urinary Biomarkers Indicative of Apoptosis and Acute Kidney Injury in the Critically Ill.

Vaara ST, Lakkisto P, Immonen K, Tikkanen I, Ala-Kokko T, Pettilä V; FINNAKI Study Group.

PLoS One. 2016 Feb 26;11(2):e0149956. doi: 10.1371/journal.pone.0149956. eCollection 2016.

17.

Potential role of sodium glucose cotransporter 2 inhibitors in the treatment of hypertension.

Tikkanen I, Chilton R, Johansen OE.

Curr Opin Nephrol Hypertens. 2016 Mar;25(2):81-6. doi: 10.1097/MNH.0000000000000199. Review.

PMID:
26808705
18.

Baroreflex activation therapy in the treatment of resistant hypertension.

Gordin D, Vikatmaa P, Vikatmaa L, Groop PH, Albäck A, Tikkanen I.

Duodecim. 2016;132(20):1874-81. Review.

PMID:
29190040
19.

PLASMA HEME OXYGENASE-1 IN PATIENTS RESUSCITATED FROM OUT-OF-HOSPITAL CARDIAC ARREST.

Siren J, Vaahersalo J, Skrifvars M, Pettilä V, Tiainen M, Tikkanen I, Lakkisto P; FINNRESUSCI Study Group.

Shock. 2016 Mar;45(3):320-5. doi: 10.1097/SHK.0000000000000521.

PMID:
26555743
20.

Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes.

Chilton R, Tikkanen I, Cannon CP, Crowe S, Woerle HJ, Broedl UC, Johansen OE.

Diabetes Obes Metab. 2015 Dec;17(12):1180-93. doi: 10.1111/dom.12572. Epub 2015 Oct 9.

21.

Vasopeptidase Inhibition Corrects the Structure and Function of the Small Arteries in Experimental Renal Insufficiency.

Haltia O, Törmänen S, Eräranta A, Jokihaara J, Nordhausen K, Rysä J, Ruskoaho H, Tikkanen I, Mustonen J, Pörsti I.

J Vasc Res. 2015;52(2):94-102. doi: 10.1159/000431368. Epub 2015 Jul 9. Erratum in: J Vasc Res. 2015;52(2):115.

PMID:
26184548
22.

Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension.

Tikkanen I, Narko K, Zeller C, Green A, Salsali A, Broedl UC, Woerle HJ; EMPA-REG BP Investigators.

Diabetes Care. 2015 Mar;38(3):420-8. doi: 10.2337/dc14-1096. Epub 2014 Sep 30.

PMID:
25271206
23.

Phosphate binding reduces aortic angiotensin-converting enzyme and enhances nitric oxide bioactivity in experimental renal insufficiency.

Eräranta A, Törmänen S, Kööbi P, Vehmas TI, Lakkisto P, Tikkanen I, Moilanen E, Niemelä O, Mustonen J, Pörsti I.

Am J Nephrol. 2014;39(5):400-8. doi: 10.1159/000362507. Epub 2014 May 6.

PMID:
24818649
24.

[Renal denervation in the treatment of hypertension].

Tikkanen I, Lappalainen K.

Duodecim. 2013;129(8):825-32. Finnish.

PMID:
23720950
25.

Effects of angiotensin II blockade on cardiomyocyte regeneration after myocardial infarction in rats.

Segersvärd H, Lakkisto P, Forsten H, Immonen K, Kosonen R, Palojoki E, Kankuri E, Harjula A, Laine M, Tikkanen I.

J Renin Angiotensin Aldosterone Syst. 2015 Mar;16(1):92-102. doi: 10.1177/1470320313487567. Epub 2013 Apr 29.

PMID:
23629679
26.

Dietary phosphate binding and loading alter kidney angiotensin-converting enzyme mRNA and protein content in 5/6 nephrectomized rats.

Eräranta A, Riutta A, Fan M, Koskela J, Tikkanen I, Lakkisto P, Niemelä O, Parkkinen J, Mustonen J, Pörsti I.

Am J Nephrol. 2012;35(5):401-8. doi: 10.1159/000337942. Epub 2012 Apr 19.

PMID:
22517117
27.

Heat shock attenuates VEGF expression in three-dimensional myoblast sheets deteriorating therapeutic efficacy in heart failure.

Augustin M, Ali Asim Mahar M, Lakkisto P, Tikkanen I, Vento A, Patila T, Harjula A.

Med Sci Monit. 2011 Dec;17(12):BR345-53.

28.

Heme oxygenase-1 induction protects the heart and modulates cellular and extracellular remodelling after myocardial infarction in rats.

Lakkisto P, Siren JM, Kytö V, Forsten H, Laine M, Pulkki K, Tikkanen I.

Exp Biol Med (Maywood). 2011 Dec;236(12):1437-48. doi: 10.1258/ebm.2011.011148. Epub 2011 Nov 15.

PMID:
22087023
29.

Effects of levosimendan on cardiac gene expression profile and post-infarct cardiac remodelling in diabetic Goto-Kakizaki rats.

Vahtola E, Storvik M, Louhelainen M, Merasto S, Lakkisto P, Lakkisto J, Tikkanen I, Kaheinen P, Levijoki J, Mervaala E.

Basic Clin Pharmacol Toxicol. 2011 Nov;109(5):387-97. doi: 10.1111/j.1742-7843.2011.00743.x. Epub 2011 Aug 17.

30.

hHGF overexpression in myoblast sheets enhances their angiogenic potential in rat chronic heart failure.

Siltanen A, Kitabayashi K, Lakkisto P, Mäkelä J, Pätilä T, Ono M, Tikkanen I, Sawa Y, Kankuri E, Harjula A.

PLoS One. 2011 Apr 26;6(4):e19161. doi: 10.1371/journal.pone.0019161.

31.

Bcl-2 improves myoblast sheet therapy in rat chronic heart failure.

Siltanen A, Kitabayashi K, Pätilä T, Ono M, Tikkanen I, Sawa Y, Kankuri E, Harjula A.

Tissue Eng Part A. 2011 Jan;17(1-2):115-25. doi: 10.1089/ten.TEA.2010.0205. Epub 2010 Sep 9.

PMID:
20677907
32.

[Which one to choose for the first antihypertensive drug?].

Tikkanen I.

Duodecim. 2010;126(8):891-6. Review. Finnish.

PMID:
20597335
33.

Heme oxygenase-1 and carbon monoxide promote neovascularization after myocardial infarction by modulating the expression of HIF-1alpha, SDF-1alpha and VEGF-B.

Lakkisto P, Kytö V, Forsten H, Siren JM, Segersvärd H, Voipio-Pulkki LM, Laine M, Pulkki K, Tikkanen I.

Eur J Pharmacol. 2010 Jun 10;635(1-3):156-64. doi: 10.1016/j.ejphar.2010.02.050. Epub 2010 Mar 19.

PMID:
20303947
34.

Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat.

Vahtola E, Louhelainen M, Forstén H, Merasto S, Raivio J, Kaheinen P, Kytö V, Tikkanen I, Levijoki J, Mervaala E.

Cardiovasc Diabetol. 2010 Jan 27;9:5. doi: 10.1186/1475-2840-9-5.

35.

Bcl-2 expression enhances myoblast sheet transplantation therapy for acute myocardial infarction.

Kitabayashi K, Siltanen A, Pätilä T, Mahar MA, Tikkanen I, Koponen J, Ono M, Sawa Y, Kankuri E, Harjula A.

Cell Transplant. 2010;19(5):573-88. doi: 10.3727/096368909X486048. Epub 2010 Jan 20.

PMID:
20089207
36.

Common genetic variations of the renin-angiotensin-aldosterone system and response to acute angiotensin I-converting enzyme inhibition in essential hypertension.

Hannila-Handelberg T, Kontula KK, Paukku K, Lehtonen JY, Virtamo J, Tikkanen I, Hiltunen TP.

J Hypertens. 2010 Apr;28(4):771-9. doi: 10.1097/HJH.0b013e328335c368.

PMID:
20027122
37.

Angiotensin receptors in the eyes of arterial hypertensive rats.

Vaajanen A, Lakkisto P, Virtanen I, Kankuri E, Oksala O, Vapaatalo H, Tikkanen I.

Acta Ophthalmol. 2010 Jun;88(4):431-8. doi: 10.1111/j.1755-3768.2009.01563.x. Epub 2009 Sep 16.

38.

Oral levosimendan prevents postinfarct heart failure and cardiac remodeling in diabetic Goto-Kakizaki rats.

Louhelainen M, Vahtola E, Forsten H, Merasto S, Kytö V, Finckenberg P, Leskinen H, Kaheinen P, Tikkanen I, Levijoki J, Mervaala E.

J Hypertens. 2009 Oct;27(10):2094-107. doi: 10.1097/HJH.0b013e32832f0ce4.

PMID:
19730126
39.

CYP2C9 genotype modifies activity of the renin-angiotensin-aldosterone system in hypertensive men.

Donner KM, Hiltunen TP, Suonsyrjä T, Hannila-Handelberg T, Tikkanen I, Antikainen M, Hirvonen A, Kontula K.

J Hypertens. 2009 Oct;27(10):2001-9. doi: 10.1097/HJH.0b013e32832f4fae.

PMID:
19593208
40.

Paricalcitol and renin-angiotensin components in remnant kidneys.

Eräranta A, Lakkisto PJ, Tikkanen I, Mustonen JT, Pörsti IH.

Kidney Int. 2009 Feb;75(3):339-40; author reply 340. doi: 10.1038/ki.2008.593. No abstract available.

41.

Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency.

Eräranta A, Kurra V, Tahvanainen AM, Vehmas TI, Kööbi P, Lakkisto P, Tikkanen I, Niemelä OJ, Mustonen JT, Pörsti IH.

J Hypertens. 2008 Aug;26(8):1661-8. doi: 10.1097/HJH.0b013e328303205d.

PMID:
18622246
42.

Laboratory tests as predictors of the antihypertensive effects of amlodipine, bisoprolol, hydrochlorothiazide and losartan in men: results from the randomized, double-blind, crossover GENRES Study.

Suonsyrjä T, Hannila-Handelberg T, Paavonen KJ, Miettinen HE, Donner K, Strandberg T, Tikkanen I, Tilvis R, Pentikäinen PJ, Kontula K, Hiltunen TP.

J Hypertens. 2008 Jun;26(6):1250-6. doi: 10.1097/HJH.0b013e3282fcc37f.

PMID:
18475165
43.

Estimated glomerular filtration rate (eGFR) as a predictor of outcome after infrainguinal bypass in patients with critical limb ischemia.

Arvela E, Söderström M, Albäck A, Aho PS, Tikkanen I, Lepäntalo M.

Eur J Vasc Endovasc Surg. 2008 Jul;36(1):77-83. doi: 10.1016/j.ejvs.2008.01.018. Epub 2008 Mar 19.

44.

Activation of protective and damaging components of the cardiac renin-angiotensin system after myocardial infarction in experimental diabetes.

Bäcklund T, Lakkisto P, Palojoki E, Grönholm T, Saraste A, Finckenberg P, Mervaala E, Tikkanen I, Laine M.

J Renin Angiotensin Aldosterone Syst. 2007 Jun;8(2):66-73.

PMID:
17703432
45.

Paricalcitol aggravates perivascular fibrosis in rats with renal insufficiency and low calcitriol.

Repo JM, Rantala IS, Honkanen TT, Mustonen JT, Kööbi P, Tahvanainen AM, Niemelä OJ, Tikkanen I, Rysä JM, Ruskoaho HJ, Pörsti IH.

Kidney Int. 2007 Oct;72(8):977-84. Epub 2007 Aug 1.

46.

Increased expression of profibrotic neutral endopeptidase and bradykinin type 1 receptors in stenotic aortic valves.

Helske S, Laine M, Kupari M, Lommi J, Turto H, Nurmi L, Tikkanen I, Werkkala K, Lindstedt KA, Kovanen PT.

Eur Heart J. 2007 Aug;28(15):1894-903. Epub 2007 May 15.

PMID:
17507367
47.

Diagnosis and treatment of dyslipidemia are neglected in patients with peripheral artery disease.

Poussa H, Strandberg TE, Tikkanen I, Kauhanen P, Lepäntalo M.

Scand Cardiovasc J. 2007 Jun;41(3):138-41.

PMID:
17487761
48.

Mutant ryanodine receptors in catecholaminergic polymorphic ventricular tachycardia generate delayed afterdepolarizations due to increased propensity to Ca2+ waves.

Paavola J, Viitasalo M, Laitinen-Forsblom PJ, Pasternack M, Swan H, Tikkanen I, Toivonen L, Kontula K, Laine M.

Eur Heart J. 2007 May;28(9):1135-42. Epub 2007 Mar 8.

PMID:
17347175
49.

Predictors of antihypertensive drug responses: initial data from a placebo-controlled, randomized, cross-over study with four antihypertensive drugs (The GENRES Study).

Hiltunen TP, Suonsyrjä T, Hannila-Handelberg T, Paavonen KJ, Miettinen HE, Strandberg T, Tikkanen I, Tilvis R, Pentikäinen PJ, Virolainen J, Kontula K.

Am J Hypertens. 2007 Mar;20(3):311-8. Erratum in: Am J Hypertens. 2018 Nov 13;31(12):1333.

PMID:
17324745
50.

Vasopeptidase inhibition has beneficial cardiac effects in spontaneously diabetic Goto-Kakizaki rats.

Grönholm T, Cheng ZJ, Palojoki E, Eriksson A, Bäcklund T, Vuolteenaho O, Finckenberg P, Laine M, Mervaala E, Tikkanen I.

Eur J Pharmacol. 2005 Sep 20;519(3):267-76.

PMID:
16137672

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