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Items: 1 to 50 of 51

1.

Scopolamine provocation-based pharmacological MRI model for testing procognitive agents.

Hegedűs N, Laszy J, Gyertyán I, Kocsis P, Gajári D, Dávid S, Deli L, Pozsgay Z, Tihanyi K.

J Psychopharmacol. 2015 Apr;29(4):447-55. doi: 10.1177/0269881114565652. Epub 2015 Jan 13.

PMID:
25586394
2.

Estradiol and isotype-selective estrogen receptor agonists modulate the mesocortical dopaminergic system in gonadectomized female rats.

Sárvári M, Deli L, Kocsis P, Márk L, Maász G, Hrabovszky E, Kalló I, Gajári D, Vastagh C, Sümegi B, Tihanyi K, Liposits Z.

Brain Res. 2014 Oct 2;1583:1-11. doi: 10.1016/j.brainres.2014.06.020. Epub 2014 Jun 26.

PMID:
24976584
3.

Ghrelin modulates the fMRI BOLD response of homeostatic and hedonic brain centers regulating energy balance in the rat.

Sárvári M, Kocsis P, Deli L, Gajári D, Dávid S, Pozsgay Z, Hegedűs N, Tihanyi K, Liposits Z.

PLoS One. 2014 May 15;9(5):e97651. doi: 10.1371/journal.pone.0097651. eCollection 2014.

4.

Vascular action as the primary mechanism of cognitive effects of cholinergic, CNS-acting drugs, a rat phMRI BOLD study.

Kocsis P, Gyertyán I, Éles J, Laszy J, Hegedűs N, Gajári D, Deli L, Pozsgay Z, Dávid S, Tihanyi K.

J Cereb Blood Flow Metab. 2014 Jun;34(6):995-1000. doi: 10.1038/jcbfm.2014.47. Epub 2014 Mar 19.

5.

Effect of tolperisone on the resting brain and on evoked responses, an phMRI BOLD study.

Kocsis P, Gajári D, Deli L, Gőcze KZ, Pozsgay Z, Tihanyi K.

Brain Res Bull. 2013 Oct;99:34-40. doi: 10.1016/j.brainresbull.2013.09.008. Epub 2013 Oct 4.

PMID:
24099980
6.

Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood-brain barrier penetration models.

Hellinger E, Veszelka S, Tóth AE, Walter F, Kittel A, Bakk ML, Tihanyi K, Háda V, Nakagawa S, Duy TD, Niwa M, Deli MA, Vastag M.

Eur J Pharm Biopharm. 2012 Oct;82(2):340-51. doi: 10.1016/j.ejpb.2012.07.020. Epub 2012 Aug 11.

PMID:
22906709
7.

Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.

Agai-Csongor E, Domány G, Nógrádi K, Galambos J, Vágó I, Keserű GM, Greiner I, Laszlovszky I, Gere A, Schmidt E, Kiss B, Vastag M, Tihanyi K, Sághy K, Laszy J, Gyertyán I, Zájer-Balázs M, Gémesi L, Kapás M, Szombathelyi Z.

Bioorg Med Chem Lett. 2012 May 15;22(10):3437-40. doi: 10.1016/j.bmcl.2012.03.104. Epub 2012 Apr 4.

PMID:
22537450
8.

Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents.

Gyertyán I, Kiss B, Sághy K, Laszy J, Szabó G, Szabados T, Gémesi LI, Pásztor G, Zájer-Balázs M, Kapás M, Csongor EÁ, Domány G, Tihanyi K, Szombathelyi Z.

Neurochem Int. 2011 Nov;59(6):925-35. doi: 10.1016/j.neuint.2011.07.002. Epub 2011 Jul 13.

PMID:
21767587
9.

Cell-based models of blood-brain barrier penetration.

Vastag M, Hellinger E, Bakk ML, Tihanyi K.

Ther Deliv. 2011 May;2(5):549-53. No abstract available.

PMID:
22833973
10.

Drug penetration model of vinblastine-treated Caco-2 cultures.

Hellinger E, Bakk ML, Pócza P, Tihanyi K, Vastag M.

Eur J Pharm Sci. 2010 Sep 11;41(1):96-106. doi: 10.1016/j.ejps.2010.05.015. Epub 2010 Jun 8.

PMID:
20595016
11.

Estradiol replacement alters expression of genes related to neurotransmission and immune surveillance in the frontal cortex of middle-aged, ovariectomized rats.

Sárvári M, Kalló I, Hrabovszky E, Solymosi N, Tóth K, Likó I, Molnár B, Tihanyi K, Liposits Z.

Endocrinology. 2010 Aug;151(8):3847-62. doi: 10.1210/en.2010-0375. Epub 2010 Jun 9.

PMID:
20534718
12.

Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile.

Kiss B, Horváth A, Némethy Z, Schmidt E, Laszlovszky I, Bugovics G, Fazekas K, Hornok K, Orosz S, Gyertyán I, Agai-Csongor E, Domány G, Tihanyi K, Adham N, Szombathelyi Z.

J Pharmacol Exp Ther. 2010 Apr;333(1):328-40. doi: 10.1124/jpet.109.160432. Epub 2010 Jan 21.

PMID:
20093397
13.

Gene expression profiling identifies key estradiol targets in the frontal cortex of the rat.

Sárvári M, Hrabovszky E, Kalló I, Galamb O, Solymosi N, Likó I, Molnár B, Tihanyi K, Szombathelyi Z, Liposits Z.

Endocrinology. 2010 Mar;151(3):1161-76. doi: 10.1210/en.2009-0911. Epub 2010 Jan 12.

PMID:
20068009
14.

NMR analysis, protonation equilibria and decomposition kinetics of tolperisone.

Orgován G, Tihanyi K, Noszál B.

J Pharm Biomed Anal. 2009 Dec 5;50(5):718-23. doi: 10.1016/j.jpba.2009.05.036. Epub 2009 Jun 6.

PMID:
19577875
15.

Translocator protein (TSPO 18kDa) is expressed by neural stem and neuronal precursor cells.

Varga B, Markó K, Hádinger N, Jelitai M, Demeter K, Tihanyi K, Vas A, Madarász E.

Neurosci Lett. 2009 Oct 25;462(3):257-62. doi: 10.1016/j.neulet.2009.06.051. Epub 2009 Jun 21.

PMID:
19545604
16.

Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model.

Nyakas C, Felszeghy K, Szabó R, Keijser JN, Luiten PG, Szombathelyi Z, Tihanyi K.

CNS Neurosci Ther. 2009 Summer;15(2):89-99. doi: 10.1111/j.1755-5949.2009.00078.x.

PMID:
19492990
17.

Effects of Vinpocetine on mitochondrial function and neuroprotection in primary cortical neurons.

Tárnok K, Kiss E, Luiten PG, Nyakas C, Tihanyi K, Schlett K, Eisel UL.

Neurochem Int. 2008 Dec;53(6-8):289-95. doi: 10.1016/j.neuint.2008.08.003. Epub 2008 Aug 28.

PMID:
18793690
18.

Physico-chemical characterization of a novel group of dopamine D(3)/D(2) receptor ligands, potential atypical antipsychotic agents.

Deák K, Takács-Novák K, Kapás M, Vastag M, Tihanyi K, Noszál B.

J Pharm Biomed Anal. 2008 Nov 4;48(3):678-84. doi: 10.1016/j.jpba.2008.06.021. Epub 2008 Jul 6.

PMID:
18692339
19.

Concerted action of antiepileptic and antidepressant agents to depress spinal neurotransmission: Possible use in the therapy of spasticity and chronic pain.

Thán M, Kocsis P, Tihanyi K, Fodor L, Farkas B, Kovács G, Kis-Varga A, Szombathelyi Z, Tarnawa I.

Neurochem Int. 2007 Mar;50(4):642-52. Epub 2007 Jan 13.

PMID:
17280740
20.

Effects of RGH-237 [N-{4-[4-(3-aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an orally active, selective dopamine D(3) receptor partial agonist in animal models of cocaine abuse.

Gyertyán I, Kiss B, Gál K, Laszlovszky I, Horváth A, Gémesi LI, Sághy K, Pásztor G, Zájer M, Kapás M, Csongor EA, Domány G, Tihanyi K, Szombathelyi Z.

J Pharmacol Exp Ther. 2007 Mar;320(3):1268-78. Epub 2006 Dec 14.

PMID:
17170312
21.

The new 2,3-benzodiazepine derivative EGIS-8332 inhibits AMPA/kainate ion channels and cell death.

Vegh MG, Kovács AD, Kovács G, Szabó G, Tihanyi K, Hársing LG Jr, Lévay G.

Neurochem Int. 2007 Feb;50(3):555-63. Epub 2006 Dec 4.

PMID:
17147974
22.

Physico-chemical profiling of antidepressive sertraline: solubility, ionisation, lipophilicity.

Deák K, Takács-Novák K, Tihanyi K, Noszál B.

Med Chem. 2006 Jul;2(4):385-9.

PMID:
16848750
23.

Insulin in flavin-containing monooxygenase regulation. Flavin-containing monooxygenase and cytochrome P450 activities in experimental diabetes.

Borbás T, Benko B, Dalmadi B, Szabó I, Tihanyi K.

Eur J Pharm Sci. 2006 May;28(1-2):51-8. Epub 2006 Feb 20.

PMID:
16488120
24.

[11C]vinpocetine: a prospective peripheral benzodiazepine receptor ligand for primate PET studies.

Gulyás B, Halldin C, Vas A, Banati RB, Shchukin E, Finnema S, Tarkainen J, Tihanyi K, Szilágyi G, Farde L.

J Neurol Sci. 2005 Mar 15;229-230:219-23. Epub 2004 Dec 16.

PMID:
15760643
25.

Assessment of the N-oxidation of deprenyl, methamphetamine, and amphetamine enantiomers by chiral capillary electrophoresis: an in vitro metabolism study.

Szöko E, Tábi T, Borbás T, Dalmadi B, Tihanyi K, Magyar K.

Electrophoresis. 2004 Aug;25(16):2866-75.

PMID:
15352021
26.

Effects of EGIS-7625, a selective and competitive 5-HT2B receptor antagonist.

Kovács A, Gacsályi I, Wellmann J, Schmidt E, Szücs Z, Dubreuil V, Nicolas JP, Boutin J, Bózsing D, Egyed A, Tihanyi K, Spedding M, Szénási G.

Cardiovasc Drugs Ther. 2003 Sep-Nov;17(5-6):427-34.

PMID:
15107597
27.

Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes.

Dalmadi B, Leibinger J, Szeberényi S, Borbás T, Farkas S, Szombathelyi Z, Tihanyi K.

Drug Metab Dispos. 2003 May;31(5):631-6.

PMID:
12695352
28.

Synthesis and evaluation of 5-HT(2A) and 5-HT(2C) receptor binding affinities of novel pyrimidine derivatives.

Bózsing D, Simonek I, Simig G, Jakóczi I, Gacsályi I, Lévay G, Tihanyi K, Schmidt E.

Bioorg Med Chem Lett. 2002 Nov 4;12(21):3097-9.

PMID:
12372510
29.

Adenovirus type 2 endoprotease: isoforms and redox effects.

Keyvani-Amineh H, Diouri M, Tihanyi K, Weber JM.

J Gen Virol. 1996 Sep;77 ( Pt 9):2201-7.

PMID:
8811020
30.

Tissue concentrations and correlations of prostaglandins in healthy and inflamed human esophageal and jejunal mucosa.

Tihanyi K, Rózsa I, Banai J, Dobó I, Bajtai A.

J Gastroenterol. 1996 Apr;31(2):149-52.

PMID:
8680531
31.

Identification of active-site residues of the adenovirus endopeptidase.

Rancourt C, Tihanyi K, Bourbonniere M, Weber JM.

Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):844-7.

32.

Adenovirus endopeptidases.

Weber JM, Tihanyi K.

Methods Enzymol. 1994;244:595-604. No abstract available.

PMID:
7845235
33.

Isolation and properties of adenovirus type 2 proteinase.

Tihanyi K, Bourbonnière M, Houde A, Rancourt C, Weber JM.

J Biol Chem. 1993 Jan 25;268(3):1780-5.

34.

Gene regulation during anaerobiosis in soya roots.

Tihanyi K, Fontanell A, Thirion JP.

Biochem Genet. 1989 Dec;27(11-12):719-30.

PMID:
2627197
35.

Soybean L-(+)-lactate dehydrogenases: purification, characterization, and resolution of subunit structure.

Tihanyi K, Fontanell A, Talbot B, Thirion JP.

Arch Biochem Biophys. 1989 Nov 1;274(2):626-32.

PMID:
2802633
36.

[Prostaglandin content of the gastrointestinal mucosa after partial gastrectomy of peptic ulcer].

Dobó I, Tihanyi K, Banai J, Szántó I, Rózsa I.

Orv Hetil. 1988 Nov 13;129(46):2469-70, 7475-6. Hungarian. No abstract available.

PMID:
3194134
37.

Mucosal prostaglandin levels of the gastric stump.

Dobó I, Tihanyi K, Banai J, Szántó I, Rózsa I.

Gastroenterol Jpn. 1988 Oct;23(5):514-20.

PMID:
3063581
38.
39.

Release of prostacyclin (PGI2) from trophoblast in tissue culture: the effect of glucose concentration.

Rákóczi I, Tihanyi K, Gerö G, Cseh I, Rózsa I, Gáti I.

Acta Physiol Hung. 1988;71(4):545-9.

PMID:
3061279
40.

Trequinsin analogues as modulators of the thrombin-mediated reactions in haemostasis.

Blaskó G, Tihanyi K, Blaskó G, Major E, Szántay C.

Thromb Res. 1986 Jul 15;43(2):249-50. No abstract available.

PMID:
3526628
41.

In vitro and ex vivo effect of cimetidine on human platelet aggregation.

Gachályi B, Tihanyi K, Vas A, Nádas B, Káldor A.

Thromb Res. 1986 Apr 1;42(1):113-4. No abstract available.

PMID:
3705022
42.

Correlation between the sensitivity of platelets to ADP and PGI2 in normal and diabetic pregnancies.

Gerö G, Rákóczi I, Tihanyi K, Blaskó G, Oláh J, Sas G.

Thromb Res. 1985 Sep 15;39(6):781-2. No abstract available.

PMID:
3909505
43.

Platelet sensitivity to adenosine diphosphate and to prostacyclin in diabetic pregnancies.

Gerö G, Rákóczi I, Tihanyi K, Oláh J, Demeter J, Gáti I.

Haemostasis. 1985;15(6):377-83.

PMID:
3908235
44.

Effect of acetylsalicylic acid on prostacyclin production in trophoblast.

Rákóczi I, Tihanyi K, Demeter J, Gáti I.

Acta Physiol Hung. 1985;65(3):379-82.

PMID:
3893039
45.

Prostacyclin content of jejunal mucosa in non-operated patients and after Billroth II gastrectomy.

Banai J, Rózsa I, Tihanyi K, Szántó I.

Prostaglandins Leukot Med. 1984 Nov;16(2):253-4. No abstract available.

PMID:
6396654
46.

In vitro effect of cimetidine on ADP induced platelet aggregation and thromboxane A2 synthesis in man.

Gachályi B, Tihanyi K, Vas A, Káldor A.

Thromb Res. 1984 Jul 1;35(1):105-9. No abstract available.

PMID:
6474407
47.

Mitochondrial substrate oxidation-dependent protection against lipid peroxidation.

Mészáros L, Tihanyi K, Horváth I.

Biochim Biophys Acta. 1982 Dec 13;713(3):675-7.

PMID:
7150635
48.

Inhibition of microsomal drug metabolism by mitochondria and cytochrome c oxidation of extramitochondrial NADPH.

Tihanyi K, Mészáros K, Horváth I.

Biochem Pharmacol. 1982 Mar 1;31(5):661-3.

PMID:
6282273
49.

Prostacyclin content of gastric and duodenal biopsies.

Rózsa I, Banai J, Tihanyi K, Rákóczi I, Kun M.

Gastroenterol Jpn. 1982;17(1):1-3. No abstract available.

PMID:
7042448
50.

Effect of succinate on aminopyrine N-demethylase activity.

Tihanyi K, Váradi G, Horváth I.

Biochim Biophys Acta. 1980 Jun 19;630(2):187-92.

PMID:
7388048

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