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Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Garg M, Royce SG, Tikellis C, Shallue C, Batu D, Velkoska E, Burrell LM, Patel SK, Beswick L, Jackson A, Britto K, Lukies M, Sluka P, Wardan H, Hirokawa Y, Tan CW, Faux M, Burgess AW, Hosking P, Monagle S, Thomas M, Gibson PR, Lubel J.

Gut. 2019 Aug 13. pii: gutjnl-2019-318512. doi: 10.1136/gutjnl-2019-318512. [Epub ahead of print]


The intestinal vitamin D receptor in inflammatory bowel disease: inverse correlation with inflammation but no relationship with circulating vitamin D status.

Garg M, Royce SG, Tikellis C, Shallue C, Sluka P, Wardan H, Hosking P, Monagle S, Thomas M, Lubel JS, Gibson PR.

Therap Adv Gastroenterol. 2019 Jan 18;12:1756284818822566. doi: 10.1177/1756284818822566. eCollection 2019.


Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis.

Pickering RJ, Tikellis C, Rosado CJ, Tsorotes D, Dimitropoulos A, Smith M, Huet O, Seeber RM, Abhayawardana R, Johnstone EK, Golledge J, Wang Y, Jandeleit-Dahm KA, Cooper ME, Pfleger KD, Thomas MC.

J Clin Invest. 2019 Jan 2;129(1):406-421. doi: 10.1172/JCI99987. Epub 2018 Dec 10.


Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis.

Brennan EP, Mohan M, McClelland A, de Gaetano M, Tikellis C, Marai M, Crean D, Dai A, Beuscart O, Derouiche S, Gray SP, Pickering R, Tan SM, Godson-Treacy M, Sheehan S, Dowdall JF, Barry M, Belton O, Ali-Shah ST, Guiry PJ, Jandeleit-Dahm K, Cooper ME, Godson C, Kantharidis P.

Diabetes. 2018 Dec;67(12):2657-2667. doi: 10.2337/db17-1317. Epub 2018 Sep 13.


Relationship Between Plasma 8-OH-Deoxyguanosine and Cardiovascular Disease and Survival in Type 2 Diabetes Mellitus: Results From the ADVANCE Trial.

Thomas MC, Woodward M, Li Q, Pickering R, Tikellis C, Poulter N, Cooper ME, Marre M, Zoungas S, Chalmers J; ADVANCE Collaborative Group.

J Am Heart Assoc. 2018 Jun 30;7(13). pii: e008226. doi: 10.1161/JAHA.117.008226.


Lipoxins Regulate the Early Growth Response-1 Network and Reverse Diabetic Kidney Disease.

Brennan EP, Mohan M, McClelland A, Tikellis C, Ziemann M, Kaspi A, Gray SP, Pickering R, Tan SM, Ali-Shah ST, Guiry PJ, El-Osta A, Jandeleit-Dahm K, Cooper ME, Godson C, Kantharidis P.

J Am Soc Nephrol. 2018 May;29(5):1437-1448. doi: 10.1681/ASN.2017101112. Epub 2018 Feb 28.


Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2.

Moran CS, Biros E, Krishna SM, Wang Y, Tikellis C, Morton SK, Moxon JV, Cooper ME, Norman PE, Burrell LM, Thomas MC, Golledge J.

Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2195-2203. doi: 10.1161/ATVBAHA.117.310129. Epub 2017 Sep 21.


Protective Effect of let-7 miRNA Family in Regulating Inflammation in Diabetes-Associated Atherosclerosis.

Brennan E, Wang B, McClelland A, Mohan M, Marai M, Beuscart O, Derouiche S, Gray S, Pickering R, Tikellis C, de Gaetano M, Barry M, Belton O, Ali-Shah ST, Guiry P, Jandeleit-Dahm KAM, Cooper ME, Godson C, Kantharidis P.

Diabetes. 2017 Aug;66(8):2266-2277. doi: 10.2337/db16-1405. Epub 2017 May 9.


Protective Effect of Inflammasome Activation by Hydrogen Peroxide in a Mouse Model of Septic Shock.

Huet O, Pickering RJ, Tikellis C, Latouche C, Long F, Kingwell B, Dickinson B, Chang CJ, Masters S, Mackay F, Cooper ME, de Haan JB.

Crit Care Med. 2017 Feb;45(2):e184-e194. doi: 10.1097/CCM.0000000000002070.


Short-term treatment with diminazene aceturate ameliorates the reduction in kidney ACE2 activity in rats with subtotal nephrectomy.

Velkoska E, Patel SK, Griggs K, Pickering RJ, Tikellis C, Burrell LM.

PLoS One. 2015 Mar 18;10(3):e0118758. doi: 10.1371/journal.pone.0118758. eCollection 2015.


ACE2 deficiency shifts energy metabolism towards glucose utilization.

Bernardi S, Tikellis C, Candido R, Tsorotes D, Pickering RJ, Bossi F, Carretta R, Fabris B, Cooper ME, Thomas MC.

Metabolism. 2015 Mar;64(3):406-15. doi: 10.1016/j.metabol.2014.11.004. Epub 2014 Nov 20.


Osteoprotegerin increases in metabolic syndrome and promotes adipose tissue proinflammatory changes.

Bernardi S, Fabris B, Thomas M, Toffoli B, Tikellis C, Candido R, Catena C, Mulatero P, Barbone F, Radillo O, Zauli G, Secchiero P.

Mol Cell Endocrinol. 2014 Aug 25;394(1-2):13-20. doi: 10.1016/j.mce.2014.06.004. Epub 2014 Jul 3.


Role of inflammation and the angiotensin type 2 receptor in the regulation of arterial pressure during pregnancy in mice.

Mirabito KM, Hilliard LM, Wei Z, Tikellis C, Widdop RE, Vinh A, Denton KM.

Hypertension. 2014 Sep;64(3):626-31. doi: 10.1161/HYPERTENSIONAHA.114.03189. Epub 2014 Jun 16.


Dicarbonyl stress in the absence of hyperglycemia increases endothelial inflammation and atherogenesis similar to that observed in diabetes.

Tikellis C, Pickering RJ, Tsorotes D, Huet O, Cooper ME, Jandeleit-Dahm K, Thomas MC.

Diabetes. 2014 Nov;63(11):3915-25. doi: 10.2337/db13-0932. Epub 2014 May 8.


Angiotensin-converting enzyme 2 mediates hyperfiltration associated with diabetes.

Tikellis C, Brown R, Head GA, Cooper ME, Thomas MC.

Am J Physiol Renal Physiol. 2014 Apr 1;306(7):F773-80. doi: 10.1152/ajprenal.00264.2013. Epub 2014 Jan 29.


Association of dietary sodium intake with atherogenesis in experimental diabetes and with cardiovascular disease in patients with Type 1 diabetes.

Tikellis C, Pickering RJ, Tsorotes D, Harjutsalo V, Thorn L, Ahola A, Wadén J, Tolonen N, Saraheimo M, Gordin D, Forsblom C, Groop PH, Cooper ME, Moran J, Thomas MC.

Clin Sci (Lond). 2013 May;124(10):617-26. doi: 10.1042/CS20120352.


Angiotensin converting enzyme 2 and atherosclerosis.

Wang Y, Tikellis C, Thomas MC, Golledge J.

Atherosclerosis. 2013 Jan;226(1):3-8. doi: 10.1016/j.atherosclerosis.2012.08.018. Epub 2012 Aug 20. Review.


Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice.

Watson AM, Gray SP, Jiaze L, Soro-Paavonen A, Wong B, Cooper ME, Bierhaus A, Pickering R, Tikellis C, Tsorotes D, Thomas MC, Jandeleit-Dahm KA.

Diabetes. 2012 Aug;61(8):2105-13. doi: 10.2337/db11-1546. Epub 2012 Jun 14.


Activation of the Renin-Angiotensin system mediates the effects of dietary salt intake on atherogenesis in the apolipoprotein E knockout mouse.

Tikellis C, Pickering RJ, Tsorotes D, Huet O, Chin-Dusting J, Cooper ME, Thomas MC.

Hypertension. 2012 Jul;60(1):98-105. doi: 10.1161/HYPERTENSIONAHA.112.191767. Epub 2012 May 29.


TNF-related apoptosis-inducing ligand significantly attenuates metabolic abnormalities in high-fat-fed mice reducing adiposity and systemic inflammation.

Bernardi S, Zauli G, Tikellis C, Candido R, Fabris B, Secchiero P, Cooper ME, Thomas MC.

Clin Sci (Lond). 2012 Nov;123(9):547-55. doi: 10.1042/CS20120176.


Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes.

Tikellis C, Pickering R, Tsorotes D, Du XJ, Kiriazis H, Nguyen-Huu TP, Head GA, Cooper ME, Thomas MC.

Clin Sci (Lond). 2012 Oct;123(8):519-29. doi: 10.1042/CS20110668.


Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease.

Tikellis C, Thomas MC.

Int J Pept. 2012;2012:256294. doi: 10.1155/2012/256294. Epub 2012 Mar 20.


The renoprotective actions of peroxisome proliferator-activated receptors agonists in diabetes.

Thomas MC, Jandeleit-Dahm KA, Tikellis C.

PPAR Res. 2012;2012:456529. doi: 10.1155/2012/456529. Epub 2012 Feb 12.


Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells.

Okabe J, Orlowski C, Balcerczyk A, Tikellis C, Thomas MC, Cooper ME, El-Osta A.

Circ Res. 2012 Apr 13;110(8):1067-76. doi: 10.1161/CIRCRESAHA.112.266171. Epub 2012 Mar 8.


Angiotensin-converting enzyme 2 regulates renal atrial natriuretic peptide through angiotensin-(1-7).

Bernardi S, Burns WC, Toffoli B, Pickering R, Sakoda M, Tsorotes D, Grixti E, Velkoska E, Burrell LM, Johnston C, Thomas MC, Fabris B, Tikellis C.

Clin Sci (Lond). 2012 Jul;123(1):29-37. doi: 10.1042/CS20110403.


High-salt diet increases glomerular ACE/ACE2 ratio leading to oxidative stress and kidney damage.

Bernardi S, Toffoli B, Zennaro C, Tikellis C, Monticone S, Losurdo P, Bellini G, Thomas MC, Fallo F, Veglio F, Johnston CI, Fabris B.

Nephrol Dial Transplant. 2012 May;27(5):1793-800. doi: 10.1093/ndt/gfr600. Epub 2011 Oct 29.


The arterial depressor response to chronic low-dose angiotensin II infusion in female rats is estrogen dependent.

Sampson AK, Hilliard LM, Moritz KM, Thomas MC, Tikellis C, Widdop RE, Denton KM.

Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R159-65. doi: 10.1152/ajpregu.00256.2011. Epub 2011 Oct 26.


Angiotensin-converting enzyme 2 is a key modulator of the renin-angiotensin system in cardiovascular and renal disease.

Tikellis C, Bernardi S, Burns WC.

Curr Opin Nephrol Hypertens. 2011 Jan;20(1):62-8. doi: 10.1097/MNH.0b013e328341164a. Review.


Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure.

Komers R, Oyama TT, Beard DR, Tikellis C, Xu B, Lotspeich DF, Anderson S.

Kidney Int. 2011 Feb;79(4):432-42. doi: 10.1038/ki.2010.428. Epub 2010 Oct 20.


Expression and function of ATIP/MTUS1 in human prostate cancer cell lines.

Louis SN, Chow L, Rezmann L, Krezel MA, Catt KJ, Tikellis C, Frauman AG, Louis WJ.

Prostate. 2010 Oct 1;70(14):1563-74. doi: 10.1002/pros.21192.


Genetic Ace2 deficiency accentuates vascular inflammation and atherosclerosis in the ApoE knockout mouse.

Thomas MC, Pickering RJ, Tsorotes D, Koitka A, Sheehy K, Bernardi S, Toffoli B, Nguyen-Huu TP, Head GA, Fu Y, Chin-Dusting J, Cooper ME, Tikellis C.

Circ Res. 2010 Oct 1;107(7):888-97. doi: 10.1161/CIRCRESAHA.110.219279. Epub 2010 Jul 29.


Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms.

Tonna S, El-Osta A, Cooper ME, Tikellis C.

Nat Rev Nephrol. 2010 Jun;6(6):332-41. doi: 10.1038/nrneph.2010.55. Epub 2010 Apr 27. Review.


Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2.

Herath CB, Lubel JS, Jia Z, Velkoska E, Casley D, Brown L, Tikellis C, Burrell LM, Angus PW.

Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G98-G106. doi: 10.1152/ajpgi.00045.2009. Epub 2009 Apr 23.


Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.

Brasacchio D, Okabe J, Tikellis C, Balcerczyk A, George P, Baker EK, Calkin AC, Brownlee M, Cooper ME, El-Osta A.

Diabetes. 2009 May;58(5):1229-36. doi: 10.2337/db08-1666. Epub 2009 Feb 10.


Quantitative gene expression analysis in kidney tissues.

Tikellis C, Koh P, Burns W, Kantharidis P.

Methods Mol Biol. 2009;466:83-107. doi: 10.1007/978-1-59745-352-3_7.


Direct antiatherosclerotic effects of PPAR agonists.

Jandeleit-Dahm KA, Calkin A, Tikellis C, Thomas M.

Curr Opin Lipidol. 2009 Feb;20(1):24-9. Review.


Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs.

Tikellis C, Thomas MC, Harcourt BE, Coughlan MT, Pete J, Bialkowski K, Tan A, Bierhaus A, Cooper ME, Forbes JM.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E323-30. doi: 10.1152/ajpendo.00024.2008. Epub 2008 May 13.


Advances in the renin-angiotensin-aldosterone system: relevance to diabetic nephropathy.

Koitka A, Tikellis C.

ScientificWorldJournal. 2008 Apr 20;8:434-45. doi: 10.1100/tsw.2008.69. Review.


Angiotensin converting enzyme 2 in the kidney.

Koitka A, Cooper ME, Thomas MC, Tikellis C.

Clin Exp Pharmacol Physiol. 2008 Apr;35(4):420-5. doi: 10.1111/j.1440-1681.2008.04889.x. Review.


Functional angiotensin II type 2 receptors inhibit growth factor signaling in LNCaP and PC3 prostate cancer cell lines.

Chow L, Rezmann L, Imamura K, Wang L, Catt K, Tikellis C, Louis WJ, Frauman AG, Louis SN.

Prostate. 2008 May 1;68(6):651-60. doi: 10.1002/pros.20738.


ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes.

Tikellis C, Bialkowski K, Pete J, Sheehy K, Su Q, Johnston C, Cooper ME, Thomas MC.

Diabetes. 2008 Apr;57(4):1018-25. doi: 10.2337/db07-1212. Epub 2008 Jan 30. Erratum in: Diabetes. 2011 Jan;60(1):360.


Reduced plaque formation induced by rosiglitazone in an STZ-diabetes mouse model of atherosclerosis is associated with downregulation of adhesion molecules.

Tikellis C, Jandeleit-Dahm KA, Sheehy K, Murphy A, Chin-Dusting J, Kling D, Sebokova E, Cooper ME, Mizrahi J, Woollard KJ.

Atherosclerosis. 2008 Jul;199(1):55-64. Epub 2008 Feb 21.


PPARs and diabetes-associated atherosclerosis.

Calkin AC, Jandeleit-Dahm KA, Sebekova E, Allen TJ, Mizrahi J, Cooper ME, Tikellis C.

Curr Pharm Des. 2007;13(26):2736-41. Review.


Increased atherosclerosis following treatment with a dual PPAR agonist in the ApoE knockout mouse.

Calkin AC, Allen TJ, Lassila M, Tikellis C, Jandeleit-Dahm KA, Thomas MC.

Atherosclerosis. 2007 Nov;195(1):17-22. Epub 2007 Jan 9.


Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease.

Burns WC, Twigg SM, Forbes JM, Pete J, Tikellis C, Thallas-Bonke V, Thomas MC, Cooper ME, Kantharidis P.

J Am Soc Nephrol. 2006 Sep;17(9):2484-94. Epub 2006 Aug 16.


Developmental expression of ACE2 in the SHR kidney: a role in hypertension?

Tikellis C, Cooper ME, Bialkowski K, Johnston CI, Burns WC, Lew RA, Smith AI, Thomas MC.

Kidney Int. 2006 Jul;70(1):34-41. Epub 2006 May 17.


Preventing diabetes in patients with hypertension: one more reason to block the renin-angiotensin system.

Cooper ME, Tikellis C, Thomas MC.

J Hypertens Suppl. 2006 Mar;24(1):S57-63. Review.


Polymorphisms in the gene encoding angiotensin I converting enzyme 2 and diabetic nephropathy.

Fröjdö S, Sjölind L, Parkkonen M, Mäkinen VP, Kilpikari R, Pettersson-Fernholm K, Forsblom C, Fagerudd J, Tikellis C, Cooper ME, Wessman M, Groop PH; FinnDiane Study Group.

Diabetologia. 2005 Nov;48(11):2278-81. Epub 2005 Oct 7.


Role of the renin-angiotensin system in the endocrine pancreas: implications for the development of diabetes.

Tikellis C, Cooper ME, Thomas MC.

Int J Biochem Cell Biol. 2006;38(5-6):737-51. Epub 2005 Sep 12. Review.


Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2.

Paizis G, Tikellis C, Cooper ME, Schembri JM, Lew RA, Smith AI, Shaw T, Warner FJ, Zuilli A, Burrell LM, Angus PW.

Gut. 2005 Dec;54(12):1790-6. Epub 2005 Sep 15.

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