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Items: 1 to 50 of 60

1.

Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner.

Zelensky AN, Schoonakker M, Brandsma I, Tijsterman M, van Gent DC, Essers J, Kanaar R.

PLoS Genet. 2020 Jan 16;16(1):e1008550. doi: 10.1371/journal.pgen.1008550. eCollection 2020 Jan.

2.

Prevalence of Pulmonary Bullae and Blebs in Postmortem CT Imaging With Potential Implications for Diving Medicine.

de Bakker HM, Tijsterman M, de Bakker-Teunissen OJG, Soerdjbalie-Maikoe V, van Hulst RA, de Bakker BS.

Chest. 2019 Nov 22. pii: S0012-3692(19)34226-6. doi: 10.1016/j.chest.2019.11.008. [Epub ahead of print]

PMID:
31759963
3.

Templated Insertions: A Smoking Gun for Polymerase Theta-Mediated End Joining.

Schimmel J, van Schendel R, den Dunnen JT, Tijsterman M.

Trends Genet. 2019 Sep;35(9):632-644. doi: 10.1016/j.tig.2019.06.001. Epub 2019 Jul 8. Review.

PMID:
31296341
4.

Postmortem radiological case series of acetabular fractures after fatal aviation accidents.

de Bakker HM, Tijsterman M, Kubat B, Soerdjbalie-Maikoe V, van Rijn RR, de Bakker BS.

Forensic Sci Med Pathol. 2018 Mar;14(1):62-69. doi: 10.1007/s12024-018-9946-1. Epub 2018 Feb 5.

5.

Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells.

Schimmel J, Kool H, van Schendel R, Tijsterman M.

EMBO J. 2017 Dec 15;36(24):3634-3649. doi: 10.15252/embj.201796948. Epub 2017 Oct 27.

6.

Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA.

Zelensky AN, Schimmel J, Kool H, Kanaar R, Tijsterman M.

Nat Commun. 2017 Jul 7;8(1):66. doi: 10.1038/s41467-017-00124-3.

7.

Combined loss of three DNA damage response pathways renders C. elegans intolerant to light.

van Bostelen I, Tijsterman M.

DNA Repair (Amst). 2017 Jun;54:55-62. doi: 10.1016/j.dnarep.2017.04.002. Epub 2017 Apr 14.

PMID:
28472716
8.

T-DNA integration in plants results from polymerase-θ-mediated DNA repair.

van Kregten M, de Pater S, Romeijn R, van Schendel R, Hooykaas PJ, Tijsterman M.

Nat Plants. 2016 Oct 31;2(11):16164. doi: 10.1038/nplants.2016.164.

PMID:
27797358
9.

Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability.

Zeller P, Padeken J, van Schendel R, Kalck V, Tijsterman M, Gasser SM.

Nat Genet. 2016 Nov;48(11):1385-1395. doi: 10.1038/ng.3672. Epub 2016 Sep 26.

PMID:
27668659
10.

Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining.

van Schendel R, van Heteren J, Welten R, Tijsterman M.

PLoS Genet. 2016 Oct 18;12(10):e1006368. doi: 10.1371/journal.pgen.1006368. eCollection 2016 Oct.

11.

Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers.

Lemmens B, van Schendel R, Tijsterman M.

Nat Commun. 2015 Nov 13;6:8909. doi: 10.1038/ncomms9909.

12.

Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis.

van Schendel R, Roerink SF, Portegijs V, van den Heuvel S, Tijsterman M.

Nat Commun. 2015 Jun 16;6:7394. doi: 10.1038/ncomms8394.

13.

FANCJ promotes DNA synthesis through G-quadruplex structures.

Castillo Bosch P, Segura-Bayona S, Koole W, van Heteren JT, Dewar JM, Tijsterman M, Knipscheer P.

EMBO J. 2014 Nov 3;33(21):2521-33. doi: 10.15252/embj.201488663. Epub 2014 Sep 5.

14.

The repair of G-quadruplex-induced DNA damage.

van Kregten M, Tijsterman M.

Exp Cell Res. 2014 Nov 15;329(1):178-83. doi: 10.1016/j.yexcr.2014.08.038. Epub 2014 Sep 1. Review.

PMID:
25193076
15.

Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans.

Roerink SF, van Schendel R, Tijsterman M.

Genome Res. 2014 Jun;24(6):954-62. doi: 10.1101/gr.170431.113. Epub 2014 Mar 10.

16.

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites.

Koole W, van Schendel R, Karambelas AE, van Heteren JT, Okihara KL, Tijsterman M.

Nat Commun. 2014;5:3216. doi: 10.1038/ncomms4216.

PMID:
24496117
17.

Mosaic analysis and tumor induction in zebrafish by microsatellite instability-mediated stochastic gene expression.

Koole W, Tijsterman M.

Dis Model Mech. 2014 Jul;7(7):929-36. doi: 10.1242/dmm.014365. Epub 2014 Jan 30.

18.

Genomes and G-quadruplexes: for better or for worse.

Tarsounas M, Tijsterman M.

J Mol Biol. 2013 Nov 29;425(23):4782-9. doi: 10.1016/j.jmb.2013.09.026. Epub 2013 Sep 25. Review.

PMID:
24076189
19.

CRISPR/Cas9-targeted mutagenesis in Caenorhabditis elegans.

Waaijers S, Portegijs V, Kerver J, Lemmens BB, Tijsterman M, van den Heuvel S, Boxem M.

Genetics. 2013 Nov;195(3):1187-91. doi: 10.1534/genetics.113.156299. Epub 2013 Aug 26.

20.

A versatile microsatellite instability reporter system in human cells.

Koole W, Schäfer HS, Agami R, van Haaften G, Tijsterman M.

Nucleic Acids Res. 2013 Sep;41(16):e158. doi: 10.1093/nar/gkt615. Epub 2013 Jul 16.

21.

Microhomology-mediated intron loss during metazoan evolution.

van Schendel R, Tijsterman M.

Genome Biol Evol. 2013;5(6):1212-9. doi: 10.1093/gbe/evt088.

22.

A role for the malignant brain tumour (MBT) domain protein LIN-61 in DNA double-strand break repair by homologous recombination.

Johnson NM, Lemmens BB, Tijsterman M.

PLoS Genet. 2013;9(3):e1003339. doi: 10.1371/journal.pgen.1003339. Epub 2013 Mar 7.

23.

COM-1 promotes homologous recombination during Caenorhabditis elegans meiosis by antagonizing Ku-mediated non-homologous end joining.

Lemmens BB, Johnson NM, Tijsterman M.

PLoS Genet. 2013;9(2):e1003276. doi: 10.1371/journal.pgen.1003276. Epub 2013 Feb 7.

24.

A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis.

Roerink SF, Koole W, Stapel LC, Romeijn RJ, Tijsterman M.

PLoS Genet. 2012 Jun;8(6):e1002800. doi: 10.1371/journal.pgen.1002800. Epub 2012 Jun 28.

25.

DNA double-strand break repair in Caenorhabditis elegans.

Lemmens BB, Tijsterman M.

Chromosoma. 2011 Feb;120(1):1-21. doi: 10.1007/s00412-010-0296-3. Epub 2010 Nov 5. Review. Erratum in: Chromosoma. 2011 Jun;120(3):321.

26.

Isolation of deletion alleles by G4 DNA-induced mutagenesis.

Pontier DB, Kruisselbrink E, Guryev V, Tijsterman M.

Nat Methods. 2009 Sep;6(9):655-7. doi: 10.1038/nmeth.1362. Epub 2009 Aug 16.

PMID:
19684597
27.

A robust network of double-strand break repair pathways governs genome integrity during C. elegans development.

Pontier DB, Tijsterman M.

Curr Biol. 2009 Aug 25;19(16):1384-8. doi: 10.1016/j.cub.2009.06.045. Epub 2009 Jul 30.

28.

Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans.

Kruisselbrink E, Guryev V, Brouwer K, Pontier DB, Cuppen E, Tijsterman M.

Curr Biol. 2008 Jun 24;18(12):900-5. doi: 10.1016/j.cub.2008.05.013. Epub 2008 Jun 5.

29.

RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.

Frische EW, Pellis-van Berkel W, van Haaften G, Cuppen E, Plasterk RH, Tijsterman M, Bos JL, Zwartkruis FJ.

EMBO J. 2007 Dec 12;26(24):5083-92. Epub 2007 Nov 8.

30.

The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2alpha.

Gort EH, van Haaften G, Verlaan I, Groot AJ, Plasterk RH, Shvarts A, Suijkerbuijk KP, van Laar T, van der Wall E, Raman V, van Diest PJ, Tijsterman M, Vooijs M.

Oncogene. 2008 Mar 6;27(11):1501-10. Epub 2007 Sep 17.

PMID:
17873906
31.

A Caenorhabditis elegans wild type defies the temperature-size rule owing to a single nucleotide polymorphism in tra-3.

Kammenga JE, Doroszuk A, Riksen JA, Hazendonk E, Spiridon L, Petrescu AJ, Tijsterman M, Plasterk RH, Bakker J.

PLoS Genet. 2007 Mar 2;3(3):e34. Epub 2007 Jan 9.

32.

Mapping determinants of gene expression plasticity by genetical genomics in C. elegans.

Li Y, Alvarez OA, Gutteling EW, Tijsterman M, Fu J, Riksen JA, Hazendonk E, Prins P, Plasterk RH, Jansen RC, Breitling R, Kammenga JE.

PLoS Genet. 2006 Dec 29;2(12):e222. Epub 2006 Nov 13.

33.

Gene expression: long-term gene silencing by RNAi.

Vastenhouw NL, Brunschwig K, Okihara KL, Müller F, Tijsterman M, Plasterk RH.

Nature. 2006 Aug 24;442(7105):882.

PMID:
16929289
34.

Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi.

van Haaften G, Romeijn R, Pothof J, Koole W, Mullenders LH, Pastink A, Plasterk RH, Tijsterman M.

Curr Biol. 2006 Jul 11;16(13):1344-50.

35.

Isolation of RNA from C. elegans.

Ketting RF, Tijsterman M, Plasterk RH.

CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4321. doi: 10.1101/pdb.prot4321. No abstract available.

PMID:
22485697
36.

Detection of si/miRNA in C. elegans by Northern Blot.

Ketting RF, Tijsterman M, Plasterk RH.

CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4320. doi: 10.1101/pdb.prot4320. No abstract available.

PMID:
22485696
37.

Detection of siRNA in C. elegans Using RNase Protection.

Ketting RF, Tijsterman M, Plasterk RH.

CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4319. doi: 10.1101/pdb.prot4319. No abstract available.

PMID:
22485695
38.

Cosuppression in C. elegans.

Ketting RF, Tijsterman M, Plasterk RH.

CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4318. doi: 10.1101/pdb.prot4318. No abstract available.

PMID:
22485694
39.

Introduction of Double-Stranded RNA in C. elegans by Feeding.

Ketting RF, Tijsterman M, Plasterk RH.

CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4317. doi: 10.1101/pdb.prot4317. No abstract available.

PMID:
22485693
40.

Introduction of Double-Stranded RNA in C. elegans by Soaking.

Ketting RF, Tijsterman M, Plasterk RH.

CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4316. doi: 10.1101/pdb.prot4316. No abstract available.

PMID:
22485692
41.

Introduction of Double-Stranded RNA in C. elegans by Injection.

Ketting RF, Tijsterman M, Plasterk RH.

CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4315. doi: 10.1101/pdb.prot4315. No abstract available.

PMID:
22485691
42.

Genomic instability and cancer: scanning the Caenorhabditis elegans genome for tumor suppressors.

van Haaften G, Plasterk RH, Tijsterman M.

Oncogene. 2004 Nov 1;23(51):8366-75. Review.

PMID:
15517018
43.

Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality.

van Haaften G, Vastenhouw NL, Nollen EA, Plasterk RH, Tijsterman M.

Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12992-6. Epub 2004 Aug 23.

44.

Dicers at RISC; the mechanism of RNAi.

Tijsterman M, Plasterk RH.

Cell. 2004 Apr 2;117(1):1-3. Review.

45.

Genes required for systemic RNA interference in Caenorhabditis elegans.

Tijsterman M, May RC, Simmer F, Okihara KL, Plasterk RH.

Curr Biol. 2004 Jan 20;14(2):111-6.

46.

Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi.

Pothof J, van Haaften G, Thijssen K, Kamath RS, Fraser AG, Ahringer J, Plasterk RH, Tijsterman M.

Genes Dev. 2003 Feb 15;17(4):443-8.

47.

The genetics of RNA silencing.

Tijsterman M, Ketting RF, Plasterk RH.

Annu Rev Genet. 2002;36:489-519. Epub 2002 Jun 11. Review.

PMID:
12429701
48.

PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of C. elegans.

Tijsterman M, Okihara KL, Thijssen K, Plasterk RH.

Curr Biol. 2002 Sep 3;12(17):1535-40.

49.

Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi.

Simmer F, Tijsterman M, Parrish S, Koushika SP, Nonet ML, Fire A, Ahringer J, Plasterk RH.

Curr Biol. 2002 Aug 6;12(15):1317-9.

50.

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